Short-Term Outcomes of Atosiban in the Treatmentof Preterm Labour at the Sultan Qaboos University Hospital, Muscat, Oman

Objectives: This study aimed to generate baseline evidence regarding the effectiveness of atosiban in delaying delivery by ≥48 hours among pregnant women presenting with threatened preterm labour (TPL). The secondary objective was to assess the relationship between atosiban success and various perinatal factors and neonatal outcomes. Methods: This retrospective study was conducted between June 2008 and May 2018 at the Sultan Qaboos University Hospital, Muscat, Oman. The medical records of all pregnant women who received atosiban between 24–34 gestational weeks for TPL during this period were reviewed. Results: A total of 159 women were included in the study. Atosiban was successful in delaying delivery by ≥48 hours in 130 cases (81.8%). Approximately half of the women (50.9%) achieved uterine quiescence in <12 hours. Failure to delay delivery by ≥48 hours was significantly lower among women with normal versus abnormal cervical findings (11.1% versus 25.6%; P = 0.023). Only 9.4% of women experienced minor side-effects. Mean birth weight (2,724.55 versus 1,707.59 g; P <0.001) and Apgar scores at 5 minutes (9.66 versus 8.28; P <0.001) were significantly higher among neonates delivered at ≥48 versus <48 hours post-atosiban, whereas the rate of neonatal respiratory distress syndrome was significantly lower (18.4% versus 81.6%; P <0.001). Conclusion: Atosiban was highly effective in delaying delivery by ≥48 hours and resulted in few adverse maternal side-effects and neonatal outcomes. To the best of the authors’ knowledge, this is the first study conducted in Oman to evaluate the effectiveness of atosiban in preventing preterm labour. Keywords: Preterm Labor; Atosiban; Tocolytic Agents; Treatment Outcome; Patient Outcome Assessment; Oman.

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Vaginal progesterone in prevention of preterm labour

International Journal of Medical Research and Review ◽

10.17511/ijmrr.2020.i06.13 ◽

2020 ◽

Vol 8 (6) ◽

pp. 449-454

Author(s):

Dr. Prativa Sahoo ◽

◽

Dr. Nayan Kumar Patel ◽

Dr. Ojaswini Patel ◽

Dr. A.K Panigrahi ◽

...

Keyword(s):

Preterm Birth ◽

Pregnant Women ◽

Preterm Labour ◽

Previous History ◽

Neonatal Morbidity ◽

Primary Objective ◽

Vaginal Progesterone ◽

History Of ◽

Secondary Objective

Introduction: Preterm birth, defined as childbirth occurring at less than 37 completed weeks or 259days of gestation since the first day of a woman’s last menstrual period, is one of the leading causesof neonatal morbidity and mortality. Across 184 countries, the rate of preterm birth ranges from 5%to 18% of babies born. Out of 27 million babies born every year (2018 data ) in India, 3.5 millionbabies born are premature. Recent literature review has shown that the use of Progesterone reducesrisk of preterm birth. But there is little information available regarding the role of Progesterone inpreventing preterm labour. Objectives: Primary objective of the study is to find out the incidence ofpreterm labour among pregnant women taking vaginal progesterone. Secondary objective istoassess the safety and efficacy of progesterone in feto-maternal outcome. Methods: This is a crosssectional study where100 prescriptions from IPD of Dept of O&G, VIMSAR, Burla of women who hadrecently undergone labour with singleton gestation and with previous history of preterm labour wereanalysed. Incidence of preterm labour among those taking and not taking vaginal progesterone werecompared. Results: There was decreased incidence of preterm labour as there is prolongation meanGestational age by 9.383 weeks among pregnant women taking vaginal progesterone. Conclusions:In the present study, women taking vaginal progesterone had significantly lowered incidencepreterm birth rate.

