scholarly journals Dietary intake and cognitive development among children in Kisumu county, Kenya

2020 ◽  
Vol 20 (06) ◽  
pp. 16585-16603
Author(s):  
Caroline Sawe ◽  
◽  
W Kogi-Makau ◽  
GAK Ettyang ◽  
CO Kimamo ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Development ◽  
Dietary Intake ◽  
Marital Status ◽  
Infant Development ◽  
Parental Education ◽  
Age Groups ◽  
Nutrient Deficiency ◽  
Early Years ◽  
Factors Associated

Varied nutrient-dense and high-quality diet are key to ideal growth and cognitive function in the early years of life. Nutrient deficiency can lead to negative functional effects of the brain and poor cognitive function. High rates of poverty in developing countries predispose children to malnutrition. This study aimed at exploring factors associated with dietary intake and cognitive development among children in Kisumu County, Kenya.This was across-sectional study survey that recruited 192 children aged less than 24 months. Food frequency questionnaire and Bayleys Scale for Infant Development kit was used to collect data.It was revealed that a total of 51% were girls with 30% aged below 6 months. Only 12%had cognitive scores above average. Child cognitive scores were linked with age (p= 0.022), carbohydrate (p=0.021), fat (p=0.011) and iron (p=0.022) intake. Only 34% and 32% of children consumed diets adequate in proteins and iron,respectively. Of children aged above 18 months, only 13% consumed diet adequate in iron. Factors associated with carbohydrate intake included:mother's marital status (p=0.036) and her level of income (p=0.028) while protein intake related to the type of housing (p=0.013). Fat intake was linked with the mother's marital status (p=0.009) and her level of income (p=0.001) while the iron intake was linked to the mother's level of income (p=<0.001) and her educational level (p< 0.001). Vitamin A intake was linked to the ability to pay rent by the household (p=0.016). Further analysis revealed that children whose fathers were earning more than Kenya shillings 3000.00 per month had 0.2 times lower risk of being above average on cognitive scores compared to those whose fathers were earning less than Kenya shillings 3000.00 per month,while those with an inadequate intake of carbohydrate had 8 times more risk of having cognitive scores above average compared to those whose diets were adequate.In conclusion, majority of children consumed diets inadequate in protein and iron while 12% of children had cognitive scores above average. Mother’s marital status, education and income influenced child’s dietary intake while their age groups and father’s income were associated with child's cognitive outcomes.Policies to enhance parental education and income level should be formulated to improve child's dietary and cognitive outcomes.

scholarly journals Sleep Disturbances, Obesity and Cognitive Function in Childhood: A Mediation Analysis

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1224-1224
Author(s):  
Paola Mattey-Mora ◽  
Erick Nelson
Keyword(s):  
Cognitive Function ◽  
Cognitive Development ◽  
Racial Differences ◽  
Mediation Analysis ◽  
Sleep Disturbances ◽  
Parental Education ◽  
Inverse Association ◽  
Learning Abilities ◽  
Mediation Effects ◽  
Mediation Analyses

Abstract Objectives Childhood cognitive development is influenced by biological and environmental factors. One such factor, obesity, impairs cognitive development and is associated with sleep disturbances (SDs). We examined the mediating role of SDs on the relationship between obesity and cognitive function in children from a large longitudinal study. Methods A total of 9951 children aged 9–11 years were included in this study. Children were recruited from 21 centers across the US from the Adolescent Brain Cognitive Development (ABCD) study. We assessed cognitive development using metrics for fluid (adaptation and new learning abilities), crystallized (experience-dependent abilities), and total cognitive function. Mediation analyses were conducted via linear regression modeling, with adjustment for potential confounders (sex, age, ethnicity, household income, parental education, and self-reported physical activity) for each of the 3 cognitive outcomes. Mediation significance was determined by bootstrapping. We also stratified our analyses by race (Caucasian, African-American, other racial minorities) to examine potential racial differences. Results We found a statistically significant inverse association between BMI and both total (β = −0.41, P &lt; 0.001) and fluid (β = −0.49, P &lt; 0.001) cognitive function. Stratified regression analyses found similar results for the Caucasians and other minorities groups, for both, fluid (Caucasian: β = −0.52, P &lt; 0.001; other minorities β = −0.75, P = 0.01) and total cognitive function (Caucasian: β = −0.45, P &lt; 0.001; other ethnicities: β = −0.76, P = 0.01). No association was observed among African Americans. Overall mediation analysis revealed that SDs were a partial mediator only for fluid cognitive function (P = 0.002). Further mediation analyses showed similar SDs partial mediation effects over fluid cognitive function in Caucasians (P = 0.002) and borderline significant mediation in the other minorities group (P = 0.06). Conclusions Our results suggest that SDs mediates the effect of obesity on cognitive functioning in children and that these effects vary across races, particularly as it pertains to fluid cognition. Fluid cognition is critical in childhood neurodevelopment, and further research is needed to address its long-term effects across the life course. Funding Sources None to declare.

