scholarly journals METHODOLOGICAL APPROACHES TO EVALUATION AND PREDICTION OF INDIVIDUAL RISK TO HEALTH UNDER THE EXPOSURE TO A COMPLEX OF DIFFERENT FACTORS FOR TASKS OF PERSONALIZED PROPHYLAXIS

2018 ◽  
Vol 97 (1) ◽  
pp. 34-43
Author(s):  
Marina A. Zemlyanova ◽  
N. V. Zaytseva ◽  
D. A. Kiryanov ◽  
O. Yu. Ustinova
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Epidemiological Studies ◽  
Individual Risk ◽  
Scientific Publications ◽  
Managerial Decisions ◽  
Model Library ◽  
Genetic Status ◽  
Somatic Status ◽  
The Individual

Methodical approaches to the assessment and prediction of the individual risk for the development of diseases associated with the effect of a complex of heterogeneous factors, taking into account the features of the genetic and somatic status of the individual for the tasks of personalized prevention, are suggested. The conceptual basis of the methodology is the presentation of the individual risk for diseases as a quantity that varies with time depending on the level and duration of the exposure of the acting factors (evolution), with respect to the contribution of natural causes. There is presented a model describing the evolution of individual risk, which takes into account a complex system of dependencies of the indices of the body’s somatic state and genetic status on the variable exposure of factors. To assess the value of the individual risk, there are proposed a scale and a system of criteria for the assessment of the likelihood of the development of the disease with taking account of its severity. The established value of the individual risk in relation to a specific disease determines the list, scope and sequence of measures for the personalized prevention, and is also a measure of their effectiveness. A large-scale epidemiological study of the population (about 10 thousand people) from 12 regions of the Russian Federation was executed. There was obtained a system of dependencies which reflects the cause-effect relationships between indices characterizing the factors of habitat and lifestyle, the body’s somatic and genetic status (more than 500 indices), the probability of diseases associated with risk factors (about 20 nosological forms). There was created a special replenished information resource «Model Library» has been created, including parameters of more than 4 thousand adequate and reliable dependencies of cause-effect relationships, revealed by relying upon the results of own epidemiological studies and analysis of domestic and foreign scientific publications. An algorithm for the estimation and prediction the individual risk has been developed for the formation of personalized prevention programs aimed at its reducing. The algorithm is implemented in the form of an information and analytical system that can be used as a tool for making managerial decisions in the field of personalized prevention of diseases associated with risk factors at the group and population levels.

scholarly journals A Critical Analysis of Risk Factors for Selected Tropical Diseases

2021 ◽  
Author(s):  
Faith-Michael Uzoka ◽  
Christie Akwaowo ◽  
Chinyere Nwafor Okoli ◽  
Victory Ekpin ◽  
Chukwudi Nwokoro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Typhoid Fever ◽  
Demographic Data ◽  
Significant Risk ◽  
Personal Hygiene ◽  
Individual Risk ◽  
Tropical Diseases ◽  
Economic Implications ◽  
Frequency Distributions ◽  
The Individual

Abstract Aim: The aim of this study was to examine the impacts of different (non-clinical) risk factors on the populations’ predisposition to tropical diseases specifically Malaria, yellow fever, typhoid fever, chicken pox, measles, hepatitis B and UTI.Subject and Methods: Data for this study was obtained through patient diagnosis forms, distributed to physicians in Nigeria. A total of 2199 patient consultation forms were returned by 102 (out of 125) physicians, and considered useful for analysis. Demographic data of patients, physicians, and diagnosis outcomes were analysed descriptively through frequency distributions, aggregate analysis, and graphs, while the influence of risk factors on the disease manifestations (diagnosis outcomes) were determined using regression analysis.Results: Findings from our study demonstrated that the difficulty in diagnosing tropical disease was associated with significant increase in morbidity and mortality especially in patients with malaria, UTI and typhoid fever. Factors such as contact with an infected person and poor personal hygiene posed significant risk, while urbanization and homelessness, posed very low risks across all the diseases. Conclusion: The risk factors identified in our study exert differential and discriminating influences in the causation, predisposition, and transmission of these conditions, understanding the individual risk factors for each condition have significant socio-economic implications for people living in tropical and endemic regions, especially with respect to management and prevention of these conditions.

