scholarly journals Drugs Loaded into Electrospun Polymeric Nanofibers for Delivery

2019 ◽  
Vol 22 ◽  
pp. 313-331 ◽  
Author(s):  
Erick José Torres-Martinez ◽  
Graciela Lizeth Pérez-González ◽  
Aracely Serrano-Medina ◽  
Daniel Grande ◽  
Ricardo Vera-Graziano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Anticancer Agents ◽  
Drug Loading ◽  
High Surface ◽  
Volume Ratio ◽  
Electrospinning Technique ◽  
Vast Number ◽  
Polymeric Nanofibers ◽  
Polymeric Solutions

The electrospinning technique is a useful and versatile approach for conversion of polymeric solutions into continuous fibers, ranging from a few micrometers (10–100 μm) to the scale of nanometers (10–100 nm) in diameters. This technique can be used in a vast number of polymers, in some cases after modifying them to the required properties. The high surface-to-volume ratio of the fibers can improve some processes like cell binding and proliferation, drug loading, and mass transfer processes. One of the most important and studied areas of electrospinning is in the drug delivery field, for the controlled release of active substances ranging from antibiotics and anticancer agents, to macromolecules such as proteins and DNA. The advantage of this method is that a wide variety of low solubility drugs can be loaded into the fibers to improve their bioavailability or to attain controlled release. This review presents an overview of the reported drugs loaded into electrospun polymeric nanofibers to be used as drug delivery systems. These drugs are classified by their applications in pharmacy.

scholarly journals Electrospun Solid Dispersions of Maraviroc for Rapid Intravaginal Preexposure Prophylaxis of HIV

2014 ◽  
Vol 58 (8) ◽  
pp. 4855-4865 ◽  
Author(s):  
Cameron Ball ◽  
Kim A. Woodrow
Keyword(s):  
Drug Delivery ◽  
Dosage Form ◽  
Drug Loading ◽  
Solid Dispersions ◽  
High Surface ◽  
Aqueous Media ◽  
Volume Ratio ◽  
Water Soluble ◽  
High Drug ◽  
Solid Dosage

ABSTRACTThe development of topical anti-human immunodeficiency virus (HIV) microbicides may provide women with strategies to protect themselves against sexual HIV transmission. Pericoital drug delivery systems intended for use immediately before sex, such as microbicide gels, must deliver high drug doses for maximal effectiveness. The goal of achieving a high antiretroviral dose is complicated by the need to simultaneously retain the dose and quickly release drug compounds into the tissue. For drugs with limited solubility in vaginal gels, increasing the gel volume to increase the dose can result in leakage. While solid dosage forms like films and tablets increase retention, they often require more than 15 min to fully dissolve, potentially increasing the risk of inducing epithelial abrasions during sex. Here, we demonstrate that water-soluble electrospun fibers, with their high surface area-to-volume ratio and ability to disperse antiretrovirals, can serve as an alternative solid dosage form for microbicides requiring both high drug loading and rapid hydration. We formulated maraviroc at up to 28 wt% into electrospun solid dispersions made from either polyvinylpyrrolidone or poly(ethylene oxide) nanofibers or microfibers and investigated the role of drug loading, distribution, and crystallinity in determining drug release rates into aqueous media. We show here that water-soluble electrospun materials can rapidly release maraviroc upon contact with moisture and that drug delivery is faster (less than 6 min under sink conditions) when maraviroc is electrospun in polyvinylpyrrolidone fibers containing an excipient wetting agent. These materials offer an alternative dosage form to current pericoital microbicides.

scholarly journals HOLLOW MESOPOROUS SILICA NANOPARTICLES FABRICATION FOR ANTICANCER DRUG DELIVERY

2020 ◽  
Vol 58 (1) ◽  
pp. 39 ◽  
Author(s):  
Ngoc Tram Nguyen Thi ◽  
Dai Hai Nguyen
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Agents ◽  
Pore Volume ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
High Surface ◽  
Loading Capacity ◽  
Hollow Mesoporous Silica