Comparison of Cognitive and Other Developmental Functions in Children With Stunting and Malnutrition

2020 ◽  
Author(s):  
Setyo Handryastuti ◽  
Hardiono D. Pusponegoro ◽  
Surastuti Nurdadi ◽  
Anita Chandra ◽  
Feka A. Pramita ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Development ◽  
Infant Development ◽  
Cross Sectional Study ◽  
National Health Survey ◽  
P Value ◽  
Cross Sectional ◽  
Developmental Problems ◽  
Growth Faltering ◽  
Normal Stature

Abstract Background. Stunting is the impairment of growth and development due to malnutrition and/or chronic disease/infection. According to the Indonesia Basic National Health Survey 2013, prevalence of stunting in Indonesia reached 37.2%. Various studies have shown that impaired cognitive development may be found in children with stunting and malnutrition. This research has purpose to determine cognitive development in stunted children and malnourished children, using Bayley Scale of Infant Development III (Bayley-III). Methods. A cross-sectional study in 51 children aged 6 month to 3 year old who fullfiled the inclusion criteria at the Outpatient Clinic of Dr.Cipto Mangunkusumo National General Hospital from June 2017 until January 2018. Cognitive development was assessed using the Bayley Scale of Infant Development Third Edition (Bayley-III). Results. Twenty six children with stunting and 25 children with malnutrition without stunting with age of subjects were 11.0 month (2.0-34.0) and 16.0 month (7.0-25.6) respectively. Bayley-III percentile in cognitive scale were 12.5 (0.1-75) and 16.0 (0.1-99.9) with P (p-value)=0.55. Conclusions: Stunted children showed lower cognitive scores compared to the children with malnutrition. Although it was not significant, but it showed that Bayley-III scores group of stunting and malnutrition groups of children with normal stature far below the 50 percentile (P50). This showed that both children with stunting and malnutrition possible to have decreased cognitive function. Further research is needed with a larger sample to get comprehensive conclusions. Early detection and intervention also should be aimed at children who are experienced growth faltering to prevent developmental problems, especially cognitive function.

scholarly journals Factors associated with head circumference and indices of cognitive development in early childhood

2020 ◽  
Vol 5 (10) ◽  
pp. e003427
Author(s):  
Laura Nicolaou ◽  
Tahmeed Ahmed ◽  
Zulfiqar Ahmed Bhutta ◽  
Pascal Bessong ◽  
Margaret Kosek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Function ◽  
Cognitive Development ◽  
Head Circumference ◽  
Brain Size ◽  
Birth Cohort Study ◽  
Intracranial Volume ◽  
Z Score ◽  
Gross Motor ◽  
Factors Associated