scholarly journals A Molecular Survey on Neglected Gurltia paralysans and Aelurostrongylus abstrusus Infections in Domestic Cats (Felis catus) from Southern Chile

Pathogens ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1195
Author(s):  
Natasha Barrios ◽  
Marcelo Gómez ◽  
Macarena Zanelli ◽  
Lisbeth Rojas-Barón ◽  
Paulina Sepúlveda-García ◽  
...  
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Nematode Species ◽  
Epidemiological Studies ◽  
Felis Catus ◽  
Domestic Cat ◽  
Southern Chile ◽  
Domestic Cats ◽  
Aelurostrongylus Abstrusus ◽  
Factors Associated

Gurltia paralysans and Aelurostrongylus abstrusus are neglected metastrongyloid nematode species which infect domestic and wild cats in South American countries and in Chile, but no epidemiological studies on concomitant infections have been conducted in Chile so far. The aim of this study was not only to evaluate the occurrence of concomitant infections, but also to identify epidemiological risk factors associated with of G. paralysans and A. abstrusus infections in urban domestic cats (Felis catus) from Southern Chile. Blood samples from clinically healthy domestic cats from three cities of Southern Chile—Temuco, Valdivia, and Puerto Montt—were analyzed by an experimental semi-nested PCR protocol. A total of 171 apparently healthy domestic cats in Temuco (n = 68), Valdivia (n = 50), and Puerto Montt (n = 53) were sampled and analyzed. A total of 93 domestic cats (54.4%) were positive for G. paralysans, and 34 (19.9%) were positive for A. abstrusus infections. From those animals, 34 (19.9%) were co-infected. Cats positive with G. paralysans were found in all three cities; 47.2% in Puerto Montt, 48% in Valdivia, and 64.7% in Temuco. Levels of infection for A. abstrusus in the population under study were 4% (Valdivia), 10% (Puerto Montt), and 32.4% (Temuco). The present large-scale epidemiological study confirmed the presence of these neglected nematodes in domestic cat populations in Southern Chile, and described the possible risk factors associated with feline gurltiosis and aelurostrongylosis.

scholarly journals Risk in the scope of research and innovative technological projects

2020 ◽  
pp. 58-67
Author(s):  
Rafał Hubicki ◽  
Maria Richert ◽  
Piotr Łebkowski ◽  
Joanna Kulczycka ◽  
Asja Mrotzek-Bloess
Keyword(s):  
Risk Factors ◽  
Risk Assessment ◽  
Assessment Methods ◽  
Individual Risk ◽  
Fruitful Cooperation ◽  
Specific Factors ◽  
The Subject ◽  
The Individual ◽  
Risk Categories ◽  
Management Of Risk

Assessment and management of risk constitute the subject of many researches. Nevertheless, many more specific factors are applicable during the implementation of innovative technological projects. On the article identified risk factors, which have been supplemented, systematized and assigned to the individual risk categories. The risk assessment methods for R&D projects have been analysed, as well as the risk sheets have been developed for the R&D project through the use of dotProject application. Also shown that networking and clustering is a change for fruitful cooperation within difference EU projects, which create trust between business and sciences and reduce the risk.

scholarly journals Artrose i Norge

2009 ◽  
Vol 18 (1) ◽  
Author(s):  
Barbara Slatkowsky-Christensen ◽  
Margreth Grotle
Keyword(s):  
Risk Factors ◽  
Subchondral Bone ◽  
Joint Space ◽  
Epidemiological Studies ◽  
Quadriceps Strength ◽  
Point Of View ◽  
The Body ◽  
Knee Oa ◽  
Geographical Variations ◽  
The Individual

