scholarly journals Topical Tacrolimus as an adjunct to Conventional Therapy for Stromal Herpetic Keratitis: a Randomized Clinical Trial

2019 ◽  
Author(s):  
Mitra Akbari ◽  
Reza Soltani Moghadam ◽  
Ramin Elmi ◽  
Amir Nosrati ◽  
Ehsan Taghiabadi ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Control Group ◽  
Case Group ◽  
Eye Drops ◽  
Slit Lamp ◽  
Herpetic Stromal Keratitis ◽  
Adjunct Treatment ◽  
Topical Tacrolimus ◽  
Corneal Inflammation ◽  
Iop Measurement

Purpose: This study investigates the effects of 0.05% topical tacrolimus as an adjunct therapy for patients with non-necrotizing herpetic stromal keratitis (HSK). Methods: Patients with non-necrotizing HSK, referred to the Cornea Clinic at Hospital in Rasht, Iran, between September 2016 and February 2018, were randomly assigned to two groups. The case group (N = 25) and the control group (N = 25) received conventional treatment with systemic acyclovir and topical prednisolone. The case group (N = 25) additionally received 0.05% tacrolimus eye drops four times a day for one month. Complete ocular examinations, including best-corrected visual acuity (BCVA) assessment, intraocular pressure (IOP) measurement, slit lamp biomicroscopy, and photo slit lamp imaging, were performed before treatment, and 3, 7, 14, 21, and 28 days after the intervention. Results: The mean age of the patients was 46.2 ± 12.9 years, and 70% of the patients were male. There was no difference between the groups in terms of age, sex, and baseline ocular measurements (P > 0.05). The case group had a lower mean logarithm of the minimum angle of resolution (LogMAR) for BCVA, lower grading scores, and steeper decreasing trends for corneal haziness, edema, neovascularization, and epitheliopathy compared to the control group after the second week (P < 0.05), while IOP remained unchanged between groups (P > 0.05). Conclusion: The addition of 0.05% topical tacrolimus enhances visual acuity and reduces corneal inflammation, neovascularization, and scarring; thus, it can used as an appropriate adjunct treatment for patients with HSK.

scholarly journals Relationship between pseudo exfoliation syndrome of pupil and increased intraocular pressure and glaucoma in patients referred to ophthalmology clinic of Ardabil city hospital

2017 ◽  
Vol 5 (2) ◽  
pp. 554
Author(s):  
Habib Ojaghi ◽  
Rahim Masoumi ◽  
Solmaz Jalalzadeh
Keyword(s):  
Visual Acuity ◽  
Risk Factor ◽  
Control Group ◽  
Case Group ◽  
Main Role ◽  
City Hospital ◽  
Exfoliation Syndrome ◽  
Slit Lamp ◽  
The Mean ◽  
The Relationship

Background: Pseudo exfoliation syndrome (PXS) widely in world occurred with various prevalence rate and its risk factor has main role in rising IOP and glaucoma. The aim of this study was to evaluate the relationship between PXS and its associations with elevation of IOP/Glaucoma.Methods: This is a cohort study that has been done on 144 patients of aged 50 and older referred to clinic of ophthalmology which was examined to the PXS depositions. PXS was diagnosed by slit lamp and a control group select matching with case group without PXS. All patients underwent a comprehensive ophthalmic evaluation by slit lamp and dilated pupil fundus for visual acuity, refraction, Tonometry and Gonioscopy.Results: Out of 144 eyes of control group, 112 (77.8%) had PXS depositions. There was a significant increase in number of PXS involved eyes with age and the frequency of disease in men was higher than women. Out of 72 patients, 40 (55.5%) patients were bilaterally and 32 (44.5%) patients were unilaterally involved. The mean of IOP in eyes with PXS with 17.9±8.9 was significantly higher than eyes without PXS with 14.5±2.9.Conclusions: PXS sediments are an important risk factor for increased IOP and glaucoma in our area and patients with PXS should be followed in term of IOP.

