scholarly journals Formulasi Tablet Paracetamol dengan Bahan Pengikat Pati Umbi Gembili (Dioscorea esculenta L)

2019 ◽  
Vol 6 (2) ◽  
pp. 55
Author(s):  
Elya Zulfa ◽  
Malinda Prihantini
Keyword(s):  
Physical Properties ◽  
Descriptive Analysis ◽  
Physical Characteristics ◽  
Wet Granulation ◽  
Test Results ◽  
Binding Agent ◽  
Disintegration Time

ABSTRAK Pati umbi gembili (PUG) memiliki kandungan utama amilopektin sebesar 75,7%. Amilopektin bersifat lekat dan dapat membentuk gel bila disuspensikan dengan air, sehingga dapat dimanfaatkan sebagai bahan pengikat. Tujuan penelitian ini adalah mengetahui sifat fisik tablet paracetamol dengan penambahan PUG sebagai bahan pengikat.  Proses pembuatan pati dari umbi gembili dilakukan dengan cara basah. Tablet Parasetamol dibuat dengan metode granulasi basah dengan variasi kadar mucilago PUG FI 5%, FII 10%, FIII 15%. Tablet yang dibuat, diuji sifat fisik (keseragaman bobot, kekerasan, kerapuhan dan waktu hancur) dan dianalisis secara deskriptif. Hasil uji sifat fisik tablet menunjukkan bahwa seluruh formula yang dibuat memenuhi syarat yang ditetapkan dalam kompendial. Kata Kunci :  Parasetamol, pati umbi gembili, bahan pengikat, granulasi basah  ABSTRACT Gembili tuber (PUG) starch has a major component of amylopectin of 75.7%. Amylopectin is sticky and can form a gel when suspended with water, so that it can be used as a tablet binding agent in the form of PUG mucilago. The purpose of this study was to determine the physical characteristics in paracetamol tablets of adding PUG mucilago (Dioscorea esculenta) as a binder. The process of making starch from gembili tuber is done by wet. Paracetamol tablets are made by wet granulation method with variations in levels of FI PUG mucilago 5%, FII 10%, FIII15%. Tablets were made, tested for physical properties (weight uniformity, hardness, friability and disintegration time) with descriptive analysis. The test results of the physical properties of tablets indicate that all formulas made meet the requirements set out in the literature Keywords: Paracetamol, gembili tuber starch, binder, wet granulation

scholarly journals Extraction and Evaluation of Lepidium Sativum and Flax Seeds Mucilage as a Pharmaceutical Granulation Binder

2021 ◽  
Author(s):  
Nagla Algali Layas
Keyword(s):  
Physical Properties ◽  
Angle Of Repose ◽  
Lepidium Sativum ◽  
Wet Granulation ◽  
Binding Agent ◽  
Flax Seeds ◽  
Good Flow

The powders holdtogether by a binder to form granule. Some excipients of natural origins arecurrently available as an alternative over the synthetic ones in pharmaceuticalformulation. The aim of this study was to isolate the mucilage from differentplant seeds and compare them to evaluate the binding effects. In present studyan effort was made to investigate the efficacy of mucilage obtained from Lepidiumsativum and flax seeds as granules excipient. The mucilage   was extracted from selected seeds byconventional method by precipitation of soaked and blended seeds in acetone.The dried mucilages were subjected to several phytochemical and physicochemicalproperties. Granules were formulated by wet granulation method by usingextracted mucilage as a binding agent and comparison was made against thegranules prepared with standard binder as PVP. The granules evaluated byvarious physical properties such as (bulk and tapped densities, Hausner’sratio, Carr’s index, angle of repose and friability). The results showed thatthe granules prepared from extracted mucilage as a binder had good flow andmechanical properties, all evaluated parameters were within the permissiblelimits. Thus, mucilage could be used as an alternative binding agent in pharmaceuticalgranules.

scholarly journals Uji Mutu Fisik Metoklopramid HCl Tablet Chewable dengan Variasi Jenis Pengisi sebagai Diluent menggunakan Metode Granulasi Basah

