scholarly journals Clinical profile of cutaneous adverse effects induced by topical corticosteroids and their source of information

2021 ◽  
Vol 7 (4) ◽  
pp. 522
Author(s):  
Aliza Zaidi ◽  
Kshitij Saxena ◽  
Ven R. Koti ◽  
Anukriti Singh ◽  
Ayesha Khalid ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Topical Corticosteroid ◽  
Skin Color ◽  
Color Change ◽  
Clinical Aspects ◽  
Cross Sectional ◽  
Topical Corticosteroids ◽  
Patterns Of Use ◽  
Wide Range ◽  
Source Of Information

<p class="abstract"><strong>Background: </strong>Steroids are a wide range of chemical molecules that have varying physiological effects. Corticosteroids own anti-inflammatory and immunosuppressive effects. They also have anti-proliferative effects on keratinocytes. The present study was undertaken to study the clinical aspects of the use of topical corticosteroids leading to adverse effects and to know the source of information leading to its abuse.</p><p class="abstract"><strong>Methods: </strong>A cross-sectional observational study was carried out on cutaneous adverse effects of TC attending the dermatology outpatient department of Era’s Lucknow medical college and hospital between December 2018 and November 2020. The patients who applied TC for more than 1 month were taken into account. Patients who had cutaneous adverse effects suggestive of TC without details of agents were excluded.</p><p class="abstract"><strong>Results:</strong> Present study explored the patterns of use of topical corticosteroid, and its associated adverse effects in a total of 380 patients (aged 3 to 71 years; mean age 27.33±11.78 years; 52.9% males). Itching (72.4%), burning skin (64.5%) and skin color change (62.4%) were the three most common presenting complaints. Dermatophytoses (66.6%), acne (17.4%) and skin lightening (6.3%) were the three most common indications for use of topical corticosteroids.</p><p class="abstract"><strong>Conclusions:</strong> The present study showed that the practice of using non-dermatologist prescribed topical corticosteroid use is highly prevalent and is associated with a high burden of adverse effects. To prevent this there is a need to spread awareness regarding harms associated with abuse of non-dermatologist prescribed topical corticosteroid use.</p>

scholarly journals Prevalence of Misuse of Topical Corticosteroid among Dermatology Outpatients

2020 ◽  
Vol 58 (231) ◽  
Author(s):  
Shristi Shrestha ◽  
Smita Joshi ◽  
Sajana Bhandari
Keyword(s):  
Adverse Effects ◽  
Confidence Interval ◽  
Topical Corticosteroid ◽  
Binary Data ◽  
Cross Sectional Study ◽  
Point Estimate ◽  
Care Hospital ◽  
Cross Sectional ◽  
Topical Corticosteroids ◽  
Number Of Patients

Introduction: Topical corticosteroids misuse has become one of the burning issues in many countries across the globe. They are known to cause a myriad of adverse effects which include local effects commonly and systemic effects rarely. In dermatology practice, one of the common problems we see these days are steroid-induced and steroid aggravated dermatoses. So, this study was done to find the prevalence of misuse of topical corticosteroid among dermatology outpatients. Methods: A descriptive cross-sectional study was done in the outpatient department of dermatology at atertiary care hospital for 18 months. Ethical clearance was obtained from the Institutional Review Committee of NMCTH (Reference no. 029-076/077). Convenient sampling was done. Statistical Package for the Social Sciences (SPSS) version 16 was used to tabulate the data and analyze the results. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Out of 19464 patients, 614 (3.15%) (2.91%-3.39% at 95% Confidence Interval) gave a history of applying steroid containing creams. Among them, 220 (35.8%) belonged to the age group 21-30 years. Dermatophytoses were the skin disease where TCS was most commonly misused followed by melasma in 425 (69.2%) and 115 (18.7%) respectively. Beclomethasone was the steroid preparation that was misused in the maximum number of patients in 271 (44.1%). Some form of adverse effects was seen in 554 (88.6%) patients. Conclusions: Non-prescription sale of topical corticosteroids is the major cause of topical corticosteroids abuse in Nepal. Creating awareness among the prescribers as well as the patients is the current need.