scholarly journals Efficacy and Safety of Topical Tacrolimus (0.03%) in the Treatment Localized Vitiligo

2017 ◽  
Vol 29 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Md Anwar Husain ◽  
Mohd Nurul Alam ◽  
Rezaur Rahim ◽  
Yasmin Joarder ◽  
Wahidujjaman ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Control Group ◽  
Case Group ◽  
Efficacy And Safety ◽  
Self Administration ◽  
Ibn Sina ◽  
Topical Tacrolimus ◽  
Medical College ◽  
The Face ◽  
Cutaneous Atrophy

Vitiligo is an acquired, pigmentary skin disorder which is disfiguring and difficult to treat. Phototherapy and application of topical corticosteroids are most commonly prescribed. However, these therapies are often not effective and use of corticosteroids on the face may lead to cutaneous atrophy, telangiectasia, and ocular complications. This case control study was conducted among the patients who sought health care in the Dermatology and Venereology out patient department of Ibn Sina Medical College, Dhaka from January, 2014 to June, 2015. The study was conducted with a view to evaluate the efficacy of topical tacrolimus in localized vitiligo and to see the adverse effects of topical tacrolimus in the treatment of vitiligo. This study assessed the efficacy and safety of tacrolimus 0.03% ointment in patients with vitiligo compared with control. 60 patients were enrolled as case group, among them 22 were male and 38 were female. There mean age was 23.33 years with a standard deviation of ±11.43 years. Another 60 patients were enrolled as control group. Patients in case group were treated with tacrolimus 0.03% ointment applied twice daily. Monthly evaluations were performed. At six months, 50 patients (89%) achieved varying levels of repigmentation. There was a statistically significant decrease depigmentation & increase pigmentation at sixth month. Mean area of repigmentation was 33.33% with a standard deviation of ±23.90. 24 patients (40.0%) had reported up to 50% repigmentation. Sign and symptoms of erythema (10%) and burning (10%) were minimal. In conclusion, it is proposed that tacrolimus ointment may be a efficacious and safe option for the treatment of vitiligo. The ease of topical self-administration with minimal side effects makes this novel immunomodulatory agent a promising addition to the therapeutic armamentarium for vitiligo.Medicine Today 2017 Vol.29(1): 1-5

scholarly journals ND: YAG LASER

2018 ◽  
Vol 25 (12) ◽  
pp. 1848-1851
Author(s):  
Mohammad Alam
Keyword(s):  
Visual Acuity ◽  
Nd:Yag Laser ◽  
Posterior Capsular Opacification ◽  
Eye Drops ◽  
Slit Lamp ◽  
Yag Laser ◽  
Corrected Visual Acuity ◽  
Nd:Yag Laser Capsulotomy ◽  
Department Of Ophthalmology ◽  
Best Corrected Visual Acuity

Objectives: To find out the visual acuity outcome after Nd: YAG laser capsulotomy in posterior capsular opacification in pseudophakic patients after cataract surgery. Study Design: Analytical study. Setting: Department of Ophthalmology Khyber Medical University Institute of Medical Sciences / K.D.A Teaching Hospital Kohat. Period: January 2016 to June 2017. Materials and methods: Special proforma was designed for record of patients. PreNd:YAG laser posterior capsulotomy best corrected visual acuity was checked and noted. Anterior and posterior segments examination was done with slit lamp and indirect slit lamp bimicroscopy. Pupils were dilated with tropicamide eye drops. Nd:YAG laser capsulotomy was done. All these procedure were conducted as out door. Patients were put on topical steroid and antiglaucoma drops for ten days to control inflammation and rise in IOP. Post laser best corrected visual acuity was recorded after one month of laser. Results: Total 92 patients were selected with age range from 21 to 83 years. Out of these patients 43(46.74%) were male and 49(53.26%) were female. Post surgical laser period was from 7 months to 13 years. Prelaser best corrected visual acuity of 6/24-6/36 was present in 59(64.13%) patients, 6/60 in 24(26.08%) patients while 9(9.78%) patients had visual acuity of counting finger (CF). Post laser best corrected visual acuity after one month of 6/6-6/9 was recorded in 43(46.39%) patients ,6/12-6/18 in 27(29.34%), 6/24-6/36 in 13(14.13%)and 6/60 & below in 9(9.71%) patients. Conclusion: Post laser best corrected visual acuity is highly improved with Nd:YAG laser capsulotomy in posterior capsular opacification.

