scholarly journals THEINCREASE OFBLOOD CHOLESTEROL LEVELS IN WHITE RATS SUPPLEMENTED WITHCASSAVA YEAST

2021 ◽  
Vol 10 (1) ◽  
pp. 21-29
Author(s):  
Serly Nur Indah Permatasari ◽  
Samsuri Samsuri ◽  
Anak Agung Sagung Kendran
Keyword(s):  
Body Weight ◽  
Rattus Norvegicus ◽  
Statistical Tests ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Cholesterol Level ◽  
Measuring Device ◽  
Blood Samples ◽  
Cholesterol Levels ◽  
White Rats

Tape yeast can be used as a source of genuine probiotics because tape yeast contain microbes such as molds, yeasts, and bacteria that are able to hydrolyze carbohydrates into glucose that are converted into alcohol. This study aimed to determine the effect of giving tape yeast for 21 days to the blood cholesterol levels of white rats(Rattus norvegicus). White rats were grouped into four treatments, namely P0: control; P1: under 100 mg/kg BW dose; P2: 200 mg/kg BW; and P3: 300 mg/kg BW of Tape yeast. The examination of blood cholesterol levels was tested by using EasyTouch GCU (Glucose, Cholesterol, and Uric Acid) with blue strips and chip tests. Blood samples were taken by cutting off tip of the tail and put the blood to the strip to see the results on the measuring device. The data obtained were analyzed by variancetest and data that were significantly different between treatments were continued with the Least Significance Different(LSD) test. The results of this study showed the average blood cholesterol level of treatment P1: 211.00 mg/dL, P2: 282.00 mg/dL and P3: 174.17 mg/dL higher than the control group P0: 149.67 mg/dL. Based on statistical tests were shown significantly different results on the treatment of P1 (100 mg/kg body weight), P2 (200 mg/kg body weight), and P3 (300 mg/kg body weight). Based on the result itcan be concluded the administration of tape yeast affects the blood cholesterol levels of white rats.

scholarly journals PENGARUH PEMBERIAN INFUSA DAUN LABU SIAM (Sechium edule) TERHADAP PENURUNAN KADAR KOLETEROL DARAH TOTAL TIKUS PUTIH JANTAN (Rattus norvegicus)

PHARMACON ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 151
Author(s):  
Ausich Singal ◽  
Edwin De Queljoe ◽  
Paulina Yamlean
Keyword(s):  
Rattus Norvegicus ◽  
Dose Group ◽  
T Test ◽  
Blood Cholesterol ◽  
Control Group ◽  
Cholesterol Levels ◽  
White Rats ◽  
Sechium Edule ◽  
One Way Anova ◽  
Paired T Test

ABSTRACT This study aims to determine the effect of infusion of conjoined pumpkin leaves (Sechium edule) on reducing total blood cholesterol of male white rats (Rattus norvegicus). The subjects of this study were 15 male white rats with an average body weight of 200 grams which were divided into 5 groups, each group consisted of 3 mice. The method used is a laboratory experiment with a completely randomized design. The results were obtained from 2 measurements of blood cholesterol levels, namely measurements before and after treatment. The treatment begins with the provision of high-fat foods for 48 days. On the 49th day a blood cholesterol level was measured before treatment. Furthermore, treatment was given to each group, namely aquades in the negative control group, simvastatin in the positive control group, and squash leaves infusion with their respective doses in the dose group I (40%), the dose group II (20%), and the dose group III (10%). Measurement of cholesterol levels after treatment was carried out on day 54. Data were analyzed by Paired t-test and One Way ANOVA. The analysis showed that there were no significant differences between treatment groups. Judging from the change in average and percentage, 40% infusion dose of siamese pumpkin leaves gives the best reduction in cholesterol levels. Keywords: Cholesterol, pumpkin leaves, male white mouse infusion. ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh pemberian infusa daun labu siam (Sechium edule ) terhadap penuruan kolesterol darah total tikus putih jantan (Rattus norvegicus). Subjek penelitian ini berupa tikus putih jantan berjumlah 15 ekor dengan berat badan rata-rata 200 gram yang dibagi dalam 5 kelompok, masing-masing kelompok sebanyak 3 ekor. Metode yang digunakan yaitu eksperimen laboratorium dengan rancangan acak lengkap. Hasil penelitian diperoleh dari 2 kali pengukuran kadar koleterol darah yaitu pengukuran sebelum dan sesudah perlakuan. Perlakuan dimulai dengan pemberian makanan tinggi lemak selama 48 hari. Pada hari ke49 dilakukan pengukuran kadar kolesterol darah sebelum perlakuan. Selanjutnya diberikan perlakuan pada tiap kelompok yaitu aquades pada kelompok kontrol negatif, simvastatin pada kelompok kontrol positif, dan infusa daun labu siam dengan dosis masing-masing pada kelompok dosis I (40 %), kelompok dosis II (20 %), dan kelompok dosis III (10%). Pengukuran kadar kolesterol sesudah perlakuan dilakukan pada hari 54. Data diananlisis dengan Paired t-test dan One Way ANOVA. Hasil analisa menunjukan tidak terdapat perbedaan yang bermakna antar kelompok perlakuan. Dilihat dari perubahan rerataan dan presentase, dosis infusa  40% daun labu siam memberikan penurunan kadar koleterol terbaik. Kata kunci : Infusa daun Labu siam, kolesterol, tikus putih jantan.