2021 ◽  
Vol 1 (2) ◽  
pp. 76-85
Author(s):  
Umi Latifiana ◽  
Deny Budi Legowo ◽  
Erna Fitriany ◽  
Andri Priyoherianto ◽  
Muhammad Novianto Ainul Huri
Keyword(s):  
New Product ◽  
Wet Granulation ◽  
Test Results ◽  
Quality Test ◽  
Disintegration Time ◽  
Chewable Tablet ◽  
Physical Quality ◽  
Chewable Tablets ◽  
Tablet Hardness

Metoclopramide HCl are used to reduce vomiting and nausea. The availability on the market in the form of tablet, syrup and injection. Patient tend to prefer take drugs by oral use because it was easier. Chewable tablet is the new product as the alternative ways to treatment children and adult patient who had difficulity problem of swallowing drugs. Objectives: This research aims to formulate the chewable metoclopramide HCl tablets using diluent variations to get a better physical quality test. Chewable tablets of metoclopramide HCl are made using diluent variations, they are mannitol, sucrose, lactose. Formula I mannitol, formula II sucrose, and formula III lactose. Chewable tablet preparations are made by the wet granulation method. Data collection was performed on physical characteristics including organoleptic, weight uniformity, uniformity of size, tablet hardness, tablet fragility, disintegration time, metoclopramide HCl levels. Physical quality test results were statistically analyzed to determine the effect of variations in the diluent on the characteristics of chewable tablets. The results of this research have an influence on the physical quality and uniformity of contents of various types of diluent variations between each formulation. In this research, fillers have an important role in the preparation of chewable metoclopramide tablets to determine the physical quality of the tablets and the uniformity of their contents. The variation of diluent that gives better results is mannitol. This is because formulas that use mannitol have uniformity in content that meets the requirements, faster disintegration time, and physical quality of tablets that still meet the requirements, when compared to the first and second formulations. The variation of diluent that gives better results is mannitol.

scholarly journals Tablet Formula Optimization From Helminthostachys Zaylanica Extract Using A Simplex Lattice Design

2021 ◽  
Vol 6 (3) ◽  
pp. 131-136
Author(s):  
Fitrya Fitrya ◽  
Najma Annuria Fithri ◽  
Budi Untari ◽  
Aprililianti
Keyword(s):  
Physical Properties ◽  
Toxicity Tests ◽  
Dissolution Time ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Weight Variation ◽  
Simplex Lattice ◽  
Helminthostachys Zeylanica

Helminthostachys zeylanica extract has pharmacological activities such as antioxidant, antiinflamatory, and antihyerucemia. This extract is nontoxic substance from the acute and subchronic toxicity tests. This extract has a potency to be formulated into tablet dosage forms. This study aims to optimize a tablet formula from Helminthostachys zeylanica extract. Disintegrant and binder concentrations were independent variables, while physical properties and dissolution time of the tablets were dependent variables. The tablet was prepared by a wet granulation method. Formula was optimized by Simplex Lattice Design. Physicochemical propertiesof granule, physical properties and dissolution of tablet were then analyzed with One Way ANOVA (p = 0.05). Based on granule analysis, specification of physicochemical parameters, such as hausner’s ratio, compressibility index, flowability, repose angle, and water content, met standard British Pharmacopeia. In addition, the starch and PVA concentrations influenced thickness, weight variation, hardness, friability, disintegration time and dissolution of the tablets (p <0.05), except for friability (p> 0.05). Based on this study, the starch and PVA concentrations for the optimum tablet formula were 19.5% and 1.05%, respectively.

scholarly journals OPTIMASI KONSENTRASI POLIVINIL PIROLIDON (PVP) SEBAGAI BAHAN PENGIKAT TEHADAP SIFAT FISIK TABLET EKSTRAK ETANOL RIMPANG BANGLE (Zingiber cassumunar Roxb)