scholarly journals Effect of Topical Nepafenac on Central Foveal Thickness following Panretinal Photocoagulation in Diabetic Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Nahla B. Abu Hussein ◽  
Ahmed A. Mohalhal ◽  
Dalia A. Ghalwash ◽  
Ahmed A. Abdel-Kader
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Controlled Study ◽  
Control Group ◽  
Diabetic Patients ◽  
Panretinal Photocoagulation ◽  
Eye Drops ◽  
Foveal Thickness ◽  
Central Foveal Thickness ◽  
Snellen Acuity

Purpose. To evaluate effectiveness of topical nepafenac in reducing macular edema following panretinal photocoagulation (PRP). Design. Prospective randomized double-blinded controlled study. Methods. Sixty eyes of 60 patients having proliferative or severe nonproliferative diabetic retinopathy had PRP. Patients were then divided into two groups: nepafenac group (30 eyes) receiving 1% topical nepafenac eye drops for 6 months and control group (30 eyes) receiving carboxymethylcellulose eye drops for 6 months. Best-corrected visual acuity (BCVA) and macular optical coherence tomography were followed up at 1, 2, 4, and 6 months after PRP. Results. BCVA was significantly better in nepafenac group than in control group at all follow-ups (P<0.01). At 6 months post-PRP, logMAR BCVA was 0.11 ± 0.04 (equivalent to 20/26 Snellen acuity) in the nepafenac group and 0.18 ± 0.08 (equivalent to 20/30 Snellen acuity) in the control group (P<0.01). Central foveal thickness (CFT) increased in both groups from the first month after PRP. Increase in CFT was higher in control group than in nepafenac group throughout follow-up, but the difference became statistically significant only after 4 months. No significant ocular adverse events were reported with topical nepafenac. Conclusion. Topical nepafenac can minimize macular edema and stabilize visual acuity following PRP for diabetic patients.

scholarly journals The Effect of Multiple Sclerosis on Nerve Fiber Layer of the Retina

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A A A Mohamed ◽  
A M Saad ◽  
T H Mohamed ◽  
Y A Elzanklony
Keyword(s):  
Multiple Sclerosis ◽  
Visual Acuity ◽  
Optic Neuritis ◽  
Control Group ◽  
Ophthalmological Examination ◽  
Slit Lamp ◽  
University Hospitals ◽  
Rnfl Thickness ◽  
Study Results ◽  
Significant Difference

