scholarly journals Morphological features of endometrial pinopodia formation during the luteal phase in women with previous unsuccessful implantation

2021 ◽  
pp. 28-33
Author(s):  
Y.G. Antypkin ◽  
O.O. Lytvak ◽  
O.G. Kuryk ◽  
G.P. Pasichnyk ◽  
Y.M. Bondarenko
Keyword(s):  
Menstrual Cycle ◽  
Morphological Changes ◽  
Morphological Structure ◽  
Secretory Cells ◽  
Apical Surface ◽  
Intravenous Anesthesia ◽  
Infertile Women ◽  
Morphological Picture ◽  
History Of ◽  
Endometrial Epithelium

Pinopodia of the receptive endometrium is one of the prerequisites for successful embryo implantation.Study objective: to analyze the morphological changes of the endometrium in infertile women, in particular to investigate the apical surface of epithelial cells and pinopodia formation. Materials and methods. 12 patients with a history of previous implantation failure were examined. Patients underwent hysteroscopy with biopsy under intravenous anesthesia on 20–24th day of the menstrual cycle. Morphological structure of pinopodia on the surface of the endometrial epithelium was evaluated by scanning electron microscopy.Results. Apical surface of epitheliocytes was damaged in 16.7% studied biopsies. Morphological picture and maturity of the endometrial glands did not correspond to the actual day of the menstrual cycle in 41.7% biopsies. Degree of glands maturity in these patients was low, so there was a delay in the menstrual cycle. Ultrastructural examination showed clear changes in the structure of secretory and ciliary cells in 33.3%. On the apical surface of the secretory cells there was no or small number of microvilli; cilia of eyelashes were shortened or sometimes fused together. Pinopodia as a one of the most important components of implantation was detected in only 50% of patients. Only in 33.3% of participants visualized fully developed, mature pinopodia. Conclusions. Analysis of own data showed that in the endometrium of women with previous unsuccessful implantation there are certain morphological changes, which are physiologically manifested by a delay in the luteinizing phase of the menstrual cycle and, possibly, as a result mismatch of endometrial structure and embryo maturity. Time of pinopodia onset in participants varied from 20 to 24 days of the menstrual cycle. It is necessary to improve the design and conduct further research to study the association between the expression of receptivity markers and ultrastructural structure.

scholarly journals Cytotoxic Effects of N,N-Diethyl-Meta-Toluamide (DEET) on Sinonasal Epithelia

OTO Open ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 2473974X2110092
Author(s):  
Jivianne T. Lee ◽  
Saroj Basak
Keyword(s):  
Cell Viability ◽  
Chronic Rhinosinusitis ◽  
Morphological Changes ◽  
Environmental Toxicants ◽  
Cytotoxic Effects ◽  
Airborne Pollutants ◽  
Cell Monitoring ◽  
History Of ◽  
And Control ◽  
Dose Dependent

Although the etiology of chronic rhinosinusitis remains unknown, environmental factors including airborne pollutants and toxicants are postulated to contribute to its pathogenesis. However, the precise pathomechanisms with which environmental toxicants may contribute to chronic rhinosinusitis are not fully understood. The purpose of this pilot study is to examine the cytotoxic effects of N,N-diethyl- meta-toluamide (DEET), a commonly used pesticide, on sinonasal epithelial cells (SNECs). Sinus mucosa was obtained from 3 subjects without a history of chronic rhinosinusitis. Cultured SNECs were exposed to various concentrations of DEET (0-5 mM) for 6 days. Cell viability, proliferation, and morphologic changes were assessed using the MTT colorimetric dye assay and the Incucyte Live Cell Monitoring System. Statistically significant dose-dependent reduction in cell viability and proliferation was observed between exposure and control groups ( P < .05) at all concentrations tested. Dose-dependent cellular morphological changes were also seen. These findings indicate that DEET exposure induces dose-dependent cytotoxicity in sinonasal epithelia.

scholarly journals Age-Specific Prevalence and Clinical Characteristics of Humeral Medial Epicondyle Apophysitis and Osteochondritis Dissecans: Ultrasonographic Assessment of 4249 Players

2017 ◽  
Vol 5 (5) ◽  
pp. 232596711770770 ◽  
Author(s):  
Kenichi Otoshi ◽  
Shinichi Kikuchi ◽  
Kinshi Kato ◽  
Ryohei Sato ◽  
Takahiro Igari ◽  
...  
Keyword(s):  
Osteochondritis Dissecans ◽  
Morphological Changes ◽  
Medial Epicondyle ◽  
Baseball Players ◽  
Elbow Pain ◽  
Elbow Injuries ◽  
Bony Healing ◽  
History Of ◽  
Study Participants ◽  
Ultrasonographic Assessment