scholarly journals Misuse of Topical Corticosteroids for Cosmetic Purpose in Antananarivo, Madagascar

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
F. A. Sendrasoa ◽  
I. M. Ranaivo ◽  
M. Andrianarison ◽  
O. Raharolahy ◽  
N. H. Razanakoto ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Skin Color ◽  
Cross Sectional Study ◽  
Peppermint Oil ◽  
Sectional Study ◽  
Cross Sectional ◽  
Topical Corticosteroids ◽  
The Face ◽  
Cutaneous Atrophy ◽  
Pigmentation Disorders

This cross-sectional study was conducted in Antananarivo, Madagascar, from June to September 2012. We aim to evaluate the misuse of TC on the face for cosmetic purpose and the adverse effects due to its application. A questionnaire-based analysis was done among females who use topical corticosteroids on the face for cosmetic purpose. Of the 770 women questioned, 384 (49,8%) used topical corticosteroids for cosmetic purpose whose mean age was 38 years (range 16–73 years). Two hundred and sixty-one females (68%) used TC combined with handcrafted cosmetics, and 123 (32%) used TC alone. “Pandalao,” which contains salicylic acid, peppermint oil, lanolin, powder of Juanes de Vigo (mercury powder), and Vaseline, is the most handcrafted cosmetic combined with TC in our study (used by 29,4% respondents). Only one (0,26%) had obtained the TC by physician’s prescription, 234 (61%) from cosmetic retailers, 92 (23%) directly from local pharmacies, 49 (12%) from beauticians, and 15 (4%) from unspecified sources. Lightening of skin color was the main reason for using TC in 44,8% of respondents in the absence of any primary dermatosis. Pigmentation disorders (63,2%) and cutaneous atrophy (52,1%) were the most adverse effects noted.

scholarly journals Alternative Medicine’ Complaints Lodged to the Tehran Forensic Medicine Organization From 2011 to 2017

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Mohammad Ali Emam Hadi ◽  
Baharak Sabet Divshaly ◽  
Farahnaz Azimy ◽  
Babak Sabet Divshaly
Keyword(s):  
Adverse Effects ◽  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Forensic Medicine ◽  
Demographic Data ◽  
Exclusion Criterion ◽  
Final Decision ◽  
Cross Sectional ◽  
Wide Range ◽  
Complementary And Alternative

Background: Complementary and alternative medicine is a non-conventional therapy and includes a wide range of medical treatments in different countries. This study was done to evaluate alternative medicine complaints lodged to the Tehran Forensic Medicine Organization from 2011-2017.Methods: In this cross-sectional study, all documented complaints of complementary medicine lodged to the Tehran Forensic Medicine Organization from 2011-2017 were reviewed and assessed with retrospective follow-up. The inclusion criterion was complaints from complementary and alternative medicine, and the exclusion criterion was incomplete data. The study data included patients’ demographic data, the therapist, the specialty of the therapist, type of disease, treatment method, adverse effects, the initial and final decision by the commission, and the amount of medical error. This information was extracted from the existing documents and recoded in the checklists.Results: Medical errors were found in 53.4% of the complaints examined. The most common cause of complaint (63%) was the adverse effects, of which the most common ones were phytotherapy (45.2%) and cupping (Hijama) (20.5%). The error was significantly different between physician and non-physician healers (P=0.001).Conclusion: Based on this study, among the alternative medicine complaints lodged to the Tehran Forensic Medicine Organization from 2011-2017, the adverse effects were the main problem of complementary therapies confirmed in more than half of the complaints.