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Comparative study of efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1-year study at navodaya medical college hospital and research centre Raichur

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20212672 ◽

2021 ◽

Vol 10 (7) ◽

pp. 2806

Author(s):

Rita D. ◽

V. Haripriya

Keyword(s):

Side Effects ◽

Preterm Labour ◽

Research Centre ◽

College Hospital ◽

Treatment Groups ◽

Medical College ◽

Uterine Contractions ◽

Significant Difference ◽

Tocolytic Agent ◽

Tocolytic Agents

Background: Tocolytic agents are used to reduce preterm deliveries. Very few studies documenting the comparison of tocolytic agents viz. nifedipine, nitroglycerin dermal patches and isoxsuprine. Other drugs are not used due to their adverse effects. Objective was to study and compare the safety efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1 year study.Methods: This was a prospective case control study was conducted for a period of 1 year. Total 90 cases selected to study were randomly distribute in to three treatment groups viz. A, B, and C nifedipine, nitroglycerin and isoxsuprine respectively. Subjects in all three groups were evaluated for maternal pulse rate, palpitation uterine contractions and fetal heart rate in order to assess efficacy of each drug under investigation.Results: There was no statistically significant difference in age of woman’s in three different groups. Among (100%) subjects, majority of the cases i.e. (27.8%) primi gravida followed by multi (72.2%). Side effects of nifedipine was less when compared to nitroglycerine dermal patch and isoxsuprine i/v/o of headache (8.9%), nausea (1.1%), vomiting (1.1%), tachycardia (3.3%), palpitation (3.3%), hypotension (1.1%). side effects were statistically significant different between the treatment groups. There was no statistically significant difference with respect to APGAR score at 1 minute and 5 minutes.Conclusions: Oral nifedipine was found to be superior and efficacious as tocolytic agent as compared to transdermal nitroglycerin and intravenous isoxsuprine.

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Pregnancy outcomes in women with a hemoglobinopathy trait: a multicenter, retrospective study

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-021-06058-y ◽

2021 ◽

Author(s):

Jan Kasparek ◽

Tilo Burkhardt ◽

Irene Hoesli ◽

Gabriela Amstad Bencaiova

Keyword(s):

Pregnant Women ◽

Neonatal Outcomes ◽

University Hospital ◽

Control Group ◽

Maternal Outcomes ◽

Adverse Neonatal Outcomes ◽

Maternal And Neonatal Outcomes ◽

Clinical Records ◽

The University ◽

Fetal Acidosis

Abstract Purpose To determine the risk of adverse maternal and neonatal outcomes in pregnant women with a hemoglobinopathy trait. Materials and methods Retrospective cohort study was conducted to compare adverse maternal and neonatal outcomes between pregnant women with a hemoglobinopathy trait (study group; n = 172), and without a hemoglobinopathy trait (control group; n = 360). The medical data were extracted from clinical records of pregnant women attending antenatal care and delivering at the University Hospital Basel or University Hospital Zurich between 2015 and 2018. Results A total of 172 pregnant women with a hemoglobinopathy trait and 360 controls were recruited. Apart from fetal acidosis, the groups did not differ significantly in any variables of adverse neonatal outcomes. Whereas, among the maternal outcomes the rate of abortion, gestational diabetes mellitus, bacteriuria or urinary tract infection, intrahepatic cholestasis, abnormal placentation and anemia postpartum were significantly increased in women with a hemoglobinopathy trait. Conclusion In our study, a hemoglobinopathy trait increased the risk of adverse maternal outcomes but did not increase adverse neonatal outcomes.

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Side Effects Experience on Behavior of Pregnant Women Consuming Iron Tablets

Midwifery and Nursing Research ◽

10.31983/manr.v2i2.6324 ◽

2020 ◽

Vol 2 (2) ◽

pp. 69-73

Author(s):

Istiana Intan ◽

Munayarokh Munayarokh ◽

Siti Rofi'ah

Keyword(s):

