scholarly journals Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair

2021 ◽  
Author(s):  
Gilyana Kazakova ◽  
Tatiana Safronova ◽  
Daniil Golubchikov ◽  
Olga Shevtsova ◽  
Julietta Rau
Keyword(s):  
Bone Regeneration ◽  
Bone Tissue ◽  
Tissue Repair ◽  
Early Stage ◽  
Biological Properties ◽  
Magnesium Ions ◽  
Comprehensive Overview ◽  
Phosphate Ions ◽  
Great Relevance

Materials based on Mg2+-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate ions, play a significant role in the process of bone remodeling, affecting the early stage of bone regeneration through active participation in the process of osteosynthesis. Here we pro-vide a comprehensive overview of the usage of biomaterials based on magnesium phosphate and magnesium calcium phosphate in bone reconstruction. The role of magnesium ions in angiogene-sis, an important process associated with osteogenesis, is considered. Finally, the biological properties of magnesium phosphates for bone regeneration are summarized. They show promis-ing results in terms of use as bone replacement material.

scholarly journals Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair

Materials ◽  
2021 ◽  
Vol 14 (17) ◽  
pp. 4857
Author(s):  
Gilyana Kazakova ◽  
Tatiana Safronova ◽  
Daniil Golubchikov ◽  
Olga Shevtsova ◽  
Julietta V. Rau
Keyword(s):  
Bone Tissue ◽  
Tissue Repair ◽  
Early Stage ◽  
Biological Properties ◽  
Magnesium Ions ◽  
Comprehensive Overview ◽  
Phosphate Ions ◽  
Calcium Magnesium ◽  
Great Relevance

Materials based on Mg2+-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate ions, play substantial roles in the process of bone remodeling, affecting the early stage of bone regeneration through active participation in the process of osteosynthesis. In this paper we provide a comprehensive overview of the usage of biomaterials based on magnesium phosphate and magnesium calcium phosphate in bone reconstruction. We consider the role of magnesium ions in angiogenesis, which is an important process associated with osteogenesis. Finally, we summarize the biological properties of calcium magnesium phosphates for regeneration of bone.

The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway

2019 ◽  
Vol 98 ◽  
pp. 246-255 ◽  
Author(s):  
Chu-Chih Hung ◽  
Amy Chaya ◽  
Kai Liu ◽  
Konstantinos Verdelis ◽  
Charles Sfeir
Keyword(s):  
Wnt Signaling ◽  
Bone Regeneration ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Magnesium Ions ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

The Significance of Blockchain Technology in Digital Transformation of Logistics and Transportation

2020 ◽  
Vol 12 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Zvonko Merkaš ◽  
Davor Perkov ◽  
Vesna Bonin
Keyword(s):  
Early Stage ◽  
Digital Transformation ◽  
Theory Building ◽  
Comprehensive Overview ◽  
Blockchain Technology ◽  
Stage Of Development ◽  
Multiple Case ◽  
Multiple Case Studies ◽  
Business Process Optimization

The purpose of this article is to identify blockchain's role in achieving logistic objectives, with the aim of pointing out the significance of blockchain technology in the digital transformation of logistics and transportation. Implementation of the blockchain technology in combination with IoT elements in logistics and transportation contributes to business process optimization, supply chain traceability and transparency, and significant financial savings. There are limitations as blockchain is at a relatively early stage of development with most projects. Therefore, the approach of theory building from multiple case studies was used. The article provides a comprehensive overview of current blockchain initiatives and use-cases. This article is believed to be the first to address the role of blockchain technology in achieving logistics objectives. Results from this research indicate that blockchain technology contributes to the achievement of logistics objectives.

scholarly journals CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

Blood ◽  
2012 ◽  
Vol 120 (3) ◽  
pp. 613-625 ◽  
Author(s):  
Sebastian Willenborg ◽  
Tina Lucas ◽  
Geert van Loo ◽  
Johanna A. Knipper ◽  
Thomas Krieg ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Early Stage ◽  
Myeloid Cell ◽  
Tissue Growth ◽  
Mouse Mutants ◽  
Skin Repair ◽  
Complementary Role ◽  
Egfp Reporter ◽  
Functional Consequences