Nursing Intervention in Decrease of Blood Cholesterol and Blood Pressure in The Lansia Group Provided Cupping Therapy in The Village of Wedomartani Sleman

2021 ◽  
Vol 15 (5) ◽  
pp. 1305-1308
Author(s):  
Su warsi
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Alternative Therapy ◽  
The Elderly ◽  
Nursing Intervention ◽  
Cupping Therapy ◽  
Blood Cholesterol ◽  
Control Group ◽  
Measuring Device ◽  
Cholesterol Levels

Background: Much alternative therapy such as cupping therapy in the community as one of the cheap treatment efforts without side effects makes the challenge and the goal for nursing staff improve nursing services. The unfinished scientific verification of cupping therapy's alternative therapy makes nurses need to prove decreased blood pressure and cholesterol levels in the elderly. Objective: Scientific proof of cholesterol and blood pressure decrease after Cupping Therapy in an elderly group in Wedomartani Village, Sleman Yogyakarta Indonesia. Method: quantitative type with pseudo experimental research design. Pre-test and Post-test nonequivalent control group. The treatment group was given wet cupping therapy, while the control group was given dry cupping. Respondents were selected using a purposive sampling technique. Blood pressure measurement uses a digital tensimeter and cholesterol measurement using a digital blood cholesterol level measuring device. Results: The elderly blood cholesterol levels after the average therapy decreased 42.89 mg/dl, whereas blood cholesterol levels in the control group decreased an average of 20.95 mg/dl. The blood pressure of the elderly systole in the intervention group after the average therapy decreased 10.74 mmHg, whereas the control group's systole blood pressure decreased an average of 1.58 mmHg. Diastole blood pressure in the treatment group decreased 3,48 mmHg, in the diastole blood pressure control group increased 5,26 mmHg. Conclusions: Wet and dry cupping are both significantly associated with decreased blood cholesterol and blood pressure levels, but wet cupping lowers blood cholesterol levels by a mean difference of 21.95 mg/dl and mean systole blood pressure of 3.74 mmHg and pressure diastole blood difference of mean 9.1 mmHg. Keyword: Blood Pressure. Cupping Therapy, Cholesterol, Elderly

scholarly journals The Correlation of Weight and Blood Cholesterol Levels of White Rat (Rattus Norvegicus) with High-Fat Diet

2016 ◽  
Vol 3 (3) ◽  
pp. 202-206
Author(s):  
Thatit Nurmawati
Keyword(s):  
Body Weight ◽  
Rattus Norvegicus ◽  
High Fat Diet ◽  
Egg Yolk ◽  
The Body ◽  
Blood Cholesterol ◽  
High Fat ◽  
Data Measurement ◽  
Cholesterol Levels