Developing Countries ◽

Data Analysis ◽

Side Effects ◽

Pregnant Women ◽

Random Sampling ◽

Health Workers ◽

Deficiency Anemia ◽

Stratified Random Sampling ◽

Cross Sectional ◽

The Relationship

Background: Anemia was a disease that attracts worldwide concern and was a very big problem, especially in developing countries. The factor that caused high iron deficiency anemia in pregnant women was the low compliance of pregnant women in consuming iron tablets. Side effects in the form of nausea were the reason pregnant women did not comply with Iron tablets. The purpose of this study was to determine the relationship between the side effects experience and the behavior of pregnant women in consuming Iron tablets. This type of research was quantitative with analytic survey and using a cross sectional approach.Methods: This type of research was quantitative with analytic survey and using a cross sectional approach. The population in this study were pregnant women in the second and third trimesters in the working areaof the Puskesmas Tempuran, Magelang Regency based on the February-March 2019 cohort, totaling 177 pregnant women with a sample of 123 pregnant women, calculated using the Slovin formula. The samplingtechnique used Proportionate Stratified Random Sampling. Data analysis used Kendall tau test.Results: The results showed that most of the pregnant women who consumed Iron tablets had side effectsexperience caused by the behavior of pregnant women in consuming Iron tablets, mostly in the low category.Conclusion: There was a relationship between the side effects experience and the behavior of pregnant women in consuming Iron tablets. It was recommended that pregnant women consume Iron tablets regularly in accordance with the recommendations of health workers so that they can prevent anemia.

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Outcomes of Women with Non-Metastatic Triple-Negative Breast Cancer in Oman: A single-centre experience

Sultan Qaboos University Medical Journal [SQUMJ] ◽

10.18295/squmj.2019.19.03.006 ◽

2019 ◽

Vol 19 (3) ◽

pp. 209

Author(s):

Shiyam Kumar ◽

Muhammad Furrukh ◽

Khalid Al-Baimani ◽

Adil Al-Ajmi ◽

Ikram A. Burney ◽

...

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Neoadjuvant Chemotherapy ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Tumour Size ◽

Patient Outcome Assessment ◽

University Hospital ◽

Stage Iii ◽

Sultan Qaboos University

Objectives: Triple-negative breast cancer (TNBC) is one of the most aggressive and heterogeneous variants of breast cancer. However, little is known regarding the prevalence and outcome of this entity in the Middle East. This study aimed to evaluate the outcomes of TNBC patients at a university hospital in Oman. Methods: This retrospective study took place at the Sultan Qaboos University Hospital, Muscat, Oman, in May 2017. All patients diagnosed with non-metastatic TNBC between December 2000 and December 2015 were included. The patients’ electronic medical records were reviewed to identify their clinical and pathological characteristics as well as survival outcomes. Results: A total of 79 patients were diagnosed with non-metastatic TNBC during the study period. The median age was 46 years, with approximately one-third of patients (31.6%) under 40 years of age. Almost half had an advanced tumour size (49.4%) or node-positive disease (48.1%) at presentation and only 16.6% demonstrated a complete pathological response (pCR) to neoadjuvant chemotherapy. The median survival for all patients was not reached within the study period; however, the median overall survival for stage III patients was 44.6 months. The five-year overall survival for all patients was 64%, increasing to 100% and 72% for patients with stage I and II, respectively, and dropping to 47% for those with stage III disease. Conclusion: The findings of this study indicate that the majority of women with TNBC in Oman present at an advanced stage; moreover, such women have low rates of pCR to neoadjuvant chemotherapy and poor five-year survival.Keywords: Breast Cancer; Triple-Negative Breast Cancer; Neoadjuvant Therapy; Survival; Patient Outcome Assessment; Oman.

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СРАВНЕНИЕ ТОКОЛИЗА ГЕКСОПРЕНАЛИНОМ И АТОЗИБАНОМ

Medical Council ◽

10.21518/2079-701x-2017-2-57-61 ◽

2017 ◽

pp. 57-61

Author(s):

О. Р. Баев ◽

О. Н. Васильченко ◽

А. О. Карапетян ◽

Н. К. Тетруашвили ◽

З. С. Ходжаева

Keyword(s):

