scholarly journals Cancer frequency: Kars province

2019 ◽  
Vol 7 (4) ◽  
pp. 1067
Author(s):  
Yasemen Adalı ◽  
Bülent Güvendi ◽  
Hatice Beşeren ◽  
Tuğba Toyran ◽  
Gülname Fındık Güvendi
Keyword(s):  
Malignant Tumors ◽  
Preventive Health Services ◽  
Geographical Location ◽  
Mortality And Morbidity ◽  
Cancer Statistics ◽  
Treatment Services ◽  
Etiologic Agents ◽  
The World ◽  
Causes Of Mortality ◽  
The Mean

Background: Malignant tumors are important causes of mortality and morbidity in the world. It is known that the incidence of tumors- in which a large number of etiologic agents are identified and continued to be investigated- varies according to age, gender and geographical location. This study aimed to determine the prevalence and localization distributions of malignant tumors in Kars.Methods: The study included 17012 patients whose biopsy materials were evaluated in the Department of Pathology of Kafkas University Health Research and Practice Hospital between 2014-2017.Results: The mean age of all cancer cases was 63.3±14.8 and the median age was 63. The cancer frequency was detected 22.6% in 2014, 23.3% in 2015, 26.9% in 2016 and 27.2% in 2017 with general slight male dominance.Conclusions: The incidence of cancer in our country is found to be lower compared to the world data. It is necessary to examine and take into account the regional and city-based cancer statistics that serve as an important key stone in the planning of health policies and health investments in our country. Regional data is not only important for treatment services, but also for preventive health services and early diagnosis.

scholarly journals Low level of stroke care awareness among stroke patients’ caregivers: an important but neglected area of stroke care

2014 ◽  
Vol 9 (3) ◽  
pp. 1-11
Author(s):  
N Sharma ◽  
M Sharma ◽  
M Lopchan ◽  
L Thapa ◽  
PVS Rana
Keyword(s):  
Knowledge Score ◽  
Stroke Care ◽  
Validity And Reliability ◽  
Medical Sciences ◽  
Stroke Patients ◽  
Mortality And Morbidity ◽  
Low Level ◽  
Causes Of Mortality ◽  
The Mean ◽  
Stroke Knowledge

Objective Stroke is one of the leading causes of mortality and morbidity worldwide. Stroke patients require longterm care for better outcome. Most often family members are the back bone of the service provided to people affected by stroke. Stroke patients and their caregivers are known to have large gaps in stroke knowledge and have suboptimal personal health behaviors, thereby putting the patient at high risk for complications. Our study was designed to explore the stroke care awareness among stroke patients' caregivers.Methods 50 stroke caregivers aged >18 years from neurology ward of College of Medical Sciences-Teaching Hospital were selected by non-probability purposive sampling from June 2012 to July 2012. Questionnaire focusing basic stroke care was prepared by researchers with the help of literature and a neurophysician. Validity and reliability of the tools were tested and data collected. Analysis of collected data was done using SPSS 16.0.Results The mean age of the respondents was 40 years (range: 20-80 years). Thirty-nine (78%) were either spouse or children. Thirty-eight (76%) caregivers were literate. Overall, 27 (54%) caregivers had low level of awareness regarding stroke care and mean knowledge score was 23.7.Conclusion This study has revealed the existence of low level of stroke care awareness amongst stroke caregivers. Interventional education program oriented to address this important yet neglected area can improve the stroke care in countries like Nepal where recent advancement for stroke management is lacking.  Journal of College of Medical Sciences-Nepal, 2013, Vol-9, No-3, 1-8 

scholarly journals Survival of Post-Transplant Lymphoproliferative Disorder after Kidney Transplantation in Patients under Rapamycin Treatment

2021 ◽  
Author(s):  
Farzaneh Ashrafi ◽  
Shahrzad Shahidi ◽  
Valiollah Mehrzad ◽  
Mojgan Mortazavi ◽  
Sayyideh Forough Hosseini
Keyword(s):  
Calcineurin Inhibitors ◽  
B Cell Lymphoma ◽  
Complete Response ◽  
Immunosuppressive Drugs ◽  
Lymphoproliferative Disease ◽  
Mortality And Morbidity ◽  
Post Transplant ◽  
Causes Of Mortality ◽  
The Mean ◽  
Transplanted Kidneys

