scholarly journals Prevalence of Helicobacter Pylori Serologically in Patients Who Presented With Dyspeptic Symptoms to Orotta Medical Surgical National Referral Hospital

2021 ◽  
Author(s):  
Bernandos Bahta Tedros ◽  
Selomie Zemicael Teklehaimanot ◽  
Tsegai Tesfagabr ◽  
Yafet Hailemichael ◽  
Sharon Woldu ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Tertiary Hospital ◽  
Referral Hospital ◽  
Pediatric Age Group ◽  
Female Predominance ◽  
Male Sex ◽  
H Pylori ◽  
Optimum Management ◽  
National Referral Hospital ◽  
Total Visit

Abstract Background: Optimum management of dyspepsia in primary care is a debatable subject. Testing and treatment for Helicobacter pylori has become widely accepted as the approach of choice for patients with chronic dyspepsia but no alarming features. We evaluated prevalence of H. pylori among outpatients with dyspepsia and serologic investigations for it in tertiary hospital Orotta Medical Surgical National Referral Hospital (OMSNRH) retrospectively.Methods: A retrospectively collected data of H. pylori status among dyspeptic patients from Out Patient Department (OPD) and laboratory of OMSNRH, who had undergone serologic test for the infection, of the year 2012 was reviewed for the period from February 2013 to May 2013.Results: The prevalence of dyspepsia visited OMSNRH was 6.08%, with female predominance, from a total visit of 30,035. Of all 1844 dyspeptic patients from the OPD, 20.93% were positive, 48.05% were negative and 31.02% were untested for H. pylori. From a total of 4136 of the laboratory results, the prevalence of H. pylori was 31%. In adults (>14 years), it was 34% and pediatric (<15 years), prevalence was 12.5%. Male sex preference was observed among the adults in this study (37.7% vs. 31.7%, P=0.034). Conclusion: The prevalence of dyspepsia was 6.08% and the prevalence of H. pylori serologically in this study was 34% in adults and 12.5% in pediatric age group.

scholarly journals Characteristics of Helicobacter pylori infection in a National Referral Hospital in Bhutan

2020 ◽  
Vol 6 (1) ◽  
pp. 6-10
Author(s):  
Chhabi Lal Adhikari ◽  
Guru Prasad Dhakal ◽  
Nongluck Suwisith ◽  
Sonam Dargay ◽  
Krishna P Sharma
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Age Groups ◽  
Referral Hospital ◽  
Upper Gastrointestinal Endoscopy ◽  
Age Group ◽  
Exact Test ◽  
Significant Difference ◽  
H Pylori ◽  
National Referral Hospital

Introduction: Helicobacter pylori (H. pylori) is a bacterium causing chronic gastric infection and may cause gastric cancer. It was necessary to see the trend of infection, especially in symptomatic patients. This retrospective descriptive study was aimed to describe the characteristics of H. pylori infection in Bhutanese patients referred for an endoscopy to the National Referral Hospital, Thimphu. Methods: The sample of the study was randomized 380 medical records of the patients who underwent upper gastrointestinal endoscopy and Rapid Urea Test for symptomatic dyspepsia and peptic ulcer. Data was collected using a survey form designed by the researchers. Data analysis was done using descriptive statistics and either Chi-square or Fisher’s exact test. Results: The prevalence of H. pylori infection was very high (76.6%). The mean age of the infection was 42 with a range from 15 to 84 years. The highest prevalence of infection was observed in the age group 20-29 years (82.7%) and lowest in the oldest age group 70-84 years (66.7%). The analysis showed no significant difference in infection amongst age groups, gender, and endoscopic findings to the positive results at 5% significant level except for monthly prevalence (p<0.001). Gastritis was the commonest endoscopy finding (153/380) and gastro-duodenitis had the highest positivity rate (88.9%). Conclusion: The prevalence of infection was relatively high compared with previous studies. Young and middle-aged adults had a high prevalence and this group needs to be given priority for screening and eradication treatment considering limited resources to prevent associated gastric cancer in Bhutan.

scholarly journals Helicobacter pylori infection and hyperemesis gravidarum: a prospective pilot study in India