Abstract Background Multiple Sclerosis is a chronic idiopathic inflammatory demyelinating disease involving Central Nervous System white matter with relapsing-remitting nature. Optic neuritis is a common initial manifestation. Multiple Sclerosis is characterized by dual pathological process of inflammation and neurodegeneration. It causes prominent retinal neural ganglion cell layer loss in addition to related axonal loss which can be identified by thinning of RNFL seen in OCT. Patients and Methods This case control study was carried out at Ain Shams University Hospitals in MS clinic of neurology department and Ophthalmology outpatient clinics. with a total of 100 eyes, from 50 subjects, Group A (10 patients, 20 eyes): normal persons with normal eyes as a Control group and 40 patients (80 eyes) having multiple sclerosis who satisfied the inclusion and exclusion criteria subdivided into 2 groups,(group B) 20 patients having previous attack of Optic Neuritis & (group C) 20 patients not having previous Optic Neuritis. Informed consents were obtained from all subjects and ethics approval were obtained from Ain Shams University Hospitals Ethical Commitee: A complete ophthalmic history and ophthalmological examination were done for each subject. Visual acuity assessment using Auto Refractometer, refraction, uncorrected visual acuity (UCVA) and best corrected visual acuity (BCVA) assessment using Snellen chart and also calculated in Logarithm of Minimum Angle of Resolution (LogMAR).Pupil reaction. Color vision assessment. Anterior segment detailed Slit Lamp examination. Posterior segment examination (ONH examination) using Slit lamp biomicroscopy, Volk +90 Diopter lens. Intraocular tension measured by Goldmann applanation tonometry. OCT to evaluate RNF layer thickness and c/d ratio. Results Our study results demonstrated that: VA & BCVA were statistically significant lower in MS group than the control group (P = 0.011, 0.006 respectively). Total, superior, inferior and temporal RNFL thickness were statistically significant lower in MS group than the control group(P = 0.003, 0.004, 0.028, 0.018 respectively), while there was no statistically significant difference between the two studied groups regarding nasal RNFL thickness. Total, all the four quadrants superior, inferior, temporal and nasal RNFL thickness were statistically significant lower in MS group with previous attack of ON compared with the MS group not having previous ON (P = 0.000, 0.000, 0.004, 0.004, 0.024 respectively). Conclusion This study also suggests a great role of ocular imaging techniques such as OCT as an effective noninvasive, high-resolution, non contact tool in mapping of subclinical retinal changes (GCIP layer) in MS patients. It may also serve as a diagnostic adjunct for monitoring disease activity and responses to neuroprotective drugs.

scholarly journals FUNGAL KERATITIS WITH CORNEAL ULCER IN FARMER

2020 ◽  
Vol 3 (1) ◽  
pp. 58
Author(s):  
Nugraha Wahyu Cahyana
Keyword(s):  
Visual Acuity ◽  
Corneal Ulcer ◽  
Fungal Keratitis ◽  
Eye Drops ◽  
Slit Lamp ◽  
Good Clinical Response ◽  
Specific Diagnosis ◽  
The World ◽  
Corneal Blindness ◽  
Test Result

Fungal keratitis is an important cause of corneal blindness all over the world, especially in developing countries. Fungal Keratitis can diagnosis by slit-lamp biomicroscopic examination and culture is essential for early specific diagnosis and must be taken into consideration to establish the most effective treatment and avoid severe complications. The study was present a case of Fungal Keratitis in Farmer with a corneal ulcer caused by rice seeds corneal corpus allienum. A corneal ulcer is a complication was caused by ineffective therapy especially Steroid topical that should be avoided. The culture test result was C. Albicans and was treated with natamycin 5% Eye drops. Finally, patients have a good clinical response, however with the sequel of decreased visual acuity.  

scholarly journals Retinal OCT Findings in Patients after COVID Infection

2021 ◽  
Vol 10 (15) ◽  
pp. 3233
Author(s):  
Dominika Szkodny ◽  
Edward Wylęgała ◽  
Paulina Sujka-Franczak ◽  
Edyta Chlasta-Twardzik ◽  
Rafał Fiolka ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Vessel ◽  
Control Group ◽  
Slit Lamp ◽  
Swept Source ◽  
Vascular Plexus ◽  
Iop Measurement ◽  
Swept Source Oct ◽  
Ocular Pressure

Purpose: The aim of this study was to assess and compare the optic nerve, retina, and retinal vessel parameters in recovered COVID-19 patients and healthy patients by using optical coherence tomography angiography (OCT-a). Methods: In all, 156 eyes of post-COVID-19 patients and 98 eyes of subjects from a control group were enrolled in our study. BCVA, intra ocular pressure (IOP) measurement, fundus examination, and OCT images, including macular cube, OCT-RNFL, and angio-OCT 6 × 6 mm examinations, were performed for both groups. The measurements were acquired using Swept Source OCT DRI OCT Triton. In the post-COVID-19 group, 762 OCT protocols were obtained. For statistical analysis, parameters from only one eye from each subject were taken. Results: In the measured parameters, no significant differences were observed, i.e., central macular thickness (p = 0.249); RNFL (p = 0.104); FAZ (p = 0.63); and vessel density of superficial retinal vascular plexus in central (p = 0.799), superior (p = 0.767), inferior (p = 0.526), nasal (p = 0.402), and temporal (p = 0.582) quadrants. Furthermore, a slit-lamp examination did not reveal any COVID-19-related abnormalities. Conclusion: OCT examination did not detect any significant changes in morphology or morphometry of the optic nerve, retina, or the retina vessels due to COVID-19.