Osteoarthritis (OA) is a complex process affecting many different joint areas in the body. The joints most commonly affected are the knees, hips, and hands. From a patho-physiological point of view, some features are crucial for the diagnosis, such as cartilage fibrillation and thinning, subchondral sclerosis and the presence of osteophytes. The currently most widely used definitions of OA include pathogenetic features (mechanical and biological events), morphologic features (changes in articular cartilage and subchondral bone) as well as clinical features (joint pain, stiffness, tenderness, limitation of movement, crepitus and occasionally inflammation/effusion).<br />The features that until now have been used for diagnosis and classification are based on radiographic and/or clinical descriptions. From a clinical perspective, OA is the most prevalent rheumatic joint disorder, causing pain and stiffness of the joints and for the individual impaired function and health status. For epidemiological descriptions of prevalence and incidence of OA, radiographic criteria are the most reliable and commonly used. Definitions of radiographic OA include descriptions of cartilage thinning (such as joint space narrowing), subchondral bone involvement (sclerosis) and/or the presence and grading of osteophytes. Although there are geographical variations in the occurrence of OA of different joint areas, OA is seen in all populations studied. The prevalence and incidence estimates show a vide variation, however. Still the epidemiological studies of OA are hampered by a number of factors including different definitions of the disorder, different subsets of disease, and low degree of correlation between different definitions (radiographic vs clinical). Several highly suggested risk factors have been identified for knee OA. Several of these may be important targets for intervention or prevention, such as physical activity, body mass index, nutritional constituents and quadriceps strength. There is a need for prospective studies evaluating risk factors in hip and hand OA. Although there are problems in studying OA epidemiologically, the available data have shown that OA is an extremely common and disabling disorder. Through a further development of both epidemiological and other methods of OA research, this area can continue to be exciting and rapidly developing.

RA09.07: SURGICAL MANAGEMENT OF EARLY ESOPHAGEAL CANCER BASED ON LYMPH NODE METASTASIS RISK.

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 41-41
Author(s):  
Xiaofeng Duan ◽  
Zhentao Yu
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Lymph Node ◽  
Lymph Node Dissection ◽  
Tumor Location ◽  
Individual Risk ◽  
Node Dissection ◽  
Early Esophageal Cancer ◽  
Node Metastasis ◽  
The Individual

Abstract Background Esophagectomy and lymph node dissection is still the main treatment for esophageal cancer. Endoscopic mucosal resection and submucosal dissection are increasingly becoming a treatment of choice to preserve the integrity of the esophagus and decrease the surgical trauma in early esophageal cancer. However, lymph node metastasos (LNM) risk is still a debate focus for the decision of treatment selection. Our objective was to evaluate the prevalence, pattern and risk factors of LNM in early stage esophageal cancer to improve surgical treatment allocation. Methods We identified patients with pathological T1 stage esophageal cancer who underwent esophagectomy and lymph node dissection. The pattern of LNM was analyzed and the risk factors related to LNM were assessed by univariate and multivariable logistic regression analysis.The nomogram model was used to estimate the individual risk of lymph node metastasis. Results In 143 patients, LNM rates were: all patients 17.5%, T1a 8.0%, and T1b 22.5% for T1b. Depth of tumor infiltration (P < 0.05), tumor size (P < 0.01), tumor location (P < 0.05), and tumor differentiation (P < 0.01) were independent risk factors related to LNM. These four parameters allowed the compilation of a nomogram to estimate the individual risk of LNM. Fig. Nomogram to estimate the individual risk of LNM. Each characteristic of the included parameters scores a specific number of points (points per parameter). The summarized total points score indicates the probability of LNM. For a middle esophageal cancer with middle differentiated (G2), 3 cm tumor (> 2.5cm) that invades the submucosa (pT1b), the calculated total scores is 129.5 = 87.5 + 21 + 0 + 21, hence the corresponding LNM risk is 20%. Conclusion T1 esophageal cancer has a relatively high LNM rate, and the depth of tumor infiltration, tumor size, tumor location and tumor differentiation are correlated with LNM. Nomograms that include factors can be used to predict individual LNM risk. The LNM risk and extent must be considered comprehensively in decision-making of a better surgical treatment and lymph node dissection strategy. Disclosure All authors have declared no conflicts of interest.