Background: One of the important causes of mortality and morbidity in kidney transplanted patients is Post Transplant Lymphoproliferative Disease (PTLD), which is due to immunosuppression therapy and viral activity. It seems that Rapamycin, with dual antineoplastic and immunosuppressive effects, may have a pivotal role in the treatment of PTLD patients and preserving transplanted kidneys. Methods and Materials: Twenty patients with PTLD were enrolled.  Immunosuppressive therapy was reduced or ceased, and Rapamycin was initiated at the time of PTLD diagnosis. We evaluated the effects of switching immunosuppressive drugs to Rapamycin on graft status, the response of tumor, and 6, 12 months, and 5-year survival in patients. Results: PTLD remission was achieved in 14 patients, while six patients died; no relapse was detected in recovered patients. The median of PTLD free time was 25 months, and the mean overall survival in patients with PTLD treated by Rapamycin was 84.8 (95% CI=61.3-108.23).The five-year survival rate was 67%, 12 months survival was 73.8%, and six months' survival was 80%. The response rate to Rapamycin and immunosuppression reduction alone was 46.6%. Four out of 13 Diffuse Large B-Cell Lymphoma patients achieved a complete response just only after the reduction of immunosuppressive drugs and the consumption of Rapamycin. Conclusion: The present study demonstrated the effectiveness of conversion from immunosuppressive medication, particularly of Calcineurin inhibitors to Rapamycin in PTLD patients. However, more research is needed to confirm the Rapamycin effect on patients with PTLD.  

scholarly journals MiR-122-5p suppresses the proliferation, migration, and invasion of gastric cancer cells by targeting LYN

2019 ◽  
Vol 52 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Lei Meng ◽  
Zhangming Chen ◽  
Zhe Jiang ◽  
Ting Huang ◽  
Jie Hu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Biological Function ◽  
Malignant Tumors ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Gastric Cancer Cells ◽  
Mortality And Morbidity ◽  
Qrt Pcr ◽  
The World ◽  
Direct Target

Abstract Gastric cancer (GC) is one of malignant tumors with high mortality and morbidity in the world. MicroRNA-122 (miR-122) acts as a tumor suppressor in a variety of cancers and has been found to be dominant in gastric adenocarcinoma. However, the specific biological function of miR-122-5p in GC is not completely clear. In this study, we found that miR-122-5p was low-expressed in GC tissues and cell lines by using qRT-PCR. Overexpression of miR-122-5p inhibited the proliferation, migration, and invasion of GC cells by using CCK-8 and transwell assays. On the contrary, downregulation of miR-122-5p promoted the proliferation, migration, and invasion of GC cells. In addition, we found that the expression of LYN, an Src family tyrosine kinase, was inversely correlated with miR-122-5p expression in GC tissues by using western blot analysis, immunohistochemistry, and qRT-PCR assays. Meanwhile, luciferase assay results indicated that LYN is a direct target of miR-122-5p in GC cells. Moreover, silencing LYN expression by its siRNA inhibited the proliferation, migration, and invasion of GC cells. Importantly, overexpression of LYN restored miR-122-5p-mediated inhibition of the proliferation, migration, and invasion of GC cells. Taken together, our results indicated miR-122-5p inhibited the proliferation, migration, and invasion by targeting LYN in GC.

scholarly journals The treatment of viral hepatitis: a review

2000 ◽  
Vol 3 (8) ◽  
pp. 258-260
Author(s):  
HJ Tan
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Hepatitis A ◽  
Remission Rate ◽  
Spontaneous Remission ◽  
Hepatitis B Infection ◽  
Mortality And Morbidity ◽  
The World ◽  
Causes Of Mortality ◽  
Viral Hepatitis A

Hepatitis B infection (HBV) affects 300 million people in the world, most of whom (75%) are Asian. It is one of the major causes of mortality and morbidity. The spontaneous remission rate for untreated HBV infection is approximately 80%, but the likelihood of chronic hepatitis approaches 90% if patients are infected early in life.

scholarly journals To Study the causes of Industrial Sickness in Nanded District (Maharashtra)