2019 ◽  
Vol 8 (7) ◽  
pp. 2856
Author(s):  
Akhila M. V. ◽  
Padmasri R.
Keyword(s):  
Socioeconomic Status ◽  
Helicobacter Pylori ◽  
Pregnant Women ◽  
Rural Areas ◽  
Hyperemesis Gravidarum ◽  
Venous Blood ◽  
Tertiary Hospital ◽  
Helicobacter Pylori Infection ◽  
H Pylori ◽  
A Prospective Study

Background: About 80% of all pregnant women experience some form of nausea and vomiting during their pregnancy. Hyperemesis gravidarum, the commonest indication for admission to hospital in the first half of pregnancy affects approximately 0.3%-2.0% of pregnancies. Helicobacter pylori infection has been implicated in the cause of nausea and occasional vomiting in early pregnancy. The objectives of this study are to determine the proportion of H. pylori seropositivity among women with hyperemesis gravidarum (HG) and determine its relation with socio-economic status.Methods: This was a prospective study conducted in a tertiary hospital in Bangalore among 60 pregnant women with HG for a period of 12 months. Venous blood samples were obtained and serum IgG for H. pylori was measured using enzyme-linked immunosorbant assay (ELISA). Details regarding socioeconomic status, recurrence of symptoms and severity were noted.Results: The proportion of H. pylori seropositivity among pregnant women with hyperemesis in our study was 70%.There was a significant increase in severity and recurrence of vomiting among seropositive cases. Women belonging to rural areas had 1.17 times the risk of infection compared to women with urban area. We also found women belonging to the lower socioeconomic status had 0.52 times more risk to develop Helicobacter pylori infection.Conclusions: This study suggests that H. pylori is an independent risk factor for vomiting in pregnancy. Effective treatment and eradication of H pylori infection may help reduce severity and recurrence of vomiting among positive cases thus reducing its adverse consequences.

scholarly journals Prevalence and predictors of ocular complications among children with nephrotic syndrome in a resource-limited setting

2020 ◽  
Author(s):  
Faith Nakubulwa ◽  
Rebecca Claire Lusobya ◽  
Anthony Batte ◽  
Bashir Ssuna ◽  
Damalie Nakanjako ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Referral Hospital ◽  
High Dose ◽  
Renal Unit ◽  
Ocular Complications ◽  
Cross Sectional ◽  
Mulago National Referral Hospital ◽  
National Referral Hospital

Abstract Background Nephrotic syndrome is the most common glomerulopathy among children aged 2–18 years and high dose corticosteroids are the backbone of its management. Potentially blinding ocular complications often result from nephrotic syndrome and/or its treatment. We conducted a study to determine the prevalence and predictors of ocular complications among children with nephrotic syndrome receiving care at Mulago National Referral Hospital. Methods This was a cross-sectional study conducted for three (3) months at pediatric renal unit of Mulago National Referral Hospital (MNRH). Data from a consecutive sample of 100 children was collected using a semi-structured questionnaire, entered into Epi-data 4.4.2 and exported to STATA 14 for analysis at univariate, bivariate and multivariate levels. A robust Poisson regression model was used to identify predictors of ocular complications. Results Out of 100 patients examined, 80(80%) had ocular complications. The median age was 10 (IQR: 7–12) and 52 (52%) were girls. The most frequent complications were hypertrichosis and refractive errors in 71%(95%CI 61.1–79.6) and 56%(95%CI 45.7–65.9) of the patients respectively. Age above 10 years was the predictor for ocular complications with a RR = 1.37 (95%CI:1.14–1.64) P = 0.001. Conclusions We found a high prevalence of ocular complications among children with nephrotic syndrome in this tertiary hospital. The predictor of ocular complications was age greater than 10 years. We recommend that all children with nephrotic syndrome undergo a baseline ocular examination prior to commencement of treatment and be reviewed periodically by an ophthalmologist.

scholarly journals Association between Chronic Urticaria and Helicobacter pylori Infection among Patients Attending a Tertiary Hospital in Tanzania

