scholarly journals Levels of serum lithium in manic depressive patients with mild persistent bronchial asthma

2020 ◽  
Vol 8 (3) ◽  
pp. 1034
Author(s):  
Subhramay Chatterjee ◽  
Sandip Chakraborti
Keyword(s):  
Signal Transduction ◽  
Bronchial Asthma ◽  
Contractile Response ◽  
Treatment Monitoring ◽  
Manic Depressive ◽  
Group A ◽  
Cell Signal Transduction ◽  
Group B ◽  
Depressive Patients ◽  
Persistent Bronchial Asthma

Background: Lithium, widely used in manic depressive (MD) patients, might protect the airways against constrictor stimuli in bronchial asthma (BA), through its effects on cell signal transduction and ion transport pathways.Methods: Serum lithium levels were studied in MD patients with better controlled mild persistent BA (group A) and MD patients with not so well controlled BA (group B).Results: Serum lithium levels were highly significantly more in group A compared to lithium levels in group B.Conclusions: Lithium may inhibit the contractile response of airway smooth muscle and can be used in treatment / monitoring of BA.

scholarly journals THE EFFECT OF MAGNETO-LASER THERAPY ON THE PHENOTYPE OF BASOPHILS IN CHILDREN WITH ATOPIC ASTHMA

2019 ◽  
Vol 29 (2) ◽  
pp. 35-38
Author(s):  
Elena Asiryn ◽  
Pavel Novikov ◽  
Volha Matsiushchanka ◽  
Nadiezhda Titova ◽  
Lukas Vaidelys ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Bronchial Asthma ◽  
Inhaled Corticosteroids ◽  
Atopic Asthma ◽  
Relative Level ◽  
Atopic Bronchial Asthma ◽  
Significant Difference ◽  
Group A ◽  
The Absolute ◽  
Group B

In recent years there has been growing evidence to suggest a major role of basophils alongside eosinophils and mast cells in allergic inflammation. The aim of this study was to analyze the dynamics of the basophil phenotypes after the use of magneto-la-ser therapy in children with atopic bronchial asthma. Materials and methods. A total of 66 children with mild persistent atopic bronchial asthma (aged 6 to 18 years old) were examined. Group A included 34 children who received magneto-laser therapy together with basic asthma treatment (low dose of inhaled corticosteroids). Group B included 32 children who received only basic asthma therapy. The level of CD203с + , CD203с + CD63 + , CD203с + IgE + basophils was determined in peripheral blood in the beginning of the study, after 2 weeks and after 3 months. Results. A statistically significant decrease in the absolute levels of CD203с+CD63+ and CD203с + IgE + basophils and in the relative level of CD203с + IgE + among all CD203с + basophils was determined in group A after magneto-laser therapy. The comparison of group A and group B indices revealed a significant difference between the relative level of CD203с + IgE + basophils after 12-15 days from the beginning of the study. This indicator was significantly lower in group A than in group B (p<0.05). The absolute level of CD203с + IgE + basophils was significantly lower in group A in comparison with group B after 82-90 days (p<0.05). Conclusions. Magneto-laser therapy can change the phenotype of basophils in children with atopic bronchial asthma, causing suppression of proallergic pa-rameters. Considering these results there is reason to believe, that it is possible to use this method as an additional immunocorrective treatment in patients with basophilic phenotype of atopic asthma.

scholarly journals Association of Nasal Polyposis with Bronchial Asthma

2020 ◽  
Vol 23 (1) ◽  
pp. 11-18
Author(s):  
Md Anamul Haque ◽  
Md Kamrul Hasan Tarafder ◽  
ABM Luthful Kabir ◽  
Mohammad Harun Or Rashid ◽  
Dhiman Pramanik ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Eosinophil Count ◽  
Nasal Polyposis ◽  
The Other ◽  
Control Group ◽  
Case Group ◽  
College Hospital ◽  
Other Hand ◽  
Group A ◽  
Group B