Pregnant Women ◽

Clinical Condition ◽

Preterm Labor ◽

Preterm Labour ◽

Premature Labour ◽

Loading Dose ◽

Efficacy And Safety ◽

Treatment Start ◽

Tocolytic Agents ◽

In Pregnancy

The aim of the study was to compare the efficacy and safety of tocolytic agents - atosiban and hexoprenaline.Patients and methods: The study included 119 pregnant women with threatening preterm labour between 28 to 34 weeks of gestation. Sixty two pregnant received 62 tocolysis by hexoprenaline and fifty seven - atosiban. There were no differences in the clinical condition of pregnant women and features of preterm labour among groups before start of the tocolysis.The degree of effectiveness is determined by the duration of the pregnancy prolongation (48 hours, 7 days, more than 14 days).Results: 9 women of 62 that received hexoprenaline tocolysis (22,6%), and 2 – atosiban (3.5%) failed to prolong the pregnancy for more than 48 hours (p < 0,05). Additionally, 5 women of the hexoprenaline group had premature labour within the first week from the treatment start and eight within 7-14 days. In the group of women with an effective atosiban tocolysis all births took place in a range of more than 7 days from the beginning of tocolysis. Four woman in hexoprenaline group received one repeated course of therapy with this drug (without a loading dose) for 24 hours. In atosiban group full repeated course was conducted in the two cases. Full-term gestation births occurred in 14 women (22.6%) after hexoprenaline tocolysis and in 19 (33.3%) – atosiban (p > 0,05%). On average, atosiban tocolysis allowed to prolong pregnancy by 6.5 days longer than hexoprenaline (p < 0,05).Conclusion: The results of study has shown that atosiban is more effective than hexoprenaline in pregnancy prolongation for more than 48 hours in threatening preterm labor.

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Modern tocolysis and adverse effects of tocolytics

GYNECOLOGY ◽

10.26442/2079-5696_2018.2.46-50 ◽

2018 ◽

Vol 20 (2) ◽

pp. 46-50

Author(s):

O R Baev ◽

O N Vasilchenko ◽

A O Karapetyan

Keyword(s):

Side Effects ◽

Adverse Effects ◽

Pregnant Women ◽

Preterm Labor ◽

Primary Outcome ◽

Comparable Efficacy ◽

Premature Births ◽

Instrumental Methods ◽

Tocolytic Agents ◽

Methods Of Control

Relevance. Toсolytic therapy is the only method that is used in the treatment of pregnant women with preterm labor. However, the effectiveness and safety of this therapy is still a matter of debate. One of the least studied issues of this problem is the safety of therapy, which is primarily manifested by the frequency of side effects. The aim is to carry out a comparative study of the safety of the most common tocolytic agents - atosiban, nifedipine and hexoprenaline sulfate. Material and methods. The study included 173 pregnant women with threatening premature births in a period of 28 to 34 weeks. In 54 cases, tocolysis with nifedipinum, 57 with atosiban, 62 with hexoprenaline was performed. To assess the effectiveness of tocolysis, clinical and instrumental methods of control (ultrasound with cervicometry) were used. The primary outcome points were the frequency of prolongation of pregnancy at 48 h and the incidence of side effects, including those requiring the termination of tocolysis. Results. Prolongation of pregnancy at 48 h was achieved in groups of nifedipine, atosiban and hexoprenaline sulfate, respectively in 46 (85.19%), 55 (96.49%) and 53 (77.40%) pregnant. Atosiban showed significantly higher efficacy. In 8 cases of tocolysis with nifedipine and 3 - hexoprenaline, the tocolysis protocol was not performed due to intolerance of treatment. In these observations, the highest frequency of preterm labor occurred. After excluding these observations from the analysis of differences in the frequency of prolongation of pregnancy was not. The overall frequency of adverse events in the groups was 38.9, 12.3 and 82.3%, and was significantly lower in the atosiban group than nifedipine and hexoprenaline sulfate. Conclusions. The effectiveness of tocolysis is affected by the tolerability of the drugs. Atosiban showed the best of the three drug safety profile. With comparable efficacy, atosiban has proven to be a drug that, to a greater extent than nifedipine and hexoprenaline sulfate, meets the current requirements for tocolytic drugs.

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Influence of Socioeconomic Status on SARS-CoV-2 Infection in Spanish Pregnant Women. The MOACC-19 Cohort

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18105133 ◽

2021 ◽

Vol 18 (10) ◽

pp. 5133

Author(s):

Javier Llorca ◽

Carolina Lechosa-Muñiz ◽

Lorena Lasarte-Oria ◽

Rocío Cuesta-González ◽

Marcos López-Hoyos ◽

...