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Magdalena F. Dennis ◽  
Daudi R. Mavura ◽  
Luryritha Kini ◽  
Rune Philemon ◽  
Elisante J. Masenga
Keyword(s):  
Helicobacter Pylori ◽  
Chronic Urticaria ◽  
Conditional Logistic Regression ◽  
Tertiary Hospital ◽  
Enzyme Linked Immunosorbent Assay ◽  
Northern Tanzania ◽  
Common Skin ◽  
Stool Samples ◽  
Matched Case ◽  
H Pylori

Background. Chronic urticaria (CU) is a common skin disease; however, its etiology is rarely recognized. Infection due to Helicobacter pylori (H. pylori) has been shown in some studies to play a significant role in the pathogenesis of CU. Objective. This study was conducted to determine the association between CU and H. pylori infection among patients attending the Regional Dermatology Training Center, Northern Tanzania, from October 2018 to April 2019. Methodology. A matched case-control study that included 55 cases and 55 controls matched by age and sex was conducted. Data were collected through direct interviews, and the results of laboratory investigations were recorded in the extraction sheet. An enzyme-linked immunosorbent assay test was used to detect H. pylori antigen in the stool samples. Conditional logistic regression was used to measure the association between CU and H. pylori. Results. The total number of participants in this study was 110 patients (55 cases and 55 controls), whereby the median age was 31 (IQR 27–45) among controls versus 34 (IQR: 22–46) years among the cases. Both cases and controls had the same number of females and males. There was no significant association between CU and baseline characteristics of the participants. There was an association between CU and H. pylori infection, such that subjects with CU had a higher number of positive H. pylori test (15/55 = 27%) versus controls (6/55 = 10.1%) (p=0.0225). The adjusted odds of CU among patients who were positive for H. pylori were sixfolds higher (OR = 6.9; CI: 1.3–36.2; p=0.021) than those of patients who were negative for H. pylori.Conclusion. There was a strong and significant association between CU and H. pylori infection. We recommend investigating for H. pylori in all cases of CU and conducting further trials on H. pylori eradication.

scholarly journals The Effect of Primary Duodenogastric Bile Reflux on the Presence and Density of Helicobacter pylori and on Gastritis in Childhood

Medicina ◽  
2019 ◽  
Vol 55 (12) ◽  
pp. 775
Author(s):  
Mehmet Agin ◽  
Yusuf Kayar
Keyword(s):  
Helicobacter Pylori ◽  
Bile Reflux ◽  
Duodenogastric Reflux ◽  
Control Group ◽  
Pediatric Age Group ◽  
Study Results ◽  
H Pylori ◽  
Reported Data ◽  
The Relationship ◽  
Upper Gastrointestinal

Background and Objectives: Although there are many studies that investigate the relationship between duodenogastric reflux (DGR) and Helicobacter pylori in adult patients, the reported data are contradictory. In addition, there are very few studies in the literature investigating the relationship between DGR and H. pylori in the pediatric age group. In the present study, we investigated the effect of primary DGR on H. pylori and gastritis. Materials and Methods: A total of 361 patients who were referred to the clinic of our hospital with dyspeptic complaints who had an upper gastrointestinal system endoscopy and a gastric biopsy were included in the study. Results: DGR was detected in 45 cases, and 316 cases that did not have DGR were considered as the control group. Comparisons were made between the DGR cases and the control group in terms of risk factors (age, gender), the presence and density of H. pylori, and the presence and severity of gastritis. The average age of the patients who were included in the study was 11.6 ± 4.6 years. A total of 128 (36%) of the cases were male and 233 (64%) were female. DGR was present in 45 (13%) of the cases. The average age of the patients with DGR was 13.9 ± 3.1 years, the average age of the control group was 11.3 ± 4.7, and there were statistically significant differences (p < 0.001). No significant differences were detected in terms of gender between DGR and the control group (p > 0.05). H. pylori (+) was detected in 29 (64%) of patients with DGR, and in 202 (64%) of the control group. No significant differences were detected between H. pylori prevalence (p = 0.947). Gastritis was detected in 37 (82%) of the patients with DGR, and in 245 (77%) of the control group (p = 0.476). No significant differences were detected between the presence and density of H. pylori, gastritis presence, severity and DGR (p > 0.05). Conclusions: The ages of patients with DGR were significantly higher than in the control group, and advanced age was shown to be a risk factor for primary DGR. It was found that the presence of DGR has no effect on the presence and severity of H. pylori. Given this situation, we consider it is important to eradicate H. pylori infection, especially in the case where H. pylori is present together with DGR.