Background: Traction apophysitis of medial epicondyle (MEC) lesions and osteochondritis dissecans (OCD) of the capitellum are common elbow injuries in adolescent baseball players. However, the age-specific prevalence of these pathologies and their influence on elbow pain remain unknown. Purpose: To investigate the age-specific prevalence of each MEC lesion and capitellar OCD and to identify the incidence of elbow pain in each condition. Study Design: Descriptive epidemiology study. Methods: Study participants consisted of 4249 baseball players aged 6 to 17 years. A questionnaire was used to assess history of elbow pain, and morphological changes of the elbow joint were assessed using ultrasonography. Results: Regarding MEC lesions, fragmented (FG) and irregular (IR) lesions both reached their greatest respective prevalence at 11 to 12 years of age. After 14 years of age, IR decreased sharply, whereas FG was maintained at approximately 10%. Hypertrophic (HT) lesions increased sharply, reaching over 50% at 16 years of age, while there was a decrease in IR and FG lesions in the same age group. The prevalence of capitellar OCD remained the same (approximately 2%) throughout all ages except for in players aged 7 to 8 years (>7%). Players with MEC lesions had significantly greater prevalence of a history of elbow pain compared with those without (68.0% vs 39.1%) and were at a significantly greater risk for FG lesions (odds ratio [OR], 4.04; 95% CI, 3.16-5.22) compared with IR (OR, 3.22; 95% CI, 2.44-4.27) and HT lesions (OR, 2.03; 95% CI, 1.75-2.36). Players with capitellar OCD also had a significantly greater risk of a history of elbow pain (OR, 2.34; 95% CI, 1.40-4.11). Conclusion: Controlling the amount of practice and its intensity according to the condition of each player in the preadolescent and adolescent periods may be important in accelerating bony healing and decreasing preventable elbow pain in adulthood.

Association of serum progesterone level and endometrial estradiol & progesterone receptors in women with unexplained recurrent miscarriage

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ihab Found Alam ◽  
Sherif Ahmed Ashoush ◽  
Ihab Adel Gomaa ◽  
Ahmed Sabry AbdEl-Hafeez
Keyword(s):  
Menstrual Cycle ◽  
Recurrent Miscarriage ◽  
Progesterone Receptors ◽  
First Trimester ◽  
Endometrial Biopsy ◽  
Serum Progesterone ◽  
Normal Endometrium ◽  
History Of ◽  
Unexplained Recurrent Miscarriage

Abstract This study investigated the endometrial tissue to study the fluctuation of estrogen receptors (ERs) and progesterone receptors (PRs) in women with recurrent miscarriage compared with normal endometrium of fertile women. Forty women were divided into two groups: 20 non-pregnant women with history of recurrent miscarriage (who had three or more first- trimester miscarriages) and 20 controls. Both groups had regular ovulatory menses and proven fertility. Endometrial biopsy was taken in the two groups during the luteal phase of the menstrual cycle, between the 8th and the 10th postovulatory days using an endometrial biopsy curette for determination of estrogen (E2) and progesterone (P4) hormones levels and their receptors. On the same day as the biopsy, a blood sample was taken for determination of estradiol (E2) and progesterone (P4) levels. The obtained results showed no significant differences between both groups regarding age, BMI, menarche, menstrual cycle & menstruation, significant decrease in E2 and P4 levels in the serum and endometrial biopsy of recurrent miscarriage women versus control. In control and recurrent miscarriage; ER levels in cytoplasm and salt extracted nucleus were higher than PR levels. ER and PR values were higher in the nuclear compartment than in the cytoplasmic compartment. The women with early recurrent miscarriage showed lower levels of both ER and PR significantly. All types of endometrial receptors (ER &PR) and hormones (E2 &P4) in serum and endometrium showed correlation relating to number of previous miscarriages.

scholarly journals Synergism of Hypothyroidism and Hyperprolactinemia to impact on efficiency of menstrual cycle and ovulatory status

2017 ◽  
Vol 1 (28) ◽  
pp. 661-670
Author(s):  
NASSER NAFAA ABRAHEM ◽  
SAAD HASSAN DREIJ ◽  
Mahdi Saber Al-Deresawi
Keyword(s):  
Thyroid Hormone ◽  
Menstrual Cycle ◽  
Teaching Hospital ◽  
Infertile Women ◽  
Menstrual Disturbance ◽  
Menstrual Irregularities ◽  
Relationship Of ◽  
The Relationship ◽  
Hormonal Assay