2017 ◽  
Vol 4 (37) ◽  
Author(s):  
Balaji S. Mudholkar
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Recent Decade ◽  
Reticuloendothelial System ◽  
Malignant Neoplasms ◽  
Mortality And Morbidity ◽  
Tissue Invasion ◽  
The World ◽  
Causes Of Mortality ◽  
Nanoparticulate Systems

Cancer, an uncontrollable growth of cells, is among the leading causes of mortality and morbidity throughout the world. Malignant neoplasms are difficult to treat diseases because of their single in kind characteristics such as tissue invasion, metastasis, evading reticuloendothelial system (RES) and so forth. In recent decade polymeric nanoparticulate systems has gained special attention in drug delivery and targeting among all biocompatible nanoforms. Among these systems, chitosan-based hydrogel nanoparticles have been wildly utilized for drug delivery purposes. The usage of chitosan nanogels in cancer therapy significantly improved in recent years. The various cancers were the target of chitosan nanogels. Also, modification of other delivery systems with chitosan were much reported. The aim of this study is the review and update of the recent studies on chitosan nanogels applications in cancer therapy by focus on cancer based classification.

Combining the basically embryological, histological and anatomical structure of coronary arteries with the clinic

2021 ◽  
pp. 58-62
Keyword(s):  
Coronary Artery ◽  
Coronary Angiography ◽  
Coronary Arteries ◽  
Anatomical Structure ◽  
Coronary Artery Diseases ◽  
Anatomical Structures ◽  
Mortality And Morbidity ◽  
Clinical Events ◽  
The World ◽  
Causes Of Mortality

Coronary artery diseases and related clinical events are the most important causes of mortality and morbidity in the world. The diagnosis of coronary artery diseases is possible by knowing the coronary artery anatomy, embryology and histology. However, in terms of terms, anatomical names of coronary arteries differ clinically. In this article, anatomical structures on coronary angiography are presented with combining clinical terms.

scholarly journals Prevalence and associated risk factors of prehypertension and hypertension among army personnel

2018 ◽  
Vol 18 (17) ◽  
pp. 113-120
Author(s):  
Sapana Gurung ◽  
Padma Rai
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Descriptive Study ◽  
Common Disease ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
The World ◽  
Causes Of Mortality ◽  
Associated Risk Factors ◽  
Army Personnel

Hypertension (HTN) is most likely a common disease in the world. In every 3 adult ages over 20 years have this disease. As a consequence, Non-communicable diseases (NCDs), such as hypertension and other cardiovascular diseases are becoming increasingly important as causes of mortality and morbidity in all developing countries. The aim of this study is to determine the prevalence of pre-hypertension and hypertension among the Army personnel in Nepal. This was a cross-sectional descriptive study of 315 respondents, who met eligible criteria. All respondents were enumerated by census method using self-interviewing questionnaire focusing measurement of the blood pressure, weight and height along with the demographic and other socio-economic as well as cultural characteristics. The study shows that overwhelming respondents (77.5%) are normal. And about 13 percent respondents are seemed to be in the pre-hypertension, followed by stage I HTN (6%) and stage II HTN (3.5%). It also shows that there is a significant association between prevalence of hypertension and body mass index of the respondents.

scholarly journals Analysis of Biological Samples Necroscopic Reports from the Death Verification Service of the State of Tocantins, Brazil

2020 ◽  
pp. 1-13
Author(s):  
Arthur Alves Borges de Carvalho ◽  
Edson Garcia Soares ◽  
Layla Rabelo Costa ◽  
Leonardo Pedro Dorneles Silva ◽  
Mateus Vieira Gama ◽  
...  
Keyword(s):  
Biological Samples ◽  
Histopathological Examination ◽  
The State ◽  
Cross Sectional ◽  
Tissue Samples ◽  
Mortality And Morbidity ◽  
Causes Of Mortality ◽  
The Mean ◽  
Histopathological Results ◽  
The Relationship