Cholesterol is an essential substance for the body. The role of cholesterol as material hormones,cell membranare needed by the body. This conditionchanges into a distrubtion if the cholesterollevels in the blood increase. Weight becomes one of this trigger. The consumption of high-fat foodsincrease weight which resulting in the increase of cholesterol cases. The purpose of this study was todetermine the level of correlations between weight and cholesterol levels after being given a high-fatdiet.The study used rats (Rattus norvegicus) sex male, 16 rats with age between 1-2 months. Rats weightrange between 100-150 gr and in healthy conditions. The giving of high-fat diet were in the form ofchicken feed, duck eggs, goat oil, lard and flour for 8 weeks. The data measurement done by scales andmeasuringcholesterol levels through the end of the tail by means of easy touch. The data analysis weredone to understand level of correlation between variables. The presentation of the data used tables. Theresults showed body weight of rats did not change after administration of a high-fat diet. The cholesterolslevels of the subjects were high. Theadministration of high-fat diet from egg yolk dan goat oilcouldincrease the level of cholesterol. There was a correlation between weight and cholesterol levels afterbeing given a high-fat diet (p <0.5). It was needed to repeatthe measurements to determine changes incholesterol levels and other factors that affect thigh blood to cholesterol levels.

scholarly journals EFEK PAPARAN DEKOK BIJI PINANG (Areca catechu) TERHADAP MOTILITAS SPERMATOZOA TIKUS (Rattus norvegicus): UPAYA MENEMUKAN KANDIDAT ANTIFERTILITAS PRIA (The Effect of Betel Nut Extract (Areca catechu) on Mice Spermatozoa Motility (Rattus norvegicus: Effort to Find Out Man Antifertility Candidate)

2016 ◽  
Vol 2 (2) ◽  
Author(s):  
Muslim Akmal
Keyword(s):  
Body Weight ◽  
Sperm Motility ◽  
Rattus Norvegicus ◽  
Control Group ◽  
Betel Nut ◽  
Spermatozoa Motility ◽  
White Rats ◽  
Areca Catechu ◽  
Different Doses

This research was conducted to prove the ability of betel nut extract (Areca catechu) in causingdegradation of sperm motility on rats (Rattus norvegicus) strain Wistar. This research used 2-3 monthsage, 200-250 g body weight of male white rats Rattus norvegicus strain Wistar. The rats were dividedinto 5 groups in equal number, 3 rats each group. They were a control group without treatment and 4treatment groups which were given different doses of betel nut extract for 7 days, i.e., 1, 2, 3, and 4 g/200g body weight respectively. The result showed that increasing doses of betel nut extract can result indegradation of sperm motility significantly (P0.05).Keywords: Areca catechu, Rattus norvegicus, sperm motility

scholarly journals Nutritional Value of Lime and Lemon in Hypercholesterolaemic Induced Rats

2013 ◽  
Vol 3 (1) ◽  
pp. 13-16
Author(s):  
Anslem O Ajugwo ◽  
Tosan Erhabor ◽  
Tom Mokogwu ◽  
Kester Digban ◽  
Godwin Ojieh ◽  
...  
Keyword(s):  
Body Weight ◽  
Cholesterol Level ◽  
Nutritional Value ◽  
Egg Yolk ◽  
Blood Cholesterol ◽  
Control Group ◽  
Albino Rats ◽  
Blood Cholesterol Level ◽  
Medical Sciences ◽  
State Water

OBJECTIVE: People generally use lime and lemon when weight reduction is anticipated. This work was carried out to determine the effect of these fruits in hypercholesterolaemic induced rats. MATERIALS AND METHOD: Sixteen (16) albino rats were used and grouped into four groups of four (4) each. The rats were allowed to acclimatize and fed with egg yolk for seven days to induce hypercholesterolaemic state. Water, lemon, lime and lime+lemon were administered to these groups respectively. Cholesterol level was analyzed in all the groups after two (2) weeks of the administration of the fruits. RESULTS: The result showed a statistical decrease in the groups treated with lime, lemon and lime+lemon. The lime+lemon group showed a more significant decrease (p<0.05) in both cholesterol level and body weight when compared with the control group and other groups. This reduction may be as a result of the contents of the fruits. CONCLUSION: It can therefore be concluded that lime and lemon helps in the lowering of blood cholesterol level and body weight. DOI: http://dx.doi.org/10.3126/ajms.v3i1.5450 Asian Journal of Medical Sciences 3(2012) 13-16

scholarly journals Uji efek perasan daging buah labu kuning (Cucurbita moschata D.) terhadap kadar kolesterol total darah tikus wistar (Rattus norvegicus)