scholarly journals Prevalence and predictors of ocular complications among children undergoing nephrotic syndrome treatment in a resource-limited setting

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Faith Nakubulwa ◽  
Rebecca Claire Lusobya ◽  
Anthony Batte ◽  
Bashir Ssuna ◽  
Damalie Nakanjako ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Referral Hospital ◽  
High Dose ◽  
Renal Unit ◽  
Ocular Complications ◽  
Cross Sectional ◽  
Mulago National Referral Hospital ◽  
National Referral Hospital

Abstract Background Nephrotic syndrome is the most common glomerulopathy among children aged 2–18 years and high dose corticosteroids are the backbone of its management. Potentially blinding ocular complications often result from nephrotic syndrome and/or its treatment. We conducted a study to determine the prevalence and predictors of ocular complications among children undergoing nephrotic syndrome treatment at Mulago National Referral Hospital. Methods This was a cross-sectional study conducted for three [3] months at the pediatric renal unit of Mulago National Referral Hospital (MNRH). Data from a consecutive sample of 100 children was collected using a semi-structured questionnaire, entered into Epi-data 4.4.2 and exported to STATA 14 for analysis at univariate, bivariate and multivariate levels. A robust Poisson regression model was used to identify predictors of ocular complications. Results Out of 100 patients examined, 80(80%) had ocular complications. The median age was 10 (IQR: 7–12) and 52 (52%) were girls. The most frequent complications were hypertrichosis and refractive errors in 71% (95%CI 61.1–79.6) and 56% (95%CI 45.7–65.9) of the patients respectively. Age above 10 years was the predictor for ocular complications with a RR = 1.37 (95%CI:1.14–1.64) p = 0.001. Conclusions We found a high prevalence of ocular complications among children with nephrotic syndrome in this tertiary hospital. The predictor of ocular complications was age greater than 10 years. We recommend that all children with nephrotic syndrome undergo a baseline ocular examination prior to commencement of treatment and be reviewed periodically by an ophthalmologist.

scholarly journals Incidence and clinicopathological profile of gestational trophoblastic disease in tertiary care centre

2018 ◽  
Vol 4 (2) ◽  
pp. 25-29
Author(s):  
Tshering Tamang ◽  
Ugyen Tshomo
Keyword(s):  
Hydatidiform Mole ◽  
Tertiary Care ◽  
Tertiary Hospital ◽  
Gestational Trophoblastic Disease ◽  
Referral Hospital ◽  
Common Symptom ◽  
Tertiary Care Centre ◽  
True Incidence ◽  
Trophoblastic Disease ◽  
National Referral Hospital

Introduction: Gestational trophoblastic disease (GTD) arises from abnormal proliferation of placental trophoblastic tissue. The aim of this study was to determine the incidence and clinicopathological profiles with treatment outcome of gestational trophoblastic disease in Jigme Dorji Wangchuck National Referral Hospital, a tertiary hospital in Bhutan. Method: A prospective and retrospective observational study was conducted over a period of 18 months. Results: A total of 121 cases of gestational trophoblastic disease were diagnosed with an incidence rate of 19.7 per 1000 deliveries. Majority comprised hydatidiform moles(115);of which, 30 (26.1%) were complete and 85(73.9%) partial moles. The mean gestational age at diagnosis of hydatidiform mole was 9.8± 1.6 weeks and the most common symptom being vaginal bleeding (72.8%). Nine (7.8%) of these progressed to gestational trophoblastic neoplasia and was strongly associated with high pre-evacuation beta-hCG level (> 100,000 mIU/ml) and larger uterine size (> 14 weeks). Conclusions: This study revealed a high incidence of gestational trophoblastic disease in national referral hospital. Further in-depth research and instituting a GTD registry can be useful to validate these findings and find the true incidence. A substantial number of molar pregnancies can progress to GTN, and thus requires strict follow-up.

scholarly journals Helicobacter pylori Seropositivity in Children in Duhok City, Iraq