BackgroundWhile head circumference (HC) has been related to intracranial volume and brain size, its association with cognitive function remains unclear. We sought to understand the relationship among various biological and socioeconomic risk factors, HC and cognitive development.MethodsWe analysed data across resource-poor settings in Bangladesh, India, Nepal, Peru, South Africa and Tanzania from the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development longitudinal birth cohort study. Participating children were enrolled and followed up between 2009 and 2014. A final sample of 1210 children aged 0–24 months were included in the analyses. The main outcomes were HC for age Z-score and cognitive, gross motor and language scores from Bayley Scales of Infant Development-III tests. Length, weight and HC were measured monthly, and cognitive tests were administered at 6, 15 and 24 months of age. To disentangle the associations between risk factors and HC from linear growth and to distinguish the direct and indirect effects of these risk factors on cognitive function, we conducted mediation analysis using longitudinal models to account for all data measured during follow-up.ResultsAverage HC-for-age Z-score (HCAZ) was −0.54 (95% CI −0.47 to −0.62) near birth and −1.01 (95% CI −0.94 to −1.08) at 24 months. Children with higher enrolment weight (p<0.0001), higher socioeconomic score (p=0.00037) and taller mothers (p=0.00084) had higher HCAZ at all ages, while enteropathogen infection (p=0.013) and more febrile episodes (p=0.013) were associated with lower HCAZ. The associations between HCAZ and enrolment weight-for-age, maternal height, socioeconomic status or pathogen burden were partly mediated through their associations with length-for-age. HCAZ showed no association with cognitive, gross motor or language skills at 6, 15 and 24 months of age.ConclusionsThe main risk factors associated with HC are similar to those associated with body length, and HC is not related to cognitive function.

scholarly journals Sleep Disturbances, Obesity, and Cognitive Function in Childhood: A Mediation Analysis

2021 ◽  
Author(s):  
Paola P Mattey-Mora ◽  
Erik J Nelson
Keyword(s):  
Cognitive Function ◽  
Cognitive Development ◽  
Sleep Disturbances ◽  
Parental Education ◽  
Cross Sectional Study ◽  
Inverse Association ◽  
Cross Sectional ◽  
Mediation Analyses ◽  
Mediating Role ◽  
Linear Regression Modeling

Abstract Background Childhood cognitive development is influenced by biological and environmental factors. One such factor, obesity, impairs cognitive development and is associated with sleep disturbances (SDs). Objective To examine the mediating role of SDs on the relationship between body mass index (BMI) and cognitive function in children. Methods A total of 9951 children aged 9–10 years were included in this cross-sectional study. Children were recruited from the longitudinal Adolescent Brain Cognitive Development (ABCD) Study. Cognitive development was assessed using metrics for fluid, crystallized, and total cognitive function. Mediation analyses were conducted via linear regression modeling, with adjustment for potential confounders (sex, age, ethnicity, household income, parental education, and self-reported physical activity) for each of the three outcomes. Mediation significance was determined by bootstrapping. Results A statistically significant inverse association was found between BMI and total (β = −0.41, P &lt; 0.001) and fluid (β = −0.49, P &lt; 0.001) cognition, but not for crystallized cognition. Total sleep disturbances partially mediated the association between BMI and fluid cognition (indirect effect: -0.02, P = 0.002; proportion on the total effect: 0.05, P = 0.002), but no mediation was found in the association between BMI and total cognition. Conclusions Sleep disturbances partially mediate the effect of childhood obesity on cognitive function, particularly in fluid cognitions. Future work is necessary to understand the effects of sleep disturbances, and obesity on reduced childhood cognition throughout time, predominantly, across the life course.

scholarly journals Exposure to unpredictable maternal sensory signals influences cognitive development across species

2017 ◽  
Vol 114 (39) ◽  
pp. 10390-10395 ◽  
Author(s):  
Elysia Poggi Davis ◽  
Stephanie A. Stout ◽  
Jenny Molet ◽  
Brian Vegetabile ◽  
Laura M. Glynn ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Development ◽  
Infant Development ◽  
Sensory Information ◽  
Quantitative Measure ◽  
Critical Determinant ◽  
Delayed Recall ◽  
Sensory Signals ◽  
Early Life Exposure ◽  
Bayley Scales

