Restructuring of erythrocytes in persons of mature and elderly age on the background of diabetes mellitus

Background: Owing to change in behavior and lifestyle patterns, diabetes mellitus and hypertension are in increasing trend worldwide. They are associated with various complications resulting in high morbidity. Early detection of these would necessitate the prevention of complications associated with it and improves the quality of life of the people. The objective of the study was to assess the prevalence and determinants of diabetes mellitus and hypertension among urban population in the field practice area of a tertiary care hospital in Coimbatore.Methods: 299 individuals of both sexes belonging to six wards in the field practice area of a tertiary care hospital in Coimbatore were randomly selected and screened for diabetes mellitus and hypertension. Diagnosis was based on American Diabetic Association and JNC 7 guidelines for diabetes mellitus and hypertension respectively. Data on various factors associated was collected using pretested validated semi structured questionnaire.Results: Overall prevalence of diabetes mellitus and hypertension was found to be 32.44% and 38.8% respectively with newly diagnosed diabetes mellitus and hypertension of 4.02% and 7.37%. Overall adherence was found to be 80%. Factors such as elderly age, sedentary life style, non-vegetarian diet, obesity are found to be associated with both diabetes mellitus and hypertension.Conclusions: Almost one in every third person found to be having either diabetes mellitus/hypertension or both with 20% non-adherence to treatment. This high prevalence necessitates the need for adoption of various strategies to combat the risk factors and to promote healthy life style.

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Diabetes Mellitus at an Elderly Age

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-1284-6023 ◽

2021 ◽

Author(s):

Andrej Zeyfang ◽

Jürgen Wernecke ◽

Anke Bahrmann

Keyword(s):

Diabetes Mellitus ◽

Elderly Age

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DIABETES MELLITUS IN THE STRUCTURE OF THE REPEATED DISABILITY OF ADULT POPULATION

Medical and Social Expert Evaluation and Rehabilitation ◽

10.18821/1560-9537-2018-21-3-156-159 ◽

2018 ◽

Vol 21 (3-4) ◽

pp. 156-159

Author(s):

Marina A. Shurgaya ◽

T. A Chludeeva ◽

A. M Mammarayeva

Keyword(s):

Diabetes Mellitus ◽

Specific Gravity ◽

Middle Age ◽

Adult Population ◽

Endocrine System ◽

Retirement Age ◽

Elderly Age ◽

Group Iii ◽

Group I ◽

Rate Of Decline

In Russia in 2005-2017 990,574 persons were repeatedly recognized as disabled due to diseases of the endocrine system. The predominant etiological cause is diabetes mellitus, the specific gravity of which in the nosological structure of repeated disability due to this pathology in the dynamics is characterized by a tendency of some growth (86.8% -87.6% in 2012-2017). In the structure of recurrent disability due to diabetes mellitus, the age-adjusted PIs of retirement age prevailed - 45.5%, their specific gravity increased (from 36.1% in 2012). A decrease in the level of repeated disability due to diabetes mellitus was revealed from 4.8 to 2.5 per 10 thousand adult population (the indicator of visibility in relation to the level of 2012 was 52.1%). This trend took place in all age sectors of the adult population, with the maximum rate of decline in the indicator in 2014-2015. In 2017, the rate of decrease in the level of repeated disability among the population of middle age was -14.6%, whereas among the population of young and elderly age the indicator was 2 times lower and did not differ significantly (-7.1% and -7.7, respectively %). In the structure of recurrent disability, due to diabetes mellitus, the III group III was prevalent, however, a negative tendency was observed to decrease their specific gravity with an increase in the IIII group IIII indices (26.4% -28.4% and group I (7.1-13,0%).

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Management of Diastolic Heart Failure

Indonesian Journal of Cardiology ◽

10.30701/ijc.v35i1.375 ◽

2015 ◽

pp. 50-8

Author(s):

Starry H. Rampengan

Keyword(s):

