Bone Tuberculosis: Clinical Profile of 40 Patients in Dr. Soetomo General Hospital Surabaya

Introduction: Bone and joint tuberculosis are specific infection inflammation of Mycobacterium tuberculosis, mostly affected bone and joint confirmed by acceleration of vascular supply to vertebrae and growth line of long bone. The aim of this study is to know clinical profile of bone and joint tuberculosis’ patients. Methods: This study was conducted using descriptive observational method, samples were tested by observation descriptive test. Results: The average ages of bone and joint tuberculosis hospitalized patients of RSUD Dr. Soetomo Surabaya are 35-44 years. There are 22 cases on male (55%) and 18 cases on female (45%) with 29 subjects of Hb’s abnormal number (72.5%), 15 subjects of abnormal leucocytes (37.5%), 20 subjects of abnormal thrombocyte (50%), 34 subjects of abnormal ESR (94.4%), 20 patients of abnormal C-reactive protein (54.1%), 11 subjects of abnormal serum creatinine (28.9%), 13 subjects of abnormal sodium level (35.1%), 15 patients of abnormal potassium level (40.5%), and 16 patients of abnormal chloride level (43.2%). There are 16 subjects with smoking history (40%), 29 subjects of positive tuberculosis history (72.5%), 6 subjects with positive tuberculosis family history (15%), 30 subjects of pain as main problems (75%), 5 subjects of swelling or pus as main problems (12.5%), 5 subjects of extremities disability as main problems (12.5%). Dominant location of infection is vertebrae (95%) which are suffered by 38 subjects with thoracal as the main level of infection, suffered by 15 subjects (50%). Other levels of infection are lumbal with 12 subjects (40%), cervical with 3 subjects (10%), and pelvis or thigh with 2 subjects (5%). Conclusion: From 40 subjects, bone and joint tuberculosis mostly suffered by elderly, male risks more than female. Most of hematology tests results were abnormal. Most subjects suffered abnormal C-reactive protein. Most subjects’ hematology tests were BUN, creatinine serum, and electrolyte normal. Number of subjects with smoking habits was dominant. Most subjects were having tuberculosis history but negative family history. Most subjects complained about pain with vertebrae level thoracal as dominant location of infection.

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Associations of Apolipoprotein A, High-Sensitivity C-Reactive Protein and Fasting Plasma Insulin in Obese Children With and Without Family History of Cardiovascular Disease

Journal of Clinical Medicine Research ◽

10.14740/jocmr2531w ◽

2016 ◽

Vol 8 (6) ◽

pp. 431-436 ◽

Cited By ~ 4

Author(s):

Zacharoula Karabouta ◽

Dimitrios Papandreou ◽

Areti Makedou ◽

Israel Rousso ◽

Fani Athanassiadou

Keyword(s):

Cardiovascular Disease ◽

Family History ◽

Plasma Insulin ◽

High Sensitivity ◽

Obese Children ◽

C Reactive Protein ◽

Reactive Protein ◽

Apolipoprotein A ◽

History Of ◽

Fasting Plasma Insulin

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Association of Testosterone, Insulin-Like Growth Factor-I, and C-Reactive Protein with Metabolic Syndrome in Chinese Middle-Aged Men with a Family History of Type 2 Diabetes

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2005-0228 ◽

2005 ◽

Vol 90 (12) ◽

pp. 6418-6423 ◽

Cited By ~ 35

Author(s):

Peter C. Y. Tong ◽

Chung-Shun Ho ◽

Vincent T. F. Yeung ◽

Maggie C. Y. Ng ◽

Wing-Yee So ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Family History ◽

Total Testosterone ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Igf I ◽

History Of ◽

Hs Crp

Context: Age-related declines in testosterone and IGF-I are associated with deposition of visceral fat, a component of the metabolic syndrome (MES). Objective: Testosterone and IGF-I may interact with familial disposition to diabetes mellitus to increase the association with MES. Design: We conducted a cross-sectional cohort study. Setting: The study was conducted in a university teaching hospital. Subjects: Study subjects included 179 middle-aged men with a family history of diabetes (FH) (aged 39.1 ± 8.1 yr) and 128 men without FH (aged 43.8 ± 8.5 yr). Main Outcome Measures: Clinical characteristics, frequency of MES using the World Health Organization criteria with Asian definitions of obesity (body mass index ≥ 25 kg/m2), and serum levels of total testosterone, IGF-I, and high-sensitive C-reactive protein (hs-CRP) were measured. Results: Men with FH had higher frequency of MES than those without FH [39.1 vs. 23.4% (P = 0.004)]. On multivariate analysis, smoking (former and current smokers), low total testosterone, and IGF-I but elevated hs-CRP levels explained 35% of the MES variance in men with FH. The frequency of MES increased with declining tertiles of total testosterone and IGF-I but increasing tertiles of hs-CRP. After adjustment for age and smoking history, subjects with all three risk factors had a 13-fold increase in risk association with MES compared with those without hormonal and inflammatory risk factors. These risk associations were not found in men without FH in whom only smoking (ex and current) and low total testosterone level were independent predictors for MES, which explained 14% of the variance. Conclusions: Clustering of FH, hormonal abnormalities, and high hs-CRP is associated with MES in Chinese middle-aged men.