Mesoporous silica nanoparticles (MSNs) have attracted significant attention from researchers thanks to their high surface area and pore volume, which can increase drug loading capacity. Moreover, MSNs, with their biocompatibility and ease of surface functionalization, are seen as potential drug delivery system. However, the loading of drug into MSNs system still needs further improvement. In this study, hollow mesoporous silica nanoparticles (HMSNs) were fabricated in order to increase the drug loading capacity of nanosilica materials. The synthesized HMSNs possessed inner hollow cores that could remarkably raise the total pore volume and thus improve the capacity for cargo loading. HMSNs were synthesized according to the hard-template method with three main steps: (1) forming of solid SiO2 nanoparticles as templates, (2) forming of core-shell structure by coating MSN layers onto the templates, and (3) forming of hollow core structure by etching away the solid template. The HMSNs product was characterized by TEM, XRD, TGA and FTIR. In addition, drug loading capacity of the material was evaluated with doxorubicin as model drug. The results indicated remarkable improvement in drug loading capacity, compared to MSN sample. Cell assays on cancer lines showed high biocompatibility. These results demonstrated the potential of HMSNs in the delivery of anticancer agents.

scholarly journals Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 98
Author(s):  
Liangyu Lu ◽  
Mengyu Ma ◽  
Chengtao Gao ◽  
Hongwei Li ◽  
Long Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Surface Area ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
High Drug Loading

Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal–organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH2) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH2@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH2@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10–100 µg/mL, as estimated by the MTT method. The UiO-66-NH2@EPSQ drug release system could be a potential platform in the field of controlled drug delivery.

Recent trends in carbon nanotubes based prostate cancer therapy: A biomedical hybrid for diagnosis and treatment

2021 ◽  
Vol 18 ◽  
Author(s):  
Raja Murugesan ◽  
Sureshkumar Raman
Keyword(s):  
Prostate Cancer ◽  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
High Capacity ◽  
Chemical Properties ◽  
Diagnosis And Treatment ◽  
High Level

: At present treatment methods for cancer are limited, partially due to the solubility, poor cellular distribution of drug molecules and, the incapability of drugs to annoy the cellular barriers. Carbon nanotubes (CNTs) generally have excellent physio-chemical properties, which include high-level penetration into the cell membrane, high surface area and high capacity of drug loading by in circulating modification with bio-molecules, project them as an appropriate candidate to diagnose and deliver drugs to prostate cancer (PCa). Additionally, the chemically modified CNTs which have excellent 'Biosensing' properties therefore makes it easy for detecting PCa without fluorescent agent and thus targets the particular site of PCa and also, Drug delivery can accomplish a high efficacy, enhanced permeability with less toxic effects. While CNTs have been mainly engaged in cancer treatment, a few studies are focussed on the diagnosis and treatment of PCa. Here, we detailly reviewed the current progress of the CNTs based diagnosis and targeted drug delivery system for managing and curing PCa.

Fabrication of Hybrid Cell-Microbead Constructs Using Laser Direct-Write of Alginate Microbeads and Adherent Breast Cancer Cells

2013 ◽  
Author(s):  
Andrew D. Dias ◽  
David M. Kingsley ◽  
Douglas B. Chrisey ◽  
David T. Corr
Keyword(s):  
Drug Delivery ◽  
Mammalian Cells ◽  
Hybrid Cell ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Direct Write ◽  
Cellular Interactions ◽  
Paracrine Signaling ◽  
Laser Direct Write

Microbeads are becoming popular tools in tissue engineering as 3D microstructure hydrogels. The gel nature of microbeads enables them to sequester soluble factors and mammalian cells, and their high surface area-to-volume ratio allows diffusion between the bead and the environment [1,2]. Microbeads are thus good systems for drug delivery and can serve as 3D microenvironments for cells. To fully maximize their potential as delivery systems and microenvironments, it is highly desirable to create spatially-precise hybrid cultures of microbeads and mammalian cells. Precise placement of microbeads in proximity to patterned cells will allow the study of spatial cellular interactions, paracrine signaling, and drug delivery.