scholarly journals Individual and Environmental Factors Associated with Recurrent Falls in Elderly Patients Hospitalized after Falls

2020 ◽  
Vol 17 (7) ◽  
pp. 2441
Author(s):  
Hai Minh Vu ◽  
Long Hoang Nguyen ◽  
Huong Lan Thi Nguyen ◽  
Giang Thu Vu ◽  
Cuong Tat Nguyen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Environmental Factors ◽  
Elderly Patients ◽  
Environmental Conditions ◽  
Social Consequences ◽  
Individual Risk ◽  
Cross Sectional ◽  
Factors Associated ◽  
Recurrent Falls ◽  
The Individual

Falls and recurrent falls cause great health and social consequences in older people. However, these problems are poorly understood in Vietnam. A cross-sectional study was performed at seven hospitals in Thai Binh province, Vietnam, to investigate the individual and environmental factors associated with recurrent falls among elderly patients hospitalized due to fall injuries in Vietnam. A history of recurrent falls within the last 12 months, sociodemographic, health, and clinical characteristics, as well as environmental conditions, were obtained via self-reported interviews. Multivariate logistic and Poisson regression models were used to identify associated factors. Overall, the mean fall episodes in the last 12 months were 1.8 (Standard deviation—SD = 1.2) episodes, and the 12-month prevalence of recurrent falls was 40.5%. The individual risk factors included not receiving fall prevention guidelines, walking with devices, loss of sensation in hand or foot, and using pain relief medications. The environmental risk factors comprised having too-high stairs and not having dry, clean, and nonslippery bathrooms. This study highlights a significantly high 12-month prevalence of recurrent falls in older patients hospitalized after falls in Vietnam. Moreover, regular assessments of functional disabilities and hazardous environmental conditions, as well as the provision of prevention programs, have potential to prevent falls and recurrent falls.

The efficacy of combining several risk factors as a screening test

2005 ◽  
Vol 12 (4) ◽  
pp. 197-201 ◽  
Author(s):  
Nicholas J Wald ◽  
Joan K Morris ◽  
Simon Rish
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
False Positive ◽  
Detection Rate ◽  
False Positive Rate ◽  
Individual Risk ◽  
Detection Rates ◽  
Screening Performance ◽  
Positive Rate ◽  
The Individual

Objective: To determine the quantitative effect on overall screening performance (detection rate for a given false-positive rate) of using several moderately strong, independent risk factors in combination as screening markers. Setting: Theoretical statistical analysis. Methods: For the purposes of this analysis, it was assumed that all risk factors were independent, had Gaussian distributions with the same standard deviation in affected and unaffected individuals and had the same screening performance. We determined the overall screening performance associated with using an increasing number of risk factors together, with each risk factor having a detection rate of 10%, 15% or 20% for a 5% false-positive rate. The overall screening performance was estimated as the detection rate for a 5% false-positive rate. Results: Combining the risk factors increased the screening performance, but the gain in detection at a constant false-positive rate was relatively modest and diminished with the addition of each risk factor. Combining three risk factors, each with a 15% detection rate for a 5% false-positive rate, yields a 28% detection rate. Combining five risk factors increases the detection rate to 39%. If the individual risk factors have a detection rate of 10% for a 5% false-positive rate, it would require combining about 15 such risk factors to achieve a comparable overall detection rate (41%). Conclusion: It is intuitively thought that combining moderately strong risk factors can substantially improve screening performance. For example, most cardiovascular risk factors that may be used in screening for ischaemic heart disease events, such as serum cholesterol and blood pressure, have a relatively modest screening performance (about 15% detection rate for a 5% false-positive rate). It would require the combination of about 15 or 20 such risk factors to achieve detection rates of about 80% for a 5% false-positive rate. This is impractical, given the risk factors so far discovered, because there are too few risk factors and their associations with disease are too weak.