Abstract Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the mechanisms that govern macrophage regenerative activities during the sequential phases of repair are largely unknown. In the present study, we examined the dynamics and functions of diverse monocyte/macrophage phenotypes during the sequential stages of skin repair. By combining the analysis of a new CCR2-eGFP reporter mouse model with conditional mouse mutants defective in myeloid cell–restricted CCR2 signaling or VEGF-A synthesis, we show herein that among the large number of inflammatory CCR2+Ly6C+ macrophages that dominate the early stage of repair, only a small fraction strongly expresses VEGF-A that has nonredundant functions for the induction of vascular sprouts. The switch of macrophage-derived VEGF-A during the early stage of tissue growth toward epidermal-derived VEGF-A during the late stage of tissue maturation was critical to achieving physiologic tissue vascularization and healing progression. The results of the present study provide new mechanistic insights into CCR2-mediated recruitment of blood monocyte subsets into damaged tissue, the dynamics and functional consequences of macrophage plasticity during the sequential repair phases, and the complementary role of macrophage-derived VEGF-A in coordinating effective tissue growth and vascularization in the context of tissue-resident wound cells. Our findings may be relevant for novel monocyte-based therapies to promote tissue vascularization.

scholarly journals Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xin Huang ◽  
Donghua Huang ◽  
Ting Zhu ◽  
Xiaohua Yu ◽  
Kaicheng Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Metal Ions ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Bone Tissue ◽  
Cell Fate ◽  
Metal Ion ◽  
Healing Process

AbstractMetal ions have been identified as important bone metabolism regulators and widely used in the field of bone tissue engineering, however their exact role during bone regeneration remains unclear. Herein, the aim of study was to comprehensively explore the interactions between osteoinductive and osteo-immunomodulatory properties of these metal ions. In particular, the osteoinductive role of zinc ions (Zn2+), as well as its interactions with local immune microenvironment during bone healing process, was investigated in this study using a sustained Zn2+ delivery system incorporating Zn2+ into β-tricalcium phosphate/poly(L-lactic acid) (TCP/PLLA) scaffolds. The presence of Zn2+ largely enhanced osteogenic differentiation of periosteum-derived progenitor cells (PDPCs), which was coincident with increased transition from M1 to M2 macrophages (M$$\varphi $$ φ s). We further confirmed that induction of M2 polarization by Zn2+ was realized via PI3K/Akt/mTOR pathway, whereas marker molecules on this pathway were strictly regulated by the addition of Zn2+. Synergically, this favorable immunomodulatory effect of Zn2+ further improved the osteogenic differentiation of PDPCs induced by Zn2+ in vitro. Consistently, the spontaneous osteogenesis and pro-healing osteoimmunomodulation of the scaffolds were thoroughly identified in vivo using a rat air pouch model and a calvarial critical-size defect model. Taken together, Zn2+-releasing bioactive ceramics could be ideal scaffolds in bone tissue engineering due to their reciprocal interactions between osteoinductive and immunomodulatory characteristics. Clarification of this synergic role of Zn2+ during osteogenesis could pave the way to develop more sophisticated metal-ion based orthopedic therapeutic strategies.

scholarly journals Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Shih-Chang Chien ◽  
Yueh-Chen Wu ◽  
Zeng-Weng Chen ◽  
Wen-Chin Yang
Keyword(s):  
Therapeutic Potential ◽  
Autoimmune Diabetes ◽  
Early Stage ◽  
Large Body ◽  
Autoimmune Disorder ◽  
Biological Properties ◽  
Naturally Occurring ◽  
New Strategy ◽  
Made In

Anthraquinones are a class of aromatic compounds with a 9,10-dioxoanthracene core. So far, 79 naturally occurring anthraquinones have been identified which include emodin, physcion, cascarin, catenarin, and rhein. A large body of literature has demonstrated that the naturally occurring anthraquinones possess a broad spectrum of bioactivities, such as cathartic, anticancer, anti-inflammatory, antimicrobial, diuretic, vasorelaxing, and phytoestrogen activities, suggesting their possible clinical application in many diseases. Despite the advances that have been made in understanding the chemistry and biology of the anthraquinones in recent years, research into their mechanisms of action and therapeutic potential in autoimmune disorders is still at an early stage. In this paper, we briefly introduce the etiology of autoimmune diabetes, an autoimmune disorder that affects as many as 10 million worldwide, and the role of chemotaxis in autoimmune diabetes. We then outline the chemical structure and biological properties of the naturally occurring anthraquinones and their derivatives with an emphasis on recent findings about their immune regulation. We discuss the structure and activity relationship, mode of action, and therapeutic potential of the anthraquinones in autoimmune diabetes, including a new strategy for the use of the anthraquinones in autoimmune diabetes.