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Lisa C. Ratulangi ◽  
Pemsi Wowor ◽  
Christi Mambo
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Negative Control ◽  
Blood Cholesterol ◽  
Control Group ◽  
Cucurbita Moschata ◽  
Fruit Pulp ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Total Blood Cholesterol

Abstract: This study aimed to obtain the effect of pumpkin fruit pulp (Cucurbita moschata D.) juice on total blood cholesterol of wistar rats (Rattus norvegicus). This was an experimental laboratory study conducted in the Laboratory of Pharmacology and Therapy Faculty of Medicine, University of Sam Ratulangi. Samples were 10 rats with an average body weight of 150 g. Samples were divided into 5 groups, each group consisted of 2 rats: negative control group, only used standard food; propylthiouracil (PTU) treatment group; positive control group used simvastatin after PTU induced for 14 days; propylthiouracil (PTU) treatment group continued with standard food; and propylthiouracil (PTU) treatment group continued with pumpkin fruit pulp juice. Doses of the pumpkin fruit pulp juice were 0.93 g/ml/day/rat as many as 2 ml/day. The measurement of total blood cholesterol levels was on days 0, 15, and 22 by using Autocheck. Conclusion: The pumpkin fruit pulp juice had an effect in reducing total blood cholesterol levels in wistar rats.Keywords: juice of pumpkin fruit pulp, total blood cholesterol, propylthiouracil.  Abstrak: Penelitian ini bertujuan untuk mengetahui efek air perasan daging buah labu kuning (Cucurbita moschata D.) terhadap kadar kolesterol darah total pada tikus wistar (Rattus norvegicus). Jenis penelitian ini eksperimental laboratorik di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Sam Ratulangi. Subjek penelitian berupa tikus wistar jantan berjumlah 10 ekor dengan berat rata-rata 150 g yang dibagi kedalam 5 kelompok, masing-masing sebanyak 2 ekor, yaitu: kontrol negatif hanya menggunakan pakan standar; kelompok perlakuan propiltiourasil (PTU); kontrol positif menggunakan simvastatin setelah diinduksi PTU selama 14 hari; kelompok perlakuan pemberian PTU dilanjutkan dengan pakan standar; dan kelompok perlakuan pemberian PTU dilanjutkan dengan perasan daging buah labu kuning (Cucurbita moschata D.). Dosis perasan daging buah labu kuning yang diberikan 0.93 g/ml/hari/ekor sebanyak 2 ml/hari. Pengukuran kadar kolesterol darah total dilakukan pada hari ke 0, 15, dan 22 menggunakan alat pengukur Autocheck. Simpulan: Perasan daging buah labu kuning berefek menurunkan kadar kolesterol total pada tikus wistar.Kata kunci: perasan daging buah labu kuning, kolesterol total darah, propiltiourasil.

scholarly journals Pengaruh Pemberian Berbagai Olahan Telur terhadap Kadar Kolesterol Total Darah Mencit

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Putri Mira Magistri ◽  
Rismawati YaswiR ◽  
Yustini Alioes
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Cholesterol Content ◽  
Blood Cholesterol ◽  
Blood Cholesterol Level ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Randomized Design ◽  
Total Blood Cholesterol