Polymeric nanoparticles as carrier for targeted and controlled delivery of anticancer agents

2019 ◽  
Vol 10 (8) ◽  
pp. 527-550 ◽  
Author(s):  
Vahid Taghipour-Sabzevar ◽  
Tahere Sharifi ◽  
Mehrdad Moosazadeh Moghaddam
Keyword(s):  
Adverse Effect ◽  
Drug Delivery ◽  
Controlled Release ◽  
Anticancer Agents ◽  
Blood Circulation ◽  
Enzymatic Degradation ◽  
Water Solubility ◽  
Polymeric Nanoparticles ◽  
Controlled Delivery ◽  
Drug Adverse Effect

In recent decades, many novel methods by using nanoparticles (NPs) have been investigated for diagnosis, drug delivery and treatment of cancer. Accordingly, the potential of NPs as carriers is very significant for the delivery of anticancer drugs, because cancer treatment with NPs has led to the improvement of some of the drug delivery limitations such as low blood circulation time and bioavailability, lack of water solubility, drug adverse effect. In addition, the NPs protect drugs against enzymatic degradation and can lead to the targeted and/or controlled release of the drug. The present review focuses on the potential of NPs that can help the targeted and/or controlled delivery of anticancer agents for cancer therapy.

scholarly journals Label-Free Optical Biosensing Using Low-Cost Electrospun Polymeric Nanofibers

Chemosensors ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 119
Author(s):  
Paula Martínez-Pérez ◽  
Salvador Ponce-Alcántara ◽  
Nieves Murillo ◽  
Ana Pérez-Márquez ◽  
Jon Maudes ◽  
...  
Keyword(s):  
Real Time ◽  
Large Scale ◽  
High Surface ◽  
Protein A ◽  
Volume Ratio ◽  
Polyamide 6 ◽  
Optical Biosensor ◽  
Label Free ◽  
Electrospinning Technique ◽  
Optical Biosensing

Polymeric nanofiber matrices are promising structures to develop biosensing devices due to their easy and affordable large-scale fabrication and their high surface-to-volume ratio. In this work, the suitability of a polyamide 6 nanofiber matrix for the development of a label-free and real-time Fabry–Pérot cavity-based optical biosensor was studied. For such aim, in-flow biofunctionalization of nanofibers with antibodies, bound through a protein A/G layer, and specific biodetection of 10 µg/mL bovine serum albumin (BSA) were carried out. Both processes were successfully monitored via reflectivity measurements in real-time without labels and their reproducibility was demonstrated when different polymeric nanofiber matrices from the same electrospinning batch were employed as transducers. These results demonstrate not only the suitability of correctly biofunctionalized polyamide 6 nanofiber matrices to be employed for real-time and label-free specific biodetection purposes, but also the potential of electrospinning technique to create affordable and easy-to-fabricate at large scale optical transducers with a reproducible performance.

scholarly journals A Mucoadhesive Electrospun Nanofibrous Matrix for Rapid Oramucosal Drug Delivery

2013 ◽  
Vol 2013 ◽  
pp. 1-19 ◽  
Author(s):  
Clare Dott ◽  
Charu Tyagi ◽  
Lomas K. Tomar ◽  
Yahya E. Choonara ◽  
Pradeep Kumar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Adhesion Force ◽  
High Surface ◽  
Experimental Studies ◽  
Volume Ratio ◽  
Work Of Adhesion ◽  
Computer Assisted ◽  
Glycerol Concentration ◽  
Disintegration Time ◽  
Fill Volume

A nanofibrous matrix system (NFMS), consisting of a drug-loaded nanofiber layer, was electrospun directly onto a polymeric backing film, the latter of which was formulated and optimized according to a 3-level, 3-factor Box-Behnken experimental design. The dependent variables, fill volume, hydroxypropylmethylcellulose (HPMC) concentration, and glycerol concentration, were assessed for their effects on measured responses, disintegration time, work of adhesion, force of adhesion, dissolution area under curve (AUC) at 1 minute, and permeation AUC at 3 minutes. Physicochemical and physicomechanical properties of the developed system were studied by rheology, FTIR, toughness determination, mucoadhesion, and nanotensile testing. Data obtained from the physicomechanical characterization confirmed the suitability of NFMS for application in oramucosal drug delivery. The optimized NFMS showed the drug entrapment of 2.3 mg/1.5 cm2with disintegration time of 12.8 seconds. Electrospinning of drug-loaded polyvinylalcohol (PVA) fibers resulted in a matrix with an exceedingly high surface-area-to-volume ratio, which enhanced the rate of dissolution for rapid oramucosal drug delivery. To corroborate with the experimental studies, the incorporation of glycerol with HPMC and PVA blend was mechanistically elucidated using computer-assisted modeling of the 3D polymeric architecture of the respective molecular complexes to envisage the likely alignment of the polymer morphologies affecting the performance of the nanofibrous device.

