scholarly journals Artrose i Norge

2009 ◽  
Vol 18 (1) ◽  
Author(s):  
Barbara Slatkowsky-Christensen ◽  
Margreth Grotle
Keyword(s):  
Risk Factors ◽  
Subchondral Bone ◽  
Joint Space ◽  
Epidemiological Studies ◽  
Quadriceps Strength ◽  
Point Of View ◽  
The Body ◽  
Knee Oa ◽  
Geographical Variations ◽  
The Individual

Osteoarthritis (OA) is a complex process affecting many different joint areas in the body. The joints most commonly affected are the knees, hips, and hands. From a patho-physiological point of view, some features are crucial for the diagnosis, such as cartilage fibrillation and thinning, subchondral sclerosis and the presence of osteophytes. The currently most widely used definitions of OA include pathogenetic features (mechanical and biological events), morphologic features (changes in articular cartilage and subchondral bone) as well as clinical features (joint pain, stiffness, tenderness, limitation of movement, crepitus and occasionally inflammation/effusion).<br />The features that until now have been used for diagnosis and classification are based on radiographic and/or clinical descriptions. From a clinical perspective, OA is the most prevalent rheumatic joint disorder, causing pain and stiffness of the joints and for the individual impaired function and health status. For epidemiological descriptions of prevalence and incidence of OA, radiographic criteria are the most reliable and commonly used. Definitions of radiographic OA include descriptions of cartilage thinning (such as joint space narrowing), subchondral bone involvement (sclerosis) and/or the presence and grading of osteophytes. Although there are geographical variations in the occurrence of OA of different joint areas, OA is seen in all populations studied. The prevalence and incidence estimates show a vide variation, however. Still the epidemiological studies of OA are hampered by a number of factors including different definitions of the disorder, different subsets of disease, and low degree of correlation between different definitions (radiographic vs clinical). Several highly suggested risk factors have been identified for knee OA. Several of these may be important targets for intervention or prevention, such as physical activity, body mass index, nutritional constituents and quadriceps strength. There is a need for prospective studies evaluating risk factors in hip and hand OA. Although there are problems in studying OA epidemiologically, the available data have shown that OA is an extremely common and disabling disorder. Through a further development of both epidemiological and other methods of OA research, this area can continue to be exciting and rapidly developing.

Osteoarthritis

2018 ◽  
Author(s):  
Michael Doherty
Keyword(s):  
Risk Factors ◽  
Bone Formation ◽  
Subchondral Bone ◽  
Environmental Risk ◽  
Hyaline Cartilage ◽  
Bone Remodelling ◽  
Interphalangeal Joint ◽  
New Bone Formation ◽  
Clinical Phenotypes ◽  
Knee Oa

Osteoarthritis (OA) is a disorder of synovial joints and is characterized by the combination of focal hyaline cartilage loss and accompanying subchondral bone remodelling and marginal new bone formation (osteophyte). It has genetic, constitutional, and environmental risk factors and presents a spectrum of clinical phenotypes and outcomes. OA commonly affects just one region (e.g. knee OA, hip OA). However, multiple hand interphalangeal joint OA, usually accompanied by posterolateral firm swellings (nodes), is a marker for a tendency towards polyarticular ‘generalized nodal OA’.

scholarly journals Nonparametric estimation of risk tracking indices for longitudinal studies

2019 ◽  
Vol 29 (2) ◽  
pp. 481-497
Author(s):  
Colin O Wu ◽  
Xin Tian ◽  
Lu Tian ◽  
Jared P Reis ◽  
Lihui Zhao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Status ◽  
Nonparametric Estimation ◽  
Epidemiological Studies ◽  
Distribution Functions ◽  
Repeated Measurements ◽  
The Body ◽  
Estimation Methods ◽  
Blood Pressure Data ◽  
Over Time