2018 ◽  
pp. 45
Author(s):  
Ida ayu Sintha Devi
Keyword(s):  
Physical Properties ◽  
Bitter Taste ◽  
Ethanol Extract ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Organoleptic Test ◽  
Size Uniformity ◽  
The Right ◽  
Test Requirements ◽  
Zingiber Cassumunar

Zingiber cassumunar Roxb contains active compounds such as cassumumin AC, cassummarin AC, phenylbutanoid, and (E) -4- (3,4-dimethoxyphenyl) but-3-en-1-ol which has activities as anti-inflammatory, antioxidant and anti-allergenic agents so that they are potentially used as anti-allergies. Zingiber cassumunar Roxb is made into tablet because it has several advantages, which are easy to consume, practical, the right amount, cover the bitter taste and the distinctive smell and its stability is maintained in storage. This study aims to produce Zingiber cassumunar Roxb tablets that have good physical properties by using PVP as a binder. Zingiber cassumunar Roxb extract was made by maceration using 70% ethanol solvent, the tablet was formulated using wet granulation method. Zingiber cassumunar Roxb ethanol extract tablet was formulated in 3 formulas with variations in the PVP FI content of 1%, FII 2.75%, and FIII 4.5%. The resulting granules were tested for physical properties including moisture test, particle size distribution, flow time, stationary angle, bulk density, and compressibility, while the tablets produced were tested for physical properties including organoleptic test, uniformity of size, uniformity of weight, friability, and disintegration time. The results showed that the optimum concentration obtained was at FIII with 4.5% PVP concentration that complied the organoleptic test requirements, uniformity of size, weight uniformity, and fragility of tablets.

scholarly journals Disintegrant Properties of Microcrystalline Cellulose isolated from Rami (Boehmeria nivea L. Gaud) in Dimenhydrinate tablets by Wet Granulation and Direct compression

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Nagina Gulab Belali ◽  
Anis Y. Chaerunisaa ◽  
Taofik Rusdiana
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Physical Properties ◽  
Process Parameters ◽  
Microcrystalline Cellulose ◽  
Wet Granulation ◽  
Direct Compression ◽  
Disintegration Time ◽  
Boehmeria Nivea ◽  
Significant Difference

Microcrystalline cellulose was isolated from rami (Boehmeria Nivea L. Gaud), and applied as disintegrant in tablets of dimenhydrinate, made by direct compression and wet granulation. The aim of this study is to produce dimenhydrinate tablets with Microcrystalline Cellulose Rami (MCC Rami) isolated from Rami (Boehmeria Nivea L. Gaud), as a disintegrant and assess the effect of MCC Rami and Granulation technique on physical properties of drug such as, disintegration time, drug release and dissolution. Formulations of dimenhydrinate 100mg tablets were prepared with a combination of mannitol and lactose as a filler and MCC Rami as disintegrant in a concentration of 10-20%. The formulas were directly compressed or were compressed into tablets after wet granulation. The mechanical properties, drug release, physical properties and effects of process parameters, methods of applying disintegrant in tablet formulas were examined. A significant difference in disintegration time of tablets that were produced by direct compression and wet granulation was seen, that can be attributed to the porous structure of granules that enhanced fast disintegration, which had eventually improved dissolution and drug release. F1 and F2 with MCC Rami and physical mixture of MCC Rami with crosspovidone as a disintegrant that were directly compressed disintegrated in 79 and 72 seconds respectively thats not a significant difference, however when MCC was applied in an intragranular way its disintegration time is 67 seconds. The results showed that the method of disintegrant application and press of tableting has a significant effect on drug release and dissolution.Keywords : Microcrystalline Cellulose, wet granulation, disintegrant, Boehmeria Nivea L. Gaud.