AbstrakMasyarakat menggunakan berbagai cara pengolahan sebelum mengonsumsi telur yang dapat berpengaruh terhadap kadar zat gizi yang terkandung didalamnya, termasuk kadar kolesterol dalam telur yang juga akan mempengaruhi kadar kolesterol dalam darah. Tujuan penelitian ini adalah menentukan pengaruh pemberian berbagai olahan telur terhadap kadar kolesterol total darah mencit. Penelitian menggunakan 24 ekor mencit (Mus musculus) jantan albino umur 3 – 4 bulan dengan berat badan sekitar 30 – 40 gram. Jenis kandang yang digunakan adalah kandang kotak (box) sebanyak 24 unit dengan ukuran 28x30x20 cm. Metode yang digunakan ialah eksperimen dengan Rancangan Acak Lengkap (RAL) terdiri dari 6 unit perlakuan, yaitu unit perlakuan K (Kontrol), unit perlakuan A (telur mentah), unit perlakuan B (telur goreng), unit perlakuan C (telur rebus), unit perlakuan D (telur setengah matang) dan unit perlakuan E (telur asin). Dosis perlakuan adalah 1,56ml/20gram berat badan/mencit dan masing-masing perlakuan diulang 4 kali. Parameter yang diukur adalah kadar kolesterol total darah mencit. Hasil analisis keragaman menunjukan bahwa pemberian berbagai olahan telur memberikan pengaruh berbeda sangat nyata (P<0.01) terhadap kadar kolesterol total darah mencit. Berdasarkan hasil penelitian dapat disimpulkan bahwa rerata kadar kolesterol total darah mencit setelah diberikan berbagai olahan telur adalah telur mentah 106.96 mg/dl, telur goreng 143.53 mg/dl, telur rebus 194.50 mg/dl, telur setengah matang 180.91 mg/dl, dan telur asin 158.27 mg/dl.Kata kunci: olahan telur, kadar kolesterol total darah, mencit AbstractPeople use various methods of processing before consumption eggs which can affect the levels of nutrients contained in, including cholesterol content which can also affect the levels of total cholesterol in blood. The objective of this study was to determine the effect of giving a variety of processed egg on total cholesterol levels of mice. The experiment used 24 male albino mice (Mus nusculus) age 3 – 4 months old with 30 – 40 grams of body weight. The den used was 24 units of box with size of 28x30x20 cm. The experiment used Completely Randomized Design (CRD) consist of 6 treatment units which was K (control), A (raw egg), B (fried egg), C (boiled egg), D (soft-boiled egg), and E (salted egg). The dosage was  1.56 ml/20 grams of body weight/mice and 4 replication for each treatment units. The parameter measured was total blood cholesterol level of mice.  Results of analysis of variance showed that giving of a variety of processed egg gave highly  significant  effect (P <0.01) on total blood cholesterol levels of mice. Based on the results of this study, it can be concluded that the average total blood cholesterol levels of mice after giving of various preparations of eggs is as follows: raw eggs 106.96 mg / dl, fried eggs 143.53 mg / dl, boiled eggs 194.50 mg / dl, soft-boiled eggs 180.91 mg / dl, and salted egg 158.27 mg / dl..Keywords: processed egg, total blood cholesterol level,  mice

scholarly journals Effects of turmeric extract (Curcuma domestica Val.) on the increase of SGOT and SGPT level in the mice (Rattus norvegicus) due to the acetaminophen administration

2005 ◽  
Vol 3 (2) ◽  
pp. 57-60 ◽  
Author(s):  
HARTONO HARTONO ◽  
IDA NURWATI ◽  
FANY IKASARI ◽  
WIRYANTO WIRYANTO
Keyword(s):  
Body Weight ◽  
Rattus Norvegicus ◽  
Data Gathering ◽  
Control Group ◽  
Blood Samples ◽  
Turmeric Extract ◽  
Body Weight Data ◽  
Post Test ◽  
Group 2 ◽  
Post Hoc

Turmeric (Curcuma domestica Val.) contains a peculiar substance called curcumin that bears medical merit. The results of various types of study with curcumin show that it is able to restore damaged lever cells; therefore, it is predicted that the turmeric extract also bears the same ability. This study aims at finding out whether there is an effect of the turmeric extract on the increase of SGOT and SGPT level in the mice due to the acetaminophen administration. This is an experimental study with a post-test only controlled group design. The research used were 20 male mice (Rattus norvegicus), Strain Wistar, aged + 2 months old, weighed 150 grams. They were divided into 4 groups, and each group consisted of 4 mice. Group 1 was control group. Group 2 was exposed to one-time administration of acetaminophen with the toxic dosage of 1.35 grams over each kilogram of body weight. Groups 3 and 4 were each given turmeric extract with the dosage of 5 milligrams and 10 milligrams over each kilogram of body weight respectively; after two hours, they were subject to one-time acetaminophen administration with the dosage of 1.35 grams over each kilogram of body weight. Data gathering was then conducted following 48 hours of the latest treatment by taking the blood samples of the mice through their sinus orbitalis. The blood samples from the 4 groups were then examined for their level of SGOT and SGPT with a kinetic method.The data were analyzed by means of ANOVA followed by Post Hoc Test using Tukey test completed with homogenous subsets. The results show a significant effect of the turmeric extract on the increase of the SGOT and SGPT level in the mice due to the acetaminophen administration.