Cannabis Use in Children With Pantothenate Kinase–Associated Neurodegeneration

2019 ◽  
Vol 35 (4) ◽  
pp. 259-264 ◽  
Author(s):  
Jenny L. Wilson ◽  
Allison Gregory ◽  
Katrina Wakeman ◽  
Alison Freed ◽  
Puneet Rai ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Behavior Change ◽  
Response Rate ◽  
Cannabis Use ◽  
Common Source ◽  
Clinical Registry ◽  
Cross Sectional ◽  
Pantothenate Kinase ◽  
And Behavior ◽  
Source Of Information

Background: Pantothenate kinase–associated neurodegeneration is characterized by severe, progressive dystonia. This study aims to describe the reported usage of cannabis products among children with pantothenate kinase–associated neurodegeneration. Methods: A cross-sectional, 37-item survey was distributed in April 2019 to the families of 44 children who participate in a clinical registry of individuals with pantothenate kinase–associated neurodegeneration. Results: We received 18 responses (40.9% response rate). Children were a mean of 11.0 (SD 4.3) years old. The 15 respondents with dystonia or spasticity were on a median of 2 tone medications (range 0-9). Seven children had ever used cannabis (38.9%). The most common source of information about cannabis was other parents. Children who had ever used cannabis were on more tone medications, were more likely to have used opiates, were less likely to be able to roll, and less likely to sit comfortably, than children who had never used cannabis. Four children reported moderate or significant improvement in dystonia with cannabis. Other areas reported to be moderate or significantly improved were pain (n = 3), sleep (n = 4), anxiety (n = 3), and behavior (n = 2). Adverse effects included sadness (n = 1), agitation/behavior change (n = 1), and tiredness (n = 1). Conclusion: Cannabis use was commonly reported among children with pantothenate kinase–associated neurodegeneration whose parents responded to a survey, particularly when many other dystonia treatments had been tried. Physicians should be aware that parents may treat their child with severe, painful dystonia with cannabis. Placebo-controlled studies of products containing cannabidiol and 9-tetrahydrocannabinol are needed for pediatric tone disorders.

scholarly journals Topical corticosteroid abuse on face: a clinical study of 100 patients

2016 ◽  
Vol 2 (3) ◽  
pp. 40 ◽  
Author(s):  
Pooja Bains
Keyword(s):  
Clinical Study ◽  
General Population ◽  
Adverse Effects ◽  
Topical Corticosteroid ◽  
Clobetasol Propionate ◽  
Age Group ◽  
Minimum Period ◽  
Topical Corticosteroids ◽  
The Face ◽  
History Of

<p class="abstract"><strong>Background:</strong> Prolonged and uninterrupted use of topical corticosteroids on face is globally prevalant and this misuse has reached monstrous proportion in India. The topical corticosteroid abuse leads to various local adverse effects on face which are difficult to treat. The aim of this study was to ascertain the magnitude, demographics, cause and adverse effects of TC abuse on the face in the dermatology out-patient department.</p><p class="abstract"><strong>Methods:</strong> A total of 100 patients with history of topical corticosteroid abuse on face for a minimum period of one month were enrolled in this study.<strong></strong></p><p class="abstract"><strong>Results:</strong> In our study, majority of the patients were females (76%) and the most common age group was 21-30 years with 49% patients. The duration of application was &lt;6 months (45%) in majority of patients. Most common topical corticosteroids abused were betamethasone valerate in 49% and clobetasol propionate in 40% cases.</p><strong>Conclusions:</strong> Topical corticosteroid abuse on face is quite common with varied presentation. There is need to take urgent remedial steps and increase awareness about this problem in general population.

scholarly journals Awareness of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) use among population in Saudi Arabia

2019 ◽  
pp. 40-52
Author(s):  
Salwa Selim Abougalambou ◽  
Siham Abdullah Abdoun ◽  
Nora SayerAlharbi
Keyword(s):  
Saudi Arabia ◽  
Adverse Effects ◽  
Educational Status ◽  
Health Care Team ◽  
P Value ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are one of the most frequently medicines used among the world. They are responsible for a wide range of adverse effects that are ranging from mild to life threatening in severe cases. The aimed of this study to ascertain user's knowledge about NSAIDs among population in Saudi Arabia Methodology: A cross-sectional study including 449 participants, who were users of NSAIDs in Saudi Arabia during October-December 2017. The data were collected using online questionnaire. The questionnaire contained basic socio-demographic information of participants and questions about the participant's knowledge of adverse effects, their types and NSAIDs uses. SPSS 23; including, frequency, description and chi square were used for analysis. Result: Majority, 80.6% of participants were female. Ibuprofen was the most common type of NSAIDs used by participants 61.9%. About 33% of participants were aware that these drugs can cause headache\dizziness and nausea\vomiting. However, 27.8% think that these drugs must be sold without a prescription. Additionally, the majority 87.5% feel that the use of NSAIDs is abused. There were a significant association between the availability of NSAIDs without a physician prescription with age, gender and employment status P-value (<0.05). While there was no significant association with educational status. Conclusion: the present study revealed a limited individual's knowledge about the NSAIDs adverse effects among Saudi Arabia. People need more educations or consultations with health care team specially the pharmacists. In a way to reduce their misuse or abuse or even unnecessarily prescribed. Keywords: NSAIDs; Saudi Arabia; Awareness; Knowledge; Saudi Arabia