scholarly journals Effects of the Ottonia martiana Miq. (Piperaceae) extract on dog's ocular surface

2012 ◽  
Vol 64 (3) ◽  
pp. 577-584
Author(s):  
C.B.S. Lisbão ◽  
M.A Corrêa ◽  
J.P.D Ortiz ◽  
B.C. Martins ◽  
J.L. Laus
Keyword(s):  
Ocular Surface ◽  
Ophthalmic Solution ◽  
Control Group ◽  
Eye Drops ◽  
Slit Lamp ◽  
Beagle Dogs ◽  
Corneal Sensitivity ◽  
Conjunctival Hyperemia ◽  
Tear Production ◽  
Slit Lamp Biomicroscopy

The anesthetics effects of aqueous extract of Ottonia martiana leaves were studied on the ocular surface of healthy beagle dogs. The dogs were divided in three groups (n=15): control group (CG), proxymetacaine group (PG) and Ottonia group (OG), which were treated with 0.9% saline, 0.5% proxymetacaine hydrochloride ophthalmic solution and O. martiana extract respectively. An oftalmic evaluation was performed before the treatments. Eye drops were instilled at time 0 (T0) and 3 minutes later (T3). Axial corneal sensitivity was evaluated by esthesiometry 5 and 10 minutes after T0. Tear production and intraocular pressure were evaluated 10 minutes after T0. Slit lamp biomicroscopy was performed 10 and 20 minutes after T0 and the eyes were stained with fluorescein 20 minutes after T0. The STT was reduced in PG. Conjunctival hyperemia was observed in 13 animals from PG and constituted the only ocular alteration observed during the study. Esthesiometry revealed a decreased corneal sensitivity for PG and OG. Those results show that the O. martiana extract acts reducing corneal sensitivity in dogs. Moreover, its use does not decrease the tear production and does not cause any clinical ophthalmic alteration.

HUBUNGAN TUNGAU DEBU RUMAH, PAPARAN ASAP ROKOK DAN RIWAYAT PENYAKIT KELUARGA TERHADAP KEJADIAN ASMA BRONKIAL PADA ANAK USIA 5 – 10 TAHUN DI WILAYAH KERJA PUSKESMAS LEMPAKE KOTA SAMARINDA TAHUN 2016

2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Sri Evi New Yearsi Pangadongan ◽  
Agustina Rahyu ◽  
Selvy Pasulu
Keyword(s):  
Cigarette Smoke ◽  
Bronchial Asthma ◽  
Sampling Technique ◽  
Total Sample ◽  
Control Group ◽  
Case Group ◽  
Chi Square ◽  
History Of ◽  
Weather Changes ◽  
And Gender

Bronchial Asthma generally starts from childhood which is condition where respiration channel experiences constriction because of hyperactivity with some specific stimulation which cause inflammation. Some risk factors are smoking exposure of cigarette smoke, weather changes, mite on house dirt, pet and history of family sickness. The purpose of this research is to know Relation of mite on house dirt, exposure of cigarette smoke  and history of family sickness with bronchial asthma incident to child 5 – 10  years old on working area of Puskesmas Lempake Samarinda City in 2016. Method which used was analytic survey with Case Control approaching. The total sample was 36 children which consisted of 18 case group and 18 control group with matching by using age and gender which submitted with Purposive Sampling technique. Data Analysis used Chi Square with wrong degree α = 0,005. The result showed that there was relation of mite of house dirt (p = 0,006), history of family sickness (p = 0,001) and no relation with exposure of cigarette smoke (p = 0,370) with bronchial asthma incident to child 5 – 10 years old on working area of Puskesmas Lempake Samarinda City in 2016.