This study aimed to determine the relationship of  thyroid hormone disturbance and prolactin over production to impact on the menstrual irregularities anovulation .This  study were carried out in Al-Karama teaching hospital and  included (47) primary infertile women, (30 ) of them were with hypothyroidism , the patients aged between (18-40). This study extended from February to June  2017. The hormonal assay of TSH, FT3, FT4 ,FSH , LH and PRL that revealed  :- There were high  significantly (p < 0.01) increased in TSH concentrations , significantly (p < 0.05) decreased in levels of FT3 and  FT4.Gonadotropins hormones recorded significantly ( p <0.05) decreased in levels of FSH and non significantly increased in levels of LH. Prolactin concentrations that obtained revealed to significantly (p < 0.05) increased in patients with hypothyroidism . This study reported there were (70%) of hypothyroidism patients with menstrual disturbance. We concluded , that hypothyroidism and Hyperprolactinemia commonly related and synergized to menstrual irregularities and ovulatory failure. 

scholarly journals Endocast of the Late Triassic (Carnian) dinosaur Saturnalia tupiniquim: implications for the evolution of brain tissue in Sauropodomorpha

2018 ◽  
Author(s):  
Mario Bronzati ◽  
Oliver W M Rauhut ◽  
Jonathas S Bittencourt ◽  
Max C. Langer
Keyword(s):  
South America ◽  
Brain Tissue ◽  
Evolutionary History ◽  
Morphological Changes ◽  
Volume Reduction ◽  
Late Triassic ◽  
History Of

The evolutionary history of dinosaurs might date back to the fist stages of the Triassic (c. 250– 240 Ma), but the oldest unequivocal records of the group come from Late Triassic (Carnian – c. 230 Ma) rocks of South America. Here, we present the fist braincase endocast of a Carnian dinosaur, the sauropodomorph Saturnalia tupiniquim, and provide new data regarding the evolution of the flccular and paraflccular lobe of the cerebellum (FFL), which has been extensively discussed in the fild of palaeoneurology. Previous studies proposed that the development of a permanent quadrupedal stance was one of the factors leading to the volume reduction of the FFL of sauropods. However, based on the new data for S. tupiniquim we identifid a fist moment of FFL volume reduction in nonsauropodan Sauropodomorpha, preceding the acquisition of a fully quadrupedal stance. Analysing variations in FFL volume alongside other morphological changes in the group, we suggest that this reduction is potentially related to the adoption of a more restricted herbivore diet. In this context, the FFL of sauropods might represent a vestigial trait, retained in a reduced version from the bipedal and predatory early sauropodomorphs.

scholarly journals Morphological alterations in the heart and aorta of rats treated with glucocorticoids

2015 ◽  
Vol 32 (04) ◽  
pp. 231-235
Author(s):  
R. Dantas ◽  
K. Souza ◽  
D. Santos ◽  
V. Feitosa ◽  
E. Fioretto ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Histological Analysis ◽  
Saline Solution ◽  
Morphological Changes ◽  
Morphological Structure ◽  
Control Group ◽  
Morphological Alterations ◽  
Heart Chamber ◽  
Male Wistar Rats ◽  
Synthetic Glucocorticoid

Abstract Introduction: The objective of this study was to analyze the morphological structure of the heart and aorta of rats treated with the synthetic glucocorticoid dexamethasone. Material and Methods: Male Wistar rats were divided into two groups: 08 control rats undergoing treatment with a 0.9% saline solution for 10 days and 08 rats treated for 10 days with dexamethasone (2mg/kg animal weight). Results: Histological analysis detected a mild cardiac hypertrophy and 15% reduction of collagen located in the aorta of animals treated with glucocorticoid when compared to the control group. Conclusion: We conclude that treatment with dexamethasone for a period of 10 consecutive days is able to promote morphological changes in the structure of the heart chamber and, impair morphological structure of aorta.

scholarly journals Selection for increased tibia length in mice alters skull shape through parallel changes in developmental mechanisms

2020 ◽  
Author(s):  
Colton M. Unger ◽  
Jay Devine ◽  
Benedikt Hallgrímsson ◽  
Campbell Rolian
Keyword(s):  
Endochondral Ossification ◽  
Morphological Changes ◽  
Cranial Base ◽  
Direct Selection ◽  
Micro Ct ◽  
Growth Plates ◽  
History Of ◽  
Selection For ◽  
Tibia Length ◽  
Shape Changes

AbstractBones in the vertebrate cranial base and limb skeleton grow by endochondral ossification, under the control of growth plates. Mechanisms of endochondral ossification are conserved across growth plates, which increases covariation in size and shape among bones, and in turn may lead to correlated changes in skeletal traits not under direct selection. We used micro-CT and geometric morphometrics to characterize shape changes in the cranium of the Longshanks mouse, which was selectively bred for longer tibiae. We show that Longshanks skulls became longer, flatter, and narrower in a stepwise process. Moreover, we show that these morphological changes likely resulted from developmental changes in the growth plates of the Longshanks cranial base, mirroring changes observed in its tibia. Thus, indirect and non-adaptive morphological changes can occur due to developmental overlap among distant skeletal elements, with important implications for interpreting the evolutionary history of vertebrate skeletal form.

