scholarly journals Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Shih-Chang Chien ◽  
Yueh-Chen Wu ◽  
Zeng-Weng Chen ◽  
Wen-Chin Yang
Keyword(s):  
Therapeutic Potential ◽  
Autoimmune Diabetes ◽  
Early Stage ◽  
Large Body ◽  
Autoimmune Disorder ◽  
Biological Properties ◽  
Naturally Occurring ◽  
New Strategy ◽  
Made In

Anthraquinones are a class of aromatic compounds with a 9,10-dioxoanthracene core. So far, 79 naturally occurring anthraquinones have been identified which include emodin, physcion, cascarin, catenarin, and rhein. A large body of literature has demonstrated that the naturally occurring anthraquinones possess a broad spectrum of bioactivities, such as cathartic, anticancer, anti-inflammatory, antimicrobial, diuretic, vasorelaxing, and phytoestrogen activities, suggesting their possible clinical application in many diseases. Despite the advances that have been made in understanding the chemistry and biology of the anthraquinones in recent years, research into their mechanisms of action and therapeutic potential in autoimmune disorders is still at an early stage. In this paper, we briefly introduce the etiology of autoimmune diabetes, an autoimmune disorder that affects as many as 10 million worldwide, and the role of chemotaxis in autoimmune diabetes. We then outline the chemical structure and biological properties of the naturally occurring anthraquinones and their derivatives with an emphasis on recent findings about their immune regulation. We discuss the structure and activity relationship, mode of action, and therapeutic potential of the anthraquinones in autoimmune diabetes, including a new strategy for the use of the anthraquinones in autoimmune diabetes.

scholarly journals CD200:CD200R Interactions and Their Importance in Immunoregulation

2021 ◽  
Vol 22 (4) ◽  
pp. 1602
Author(s):  
Katarzyna Kotwica-Mojzych ◽  
Barbara Jodłowska-Jędrych ◽  
Mariusz Mojzych
Keyword(s):  
Transplant Rejection ◽  
Large Body ◽  
Structural Constraints ◽  
Relative Importance ◽  
The Past ◽  
Naturally Occurring ◽  
Biochemical Level ◽  
Important Marker ◽  
Made In

The molecule CD200, described many years ago as a naturally occurring immunomodulatory agent, capable of regulating inflammation and transplant rejection, has attracted additional interest over the past years with the realization that it may also serve as an important marker for progressive malignancy. A large body of evidence also supports the hypothesis that this molecule can contribute to immunoregulation of, among other diseases, infection, autoimmune disease and allergy. New data have also come to light to characterize the receptors for CD200 (CD200R) and their potential mechanism(s) of action at the biochemical level, as well as the description of a novel natural antagonist of CD200, lacking the NH2-terminal region of the full-length molecule. Significant controversies exist concerning the relative importance of CD200 as a ligand for all reported CD200Rs. Nevertheless, some progress has been made in the identification of the structural constraints determining the interaction between CD200 and CD200R, and this information has in turn proved of use in developing novel small molecule agonists/antagonists of the interaction. The review below highlights many of these newer findings, and attempts to place them in the broad context of our understanding of the role of CD200-CD200R interactions in a variety of human diseases.

scholarly journals Protective Role of Naturally Occurring Interleukin-17A-Producing γδ T Cells in the Lung at the Early Stage of Systemic Candidiasis in Mice

2011 ◽  
Vol 79 (11) ◽  
pp. 4503-4510 ◽  
Author(s):  
Takashi Dejima ◽  
Kensuke Shibata ◽  
Hisakata Yamada ◽  
Hiromitsu Hara ◽  
Yoichiro Iwakura ◽  
...  
Keyword(s):  
T Cells ◽  
Early Stage ◽  
Γδ T Cells ◽  
Protective Role ◽  
Dependent Manner ◽  
Peripheral Tissues ◽  
Content Type ◽  
Naturally Occurring ◽  
Interleukin 17A

ABSTRACTInterleukin-17A (IL-17A)-producing γδ T cells differentiate in the fetal thymus and reside in the peripheral tissues, such as the lungs of naïve adult mice. We show here that naturally occurring γδ T cells play a protective role in the lung at a very early stage after systemic infection withCandida albicans.Selective depletion of neutrophils byin vivoadministration of anti-Ly6G monoclonal antibody (MAb) impaired fungal clearance more prominently in the lung than in the kidney 24 h after intravenous infection withC. albicans.Rapid and transient production of IL-23 was detected in the lung at 12 h, preceding IL-17A production and the influx of neutrophils, which reached a peak at 24 h after infection. IL-17A knockout (KO) mice showed reduced infiltration of neutrophils concurrently with impaired fungal clearance in the lung after infection. The major source of IL-17A was the γδ T cell population in the lung, and Cδ KO mice showed little IL-17A production and reduced neutrophil infiltration after infection. Early IL-23 production in a TLR2/MyD88-dependent manner and IL-23-triggered tyrosine kinase 2 (Tyk2) signaling were essential for IL-17A production by γδ T cells. Thus, our study demonstrated a novel role of naturally occurring IL-17A-producing γδ T cells in the first line of host defense againstC. albicansinfection.