Keyword(s):

Pregnant Women ◽

University Hospital ◽

Past Infection ◽

Logistic Regression Models ◽

Factors Associated ◽

Housing Characteristics ◽

The University ◽

Educational Variables ◽

The Relationship ◽

Socio Economic Factors

Little is known on socio-economic factors associated with SARS-CoV-2 infection in pregnant women. Here, we analyze the relationship between educational, occupational, and housing variables with SARS-CoV-2 infection in a cohort of 988 pregnant women in Spain. Pregnant women were recruited at the University Hospital Marques de Valdecilla, Santander, Spain, among those delivering from 23 March 2020 onwards or consulting for their 12th week of pregnancy from 26 May 2020 onwards. Information on occupational variables and housing characteristics was self-reported. Pregnant women were tested for a current or past infection of SARS-CoV-2 using both PCR and antibodies detection (ELISA). Logistic regression models were used to analyze factors associated with SARS-CoV-2 infection, adjusting for age and country of origin. Infection by SARS-CoV-2 was not associated with educational level or occupational variables, except for where the pregnant woman was a healthcare worker (odds ratio (OR) = 2.87, 95% confidence interval (CI): 0.84–9.79). Housing with four or more rooms (OR = 2.07, 95% CI: 0.96–4.47), four or more people in the household (OR = 1.91, 95% CI: 0.89–4.14), lack of heating (OR = 2.81, 95% CI: 1.24–6.34) and less than 23 square meters per person (OR = 3.97, 95% CI: 1.43–11.1) were the housing characteristics associated with SARS-CoV-2 infection. Housing characteristics, but not occupational or educational variables, were associated with SARS-CoV-2 infection. Guidelines on the prevention of COVID-19 should reinforce household measures to prevent pregnant women from becoming infected by their relatives.

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Epidemiology, Outcomes and Coronary Angiography Findings of Patients Following Out-of-Hospital Cardiac Arrest: A single-centre experience from Oman

Sultan Qaboos University Medical Journal [SQUMJ] ◽

10.18295/squmj.2018.18.02.006 ◽

2018 ◽

Vol 18 (2) ◽

pp. 155 ◽

Cited By ~ 2

Author(s):

Sunil K. Nadar ◽

Mohammed Mujtaba ◽

Hafidh Al-Hadi ◽

Muhammed Sadiq ◽

Adil Al-Riyami ◽

...

Keyword(s):

Cardiac Arrest ◽

Survival Rate ◽

Coronary Angiography ◽

Cardiopulmonary Resuscitation ◽

Patient Outcome Assessment ◽

Spontaneous Circulation ◽

University Hospital ◽

Sultan Qaboos University ◽

St Segment Elevation ◽

Hospital Cardiac Arrest

Objectives: Out-of-hospital cardiac arrests (OHCAs) are a leading cause of death worldwide. However, data regarding the management and outcomes of affected patients are lacking in the Middle East. The current study aimed to present the angiographic findings and outcomes of patients presenting with OHCA in Muscat, Oman. Methods: This retrospective study took place between January 2012 and December 2016 at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman. All adult patients who presented following an OHCA to the Emergency Department of SQUH during the study period were included. Demographic and clinical data were collected from electronic medical records. Results: A total of 216 patients were included in the study. The majority (63.9%) presented after having collapsed, while 22.3% presented with chest pains. Asystole was the most frequent initial cardiac rhythm (62.5%), with only 10% having ventricular tachycardia/fibrillation. Very few patients (1.4%) had received cardiopulmonary resuscitation (CPR) prior to presentation. In total, 85 patients (39.4%) returned to spontaneous circulation (RSC); of these, post-RSC electrocardiography revealed an ST-segment elevation in 41.2% and normal findings in 23.5%. There were 63 patients who underwent coronary angiography, with 28 requiring stenting. Overall, 13% of patients survived and were discharged, although three survivors suffered permanent hypoxic brain damage. Conclusion: The overall survival rate of patients who had experienced an OHCA was low. Education programmes should focus on the benefits of immediate CPR for individuals experiencing an OHCA, with more opportunities for CPR training to be made available to the general public in Oman.Keywords: Out-of-Hospital Cardiac Arrest; Cardiopulmonary Resuscitation; Patient Outcome Assessment; Survival Rate; Coronary Angiography; Oman.

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