Analyze, in the necroscopic reports of the Death Verification Service of the State of Tocantins (SVO-TO), the records of biological samples collected for histopathological examination and records of autolysis in histopathological results and correlate them with records of causes of mortality and morbidity. Cross-sectional observational analytical study conducted in 494 autopsy reports completed and filed in SVO-TO, Brazil, between 2012 and 2016. Records of the number of biological samples collected for histopathology, number of autolysis, number of causes of mortality and number of causes of morbidity were extracted and identified. For the analysis of the relationship between the variables, descriptive and analytical statistics were used in SAS SYSTEM software. The mean number of mortality records was 5.72 ± 2.42 (CV 42.32%), causes of morbidity: 0.2 ± 0.5 (CV 251.46%), number of biological samples collected: 2.66 ± 1.13 (CV 42.59%), number of autolysis: 1.74 ± 1.05 (CV 60.06%). The number of mortality and morbidity diagnoses recorded in SVO reports increases the higher the number of samples collected by necropsies physicians. The number of biological samples collected by necropsy positively impacts the number of causes of mortality and morbidity. Collecting more than seven tissue samples by necropsy does not impact the number of causes of mortality and morbidity. The low numbers of autolysis records suggest efficacy in the collection of biological samples in SVO-TO.

Perbedaan Pengetahuan Siswa Tentang Penyakit Hepatitis A Sebelum Dan Sesudah Penyuluhan Di MTsN 02 Bondowoso Tahun 2015

2017 ◽  
Vol 4 (2) ◽  
pp. 14
Author(s):  
Putri Megasari
Keyword(s):  
Hepatitis A ◽  
Hepatitis Virus ◽  
Sampling Technique ◽  
Mean Value ◽  
Test Design ◽  
The World ◽  
Before And After ◽  
Post Test ◽  
The Mean ◽  
Paired T Test

Hepatitis has become a health problem in the world. The hepatitis virus infected many people. According to the teacher of MTsN 02 Bondowoso more than 20 students have hepatitis A viral infection. The purpose of this research was to know the differences of students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study used pre-experimental (pre-post test design). This study used stratified random sampling technique, 127 students from 270 sample involved this research,and 143 students was excluded. We used questionnaires to collect data. The results showed that the mean value of the students 'knowledge about hepatitis A before counseling in MTsN 02 Bondowoso 2015 was 83.96 with the lowest value of 37.5 and the highest value was 100. The mean value of the students' knowledge about hepatitis A after counseling in MTsN 02 Bondowoso 2015 was 93.21 with the lowest value waf 62.5 and the highest value was 100. Paired t test showed that t (-9.07) > t table (1.98), the null hypothesis (H0) was rejected. There was a difference between students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study showed that routine counseling by healthcare provider was important to prevent hepatitis A infection.; Keywords: counseling, knowledge of students, hepatitis

Hybrid Endovascular Repair of Thoracoabdominal Aorta: Early Results

2014 ◽  
Vol 17 (3) ◽  
pp. 146
Author(s):  
Osman Tansel Darcin ◽  
Mehmet Kalender ◽  
Ayse Gul Kunt ◽  
Okay Guven Karaca ◽  
Ata Niyazi Ecevit ◽  
...  
Keyword(s):  
Endovascular Repair ◽  
Therapeutic Option ◽  
Complete Recovery ◽  
Aortic Aneurysms ◽  
Thoracoabdominal Aorta ◽  
Mortality And Morbidity ◽  
Early Results ◽  
The Mean ◽  
Procedural Success

<p><b>Background:</b> Thoracoabdominal aortic aneurysms (TAAA) present a significant clinical challenge, as they are complex and require invasive surgery. In an attempt to prevent considerably high mortality and morbidity in open repair, hybrid endovascular repair has been developed by many authors. In this study, we evaluated the early-term results obtained from this procedure.</p><p><b>Methods:</b> From November 2010 to February 2013, we performed thoracoabdominal hybrid aortic repair in 18 patients. The mean age was 68 years (12 men, 6 women). All of the patients had significant comorbidities. Follow-up computed tomography (CT) scans were performed at 1 week, 3 months, 6 months, and annually thereafter.</p><p><b>Results:</b> All patients were operated on in a staged procedure and stent graft deployment was achieved. Procedural success was achieved in all cases. All patients were discharged with complete recovery. No endoleaks weres detected in further CT examination.</p><p><b>Conclusion:</b> Our results suggests that hybrid debranching and endovascular repair of extensive thoracoabdominal aneurysms represents a suitable therapeutic option to reduce the morbidity and mortality of TAAA repair, particularly in those typically considered at high risk for standard repair.</p>

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