scholarly journals Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair

2021 ◽  
Author(s):  
Gilyana Kazakova ◽  
Tatiana Safronova ◽  
Daniil Golubchikov ◽  
Olga Shevtsova ◽  
Julietta Rau
Keyword(s):  
Bone Regeneration ◽  
Bone Tissue ◽  
Tissue Repair ◽  
Early Stage ◽  
Biological Properties ◽  
Magnesium Ions ◽  
Comprehensive Overview ◽  
Phosphate Ions ◽  
Great Relevance

Materials based on Mg2+-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate ions, play a significant role in the process of bone remodeling, affecting the early stage of bone regeneration through active participation in the process of osteosynthesis. Here we pro-vide a comprehensive overview of the usage of biomaterials based on magnesium phosphate and magnesium calcium phosphate in bone reconstruction. The role of magnesium ions in angiogene-sis, an important process associated with osteogenesis, is considered. Finally, the biological properties of magnesium phosphates for bone regeneration are summarized. They show promis-ing results in terms of use as bone replacement material.

scholarly journals Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair

Materials ◽  
2021 ◽  
Vol 14 (17) ◽  
pp. 4857
Author(s):  
Gilyana Kazakova ◽  
Tatiana Safronova ◽  
Daniil Golubchikov ◽  
Olga Shevtsova ◽  
Julietta V. Rau
Keyword(s):  
Bone Tissue ◽  
Tissue Repair ◽  
Early Stage ◽  
Biological Properties ◽  
Magnesium Ions ◽  
Comprehensive Overview ◽  
Phosphate Ions ◽  
Calcium Magnesium ◽  
Great Relevance

Materials based on Mg2+-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate ions, play substantial roles in the process of bone remodeling, affecting the early stage of bone regeneration through active participation in the process of osteosynthesis. In this paper we provide a comprehensive overview of the usage of biomaterials based on magnesium phosphate and magnesium calcium phosphate in bone reconstruction. We consider the role of magnesium ions in angiogenesis, which is an important process associated with osteogenesis. Finally, we summarize the biological properties of calcium magnesium phosphates for regeneration of bone.

scholarly journals The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Paz Nombela ◽  
Borja Miguel-López ◽  
Sandra Blanco
Keyword(s):  
Gene Expression ◽  
Rna Processing ◽  
Therapeutic Potential ◽  
Biological Processes ◽  
Rna Modifications ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
And Function ◽  
Made In

AbstractRNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA processing and function, which in turn thoroughly shape distinct gene expression programmes. They affect diverse biological processes, and the correct deposition of many of these modifications is required for normal development. Alterations of their deposition are implicated in several diseases, including cancer. In this Review, we focus on the occurrence of N6-methyladenosine (m6A), 5-methylcytosine (m5C) and pseudouridine (Ψ) in coding and non-coding RNAs and describe their physiopathological role in cancer. We will highlight the latest insights into the mechanisms of how these posttranscriptional modifications influence tumour development, maintenance, and progression. Finally, we will summarize the latest advances on the development of small molecule inhibitors that target specific writers or erasers to rewind the epitranscriptome of a cancer cell and their therapeutic potential.

scholarly journals Mutagenic strategies against luxS gene affect the early stage of biofilm formation of Campylobacter jejuni

2021 ◽  
Author(s):  
Martin Tereň ◽  
Ekaterina Shagieva ◽  
Lucie Vondrakova ◽  
Jitka Viktorova ◽  
Viviana Svarcova ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Biofilm Formation ◽  
Early Stage ◽  
Wild Type ◽  
Genetic Determinants ◽  
Autoinducer 2 ◽  
Naturally Occurring ◽  
Mutant Strains ◽  
The Impact

Abstract Currently, it is clear that the luxS gene has an impact on the process of biofilm formation in Campylobacter jejuni. However, even within the species naturally occurring strains of Campylobacter lacking the luxS gene exist, which can form biofilms. In order to better understand the genetic determinants and the role of quorum sensing through the LuxS/AI-2 pathway in biofilm formation, a set of mutant/complemented strains of C. jejuni 81–176 were prepared. Additionally, the impact of the mutagenic strategy used against the luxS gene was investigated. Biofilm formation was affected by both the presence and absence of the luxS gene, and by the mutagenic strategy used. Analysis by CLSM showed that all mutant strains formed significantly less biofilm mass when compared to the wild-type. Interestingly, the deletion mutant (∆luxS) showed a larger decrease in biofilm mass than the substitution (∙luxS) and insertional inactivated (⸬luxS) mutants, even though all the mutant strains lost the ability to produce autoinducer-2 molecules. Moreover, the biofilm of the ∆luxS mutant lacked the characteristic microcolonies observed in all other strains. The complementation of all mutant strains resulted in restored ability to produce AI-2, to form a complex biofilm, and to develop microcolonies at the level of the wild-type.