Diabetes Mellitus ◽

Heart Failure ◽

Systolic Function ◽

Diastolic Heart Failure ◽

Angiotensin Receptor Blockers ◽

Venous Pressure ◽

Left Ventricular Systolic Function ◽

Left Ventricular ◽

Ventricular Systolic Function ◽

Elderly Age

The diastolic heart failure also referred to as heart failure with preserved left ventricular systolic function (preserved ejection fraction). The difference between systolic and diastolic HFs is a pathophysiological one and isolated forms of left ventricular dysfunction are rarely observed. In diastolic HF left ventricular systolic function is normal or only slightly impaired, and the typical manifestations of HF result from increased filling pressure caused by impaired relaxation and compliance of the left ventricle. The management should include antihypertensive treatment, maintenanceof the sinus rhythm, prevention of tachycardia, venous pressure reduction, prevention of myocardial ischemia and prevention of diabetes mellitus. Treatment of diastolic HF is aimed to stop the progression of the disease, relieve its symptoms, eliminate exacerbations and reduce the mortality. The predisposing factors for diastolic dysfunction include elderly age, female sex, obesity, coronary artery disease, hypertension and diabetes mellitus. The European Society of Cardiology specifies the type of therapy in diastolic HF based on: angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, non dihydropyridine calcium channel blockers, diuretics.

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Risk Factors for Mortality of Patients with COVID-19 in Korea: A Nationwide Population-based Study

10.21203/rs.3.rs-143694/v1 ◽

2021 ◽

Author(s):

Se Jun Park ◽

Hyungkook Lee ◽

Tae Mi Youk ◽

Han Ho Jeon

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Population Based ◽

Chronic Obstructive ◽

Elderly Age ◽

Health Crisis ◽

Medical Aid ◽

Logistic Regression Models ◽

Outbreak Area ◽

Large Outbreak

Abstract Background: Coronavirus Disease 2019 (COVID-19) is an ongoing major global health crisis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outcomes of COVID-19 in patients remain unclear. We aimed to identify risk factors for the mortality of COVID-19 in the Republic of Korea without health system disruption.Methods: The data of confirmed COVID-19 patients were retrieved from Health Insurance Review and Assessment Service (HIRA) dataset between January 3 and June 1, 2020. We used multivariable logistic regression models to identify risk factors for mortality in patients with COVID-19.Results: We identified 7,333 COVID-19 patients, of whom 227 (3.1%) died. Hypertension was the most common (26%), followed by diabetes mellitus (23.0%). In multivariate analysis, male (OR: 1.92, P <0.0001), elderly (age >65) (OR: 11.00, P < 0.0001), living in a large outbreak area (OR: 2.61, P < 0.0001), Medical Aid beneficiaries (OR: 1.54, P = 0.0282), Charlson Comorbidity Index (CCI) score ≥3 (OR: 3.25, P = 0.029), hypertension (OR: 1.90, P = 0.0013), chronic obstructive pulmonary disease (COPD) (OR: 1.61, P = 0.0374), congestive heart failure (CHF) (OR: 2.14, P = 0.0001), and end-stage renal disease (ESRD) (OR: 5.69, P = 0.0090) were independent risk factors associated with mortality in COVID-19 patients. However, diabetes mellitus, liver cirrhosis, and inflammatory bowel disease were not risk factors for mortality.Conclusion: Male, elderly patients ˃65 years old, Medical Aid beneficiaries, higher CCI (≥3), and living in a large outbreak area might have a greater risk of mortality and comorbidities such as hypertension, COPD, CHF, and ESRD could also greatly affect the mortality in COVID-19 patients.

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SELF-CARE MANAJEMEN GLUKOSA DAN PENGENDALIAN DIET SEBAGAI UPAYA PENGENDALIAN KADAR GLUKOSA DARAH PENYANDANG DIABETES MELLITUS

Jurnal Ilmiah Kesehatan Keperawatan ◽

10.26753/jikk.v14i3.349 ◽

2019 ◽

Vol 14 (3) ◽

pp. 83

Author(s):

Ahmad Asyrofi ◽

Triana Arisdiani ◽

Yuni Puji Widiastuti

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Self Care ◽

Control Design ◽

Case Control ◽

Dietary Control ◽

Research Needs ◽

Elderly Age ◽

Cultural Changes ◽

Glucose Management

The phenomenon of the number of people with diabetes mellitus (DM) in theworld today is increasing along with socio-cultural changes, and the largenumber of people with DM who are undiagnosed becomes increasinglypotential to cause further complications. Self-care glucose management anddietary control are part of the pillars in DM care. The aim of the study was todetermine differences in blood glucose management and dietary controlbetween uncontrolled glycemic (HbA1c > 7%) and controlled glycemic(HbA1c ≤ 7%). The study uses a case control design. The sample of this studywas DM patients with adult and elderly age of 104 samples including: 52uncontrolled glycemic groups and 52 controlled glycemic groups, withconvinience techniques. The research tool uses Diabetes Self-ManagementQuestionnaire (DSMQ) subscale glucose management and dietary control.Data analysis using Mann-Whitney U Test. The results showed significantdifferences in glucose management (p = 0.034) and dietary control (p = 0.001)between uncontrolled glycemic groups and controlled glycemic groups.Recommended for people with diabetes mellitus to improve glucosemanagement self-care activities and dietary control to control glycemic(HbA1c ≤ 7). Subsequent research needs to look for factors that predict glucosemanagement and dietary control for people with diabetes.