Mimicking the electrophysiological microenvironment of bone tissue using electroactive materials to promote its regeneration

2020 ◽  
Vol 8 (45) ◽  
pp. 10221-10256
Author(s):  
Tianyi Zheng ◽  
Yiqian Huang ◽  
Xuehui Zhang ◽  
Qing Cai ◽  
Xuliang Deng ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Tissue ◽  
Biological Properties ◽  
Electroactive Materials ◽  
Comprehensive Account ◽  
Physicochemical And Biological Properties

A timely and comprehensive account of electroactive biomaterials promoting bone regeneration is provided by reviewing their physicochemical and biological properties.

scholarly journals The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions

2022 ◽  
Vol 23 (2) ◽  
pp. 761
Author(s):  
Magdalena Sustkova-Fiserova ◽  
Chrysostomos Charalambous ◽  
Anna Khryakova ◽  
Alina Certilina ◽  
Marek Lapka ◽  
...  
Keyword(s):  
Drug Addiction ◽  
Addiction Treatment ◽  
Early Stage ◽  
Human Society ◽  
Growth Hormone Secretagogue Receptor ◽  
Comprehensive Overview ◽  
Growth Hormone Secretagogue ◽  
Addictive Drugs ◽  
Abused Drugs

Drug addiction causes constant serious health, social, and economic burden within the human society. The current drug dependence pharmacotherapies, particularly relapse prevention, remain limited, unsatisfactory, unreliable for opioids and tobacco, and even symptomatic for stimulants and cannabinoids, thus, new more effective treatment strategies are researched. The antagonism of the growth hormone secretagogue receptor type A (GHS-R1A) has been recently proposed as a novel alcohol addiction treatment strategy, and it has been intensively studied in experimental models of other addictive drugs, such as nicotine, stimulants, opioids and cannabinoids. The role of ghrelin signaling in these drugs effects has also been investigated. The present review aims to provide a comprehensive overview of preclinical and clinical studies focused on ghrelin’s/GHS-R1A possible involvement in these nonalcohol addictive drugs reinforcing effects and addiction. Although the investigation is still in its early stage, majority of the existing reviewed experimental results from rodents with the addition of few human studies, that searched correlations between the genetic variations of the ghrelin signaling or the ghrelin blood content with the addictive drugs effects, have indicated the importance of the ghrelin’s/GHS-R1As involvement in the nonalcohol abused drugs pro-addictive effects. Further research is necessary to elucidate the exact involved mechanisms and to verify the future potential utilization and safety of the GHS-R1A antagonism use for these drug addiction therapies, particularly for reducing the risk of relapse.

scholarly journals The role of synthetic biomaterials in resorptive alveolar bone regeneration

2007 ◽  
Vol 61 (2) ◽  
pp. 96-100
Author(s):  
Biljana Kalicanin ◽  
Zorica Ajdukovic ◽  
Milena Kostic ◽  
Stevo Najman ◽  
Vojin Savic ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Significant Role ◽  
Alveolar Bone ◽  
Phosphate Content ◽  
Synthetic Material ◽  
Nano Composite ◽  
Mandibular Bone

The alveolar bone tissue resorption defect has a significant role in dentistry. Because of the bone tissue deficit developed by alveolar resorption, the use of synthetic material CP/PLGA (calcium-phosphate/polylactide-co-gliycolide) composite was introduced. Investigations were performed on rats with artificially produced resorption of the mandibular bone. The results show that the best effect on alveolar bone were attained by using nano-composite implants. The effect of the nanocomposite was ascertained by determining the calcium and phosphate content, as a basis of the hydroxyapatite structure. The results show that synthetic CP/PLGA nanocomposite alleviate the rehabilitation of weakened alveolar bone. Due to its osteoconductive effect, CP/PLGA can be the material of choice for bone substitution in the future.

scholarly journals Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

2021 ◽  
Vol 9 ◽  
Author(s):  
Junyao Cheng ◽  
Jianheng Liu ◽  
Bing Wu ◽  
Zhongyang Liu ◽  
Ming Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Grafts ◽  
Biological Properties ◽  
In Vivo Evaluation

Bone regeneration or replacement has been proved to be one of the most effective methods available for the treatment of bone defects caused by different musculoskeletal disorders. However, the great contradiction between the large demand for clinical therapies and the insufficiency and deficiency of natural bone grafts has led to an urgent need for the development of synthetic bone graft substitutes. Bone tissue engineering has shown great potential in the construction of desired bone grafts, despite the many challenges that remain to be faced before safe and reliable clinical applications can be achieved. Graphene, with outstanding physical, chemical and biological properties, is considered a highly promising material for ideal bone regeneration and has attracted broad attention. In this review, we provide an introduction to the properties of graphene and its derivatives. In addition, based on the analysis of bone regeneration processes, interesting findings of graphene-based materials in bone regenerative medicine are analyzed, with special emphasis on their applications as scaffolds, membranes, and coatings in bone tissue engineering. Finally, the advantages, challenges, and future prospects of their application in bone regenerative medicine are discussed.

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