Tracking a subject's risk factors or health status over time is an important objective in long-term epidemiological studies with repeated measurements. An important issue of time-trend tracking is to define appropriate statistical indices to quantitatively measure the tracking abilities of the targeted risk factors or health status over time. We present a number of local and global statistical tracking indices based on the rank-tracking probabilities, which are derived from the conditional distribution functions, and propose a class of kernel-based nonparametric estimation methods. Confidence intervals for the estimators of the tracking indices are constructed through a resampling subject bootstrap procedure. We demonstrate the application of the tracking indices using the body mass index and systolic blood pressure data from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Statistical properties of the estimation methods and bootstrap inference are investigated through a simulation study and an asymptotic development.

scholarly journals METHODOLOGICAL APPROACHES TO EVALUATION AND PREDICTION OF INDIVIDUAL RISK TO HEALTH UNDER THE EXPOSURE TO A COMPLEX OF DIFFERENT FACTORS FOR TASKS OF PERSONALIZED PROPHYLAXIS

2018 ◽  
Vol 97 (1) ◽  
pp. 34-43
Author(s):  
Marina A. Zemlyanova ◽  
N. V. Zaytseva ◽  
D. A. Kiryanov ◽  
O. Yu. Ustinova
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Epidemiological Studies ◽  
Individual Risk ◽  
Scientific Publications ◽  
Managerial Decisions ◽  
Model Library ◽  
Genetic Status ◽  
Somatic Status ◽  
The Individual

Methodical approaches to the assessment and prediction of the individual risk for the development of diseases associated with the effect of a complex of heterogeneous factors, taking into account the features of the genetic and somatic status of the individual for the tasks of personalized prevention, are suggested. The conceptual basis of the methodology is the presentation of the individual risk for diseases as a quantity that varies with time depending on the level and duration of the exposure of the acting factors (evolution), with respect to the contribution of natural causes. There is presented a model describing the evolution of individual risk, which takes into account a complex system of dependencies of the indices of the body’s somatic state and genetic status on the variable exposure of factors. To assess the value of the individual risk, there are proposed a scale and a system of criteria for the assessment of the likelihood of the development of the disease with taking account of its severity. The established value of the individual risk in relation to a specific disease determines the list, scope and sequence of measures for the personalized prevention, and is also a measure of their effectiveness. A large-scale epidemiological study of the population (about 10 thousand people) from 12 regions of the Russian Federation was executed. There was obtained a system of dependencies which reflects the cause-effect relationships between indices characterizing the factors of habitat and lifestyle, the body’s somatic and genetic status (more than 500 indices), the probability of diseases associated with risk factors (about 20 nosological forms). There was created a special replenished information resource «Model Library» has been created, including parameters of more than 4 thousand adequate and reliable dependencies of cause-effect relationships, revealed by relying upon the results of own epidemiological studies and analysis of domestic and foreign scientific publications. An algorithm for the estimation and prediction the individual risk has been developed for the formation of personalized prevention programs aimed at its reducing. The algorithm is implemented in the form of an information and analytical system that can be used as a tool for making managerial decisions in the field of personalized prevention of diseases associated with risk factors at the group and population levels.

scholarly journals Risk factors and molecular entities of the etiopathogenesis of the knee osteoarthritis (literature review)

2021 ◽  
Vol 27 (1) ◽  
pp. 112-120
Author(s):  
V.B. Novakov ◽  
◽  
O.N. Novakova ◽  
M.I. Churnosov ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Knee Osteoarthritis ◽  
Subchondral Bone ◽  
Molecular Mechanisms ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Bibliographic Databases ◽  
Joint Involvement ◽  
Knee Oa