Objective: To find out association between Nasal polyposis and bronchial asthma. Methods: This was a cross sectional study which was carried out in the departments of Otolaryngology and Head-Neck surgery of Bangabondhu Sheikh Mujib Medical University and Dhaka Medical College Hospital during the period of February 2014 to July 2014. A Total 230 patients were selected according to selection criteria among which 30 subjects had nasal polyposis (designated as group A or cases) and 200 subjects had no nasal polyposis (designated as group B or control group). Results: In group (A), asthma was found in 30.0% cases. On the other hand, asthma was found in 2.5% of control group (B). The association of nasal polyposis with bronchial asthma was highly significant (p<.05). In both group 40.0% patients were within the 38-47 year’s age group. In case group, 80.0% patients had any sorts of allergic history on the other hand, only 15.0% patients had allergic history in control group. High eosinophil count was found 66.7% patients suffering from nasal polyposis with bronchial asthma and in comparison to patients suffering from nasal polyposis without bronchial asthma had high eosinophil count 42.85%. In group A High IgE level was found 66.7% patients suffering from nasal polyposis with bronchial asthma, on the other hand, 42.85% had IgE level among patients suffering from nasal polyposis without bronchial asthma. Conclusion: Patients with nasal polyposis and asthma are significantly associated. Both serum IgE and total circulating eosinophil count are significant associated with nasal polyposis and bronchial asthma. Bangladesh J Otorhinolaryngol; April 2017; 23(1): 11-18

scholarly journals Effectiveness of Buteyko Breathing Technique versus Nadi Shuddhi Pranayama to Improve Pulmonary Function in Subjects with Bronchial Asthma

2021 ◽  
Vol 6 (4) ◽  
pp. 124-135
Author(s):  
G Swathi ◽  
T Sunil Kumar ◽  
N Raghunadh
Keyword(s):  
Pulmonary Function ◽  
Bronchial Asthma ◽  
Statistical Significance ◽  
T Test ◽  
Age Group ◽  
Consent Document ◽  
Post Test ◽  
Life Threatening ◽  
Group A ◽  
Group B

Background: Asthma is a chronic life-threatening disease as the airways in the lungs often swollen or inflamed, which makes the airways very sensitive. So, the exposure to the environment in day-to-day life triggers asthma. Asthma can affect at any age group. This study mainly focuses on comparing the effects of Buteyko breathing technique and Pranayama on improving Pulmonary Function in subjects with Bronchial Asthma. Method: Total of 79subjects selected, out of those 66 subjects were included after obtaining the consent document. Subjects are divided into two groups by lottery method, in which 6 subjects dropped. So, the study was completed with 60 subjects. Both groups performed intervention for 1 hour a day 5 days week for 4 weeks. The outcomes of the study were FEV1, FVC & FEV1/FVC ratio. Results: Paired t test was used to assess statically significance between pre and post test scores with in the groups, independent t test was used to access statistical significance of post-test mean score between the groups, statistical analysis of the data revealed that Buteyko Breathing technique group has more difference when compare to Pranayama group. Conclusion: The results had shown that both Group-A (Buteyko Breathing Group) and Group-B (Pranayama Group) has improved significantly on pre and post-test values within the groups but when compared between the groups statistical significance is noted in Group-A. So, this study concludes that Group-A showed significant improvement on Pulmonary Function in subjects with Bronchial Asthma. Keywords: Buteyko Breathing technique, Nadishuddhi Pranayama, FEV1/FVC, Bronchial Asthma.

scholarly journals A RANDOMIZED COMPARATIVE CLINICAL EVALUATION OF HARIDRADI LEHA AND VASADI KASHAYA IN THE MANAGEMENT OF TAMAKA SHWASA (BRONCHIAL ASTHMA)

2021 ◽  
Vol 12 (3) ◽  
pp. 3-12
Author(s):  
Rashmi Mutha ◽  
Ajay Kumar Sahu ◽  
Jai Prakash Singh ◽  
Ram Kishor Joshi ◽  
Shankar Gautam
Keyword(s):  
Heart Rate ◽  
Bronchial Asthma ◽  
Body Position ◽  
Forced Expiratory Volume ◽  
P Value ◽  
Precipitating Factors ◽  
Accessory Muscle ◽  
Group A ◽  
Group B ◽  
Lukewarm Water