FORMULASI TABLET EKSTRAK ANGKAK (RED YEAST RICE) DENGAN VARIASI CROSCARMELLOSE SODIUM SEBAGAI PENGHANCUR DAN LAKTOSA SEBAGAI PENGISI

2017 ◽  
Vol 3 (1) ◽  
pp. 83
Author(s):  
Adestria Resti ◽  
Aris Perdana Kusuma ◽  
Achmad Fudholi
Keyword(s):  
Physical Properties ◽  
The Body ◽  
Wet Granulation ◽  
Red Yeast Rice ◽  
Disintegration Time ◽  
Lattice Design ◽  
Red Yeast ◽  
Croscarmellose Sodium ◽  
Simplex Lattice ◽  
Optimum Formula

Angkak or better known as Red yeast rice is fermentation rice using a mold Monascus purpureus. Some studies of red yeast rice can lower cholesterol levels in the body because it contains monoakolin K or similliar with lovastatin compound. Generally in community consumption of red yeast rice only with pour in the boilling water so it can causing inconvenience for its customers. This study aims to make a formulation tablet of red yeast rice extract which varied with the levels of croscarmellose sodium 5% -1% (32mg, 26mg, 19,5mg, 13mg, 6,5mg) and lactose (75,75mg, 82.25 mg, 88,75mg , 95,25mg, 101,75mg) in order to get a best physical properties of the tablet including friability and disintegration time. Angkak extract was made by remaseration method using ethanol 75% and the manufacture of tablets using wet granulation method. Stastical test tablet extract angkak using One Way ANOVA with 95% confidence level. Optimum formula obtained by using the Simplex Lattice Design (SLD) using Design Expert version 8.0.7.1 program and statistically tested using one-sample t-test. The results from test showed the proportion of croscarmellose sodium 6.5mg and 101.75mg lactose produces tablets with the best of physical properties of red yeast rice extract.The result is indicate that the combination of croscarmellose sodium and lactose may affect response the physical properties of red yeast rice extract tablets.

scholarly journals Physical Properties of the Probiotic Effervescent Tablet from Tapioca and Maltodextrin Coatings

2020 ◽  
Vol 147 ◽  
pp. 03024
Author(s):  
Devi Ambarwaty Oktavia ◽  
Diah Lestari Ayudiarti ◽  
Dita Febrianti
Keyword(s):  
Physical Properties ◽  
Shrimp Farming ◽  
Wet Granulation ◽  
Drying Process ◽  
Disintegration Time ◽  
Brevibacillus Laterosporus ◽  
South Sulawesi ◽  
Coastal Aquaculture ◽  
Effervescent Tablet

The purpose of this study was to determine the physical properties of probiotic effervescent tablets with two different coatings that are tapioca and maltodextrin to improve water quality in shrimp farming ponds. This study used probiotics to improve the environmental quality of shrimp pond waters. Liquid probiotics from Research Institute for Coastal Aquaculture in Maros, South Sulawesi that contain Brevibacillus laterosporus. Probiotics that have been used are liquid and difficult to transport, therefore microencapsulation is carried out on liquid probiotics aimed at facilitating their distribution. The use of microencapsulating materials is to entrap or immobilize probiotic bacteria within microcapsule and to protect the bacteria during the drying process. Effervescent tablets were prepared in a dosage of 800 mg by wet granulation methods. This experiment was replicated 3 times. Tablets were evaluated for their physical properties there are mean weight, friability, hardness, disintegration time and pH. The results showed that mean weight for effervescent tablets with maltodextrin coatings was 796 mg, had a friability value 0.09%, a hardness value of 13.7 N and disintegration time of 10.68 minutes. Both probiotic effervescent tablets meet the standards pH of 7.07 and 6.67. The maltodextrin coatings was the best treatment of this study.

scholarly journals Studies on Fruit Pectin in the Development of Tablet Formulations of Ibuprofen

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Nausheen Tariq Siddiqui ◽  
Ramla Binte Baber ◽  
Rsfi Akhtar Sultan ◽  
Iqbal Azhar ◽  
Waseemuddin Ahmed ◽  
...  
Keyword(s):  
Pharmaceutical Formulations ◽  
Gelling Agent ◽  
Wet Granulation ◽  
Binding Agent ◽  
Disintegration Time ◽  
Compression Properties ◽  
Naturally Occurring ◽  
Manufacture Process ◽  
Tablet Formulations ◽  
Tablet Manufacture