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GRP78: THE CONNECTING LINK BETWEEN COVID-19 AND MUCORMYCOSIS?

10.36106/ijsr/7621620 ◽

2021 ◽

pp. 53-53

Author(s):

Abhijeet Anand ◽

Rohini R Nair

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Acute Respiratory Distress Syndrome ◽

Distress Syndrome ◽

Disease Process ◽

Respiratory Illness ◽

Acute Respiratory Illness ◽

Elderly Age ◽

The World ◽

The One

The ongoing pandemic of COVID-19 acute respiratory illness has affected the world in unimaginable manner. The treatment of moderate to severe COVID-19 Acute Respiratory Distress Syndrome (ARDS) includes use of steroids as proven therapy to reduce mortality.(1) The observed severity and mortality of COVID-19 is more in patients with co-morbidities and elderly age. Diabetes mellitus being the one of the most commonly associated comorbidities with poor outcome.(2) The stress response to the disease process as well as the use of steroids is causing a state of hyperglycemia due to insulin resistance, for which vigilant monitoring and insulin is needed.(3)

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Faktor Risiko Terjadinya Coronavirus Disease 2019 (Covid-19) pada Penyandang Diabetes Melitus Tipe 2

e-CliniC ◽

10.35790/ecl.v9i1.32301 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Pomantow A. L. Roeroe ◽

Bisuk P. Sedli ◽

Octavianus Umboh

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Literature Review ◽

Blood Glucose Control ◽

Google Scholar ◽

Elderly Age ◽

Coagulation Activity ◽

Review Study ◽

Diabetes Melitus

Abstract: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 and has been declared as a pandemic by WHO in March 11, 2020. This disease is an additional problem in people with type 2 diabetes mellitus (T2DM). Several studies have shown that diabetes is a risk factor for COVID-19. This study was aimed to determine the risk factors for the occurrence of Coronavirus Disease 2019 (COVID-19) in T2DM patients. This was a literature review study using several journal databases, namely Google Scholar, PubMed, and Science Direct. Literature searching was performed by using the PICOS method and the analysis was carried out qualitatively The results obtained 10 literatures reporting that T2DM would increase the severity and mortality of COVID-19 patients related to elderly age, obesity, chronic systemic inflammation, increased coagulation activity, potential direct damage to the pancreas, changes in expression of ACE2 receptors, dysregulation of the number, activity of immune cells, alveolar dysfunction, and endothelial dysfunction. There was not yet strong evidence regarding discontinuation or continuation of various diabetes drugs in COVID-19 patients, but insulin remains the recommended agent for blood glucose control. In conclusion, T2DM increases the severity and mortality rate of COVID-19 patients Keywords: diabetes mellitus; COVID-19; risk factors Abstrak: Coronavirus Disease 2019 (COVID-19) merupakan salah satu penyakit infeksi yang disebabkan oleh SARS-CoV-2 dan telah ditetapkan sebagai pandemi oleh WHO pada 11 Maret 2020. Penyakit ini menjadi masalah tambahan bagi penyandang diabetes melitus tipe 2 (DMT2). Beberapa penelitian menunjukkan bahwa diabetes merupakan salah satu faktor risiko terjadinya COVID-19. Penelitian ini bertujuan untuk mengetahui faktor risiko terjadinya COVID-19 pada penyandang DMT2. Jenis penelitian ialah literature review menggunakan laporan penelitian dari beberapa database jurnal, yaitu google scholar, PubMed, dan ClinicalKey. Pencarian artikel menggunakan metode PICOS dan analisis dilakukan secara kualitatif. Hasil penelitian mendapatkan 10 laporan penelitian yang melaporkan bahwa DMT2 meningkatkan tingkat keparahan dan mortalitas pasien COVID-19 akibat adanya mekanisme terkait dengan usia lanjut, obesitas, peradangan sistemik kronis, peningkatan aktivitas koagulasi, potensi kerusakan langsung pankreas, perubahan ekspresi reseptor ACE2, disregulasi jumlah dan aktivitas sel imun, disfungsi alveolar, dan disfungsi endotel. Belum terdapat bukti kuat mengenai penghentian atau pelanjutan berbagai obat diabetes pada pasien COVID-19, tetapi insulin tetap menjadi obat yang disarankan untuk mengontrol glukosa darah. Simpulan penelitian ini ialah DMT2 meningkatkan tingkat keparahan dan mortalitas dari pasien COVID-19.Kata kunci: diabetes melitus tipe 2 (DMT2), COVID-19, faktor risiko