Tamaka Shwasa in Ayurveda is analogous to Bronchial Asthma due to similarity in causative and precipitating factors, onset, pathogenesis and symptoms. An estimated 300 million people worldwide suffer from asthma, with 250,000 annual deaths attributed to the disease. The Objective is to evaluate and compare the efficacy of Haridradi Leha with and without Vasadi Kashaya in the management of Tamaka Shwasa. Total 30 patients were registered for the present study. The patients of group A were administered Haridradi Leha in a dose of 20 grams BD (Bis in die i.e., twice daily) in empty stomach orally with lukewarm water for 21 days. The patients of group B were administered Haridradi Leha (20 grams BD) and Vasadi Kashaya (50 ml BD) with Anupana (co-administers with medicine) of honey orally for 21 days. There are highly significant results (p value: p<0.01, p<0.001) in breathlessness, cough, body position, wheezing in a day, wheezing in night, heart rate in both group but quantity of sputum, respiratory rate, use of accessory muscle and mental status shows highly significant result only in Group B. Both groups have highly significant result in peak expiratory flow rate (PEFR) and forced expiratory volume in one second (FEV1). Both the Haridradi Leha and Vasadi Kashaya are highly effective in the management of Tamaka Shwasa. Haridradi Leha along with Vasadi Kashaya provided better relief than Haridradi Leha alone in most of the sign and symptom of the disease at significant level.

scholarly journals The effect of Dhumpana therapy in comparative study of Haridra Dhumpana and Behada Dhumvarti in the preventive management of Tamak Shwasa

2020 ◽  
Vol 5 (01) ◽  
Author(s):  
Lina S. Tawar ◽  
Varsha Jaraje ◽  
Rajesh M. Shah ◽  
Sushil Navsare
Keyword(s):  
Comparative Study ◽  
Bronchial Asthma ◽  
Medical Science ◽  
Young Age ◽  
Major Disease ◽  
Group A ◽  
Group B ◽  
Experimental Group

Tamak shwasa is one among the major disease explained in Ayurveda is caused due to infection of Kapha and Vata Dosha in pranvaha Srotas. The condition is analogues to Bronchial asthma as explained in modern medical science. India has an estimated 15-20 million Asthmatic every year and the disease occurs at very young age that survey status one in every six child under the age of 16 is affected. In Ayurveda for management of Tamak shwasa medicines are available and for prevention some method like Dhumpana, Vamana, Swedan, Virechna, Pratimarshya Nasyakarma. It may help to relive the complaints and prevents further attack. 10 patients were selected for study of Tamak shwasa and divided in two groups. 5 patient in each group. Group A is given Haridra Dhumpana and group B is experimental group. Behada Dhumavarti is given to group B.

scholarly journals The comparison of clinical efficacy of formoterol and fluticasone versus salmeterol and fluticasone in patients of bronchial asthma

2018 ◽  
Vol 7 (5) ◽  
pp. 947
Author(s):  
Akashdeep Rattu ◽  
Inderpal Kaur ◽  
Ashok Goel ◽  
Nirmal Chand Kajal
Keyword(s):  
Bronchial Asthma ◽  
Inhaled Corticosteroids ◽  
Beta Agonist ◽  
Fixed Dose ◽  
Dose Inhaler ◽  
Open Label ◽  
Group A ◽  
Baseline Values ◽  
Long Acting ◽  
Group B

Background: Fixed-dose combinations of Inhaled corticosteroids (ICS) and Long acting beta agonist (LABA) are established and widely used treatment for bronchial asthma when ICSs as monotherapy are ineffective. This study attempted to compare the efficacy of salmeterol and fluticasone with formoterol (newer LABA) and fluticasone in patients of bronchial asthma.Methods: An open label, randomized, prospective, parallel and comparative study of eight-week duration was conducted on 80 patients of bronchial asthma, with the collaboration of Department of pharmacology and Department of Tuberculosis and Chest Diseases Hospital, Government medical college, Amritsar. Patients in Group A were treated with 2 actuations of Formoterol and Fluticasone (6/125µg) twice daily and group B patients were treated with 2 actuations of Salmeterol and Fluticasone (50/125µg) twice daily for 8 weeks with metered dose inhaler (MDI). Patients in group A and B were assessed on day zero, 4 weeks and 8 weeks for clinical assessment and computerized spirometry for FVC, FEV1, FEV1/FVC and PEFR.Results: In group A mean±SD of FEV1 statistically significantly increased (<0.001) after eight week of therapy (1.50±0.12) from its baseline values (1.34±0.11). Similarly, in group B mean ± SD of FEV1 statistically significantly increased (<0.001) after eight weeks (1.48±0.13) from its baseline values (1.36±0.12). There was statistically significant (<0.001) improvement in other parameters of spirometry in patients of both the groups.Conclusions: It was observed that both the combination of Fluticasone + Formoterol and Fluticasone + Salmeterol are effective in the treatment of bronchial asthma.