Public Attitude toward Drug Technical Package Inserts in Saudi Arabia

2003 ◽  
Vol 19 (3) ◽  
pp. 209-218 ◽  
Author(s):  
Saleh A Bawazir ◽  
Hisham S Abou-Auda ◽  
Othman A Gubara ◽  
Khalil I Al-Khamis ◽  
Mohammed JMS Al-Yamani
Keyword(s):  
Saudi Arabia ◽  
Adverse Effects ◽  
Package Insert ◽  
Drug Effects ◽  
Community Pharmacies ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Proper Action ◽  
Self Administered Questionnaire ◽  
Source Of Information

Objective: To examine public opinion in Saudi Arabia regarding the technical drug package insert (PI) as a source of information and to assess the need for potential changes to the existing format in favor of a more patient-oriented package insert (PPI). Design: A cross-sectional survey was conducted from March through May 1998 by means of a self-administered questionnaire. Setting: Eighty-four community pharmacies in Riyadh. Participants: Two thousand twenty-nine customers entering community pharmacies in Riyadh were enrolled in this survey. Results: Results of the survey showed that 88% of the respondents read the PI. The motives for reading the PI included the desire to know more about the medication (48.7%), to adhere to the prescription (21.7%), and to decide whether to take the medication (13.1%). From the list of information contained therein, respondents listed indications (47.1%) and adverse drug effects (46.6%) as the principal sections of interest. Respondents overwhelmingly endorsed the PI as a complementary source of drug information to the verbal instructions of the physician and the pharmacist. However, readers did criticize its detail, legibility, and poor graphic illustration. Respondents indicated their desire to see a concise PPI introduced, one that highlights only the most common adverse effects of a drug. It should be written in simple Arabic and include, whenever possible, illustrations to enhance comprehension. Conclusions: The PI does not have the power to overrule the physician's or pharmacist's instructions. Since some patients may cease taking their medicines if they feel threatened by the adverse effects mentioned in the PI, precautionary statements should be prominently placed in the PI to explain the purpose of mentioning such information and what proper action should be taken by the patient.

A Cross Sectional Survey of Chicken Astroviruses Antibody in Broiler and Sonali (Cross-Bred) Chickens in Selected Areas in Bangladesh

2020 ◽  
Vol 43 (1) ◽  
pp. 75-80
Author(s):  
Md Zulfekar Ali ◽  
Mohammad Moktader Moula ◽  
Zafar Ahmed Bhuiyan ◽  
Muhammad Tariq Javed
Keyword(s):  
Age Groups ◽  
Winter Season ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Blood Samples ◽  
Elisa Kit ◽  
Published Report ◽  
Poultry Birds ◽  
Wide Range ◽  
Group B