Nursing Intervention in Decrease of Blood Cholesterol and Blood Pressure in The Lansia Group Provided Cupping Therapy in The Village of Wedomartani Sleman

2021 ◽  
Vol 15 (5) ◽  
pp. 1305-1308
Author(s):  
Suwarsi .
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Alternative Therapy ◽  
The Elderly ◽  
Nursing Intervention ◽  
Cupping Therapy ◽  
Blood Cholesterol ◽  
Control Group ◽  
Measuring Device ◽  
Cholesterol Levels

Background: Much alternative therapy such as cupping therapy in the community as one of the cheap treatment efforts without side effects makes the challenge and the goal for nursing staff improve nursing services. The unfinished scientific verification of cupping therapy's alternative therapy makes nurses need to prove decreased blood pressure and cholesterol levels in the elderly. Objective: Scientific proof of cholesterol and blood pressure decrease after Cupping Therapy in an elderly group in Wedomartani Village, Sleman Yogyakarta Indonesia. Method: quantitative type with pseudo experimental research design. Pre-test and Post-test nonequivalent control group. The treatment group was given wet cupping therapy, while the control group was given dry cupping. Respondents were selected using a purposive sampling technique. Blood pressure measurement uses a digital tensimeter and cholesterol measurement using a digital blood cholesterol level measuring device. Results: The elderly blood cholesterol levels after the average therapy decreased 42.89 mg/dl, whereas blood cholesterol levels in the control group decreased an average of 20.95 mg/dl. The blood pressure of the elderly systole in the intervention group after the average therapy decreased 10.74 mmHg, whereas the control group's systole blood pressure decreased an average of 1.58 mmHg. Diastole blood pressure in the treatment group decreased 3,48 mmHg, in the diastole blood pressure control group increased 5,26 mmHg. Conclusions: Wet and dry cupping are both significantly associated with decreased blood cholesterol and blood pressure levels, but wet cupping lowers blood cholesterol levels by a mean difference of 21.95 mg/dl and mean systole blood pressure of 3.74 mmHg and pressure diastole blood difference of mean 9.1 mmHg. Keyword: Blood Pressure. Cupping Therapy, Cholesterol, Elderly

scholarly journals Pemanfaatan Seduhan Daun Ashitaba dengan Simvastatin dalam Menurunkan Kadar LDL Tikus Putih Jantan Strain Wistar

2018 ◽  
Vol 7 (1) ◽  
pp. 31
Author(s):  
Ernawati Ernawati ◽  
Theresia Ratnasari Widjaja
Keyword(s):  
Rattus Norvegicus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Cholesterol ◽  
P Value ◽  
Simvastatin Treatment ◽  
Cholesterol Levels ◽  
White Rats ◽  
Angelica Keiskei ◽  
Herbal Plants

High levels of blood cholesterol or hypercholesterolemia is an important risk factor for a cardiovascular disease. In order to overcome this problem, giving statins drug such as simvastatin is an intervention that is often applied. Besides using this drug, it can also be accompanied by consuming herbal plants which is Ashitaba leaves (Angelica keiskei). It contains Chalcones which demonstrates anti tumour property and also antioxidant activity that can lower cholesterol levels, especially LDL in the blood. This study aimed to investigate the effect of Ashitaba leaves (Angelica keiskei) steeping administration in assisting simvastatin drugs to decrease the levels of Low Density Lipoprotein (LDL) in the blood serum of male white rats Strain wistar (Rattus Norvegicus) with hypercholesterolemia. The population for this study was male white rats Strain wistar (Rattus Norvegicus) with samples taken in this study were 33 white rats. Data analysis for this study is using One Way Anova test.The result showed that supplementation of simvastatin treatment using steeping Ashitaba leaves might slightly reduce LDL level among male white rats Strain wistar (Rattus Norvegicus) with hypercholesterolemia. However, the result demonstrated not significant different.  To assist simvastatin drugs in lowering LDL levels in male white rats Strain wistar (Rattus Norvegicus) which is made to be hypercholesterolemia can lower LDL levels slightly but not significantly (p-value = 0,177) which is >a (0,05).

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