Introduction Osteoarthritis (OA) is a heterogenic group of disorders of different etiology with similar biological, morphological and clinical manifestations and outcomes. OA is now considered a disease of the whole joint, including alterations in the articular cartilage, subchondral bone, synovial membrane, ligaments, capsule and periarticular muscles. OA of the knee as the most commonly affected joint accounts for the great medical, medical, social and economic impact. Material and methods A literature review assessing Russian and foreign studies on molecular mechanisms of etiology and pathogenesis of knee OA identified a set of factors for which there was consistent evidence for their association with onset of knee OA. A search of studies published in Russian and in English for the last ten years was conducted using bibliographic databases, including PubMed, PubMedCentral, GoogleScholar, eLIBRARY. Search terms included 'knee osteoarthritis', 'etiology', 'pathogenesis', 'risk factors'. Results Review of the literature showed that patients with knee OA are characterized by changes in cartilage, subchondral bone, synovium, suggesting common mechanisms of joint degeneration during OA development. Osteoarthritis (OA) is multifactorial in origin and closely associated with a wide spectrum of local (previous injury, muscle weakness, knee malalignment, knee surgeries, abnormal mechanical loading, excessive high impact sports, occupational physical activities) and systemic risk factors (advanced age, female sex, height, greater body mass index and obesity, hormone status, family history, mineral bone density, vitamin D deficiency, ethnicity). The prevalence of the knee OA and patterns of joint involvement vary among different racial and ethnic groups. Conclusion The literature review allowed us to identify the molecular mechanisms of etiopathogenesis of knee OA and the major risk factors for the pathology.

scholarly journals Body, Possibility and Biographical Interpretation

2012 ◽  
Vol 8 (3) ◽  
pp. 64-87
Author(s):  
Anabela Pereira
Keyword(s):  
Point Of View ◽  
The Body ◽  
The Other ◽  
Discursive Construction ◽  
Visual Interpretation ◽  
Individual Interaction ◽  
The One ◽  
The Individual ◽  
World Perspective

The aim of this article is to demonstrate how body-representations offer an opportunity for its visual interpretation from a biographical point of view, enhancing, on the one hand, the image’s own narrative dynamics, and, on the other, the role of the body as a place of incorporation of experiences, as well as, a vehicle mediating the individual interaction with the world. Perspective founded in the works of the artists Helena Almeida and Jorge Molder, who use self-representation as an expression of these incorporated (lived) experiences, constitutes an important discursive construction and structuring of their narrative identity through visual creation, the artists enable the other with moments of sharing knowledge, creativity and subjectivity, contributing also to the construction of the contemporary, cultural and social imagery.

scholarly journals Pharmaceutico - Analytical study of Durvadya Taila and its conversion into cream

2020 ◽  
Vol 5 (05) ◽  
pp. 241-244
Author(s):  
Baban Rathod ◽  
Gangaprasad Asore ◽  
Sujata Haribhau Sankpal
Keyword(s):  
Major Part ◽  
Analytical Study ◽  
Skin Diseases ◽  
Point Of View ◽  
The Body ◽  
Special Importance ◽  
Physico Chemical ◽  
Oil In Water ◽  
The Individual ◽  
Oil Type

Durvadya Taila is medicated oil used in Ayurveda for Kacchu, Vicharchika and Pama (types of Skin diseases) which is caused by vitiated Kapha or Pitta Dosha. Durva is one of the classical drugs of herbal origin, for the management of different disease conditions. The aim of the present study is to do physico-chemical standards for above Durvadya Taila and its conversion into Durvadya Taila Cream. These two formulations have a special importance from pharmaceutical point of view when compared to usual Taila or cream. In present article, we are trying to study analytical results of Durvadya Taila w.s.r. to Durvadya Taila cream. The skin constitutes a major part of the body and serves as a dividing line between the individual and his environment. In the Ayurvedic classics, Bahir Parimarjana means, the medicine intended for external use only. For that purpose, in Ayurveda different forms of external applications are described for the convenience of treatment of different diseases. They are Lepa, Udvartana, Upanaha, Abhyanga, Malahara etc. Without defining creams under Panchavidha Kashaya Kalpana, we can correlate Cream preparation with Lepa or Malahara Kalpana. Creams are those emulsions, which are either oil in-water or water-in-oil type. Durvadya Taila is medicated oil used in Ayurveda for Kacchu, Vicharchika and Pama which comes under Kushtha Rogadhikar.