scholarly journals A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy

2021 ◽  
Author(s):  
Wesley A. Williams ◽  
Ashley J. Denslow ◽  
Peter W. Radulovic ◽  
Daniel J. Denmark ◽  
Shyam S. Mohapatra
Keyword(s):  
Operating System ◽  
Drug Delivery ◽  
Surface Area ◽  
Imaging Modality ◽  
Drug Loading ◽  
Volume Ratio ◽  
Computational Approach ◽  
Inorganic Nanoparticles ◽  
Computational Method ◽  
Simultaneous Sensing

Inorganic nanoparticles are utilized for therapeutic, diagnostic, or theranostic purposes and the latter involve simultaneous sensing, imaging, or tracking of drug delivery. Further, these nanoparticles differ in their morphologies, which affect outcomes such as the effectiveness of hyperthermia, induction, drug loading, circulation time by escaping the body's immune system, imaging modality clarity, and biosensing. However, design of these theranostics is limited by the lack of a method to predict their therapeutic efficacy. Herein, we report a computational approach involving the surface area (SA) to volume (V) ratios (SA:V), which can help predict the efficacy of the inorganic nanoparticles. The approach comprises a coding platform for the comparator pro-gram and uses a Python 3 on a Windows 10 operating system. Analyses of 22 polyhedral morphologies that inorganic nanoparticles could assume ex silico showed that only particular concave morphologies in this size regime are more productive over the standard sizes. Our results provide a method that can aid in the predicting efficacy of inorganic nanoparticles with certain morphology.

Development of Diclofenac Sodium Releasing Bio-Erodible Polymeric Nanomats

2006 ◽  
Vol 6 (9) ◽  
pp. 3310-3320 ◽  
Author(s):  
A. M. Piras ◽  
L. Nikkola ◽  
F. Chiellini ◽  
N. Ashammakhi ◽  
E. Chiellini
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Kinetics ◽  
Diclofenac Sodium ◽  
High Surface ◽  
Active Agent ◽  
Volume Ratio ◽  
Homogeneous Distribution ◽  
Scanning Calorimetry ◽  
Nano Structure

Application of nanofiber-based nanomats in medicine is attractive and thanks to the 3D nano-structure and the high surface to volume ratio they are excellent for local controlled drug delivery. The use of bioactive bioerodible polymers for developing drug delivery nanomats may allow for drug release and targeting control. Objective of the current study was to evaluate the suitability of bioerodible polymeric material based on n-butyl hemiester of [poly(maleic anhydride-alt-2-methoxyethyl vinyl ether)] (PAM14) for the preparation of nanomats for controlled administration of anti-inflammatory, diclofenac sodium (DS) drug. Samples were prepared using different polymer concentrations (5–10%) in either ethanol or acetic acid as solvent. Morphology was investigated by using scanning electron microscopy (SEM). Thermal analysis such as differential scanning calorimetry (DSC) was performed to detect effect on polymer arrangement. DS localization in electrospun nanomats was evaluated by using electron back scattering microanalysis, based on the detection of chlorine, and drug release kinetics was assessed using UV-Vis. Average fiber diameter resulted in the range of 100 nm to 1.0 μm and a homogeneous distribution of the loaded drug into the fibers was observed. The DS release was immediate and despite the preliminary nature of the performed electrospinning experiments, the achieved results appear promising for the future development of a novel system for the controlled and targeted administration of drug and active agent.

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