Maternal care is a critical determinant of child development. However, our understanding of processes and mechanisms by which maternal behavior influences the developing human brain remains limited. Animal research has illustrated that patterns of sensory information is important in shaping neural circuits during development. Here we examined the relation between degree of predictability of maternal sensory signals early in life and subsequent cognitive function in both humans (n = 128 mother/infant dyads) and rats (n = 12 dams; 28 adolescents). Behaviors of mothers interacting with their offspring were observed in both species, and an entropy rate was calculated as a quantitative measure of degree of predictability of transitions among maternal sensory signals (visual, auditory, and tactile). Human cognitive function was assessed at age 2 y with the Bayley Scales of Infant Development and at age 6.5 y with a hippocampus-dependent delayed-recall task. Rat hippocampus-dependent spatial memory was evaluated on postnatal days 49–60. Early life exposure to unpredictable sensory signals portended poor cognitive performance in both species. The present study provides evidence that predictability of maternal sensory signals early in life impacts cognitive function in both rats and humans. The parallel between experimental animal and observational human data lends support to the argument that predictability of maternal sensory signals causally influences cognitive development.

Age and marital status predictors of binge alcohol use among adults with major depressive episode

2020 ◽  
Author(s):  
Areen Omary
Keyword(s):  
At Risk ◽  
Alcohol Use ◽  
Marital Status ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Age Groups ◽  
Future Research ◽  
Major Depressive ◽  
Never Married ◽  
At Risk Populations

Aims: This study aims to examine if age and marital status can predict the risk for binge alcohol use (BAU) among adults with a major depressive episode (MDE). Methods: Data from the Substance Abuse and Mental Health Services Administration’s (SAMHSA) 2018 National Survey for Drug Use and Health (NSDUH) were analyzed. The unweighted sample included 6,999 adults representing a weighted population size of 33,900,452.122 in the US. Results and Conclusions: The findings of this retrospective research confirmed that age and marital status significantly predicted BAU in the past month among adults with MDE. Adults with MDE at higher risk for BAU were adults under the age of 50, adults who were never married, and adults who were divorced/separated. Special attention must be paid to those in age groups under 50, never married, and have been separated/divorced who are particularly at-risk for future alcohol abuse. Future research should consider examining additional potential confounders for BAU among other at-risk populations.

scholarly journals Effects of physical activity on cognitive function among patients with diabetes in China: a nationally longitudinal study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anying Bai ◽  
Liyuan Tao ◽  
Jia Huang ◽  
Jing Tao ◽  
Jue Liu
Keyword(s):  
Physical Activity ◽  
Executive Function ◽  
Longitudinal Study ◽  
Cognitive Function ◽  
Episodic Memory ◽  
Age Groups ◽  
Screening Tools ◽  
Diabetic Patients ◽  
Patients With Diabetes ◽  
Lagged Dependent Variable

Abstract Background We aimed to examine the effect of physical activity on different cognitive domains among patients with diabetes. Methods We used two waves of data from the Chinese Health and Retirement Longitudinal Study (CHARLS, 2013–2015), a nationally representative dataset of Chinese population aged over 45. Total physical activity scores were calculated based on the International Physical Activity Questionnaire (IPAQ). Executive function and episodic memory were used as measures of cognitive function. We conducted lagged dependent variable models to explore the association between physical activity and cognitive function in full sample as well as two different age groups (45–65, ≥65). Results: 862 diabetic patients were included. We found that diabetic participants who had greater level of physical activity at baseline were associated with better episodic memory function in 2 years (p < 0.05). Moreover, physical activity was significantly associated with less decline in episodic memory in fully adjusted models, and the associations were stronger among patients aged 45–65 years (p < 0.05). No statistically significant association was found between physical activity and executive function in all age groups. Conclusions Physical activity may prevent some of the potential decline in episodic memory in diabetic patients. Clinicians and public health departments should strengthen the promotion of physical activity and develop early screening tools among diabetic participants to prevent the progression of cognitive impairment.

scholarly journals Reference values and factors associated with hand grip strength among older adults living in southeastern Poland

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Agnieszka Wiśniowska-Szurlej ◽  
Agnieszka Ćwirlej-Sozańska ◽  
Justyna Kilian ◽  
Natalia Wołoszyn ◽  
Bernard Sozański ◽  
...  
Keyword(s):  
Older Adults ◽  
Older People ◽  
Reference Values ◽  
Handgrip Strength ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Normative Values ◽  
Dominant Hand ◽  
Cross Sectional ◽  
Factors Associated