scholarly journals Therapeutic Potential of Multifunctional Tacrine Analogues

2019 ◽  
Vol 17 (5) ◽  
pp. 472-490 ◽  
Author(s):  
Maja Przybyłowska ◽  
Szymon Kowalski ◽  
Krystyna Dzierzbicka ◽  
Iwona Inkielewicz-Stepniak
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Liver Toxicity ◽  
Potent Inhibitor ◽  
Therapeutic Potential ◽  
Treatment Strategies ◽  
Biological Properties ◽  
New Paradigm ◽  
Experimental Systems

Tacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in the therapy of Alzheimer’s disease. The interest in these compounds is mainly related to a high variety of their structure and biological properties. In the present review, we have described the role of cholinergic transmission and treatment strategies in Alzheimer’s disease as well as the synthesis and biological activity of several recently developed classes of multifunctional tacrine analogues and hybrids, which consist of a new paradigm to treat Alzheimer’s disease. We have also reported potential of these analogues in the treatment of Alzheimer’s diseases in various experimental systems.

Rola tłuszczu w żywieniu człowieka

2019 ◽  
Vol 22 (4) ◽  
Author(s):  
Magdalena Rudzińska ◽  
Roman Przybylski
Keyword(s):  
Unsaturated Fatty Acids ◽  
Large Body ◽  
Calorific Value ◽  
Fats And Oils ◽  
Biological Properties ◽  
The Body ◽  
Dietary Fats ◽  
Human Diet ◽  
Wide Range

Along with proteins and carbohydrates, fat is one of the three most important components of the human diet. For years, it was recommended that the intake of fats should be as low as possible due to their high calorific value. It is currently assumed that 30-35% of dietary energy should come from fat as it is a source of many bioactive compounds, such as essential unsaturated fatty acids (EUFAs), antioxidants and vitamins (A, D, E, K), which must be delivered to the body with food. Their content in vegetable fats and oils varies greatly, and the existing consumer opinions and beliefs often contradict scientific knowledge. Currently, a large body of evidence supporting the important role of fats in the human diet may be found in literature. This paper discusses the basic components of vegetable fats and oils in terms of their chemical structure and biological properties. A wide range of dietary fats were reviewed for their fatty acid, tocopherol and sterol profiles. Based on these facts, criteria to be taken into account in the selection of dietary fats and food products were identified.

scholarly journals The Role of Autophagy in Pancreatic Cancer—Recent Advances

Biology ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 7 ◽  
Author(s):  
Maria New ◽  
Sharon Tooze
Keyword(s):  
Pancreatic Cancer ◽  
Early Stage ◽  
Large Body ◽  
Ductal Adenocarcinoma ◽  
Improve Treatment ◽  
Recent Advances ◽  
Dismal Prognosis ◽  
Tumor Survival ◽  
Metastasis Development

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with a 5-year survival rate of only 9%, despite ongoing efforts to improve treatment. This dismal prognosis is due to the difficulty of early stage diagnosis, drug resistance, and likelihood of metastasis development. It is therefore of great importance to identify appropriate therapeutic targets and gain a greater understanding of PDAC biology. Autophagy is a membrane-mediated degradation and recycling mechanism, which is crucial for cell homeostasis. There is evidence for both a tumor-suppressive and a tumor-promoting role of autophagy in cancer, and this is likely context dependent. Within PDAC, a large body of evidence points towards autophagy being required for tumor survival and metabolism. In this review, we describe the recent advances in the understanding of the role and regulation of autophagy in PDAC.

scholarly journals Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms

Plants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1784
Author(s):  
Azher Arafah ◽  
Muneeb U. Rehman ◽  
Tahir Maqbool Mir ◽  
Adil Farooq Wali ◽  
Rayeesa Ali ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Biological Effects ◽  
Biological Properties ◽  
Primary Role ◽  
Citrus Fruits ◽  
Pharmacological Activities ◽  
Medicinal Properties

Extensive research has been carried out during the last few decades, providing a detailed account of thousands of discovered phytochemicals and their biological activities that have the potential to be exploited for a wide variety of medicinal purposes. These phytochemicals, which are pharmacologically important for clinical use, primarily consist of polyphenols, followed by terpenoids and alkaloids. There are numerous published reports indicating the primary role of phytochemicals proven to possess therapeutic potential against several diseases. However, not all phytochemicals possess significant medicinal properties, and only some of them exhibit viable biological effects. Naringenin, a flavanone found in citrus fruits, is known to improve immunity, repair DNA damage, and scavenge free radicals. Despite the very low bioavailability of naringenin, it is known to exhibit various promising biological properties of medicinal importance, including anti-inflammatory and antioxidant activities. This review focuses on the various aspects related to naringenin, particularly its physicochemical, pharmacokinetic, and pharmacodynamic properties. Furthermore, various pharmacological activities of naringenin, such as anticancer, antidiabetic, hepatoprotective, neuroprotective, cardioprotective, nephroprotective, and gastroprotective effects, have been discussed along with their mechanisms of action.

Sign in / Sign up

Export Citation Format

Share Document