Background: Pectin, a naturally occurring polysaccharide is more than a food additive and has got amazing properties as a gelling agent and as a binder. Objective: The current research entails the extraction and identification of pectin from peels of selected fruits mango (Magnifera indica) and banana (Musa paradisiaca) by direct heating and using alcohol as precipitating agent. The potential of pectin as a binding agent in tablet formulation was evaluated by screening its micromeritics and post compression properties. Method: quadruple formulations of ibuprofen with crude peel pectin extracted from mango and banana in concentration of 50, 75, 100 and 125 mg respectively were employed in the tablet manufacture process by wet granulation method. Results: Successful formulation of tablet was done with the extracted pectin from the two fruit peels. The micromeritics properties showed good binding and flowing properties. An increase in concentration of pectin increased the hardness and also the dissolution of tablets up to a certain extent. The disintegration time was suitable for all formulations. Conclusion: It was concluded that pectin extracted from mango and banana peels can be used as a super disintegrating agent in pharmaceutical formulations, where needed.

scholarly journals FORMULATION OF TABLET FROM PAPAYA AND BAY LEAF EXTRACT WITH VARIATION OF CONCENTRATION POLYVINYLPYRROLIDONE AS A BINDER

2017 ◽  
Vol 10 (17) ◽  
pp. 169
Author(s):  
Erni Rustiani ◽  
Mira Miranti ◽  
Nurul Karima Rahmahuda
Keyword(s):  
Physical Properties ◽  
Bitter Taste ◽  
Total Flavonoid ◽  
Wet Granulation ◽  
Flavonoid Content ◽  
Leaf Extracts ◽  
Pharmacological Activities ◽  
Disintegration Time ◽  
Weight Variation ◽  
Specific Odor

 Objectives: Extensive studies on the pharmacological activities of papaya and bay leaf exhibit that these plants effectively alleviate degenerative diseases including diabetes. However, herbal drugs from papaya and bay leaf have never been made. The aim of this research was to formulate a tablet from the combination of papaya extract and bay leaf with different concentrations (1%, 2%, and 3%) of polyvinylpyrrolidone (PVP) K30 as a binder using the wet granulation method.Methods: Evaluation of the tablet’s physical properties (i.e., weight variation, friability, hardness, disintegration time, and physical appearance) was done using standard methods while total flavonoid in the extracts was determined by the spectrophotometry method.Results: The tablet was light brown and had both flat top and bottom, a specific odor and a bitter taste. The physical properties of the tablet were in accordance with pharmaceutical standards. The total flavonoid content in the papaya and bay leaves extract was 1.562% and 2.240%, respectively.Conclusions: It can be concluded that PVP K-30 concentration can be used as a binder to formulate dry papaya and bay leaf extracts into high-quality and ready-to-consume tablets.

Formulation and Evaluation of Fast Disintigrating Meloxicam Tablets and Its Comparison with Marketed Product

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Suresh Kulkarni ◽  
Ranjit P. ◽  
Nikunj Patel ◽  
Someshwara B. ◽  
Ramesh B. ◽  
...  
Keyword(s):  
Water Absorption ◽  
In Vitro Dissolution ◽  
Thickness Variation ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Absorption Ratio ◽  
Wetting Time ◽  
Fast Disintegrating Tablets ◽  
Cox 1

The present investigation deals with the formulation of fast disintegrating tablets of Meloxicam that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Meloxicam is a newer selective COX-1 inhibitor. The tablets were prepared by wet granulation procedure. The influence of superdisintegrants, crosspovidone, croscaremellose sodium on disintegration time, wetting time and water absorption ratio were studied. Tablets were evaluated for weight and thickness variation, disintegration time, drug content, in vitro dissolution, wetting time and water absorption ratio. The in vitro disintegration time of the best fast disintegrating tablets was found to be 18 sec. Tablets containing crospovidone exhibit quick disintegration time than tablets containing croscaremellose sodium. The fast disintegrating tablets of Meloxicam with shorter disintegration time, acceptable taste and sufficient hardness could be prepared using crospovidone and other excipients at optimum concentration.

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