scholarly journals The Hamstrings: Anatomic and Physiologic Variations and Their Potential Relationships With Injury Risk

2021 ◽  
Vol 12 ◽  
Author(s):  
José Afonso ◽  
Sílvia Rocha-Rodrigues ◽  
Filipe M. Clemente ◽  
Michele Aquino ◽  
Pantelis T. Nikolaidis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Injury Risk ◽  
Individual Characteristics ◽  
Individual Risk ◽  
Modifiable Risk Factors ◽  
Fiber Types ◽  
Cross Sectional ◽  
Exercise Interventions ◽  
Age Related ◽  
The Individual

The incidence and recurrence of hamstrings injuries are very high in sports, posing elevated performance and financial-related costs. Attempts to identify the risk factors involved in predicting vulnerability to hamstrings injury is important for designing exercise-based programs that aim to mitigate the rate and severity of hamstrings injuries and improve rehabilitation strategies. However, research has shown that non-modifiable risk factors may play a greater role than modifiable risk factors. Recognizing non-modifiable risk factors and understanding their implications will afford the prescription of better suited exercise programs, i.e., that are more respectful of the individual characteristics. In a nutshell, non-modifiable risk factors can still be acted upon, even if indirectly. In this context, an underexplored topic is how intra and inter- individual anatomic and physiologic variations in hamstrings (e.g., muscle bellies, fiber types, tendon length, aponeurosis width, attachment sites, sex- and age-related differences) concur to alter hamstrings injuries risk. Some anatomic and physiologic variations may be modifiable through exercise interventions (e.g., cross-sectional area), while others may not (e.g., supernumerary muscle bellies). This apparent dichotomy may hide a greater complexity, i.e., there may be risk factors that are partially modifiable. Therefore, we explored the available information on the anatomic variations of the hamstrings, providing a deeper insight into the individual risk factors for hamstrings injuries and contributing with better knowledge and potential applications toward a more individualized exercise prescription.

scholarly journals The Population of the Bronze Age of the Lower Volga Region in the Works of Russian Anthropologists

2019 ◽  
pp. 205-223
Author(s):  
Evgeny Pererva ◽  
Alexandr Djachenko
Keyword(s):  
Bronze Age ◽  
Large Scale ◽  
Volga Region ◽  
Soviet Period ◽  
Scientific Publications ◽  
Lower Volga Region ◽  
Lower Volga ◽  
Using Data ◽  
The Individual ◽  
The Bronze Age

Introduction. This work is a review of scientific publications on studying paleoanthropological materials of the Bronze Age originating from burial mounds of the Lower Volga region. Materials and Analysis. The paper begins with the analysis of articles and monographic studies of domestic authors, whose works were written in the period from the 30s to the late 80s of the 20th century. The so-called Soviet period in Russian anthropology is characterized by the dominance of the individual-typological approach in describing skeletal series of representatives of the Bronze Age cultures. The osteological collections from burial complexes of the Bronze Age of the Lower Volga region accumulated at this stage of the study were distinguished by a small number and low representativeness. The main conclusions were based on studying craniological samples. A great contribution to developing ideas on the racial and ethnic history of the Lower Volga region during this period was made by researchers G.F. Debets, V.V. Gizburg, V.I. Vuich, B.V. Firshtein, A.V. Shevchenko. The second part of the article is devoted to analyzing the results of anthropological research in the region in the works of modern Russian scientists.A distinctive feature of these works is that they are based on studying large-scale craniological series of broad temporal and territorial coverage. The studies of such scientists as A.A. Khokhlov, E.F. Batieva, A.A. Kazarnitsky, M.A. Balabanova use the complex approach in which classical methods of physical anthropology (craniology, osteology) are combined with the methods of statistical analysis and using data from Archaeology, Paleodemography, and Paleoecology. Results. The work shows the importance of using anthropological data as an independent source in paleohistorical constructions, as well as in the process of the archaeological study of various cultures of the Bronze Age that existed in the Lower Volga region.

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