AbstractChicken astroviruses (CAstV) are enteric viruses of poultry causing gastroenteritis, malabsorption, gout and white chick disease commonly known as runting-stunting syndrome (RSS). It can affect the wide range of poultry birds, especially chicken, turkey and duck worldwide. To our best knowledge there is no published report on presence of antibodies against CAstV in Bangladesh. Therefore, the study aimed to detect the presence of CAstV antibodies in broilers and sonali chickens (a cross-bread) in Bangladesh through a cross-sectional survey. A total of 454 blood samples from 66 flocks of broiler (n=343) and sonali chickens (n=111) of different ages were obtained during 2017 from four districts. The birds were healthy but were not vaccinated against CAstV. The samples were tested for specific antibodies against CAstV Group B by using commercially available ELISA kit. Overall, 16.74% (76/454) samples and 34.84% (23/66) flocks were positive for CAstV antibodies. The seroprevalence of CAstV was significantly (p=0.001) higher in sonali chickens (36.96%) than broiler (10.20%), while it was significantly higher (p=0.001) in birds of Bogura district (36.94%) than the other three districts. Regarding the age groups, seroprevalence was insignificantly (p=0.192) higher in sonali chicken before laying age (45%) than during laying age (27.45%). Regarding the seasons, CAstV infection was prevalent significantly (p=0.001) higher in winter season. Thus, the present study indicated the presence of CAstV in poultry in Bangladesh, so further studies are required to find out the magnitude of the problem in the country.

EFFICACY OF TREATMENT OF H.PYLORI EARDICATION WITH STANDARD TRIPLE THERAPY IN PEPTIC ULCER PATIENTS

2011 ◽  
pp. 122-129
Author(s):  
Quang Di Bui ◽  
Phuoc Lam Nguyen
Keyword(s):  
Peptic Ulcer ◽  
Adverse Effects ◽  
Triple Therapy ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Intention To Treat ◽  
Standard Triple Therapy

Objectives: The aim of study is to evaluate the efficacy, tolerability and adverse effects of a standard triple therapy including Rabeprazole, Clarithromycin and Amoxicilline at Sai gon Hoan My hospital in order to consider treatment H.pylori for patients who have not yet eradicated before or need to be undertaked by alternative regimens. Methods: By descriptive cross-sectional study, the authors have examined 116 patients sufferring from peptic ulcer received 10-day therapy including Rabe (20mg b.d) plus Clari(500mg b.d) plus Amoxi(1g b.d). Eradication is confirmed with endoscopy after 4 weeks from completing of treatment. Results and Discussion: 100% of patients were initially included and noboby was dropped out of the follow-up satges. The mean age was 49 in which 62% was male, 73(62,9%) presented duodenal ulcer, 28(24,1%) gastric ulcer and 15(13%) simultaneous gastric and duodenal ulcers. All patients took medications correctly. Per-protocol and intention to treat eradication rates were both 75%(95% CI=73,4-78,3). Additionally, 62(53,4%) patients had at least one risky factor for peptic ulcer disease, smoking being the most common one 44(37,9%).The adverse effects were reported overall in 67% of the patients, mainly including changed taste, very bitter, tired 49%, trouble sleeping 12% and diarrhea 5%. Conclusion: this ten-day standard triple therapy used in this study is ineffective with high adverse effects.The first line eradication with new regimens should be alternative.

Influencia de las condiciones de secado solar en la coloración de plantas medicinales

2019 ◽  
pp. 28-34
Author(s):  
Margarita Castillo-Téllez ◽  
Beatriz Castillo-Téllez ◽  
Juan Carlos Ovando-Sierra ◽  
Luz María Hernández-Cruz
Keyword(s):  
Medicinal Plants ◽  
Forced Convection ◽  
Rural Areas ◽  
Color Change ◽  
Drying Process ◽  
Scientific Medicine ◽  
Drying Time ◽  
Bacterial Proliferation ◽  
Wide Range ◽  
Very High

For millennia, humans have used hundreds of medicinal plants to treat diseases. Currently, many species with important characteristics are known to alleviate a wide range of health problems, mainly in rural areas, where the use of these resources is very high, even replacing scientific medicine almost completely. This paper presents the dehydration of medicinal plants that are grown in the State of Campeche through direct and indirect solar technologies in order to evaluate the influence of air flow and temperature on the color of the final product through the L* a* scale. b*, analyzing the activity of water and humidity during the drying process. The experimental results showed that the direct solar dryer with forced convection presents a little significant color change in a drying time of 400 min on average, guaranteeing the null bacterial proliferation and reaching a final humidity between 9 % and 11 %.

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