Faktor-Faktor Determinan yang melatar belakangi Kehamilan Remaja di Desa Pandansari Kecamatan Poncokusumo Kabupaten Malang

2020 ◽  
Vol 7 (2) ◽  
pp. 247-255
Author(s):  
Maria Magdalena Setyaningsih ◽  
Emy Sutiyarsih
Keyword(s):  
Sex Education ◽  
Teen Pregnancy ◽  
Teenage Pregnancy ◽  
Well Being ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
The Family ◽  
History Of ◽  
First Time

Kehamilan remaja adalah kehamilan yang terjadi pada remaja berusia kurang dari 20 tahunan. Kehamilan remaja memberikan banyak kerugian bagi kesehatan, mental dan psikologis, kesejahteraan ekonomi dan peluang karier, kemiskinan dan prospek kehidupan masa depan remaja. Tujuan penelitian mengidentifikasi faktor determinan yang melatarbelakangi terjadinya kehamilan remaja. Jenis penelitian adalah penelitian analitik kategorik jenis survei kuantitatif dengan desain case control. Populasi semua perempuan yang bertempat tinggal di wilayah dusun Wonosari, Sukosari, dan Krajan Pandansari dan pernah/sedang hamil pertama kali pada usia kurang dari 20 tahun. Teknik pengambilan sampel cluster random sampling besar sampel 73. Berdasarkan hasil model akhir analisis multivariat, diketahui bahwa variabel pendidikan, riwayat kehamilan remaja pada keluarga dan usia menikah merupakan variabel yang berhubungan dengan kejadian kehamilan remaja setelah dikontrol oleh variabel akses informasi, responden berpendidikan rendah memiliki peluang 20,8 kali lebih tinggi, responden yang memiliki riwayat kehamilan remaja pada keluarga memiliki peluang 14,9 kali lebih tinggi, responden yang menikah pada usia <20 tahun memiliki peluang 12,1 kali lebih tinggi, responden dengan pemahaman yang kurang baik terkait penggunaan kondom memiliki peluang 5,9 kali lebih tinggi untuk terjadi kehamilan remaja. Oleh karena itu perlu dibangun karakter buiding, sosial karakter suport untuk para ibu remaja dan keluarga sehingga terbangun interaksi yang baik dalam keluarga yang dilandasi dengan pendidikan dan pemahaman yang baik tentang Pendidikan seksualitas. Teen pregnancy is a pregnancy that occurs in adolescents aged less than 20 years old. Teen pregnancy provides many disadvantages for health, mental, psychological, economic well-being, career opportunities, poverty, and the future life. The aim of the study was to identify the determinants underlying teen pregnancy incidence. This study was a quantitative study with categorical analytic method. The study design used a case control with two comparison groups. The groups were control group and case group. The population in this study was all women who lived in the Wonosari, Sukosari, and Krajan Pandansari district and had or were pregnant for the first time at the age of less than 20 years old. Seventy three respondents were recruited using cluster sampling technique. The case group consists of women who were or had pregnant for the first time at the age of less than 20 years old and their children are currently aged ≤ 1 years old. The control group consists of women who were pregnant for the first time at the age of > 20 years old. The data was collected using a questionnaire. The findings showed that education, history of teen pregnancy in family and the age of marriage were related to the incidence of teen pregnancy after being controlled by information access. Low-educated respondents had 20.8 times higher chance of experiencing teen pregnancy; respondents with a history of teen pregnancy in the family had 4.9 times higher chance of experiencing teen pregnancy; respondents who were married at the age of < 20 years old had 12.1 times higher chance of experiencing teen pregnancy; respondents with poor understanding of condom use had 5.9 times higher chance of teenage pregnancy. In conclusion, the findings suggest to build good interactions in the family based on education and a good understanding of sex education.

Sign in / Sign up

Export Citation Format

Share Document