scholarly journals Features of the morphological structure of the placenta in pregnant women with preeclampsia

2021 ◽  
pp. 10-15
Author(s):  
Volodymyr I. Chermak ◽  
Ihor I. Chermak ◽  
Chukwuanyinonso O. Ikeotuonye ◽  
Anatolii Ya. Senchuk
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
High Frequency ◽  
Morphological Changes ◽  
Morphological Structure ◽  
Morphological Features ◽  
Placental Insufficiency ◽  
Control Group ◽  
Basic Group ◽  
Adaptive Reactions

To study morphological features of the placenta in women in labor, pregnancy which complicated by preeclampsia we studied 26 placentae, of which 17 were from pregnant women with mild to moderate preeclampsia (basic group) and 9 from healthy women (control group). Histologically the study was conducted with methodically recommendations of T.D. Zadorozhnaya et al. for light microscopy. During the study of morphological features of the placenta in women in labor with preeclampsia were installed morphological changes in the placenta, which reflect a tendency to develop compensatory-adaptive reactions following their stress and exhaustion, which is a sign of placental insufficiency. Received data allow claiming a high frequency of development placental insufficiency in pregnant women with risk factors such as chronic salpingo-oophoritis, anemia, late preeclampsia, and inflammation diseases kidney.

Paracrystalline bundles of large tubules, induced in vitro by Mebendazole in Cysticercus cellulosae

Parasitology ◽  
1981 ◽  
Vol 83 (3) ◽  
pp. 513-518 ◽  
Author(s):  
J. P. Laclette ◽  
Marie Therese Merchant ◽  
Kaethe Willms ◽  
L. Cañedo
Keyword(s):  
Electron Microscopy ◽  
Culture Medium ◽  
Morphological Changes ◽  
Bladder Wall ◽  
Secretory Cells ◽  
External Diameter ◽  
Nematode Larvae ◽  
Transmission Electron ◽  
Cysticercus Cellulosae

SUMMARYThe effect of the anthelmintic Mebendazole on Cysticercus cellulosae maintained in culture medium was studied by transmission electron microscopy. In addition to the well-known morphological changes induced by Mebendazole in other cestode and nematode larvae, it also induced the cytoplasmic appearance of paracrystalline bundles in the secretory cells of the bladder wall. These bundles were formed by groups of large parallel tubules arranged in a hexagonal-like pattern. The tubules, which had an external diameter of about 50 nm and a length that might exceed 5 μm, were surrounded by a matrix and a distance between neighbouring tubules of 80–120 nm centre to centre was estimated. The tubules were stable to colchicine and low temperature. The temporary appearance of bundles is described and some alternative explanations on their origin are advanced.

Opportunities to use historical comments in teaching morphology

2021 ◽  
Vol 66 (05) ◽  
pp. 45-48
Author(s):  
Tərlan Əliş qızı Əliyeva ◽  
Keyword(s):  
Key Words ◽  
Historical Memory ◽  
Morphological Structure ◽  
Modern State ◽  
Young Generation ◽  
Ancient History ◽  
Correct Definition ◽  
History Of ◽  
Definition Of ◽  
Rich History

Our language reflects the historical memory, traditions, ethnic and moral views of our people and so on. it is our invaluable spiritual wealth that always lives in us. One of the main tasks of the Azerbaijani language is to educate the young generation in the spirit of love for our national and spiritual resources, ancient history, loyalty to our people and, most importantly, knowledge of the subtleties of the language, using these inexhaustible opportunities. When using historical comments as a tool in the process of teaching the morphology of the Azerbaijani language in the acquisition of grammatical forms regulated by a number of intra-linguistic and extra-linguistic events that are difficult to comprehend, students gain more information about the morphological structure of our language. The use of historical comments in Azerbaijani language lessons should be done systematically. The advantages of referring to its ancient and rich history in the study of the modern state of language are reflected in the correct definition of the morphological structure of the language. We can even point out the importance of commenting on the history of writing in the teaching of the alphabet. In the process of teaching morphology, we can note the importance of commentary in the deep mastery of individual speech senses. The study of morphological features of the Azerbaijani language is based on the principle of history. Because the goal is to instill in today's young generation some information about the history of our language. Key words: Azerbaijani language, morphology, history, modern state of language, derivations, word creation, suffixes, historical commentary

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