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C-reactive protein and family history of myocardial infarction

Atherosclerosis ◽

10.1016/s0021-9150(99)80061-6 ◽

1999 ◽

Vol 144 ◽

pp. 17

Author(s):

M. Margaglione ◽

G. Cappucci ◽

D. Colaizzo ◽

G. Vecchione ◽

E. Grandone ◽

...

Keyword(s):

Myocardial Infarction ◽

Family History ◽

C Reactive Protein ◽

Reactive Protein ◽

History Of

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Beyond Coronary Calcification, Family History, and C-Reactive Protein

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2016.03.538 ◽

2016 ◽

Vol 67 (21) ◽

pp. 2480-2487 ◽

Cited By ~ 39

Author(s):

Purav Mody ◽

Parag H. Joshi ◽

Amit Khera ◽

Colby R. Ayers ◽

Anand Rohatgi

Keyword(s):

Family History ◽

Coronary Calcification ◽

C Reactive Protein ◽

Reactive Protein

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Association between C reactive protein and depression in a population of healthy adults: the Cooper Center Longitudinal Study

Journal of Investigative Medicine ◽

10.1136/jim-2019-001254 ◽

2020 ◽

Vol 68 (5) ◽

pp. 1019-1023 ◽

Cited By ~ 1

Author(s):

Amber Khan ◽

David Leonard ◽

Laura Defina ◽

Carolyn E Barlow ◽

Benjamin Willis ◽

...

Keyword(s):

Depressive Symptoms ◽

Menopausal Status ◽

White Male ◽

Depression Scale ◽

Healthy Adults ◽

Smoking History ◽

C Reactive Protein ◽

Male Population ◽

Reactive Protein ◽

Hs Crp

The relationship between depression and inflammation is currently a topic of much interest. Previous studies have produced mixed results regarding the association between depression and high-sensitivity C reactive protein (hs-CRP). The aim of this report was to determine the association between hs-CRP and depression in a large sample of healthy adults. This is a cross-sectional study of 26,638 healthy adults seen for preventive medical examinations between December 2000 and August 2018 at the Cooper Clinic in Dallas, Texas. Multivariable logistic regression was used to evaluate the association between hs-CRP levels and depressive symptoms as measured by the 10-item Center for Epidemiologic Studies Depression Scale. Covariates included race, age, education, smoking history, alcohol use, menopausal status, body mass index (BMI), and medication use. The Hs-CRP level demonstrated a weakly positive association with depressive symptoms (OR 1.06 per mg/L, 95% CI 1.03 to 1.09 for women; OR 1.05 per mg/L, 95% CI 1.02 to 1.09 for men) that became insignificant when controlling for BMI in women (OR 1.02 per mg/L, 95% CI 0.98 to 1.05) and men (OR 1.02 per mg/L, 95% CI 0.98 to 1.05). Adjusting for antidepressant and statin use did not affect the association between hs-CRP and depressive symptoms in women (OR 0.99 per mg/L, 95% CI 0.96 to 1.03) or men (OR 1.01 per mg/L, 95% CI 0.97 to 1.05). Levels of hs-CRP were not associated with depression independent of BMI in a predominantly white, male population of higher socioeconomic status. This finding suggests that associations between hs-CRP and depression may be explained by obesity, which warrants further investigation into shared pathways between obesity and depression.

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Abstract 874: MLN1202, a Novel CCR2 Antagonist, Decreases C-reactive protein in Patients at Risk for Atherosclerotic Cardiovascular Disease in a Double Blind Placebo Controlled study

Circulation ◽

10.1161/circ.116.suppl_16.ii_171 ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

M. Davidson ◽

J. Lekstrom-Himes ◽

J. Gilbert ◽

D. Donaldson ◽

Y. Lee ◽

...

Keyword(s):