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Peculiarities of clinical characteristics in different aged patients with vulvar cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e16512 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e16512-e16512

Author(s):

Victoria Aleksandrovna Ivanova ◽

Galina Nerodo ◽

Ekaterina Alekseevna Nerodo

Keyword(s):

Diabetes Mellitus ◽

Human Papilloma Virus ◽

Old Age ◽

Vulvar Cancer ◽

Reproductive Age ◽

Hypertensive Disease ◽

Elderly Age ◽

Aged Patients ◽

Papilloma Virus ◽

Early Stages

e16512 Background: Comparison of vulvar cancer clinical flow in patients of reproductive and old age. Methods: The studying of vulvar cancer clinical delopment included 64 patients of reproductive age and 775 patients of old age. Results: The patients were from 20 to 90 years old; 64 (7.6%) of them were from 20 to 50 years old; the other 92.4% were more than 50 years old. The patients of reproductive age at early stages made up 70.3%; the patients of old age at early stages made up 70.3%. Hypertensive disease (13.5%), obesity (13.5%), diseases of liver and stomach (11.8%) and the sole case of diabetes mellitus (1.6%) were among the concomitant diseases of the reproductive age patients. Among the seniors,: hypertensive disease (77.7%), atherosclerosis (42.9%), obesity (62.8%), osteochondrosis (18.3%), diabetes mellitus (9.1%), diseases of liver and gall bladder (29.95%). Only 16% of the patients from the younger group had leukokeratosis and kraurosis; among the seniors, 62% had those diseases. At the same time, the younger the group of patients with vulvar cancer, the more often they had papilloma, condyloma on vulva in their anamnesis, and infection of human papilloma virus. In the group under 50 such patients made up 87.5%, and in the group of seniors there was one case of infection of human papilloma virus – 0.48%. All the patients undergone different types of complex curing; more than half of the patients undergone chemotherapy. 17% of the patients of the reproductive age, and 23.3% of the seniors had the relapses of the disease. Conclusions: Our study proved the statement about existence of two pathogenetic variants of vulvar cancer appearance: the first variant is HPV– positive, diagnosed in young women; the second variant is HPV– negative, diagnosed in women of elderly age, associated with neurodystrophic processes and chronic infection.

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Gambaran Perilaku Perawatan Kaki Dan Faktor-Faktor Yang Mempengaruhi Perawatan Kaki Pada Penderita Diabetes Mellitus di Garut

Jurnal Keperawatan Muhammadiyah ◽

10.30651/jkm.v6i3.8265 ◽

2021 ◽

Vol 6 (3) ◽

Author(s):

Citra Windani Mambang Sari ◽

Tina Lestari ◽

Sandra Pebrianti

Keyword(s):

Diabetes Mellitus ◽

Health Center ◽

Sex Education ◽

Demographic Data ◽

Sampling Technique ◽

Education Level ◽

Foot Care ◽

Elderly Age ◽

Questionnaire Result ◽

Care Behavior

Introduction: Foot care behavior is an important component in the prevention of diabetic feet, but most DM sufferees ignore this. Factors that influence the foot care behavior in people with diabetes mellitus, namely age, sex, education, knowledge, income and duration of diabetes. The purpose of this research was to determine the description of foot care behavior and the factors that influence foot care at Bayongbong Health Center. Method: This Research conducted using quantitative approach. The population in this research amounted to 35 respondents using total sampling technique. The instrument used was questionnaire which included: demographic data, health characteristics, knowledge and foot care behavior using the Nothingham Assessment of Functional Foot care (NAFF) questionnaire. Result: The result showed that most of the respondents had poor foot care behavior and almost half were in the vulnerable pre-elderly age 45-59 years with the sex of mostly women with an education level almost half elementary school, most of the income of respondents was > 1.8 M with the duration of suffering DM was mostly ≥ 3 years old and most respondents had good knowledge. Conclusion: From the result of the research, there needs to be education related to foot care that is more specific and more emphasized about the importance of good behavior in foot care, while the behaviors that need to be improved are foot hygiene, foot examination, footwear selection, prevention and management of injuries.

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