Cross-education. (Studies from the Yale Psych. Lab., 1900.) Davis, Walter G.

1902 ◽  
Vol 48 (200) ◽  
pp. 156-156
Author(s):  
Havelock Ellis
Keyword(s):  
Mixed Type ◽  
Point Of View ◽  
The Body ◽  
Marked Influence ◽  
Cross Education ◽  
Mental Reaction ◽  
Is Development ◽  
Mental Factor ◽  
The Individual ◽  
Hand Length

In continuing his investigations into this subject, Davis has confirmed his earlier result as to the marked influence of exercise on one side or the body in increasing power on the unexercised side, while bringing out many new results in matters or detail. The experiments were made with the dynamometer and the ergograph. The influence of the factors of length of hand, length of fore-arm, previous muscular development, and temperament are taken into account, and the sexual differences also noted. As regards temperament, Davis finds it most convenient, from this point of view, to recognise three temperaments: the nervous, the motor, and the phlegmatic. The influence of this factor of type is found to be very important. Persons of the nervous type tend to be quick in muscular and mental reaction, short as regards height, and light in weight. Persons of the phlegmatic temperament are found to be slow in muscular and mental reaction, tall as regards height, and heavy in weight. Persons of the motor type are in all respects medium. There are, of course, many cases of mixed type. On the whole, however, they require different degrees of exercise to produce the full effects of cross-education, the phlegmatic, as a rule, considerably more than the motor. Exercise that is too slight, or too severe and fatiguing for the individual, will fail to produce proper development. “If the work is just right in intensity and amount the anabolism provoked is greater than the katabolism, and there is development of the part used. An almost endless variation of conditions would be necessary to make the adjustment of exercise suitable to all individuals. Exercise must be prescribed per order just as a dress must be fitted to the individual.’’ Davis emphasises the conclusion to which his experiments point: that the mental factor is of much more importance than the muscular factor. Cross-education is mainly a matter of nervous centres and nervous channels. These researches are of considerable interest, both theoretical and practical.

scholarly journals REWIEV ON THE BOOK “TERRITORIAL SOVEREIGNTY. A PHILOSOPHICAL EXPLORATION” BY ANNA STILZ

2020 ◽  
Vol 14 (4) ◽  
pp. 153-156
Author(s):  
Nikita Bondarenko ◽  
Keyword(s):  
Political Science ◽  
Current System ◽  
Core Values ◽  
Point Of View ◽  
The Body ◽  
State Sovereignty ◽  
Princeton University ◽  
Territorial Sovereignty ◽  
The Individual ◽  
Territorial States

The review is devoted to the book by the professor of political science at Princeton University Anna Stilz “Territorial Sovereignty. A Philosophical Exploration” (2019). The main issues of the researcher's work are territoriality, sovereignty, and the system of territorial states. The author proposes a revision of this system from a philosophical point of view. Professor Stilz defends the concept of a state's territorial sovereignty against contemporary criticism. Her position is based on arguments of both cosmopolitanism and liberal nationalism. The researcher recognizes principles of open borders, aid to refugee, global cooperation and criticizes the nationalist interpretation of state sovereignty. However, unlike the view of the cosmopolitan school, A. Stilz believes that the implementation of these liberal principles is possible within the system of territorial states. Moreover, defending state sovereignty, the professor uses ideas of the philosophy of the Enlightenment, Kant's doctrines about the interaction between the individual and the state, and about state sovereignty. The main contribution of this work to the body of political science is three core values: occupancy right, basic justice, and collective self-determination. According to Anna Stilz, three core values can modify the current system of territorial states in accordance with new global challenges.

scholarly journals APGLĖBIANTIS MĄSTYMO BŪDAS

Problemos ◽  
2006 ◽  
Vol 69 ◽  
Author(s):  
Viktorija Daujotytė-Pakerienė
Keyword(s):  
Literary Criticism ◽  
Common Ground ◽  
Marcel Proust ◽  
Jorge Luis Borges ◽  
Point Of View ◽  
The Body ◽  
Theoretical Point ◽  
The Common ◽  
General Mode ◽  
The Individual