AbstractHandgrip strength (HGS) is used as a biomarker for the state of health of older people, but the number of research publications containing the normative values of HGS in older adult populations is limited. The aim of the study was to define reference values and factors associated with HGS in older adults living in southeastern Poland. A cross-sectional study including 405 participants aged 65 and older was conducted. Handgrip strength for the dominant hand was assessed by the average of three trials using a JAMAR dynamometer. The sample was categorized into the following age groups: 65–69 years, 70–74 years, 75–79 years, 80–84 years, 85 and over. The average HGS was 19.98 kg (16.91 kg for women and 26.19 kg for men). There was a decrease in handgrip strength across the age range in both sexes. The average handgrip strength of the older people was 17.97 kg (14.47 kg for women and 25.66 kg for men) for those aged 80–85 and 16.68 kg (13.51 kg for women and 21.77 kg for men) in the group over 85 years old. In both sexes, marital status was an independent factor associated with reduced handgrip strength. In conclusion, this study described, for the first time, handgrip strength values for the southeastern Polish population aged ≥ 65 years according to age and gender.

Age differences in mortality in patients undergoing surgery for infective endocarditis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
L Ostergaard ◽  
M.H Smerup ◽  
K Iversen ◽  
A.D Jensen ◽  
A Dahl ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Aortic Valve ◽  
Hospital Mortality ◽  
Hazard Analysis ◽  
Age Groups ◽  
Prosthetic Heart Valve ◽  
Valve Surgery ◽  
Aortic Valve Surgery ◽  
Factors Associated ◽  
Increased Risk

Abstract Background Infective endocarditis (IE) is associated with high mortality. Surgery may improve survival, but the intercept between benefit and harm is hard to balance and may be closely related to age. Purpose To examine the in-hospital and 90-day mortality in patients undergoing surgery for IE and to identify differences between age groups and type of valvular intervention. Methods By crosslinking nationwide Danish registries we identified patients with first-time IE undergoing surgical treatment in the period from 2000 to 2017. The study population was grouped in patients &lt;60 years, 60–75 years, and ≥75 years of age. High-risk subgroups by age and surgical valve intervention (mitral vs aortic vs mitral+aortic) during IE admission were examined. Kaplan Meier estimates was used to identify 90-day mortality by age groups and multivariable adjusted Cox proportional hazard analysis was used to examine factors associated with 90-day mortality. Results We included 1,767 patients with IE undergoing surgery, 735 patients &lt;60 years (24.1% female), 766 patients 60–75 years (25.8% female), and 266 patients &gt;75 years (36.1% female). The proportion of patients with IE undergoing surgery was 35.3%, 26.9%, and 9.1% for patients &lt;60 years, 60–75 years, and &gt;75 years, respectively. For patients with IE undergoing surgery, the in-hospital mortality was 6.4%, 13.6%, and 20.3% for patients &lt;60 years, 60–75 years, and ≥75 years of age, respectively and mortality at 90 days were 7.5%, 13.9%, and 22.3%, respectively. Factors associated with an increased risk 90-day mortality were: mitral valve surgery and a combination of mitral and aortic valve surgery as compared with isolated aortic valve surgery, patients 60–75 years and &gt;75 years as compared with patients aged &lt;60 years, prosthetic heart valve prior to IE admission, and diabetes, Figure. Patients &gt;75 years undergoing a combination of mitral and aortic valve surgery had an in-hospital mortality of 36.3%. Conclusion In patients undergoing surgery for IE, a stepwise increase in 90-day mortality was seen for age groups, highest among patients &gt;75 years with a 90-day mortality of more than 20%. Patients undergoing mitral and combined mitral and aortic valve surgery as compared to isolated aortic valve surgery were associated with a higher mortality. These findings may be of importance for the management strategy of patients with IE. Mortality risk Funding Acknowledgement Type of funding source: None

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