Vitamin D, ventilatory function and asthma control among bronchial asthma patients

2020 ◽  
Vol 7 (3) ◽  
pp. 74-77
Author(s):  
Mohammed H. Saiem Al-Dahr
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Direct Relationship ◽  
Ventilatory Function ◽  
Asthma Control Test ◽  
Group A ◽  
Group B ◽  
Deficiency Group

Background: Asthma is a chronic conducting airway disorder which characterized by reversible airway inflammation and obstruction. However, prevalence of some pulmonary disorders as bronchial asthma is increased with Vitamin D deficiency. Objective: The target of this study is to evaluate the association between status of vitamin D and ventilatory function & asthma control in patients with bronchial asthma in Jeddah area. Material and methods: One hundred Saudi patients with asthma of both sex; their age mean was 35.18±6.27 year were selected on referral to Internal Medicine Department, King Abdulaziz University Teaching Hospital, Saudi Arabia. Asthma was diagnosed by spirometry tests. Criteria for asthma diagnosis were in accordance with the Global Strategy for Asthma Management and Prevention (GINA 2016). Exclusion criteria included patients with renal, cardiac and liver diseases. All participants will be free to withdraw from the study at any time. Following pre-training testing, participants were enrolled in three groups according to 25-OHD levels: vitamin D deficiency group (A) 25-OHD level <20ng/ml, vitamin D deficiency group (B) 25-OHD level=20–30 ng/ml and normal vitamin D group(C) 25-OHD level >30ng/ml. Results: There was significant higher values of FVC, FEV1 and FEV1/FVC in group (C) compared to subgroup (A) and group (B) in addition to lower values of asthma control test in subgroup (C) compared to group (A) and group (B). While there was significant difference between groups. Moreover, the 25-OHD showed a strong direct relationship with FVC, FEV1, FEV1/FVC and asthma control test in the three groups (P<0.05). Conclusion: There is a close direct relationship between level of vitamin D, ventilatory function and asthma control in patients with bronchial asthma.

scholarly journals A RANDOMISED CONTROLLED CLINICAL TRIAL TO STUDY THE EFFICACY OF SATYADI CHURNA AND VYAGHRI CHURNA IN TAMAKA SWASA

2021 ◽  
Vol 9 (9) ◽  
pp. 2006-2011
Author(s):  
Anagha Narayanan ◽  
Susheel Shetty
Keyword(s):  
Bronchial Asthma ◽  
Treatment Modalities ◽  
Rank Test ◽  
Controlled Clinical Trial ◽  
Group Comparison ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Group A ◽  
Group B ◽  
Randomised Controlled

Background and Objectives: Tamaka Swasa is a form of Swasa Roga primarily affecting the Pranavaha Srotas characterized by Swasakrichratha, Ghurghuraka, Teevra vega Swasa etc. Tamaka Swasa in Ayurvedic classics appears to be similar to Bronchial Asthma. Several medications are available in today’s medical system to treat this disease, but they are known to cause a variety of side effects. Hence, the suffering population is turning to conventional remedies for better relief. In this regard, Ayurveda can provide promising results in Tamaka Swasa with varieties of treatment modalities. In light of these considerations, the aim of the study was to assess the efficacy of two Ayurvedic formulations Satyadi Churna listed in Swasakarmavipaka adhyaya in Brihat Nighantu Ratnakara and Vyaghri Churna mentioned in Curnakalpana Adhyaya in Sharangdhara Samhita in the treatment of mild to moderate Bronchial Asthma. Materials and Methods: 40 Tamaka Swasa Subjects were selected those fulfilling the diagnostic and inclusion criteria. They were randomly assigned into two equal groups. Comparative analysis of the overall effect of the treatments in both the Groups was done statistically with Mann- Whitney Rank Sum Test and within the Group comparison with Wilcoxon Signed Rank Test. Results: Within the group comparison showed statistically significant results for all the criteria in Group A while in Group B except Peenasa all other criteria showed statistically significant results. Conclusion: When comparing both groups Satyadi Churna showed better improvement in the symptoms of Tamaka Swasa than Vyaghri Churna. Hence H1 holds good and proved. Keywords: Tamaka Swasa, Bronchial Asthma, Satyadi Churna, Vyaghri Churna, Peak flow meter.

scholarly journals Effect of long-term low dose glucocorticoid on children with bronchial asthma