Straipsnyje, remiantis moksline ir menine medžiaga, aptariama humanistikos metodų problema. Keliama mintis, kad vaisingiausi metodai yra susiję su bendresniu mąstymu, su teorija. Jei metodas tik perimamas, jis virsta įrankiu, metodologijos dažnai, ypač disertacijose, tik imituojamos. Pasiremiama A. J. Greimo mintimi apie „apglėbiantį mąstymo būdą“. Trumpai aptariant pirmą kartą lietuviškai pasirodžiusias E. Husserlio „Karteziškąsias meditacijas“, ieškoma ir fenomenologinio tako humanistikoje, ypač literatūros moksle. Pabrėžiamas filosofijos ir literatūros ryšys. Keliama mintis, kad humanistikos metodologinės nuostatos turėtų labiau remtis pačia kūryba.Reikšminiai žodžiai: metodas, teorija, mąstymas, filosofija, poezija, fenomenologija. THE EMBRACING MODE OF THINKING Viktorija Daujotytė-Pakerienė Summary The author sets out to reconsider the problem of humanistic methods. It expresses the doubt as to the application of the methods which are detached from theories and a more general mode of thought. The title of the article is taken from the Lithuanian edition of the preface to “Semiotics” (1989) written by A. J. Greimas. The mode of thought, embracing the multifarious worlds of meaning, is considered as a humanistic universal, it is also perceived as a bridge of thought to prevailing phenomenology. The concept of embrace encompasses the dimension of the body and the full mental participation of the individual. A brief review of the first translation of Edmund Husserl’s “Cartesian Meditations” into Lithuanian by Tomas Sodeika (2005) are presented. Meditation is viewed as the common ground-substratum shared by philosophy and poetry. “Meditations” (1997) of Donaldas Kajokas are introduced. Algis Mickūnas and Arūnas Sverdiolas’s dialogues “The All-Embracing Present” (2004) are referred to as a personal testimony of the inner participation in the theories. The significance of A. Ðliogeris’s study “Thing and Art“ (1988), which discusses the creative work of P. Cezanne and R. M. Rilke, is reflected within the framework of the tradition of phenomenological thought; here the concept of theoretical point of view was first formulated in Lithuanian humanistics. The article suggests that in approaching the problems of method in humanistics, and especially in literary criticism, the participation of creation itself is very important, and particularly the experiences that open up in original texts (like in the writings of Marcel Proust, Jorge Luis Borges). It is important to reveal the equivalents, to reflect them, to extract the method from the texts. The article arrives at the conclusion that the recognition of the organizing inner text system is the essential principle of humanistic methodology, which is in close connection with the embracing mode of thought.Keywords: method, theory, thought, philosophy, poetry, phenomenology.

scholarly journals Selected socio-economic aspects of the risk of hypertension

2020 ◽  
Vol 26 (2) ◽  
pp. 155-162
Author(s):  
D. P. Tsygankova ◽  
N. V. Fedorova
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Large Scale ◽  
Pathological Condition ◽  
Economic Status ◽  
Epidemiological Studies ◽  
Convincing Evidence ◽  
The Body ◽  
Rapid Urbanization ◽  
Prevention And Treatment

Hypertension (HTN) is one of the most common diseases and a risk factor leading to disabling and fatal complications. Large-scale epidemiological studies in all countries convincingly prove the need for early prevention and treatment of this pathological condition. In conditions of rapid urbanization, it is necessary to look for individual measures for the prevention and treatment. In addition to the main risk factors for HTN, such as low physical activity and increased body weight, smoking, alcohol abuse, as well as sex and age, there is convincing evidence that the level of education, economic status, professional affiliation, living conditions are also potential predictors of HTN. The review presents an analysis of the main socio-economic risk factors for HTN and the mechanisms of their influence on blood pressure. The article discusses each factor, its impact on blood pressure and the body as a whole, as well as approaches for the identification of these factors.

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