At Risk ◽

Lipid Lowering ◽

Smoking History ◽

Controlled Study ◽

C Reactive Protein ◽

Double Blind ◽

Double Blind Placebo ◽

Reactive Protein ◽

Patients At Risk ◽

Circulating Levels

Background: Macrophages play a central role in atherosclerotic plaque formation. The CC chemokine receptor 2 (CCR2), expressed on the surface of circulating monocytes, and its ligand MCP-1 (CCL2), are present in atherosclerotic plaques and may play a critical part in endothelial monocyte recruitment and activation. MLN1202 is a humanized monoclonal antibody with high specificity to CCR2, which interrupts MCP-1 binding to CCR2. MLN1202 is being developed for the treatment of immune mediated diseases. Hypothesis: We tested the hypothesis that MLN1202 significantly influences disease activity in patients at risk for ASCVD as measured by a reduction in circulating levels of high sensitivity C-reactive protein (hsCRP), an established biomarker of inflammation. Trial Design: In this double-blind placebo controlled study patients with at least 2 or more risk factors for ASCVD, no history or symptoms of ASCVD disease, and circulating levels of hsCRP > 3mg/L, were randomized 1:1 to receive a single infusion of 10 mg/kg MLN1202 (n 56) or placebo (n = 56). Subjects with hypercholesterolemia on stable doses of lipid-lowering agents were included. Circulating levels of hsCRP were determined every 2 weeks, and clinical examination performed every 4 weeks for 16 weeks following treatment. Results and Conclusion: Patients were recruited from nine centers in the US. The study population had a mean age of 60.9 years and included subjects with hypertension (59%), hypercholesterolemia (70%), significant smoking history (28%), and type 2 diabetes (16%). At screening the median value CRP was 6.8 mg/L with interquartile range from 4.7–9.3 mg/L. PK/PD results showed that the plasma level of MLN1202 required for > 90% receptor saturation was maintained for 6 to 8 weeks. A between-group difference in reduction of hsCRP was statistically significant from week 4 through week 8 following dosing. The maximum difference in absolute median reduction was observed at week 8 and it was 1.6 mg/L (p = 0.0275; Wilcoxon); the observed median percent reduction of hsCRP was 24.2% for MLN1202 group versus 2.5% increase for placebo group at 8 weeks (p = 0.0089; Wilcoxon). These data indicate that blockade of CCR2 reduces a biomarker related to inflammation in patients at risk for ASCVD.

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Relationship between Plasma C-Reactive Protein and Troponin T , Risk Factors and Relevant Medical Family History in Sudanese Acute Coronary Syndrome Patients

Aljouf University Medical Journal ◽

10.12816/0017366 ◽

2015 ◽

Vol 2 (2) ◽

pp. 13-16

Author(s):

Hassan Ahmed Abdulla Eltom ◽

Hajer Abdalla Mohamed ◽

Hyder Osman Mirghani ◽

Abdelsalam M. A. Nail

Keyword(s):

Risk Factors ◽

Acute Coronary Syndrome ◽

Family History ◽

Troponin T ◽

C Reactive Protein ◽

Reactive Protein ◽

Coronary Syndrome

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Can CRP Levels Predict Infection in Presumptive Aseptic Long Bone Non-Unions? A Prospective Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm10030425 ◽

2021 ◽

Vol 10 (3) ◽

pp. 425

Author(s):

Theodoros H. Tosounidis ◽

Colin Holton ◽

Vasileios P. Giannoudis ◽

Nikolaos K. Kanakaris ◽

Robert M. West ◽

...

Keyword(s):

Revision Surgery ◽

Blood Count ◽

Clinical Signs ◽

Long Bone ◽

White Blood Count ◽

Full Blood Count ◽

Low Grade ◽

Risk Of Infection ◽

C Reactive Protein ◽

Reactive Protein

Nonunion remains a major complication of the management of long bone fractures. The primary aim of the present study was to investigate whether raised levels of C-reactive protein (CRP) and white blood cell count (WBC), in the absence of clinical signs, are correlated with positive intraoperative tissue cultures in presumptive aseptic long-bone nonunions. Infection was classified as positive if any significant growth of microorganisms was observed from bone/tissue samples sent from the theater at the time of revision surgery. Preoperatively all patients were investigated with full blood count, white blood count differential as well as C-reactive protein (CRP). A total of 105 consecutive patients (59 males) were included in the study, with an average age of 46.76 years (range 16–92 years) at the time of nonunion diagnosis. The vast majority were femoral (56) and tibial (37) nonunions. The median time from the index surgical procedure to the time of nonunion diagnosis was 10 months (range 9 months to 10 years). Positive cultures revealed a mixed growth of microorganisms, with coagulase-negative Staphylococcus (56.4%) being the most prevalent microorganism, followed by Staphylococcusaureus (20.5%). Pseudomonas, Methicillin-Resistant Staphylococcus aureus (MRSA), coliforms and micrococcus were present in the remainder of the cases (23.1%). Overall, the risk of infection with normal CRP levels (<10 mg/L) was 21/80 = 0.26. Elevated CRP levels (≥10 mg/L) increased the risk of infection to 0.72. The relative risk given a positive CRP test was RR = 0.72/0.26 = 2.74. Overall, the WBC count was found to be an unreliable marker to predict infection. Solid union was achieved in all cases after an average of 6.5 months (3–24 months) from revision surgery. In patients with presumed aseptic long bone nonunion and normal CRP levels, the risk of underlying low-grade indolent infection can be as high as 26%. Patients should be made aware of this finding, which can complicate their treatment course and outcomes.

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