2021 ◽  
Author(s):  
Xueping Du ◽  
Yanjun Guo ◽  
Junzheng Yang
Keyword(s):  
Growth Factor ◽  
Treatment Group ◽  
Bronchial Asthma ◽  
Low Dose ◽  
Control Group ◽  
Insulin Like Growth Factor ◽  
Act Scores ◽  
Group A ◽  
Group B

Objectives: To investigate the clinical efficacy of long-term of low-dose inhaled glucocorticoid (ICS) in the treatment on children with bronchial asthma, and to evaluate its effects on the height, weight and expression of serum insulin-like growth factor of children with bronchial asthma. Methods: 91 children with bronchial asthma treated in our hospital from January 2017 to December 2017 were chosen, and 31 healthy children without asthma history in our hospital were selected as the control group (Group C); For the different treatment methods comparison, 91 children with bronchial asthma were divided into treatment group A (48 children) and treatment group B (43 children) randomly. In treatment group A, children were treated with low-dose ICS for more than 1 year; in treatment group B, children were treated with low-dose ICS for less than 1 year or received low-dose ICS for less than 2 months/year. For treatment evaluation, the asthma control test (C-ACT) were scored at 0 months, 12 months and 24 months in three groups, and the height and weight of children, the levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) in serum in each group were also measured. Results: In the control group, the C-ACT scores were increased with time (P<0.01); the C-ACT scores of treatment group A at 12 months and at 24 months was significantly higher than that of treatment group B (P<0.05); there was no significant difference in height and weight between the treatment group and the control group at 0 months, 12 months and 24 months after treatment (P>0.05); there was no significant difference in the expression levels of IGF-1 and IGFBP-3 in serum between treatment group and control group (P>0.05). Compared with the C-ACT scores in treatment group A and treatment group B at 0 month, the C-ACT scores were significantly higher at 12 months and at 24 months , and there was a statistical difference among 0 month, 12 months and at 24 months in treatment group A and treatment group B (P<0.01); The C-ACT score of treatment group A at the 12 month was significantly higher than that in treatment group B at the 12 months(P<0.05), and the C-ACT score in treatment group A at the 24 months was significantly higher than that of treatment group B (P<0.001). Conclusions: Treatment for children with bronchial asthma by long-term use of low-dose ICS is safe and effective, it does not affect health and development of children with bronchial asthma; children with bronchial asthma were treated with low-dose ICS for more than 1 year had a better effective than children were treated with low-dose ICS for less than 1 year or received low-dose ICS for less than 2 months/year.

scholarly journals RESPIRATORY MUSCLE TRAINING WITH THERABAND VERSUS INCENTIVE SPIROMETER AMONG INDIVIDUALS WITH BRONCHIAL ASTHMA

2020 ◽  
pp. 117-120
Author(s):  
K. REKHA ◽  
D. SAMUEL SUNDAR DOSS ◽  
MOHAMMED ABUBAKKER SIDDIUE
Keyword(s):  
Muscle Strength ◽  
Bronchial Asthma ◽  
Respiratory Muscle ◽  
Diaphragm Muscle ◽  
Respiratory Muscle Strength ◽  
Total Period ◽  
Muscle Testing ◽  
Post Test ◽  
Group A ◽  
Group B

Objective: To determine and compare the effects of Theraband exercises with Incentive Spirometer exercise in improving respiratory muscle strength among bronchial asthma. Methods: In this study, 30 Individuals with Bronchial asthma were taken and assessed for FEV1/FVC, Maximum voluntary ventilation (MVV) using a computerized spirometer, dyspnea level graded using MMRC scale and diaphragm muscle strength assessed using manual muscle testing (MMT) as pre-test then the individuals were randomly allocated in two groups: Group A and Group B. Group A (n=15) received Theraband exercise and Group B (n=15) were treated with incentive spirometer for a total period of 4 w following which the outcome measures were repeated for post-test. Results: Based on the obtained statistics, both the groups showed significant improvement within groups when comparing pre and post-test measures. On comparing the mean values of the post-test between the groups, theraband exercises showed clinically higher significant results than incentive spirometer exercises. Conclusion: From the result, it shall been concluded that both theraband exercises and incentive spirometer exercises shows improvement in MVV, FEV1/FVC, reduced dyspnea and increased respiratory muscle strength. Hence, theraband exercises are effective compared to the incentive spirometer.

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