2018 ◽  
Vol 6 (3) ◽  
pp. 82-87 ◽  
Author(s):  
Nizar B. Yahya
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Positive Association ◽  
Significant Positive Association ◽  
Ulcer Disease ◽  
Face To Face ◽  
Pediatric Age Group ◽  
Significant Relationships ◽  
H Pylori ◽  
Associated Risk Factors

Introduction: Helicobacter pylori(H. pylori) is a gram negative bacteria that causes gastritis and peptic ulcer disease (PUD). It is widely accepted that the infection may occur early in life and may persist for decades before causing diseases. The aim of this paper was to determine the prevalence of H. pyloriseropositivity in pediatric age group and to examine the associated risk factors. Patients and methods: Blood samples were collected from 100 subjects attending Hevi Pediatric Teaching Hospital over a period of 6 months and IgG positivity was determined. A questionnaire sheet was prepared and used for each study subject. Data were collected by a face-to-face interview.Results: It was found that 28/100 (28%) of the recruited sample was positive for H. pyloriseropositivity. A significant association was found between the number of siblings and H. pyloripositivity (P=0.01, OR=1.3). No significant relationships were found between other factors and H. pyloripositivity. Conclusions: The prevalence of H. pyloriinfection was less than that reported in the city previously and less than that reported in neighboring countries. A significant positive association was found between number siblings and H. pyloriinfection rate. Further studies are needed recruiting larger sample size to explore H. pyloriprevalence and its associated risk factors.

scholarly journals Occurrence of Helicobacter Pylori in Specimens of Chronic Gastritis and Gastric Adenocarcinoma Patients: A Retrospective Study at University Teaching Hospital, Kigali, Rwanda

2021 ◽  
Vol 5 (2) ◽  
pp. 159-163
Author(s):  
Theoneste Nizeyimana ◽  
Belson Rugwizangoga ◽  
Felix Manirakiza ◽  
Alvaro C Laga
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Adenocarcinoma ◽  
Chronic Gastritis ◽  
Tertiary Hospital ◽  
University Teaching ◽  
Tissue Samples ◽  
Bacterial Morphology ◽  
Gastric Biopsies ◽  
H Pylori ◽  
Timely Treatment

Introduction: Helicobacter pylori (H. pylori) infection is the major cause of gastroduodenal diseases in populations of different ages.We conducted aretrospective studyusing archived tissue samples to determine the prevalence of H. pylori infection among patients diagnosed with gastritis and gastric adenocarcinoma by histopathology cases in one hospital in Rwanda. Materials and methods: Cases of chronic gastritis and gastric adenocarcinoma histologically diagnosed in a tertiary hospital in Rwanda over the period of 2016-2018 were studied for the presence of H. pylori using immunohistochemistry. Diagnosis of positive cases considered immunoreactivity as well as bacterial morphology, including spiral, rod-shaped, angulated and coccoid forms. Results: Three hundred and seven cases were included in this study; chronic gastritis and gastric adenocarcinoma representing 39% and 61%, respectively. The overall frequency of H. pylori infection was 77.5% (80% among chronic gastritis cases versus 76% among gastric adenocarcinoma cases). Prevalence of H. pylori infection in chronic gastritis and adenocarcinoma did not significantly associate with age and sex. Conclusion: The prevalence of H. pylori was high among chronic gastritis and gastric adenocarcinoma cases in Rwanda. Pathologists should investigate the presence of H. pylori in gastric biopsies. Our data shows immunohistochemistry method is feasible and adequate to facilitate detection of H. pylori, which may guide timely treatment.

scholarly journals High prevalence of clarithromycin resistance and effect on Helicobacter pylori eradication in a population from Santiago, Chile: cohort study and meta-analysis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
A. Arenas ◽  
C. Serrano ◽  
L. Quiñones ◽  
P. Harris ◽  
M. Sandoval ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Meta Analysis ◽  
Dual Therapy ◽  
Tertiary Hospital ◽  
High Dose ◽  
Rapid Urease Test ◽  
Clarithromycin Resistance ◽  
Pooled Prevalence ◽  
Urease Test ◽  
H Pylori

AbstractHelicobacter pylori (H. pylori) eradication using standard triple therapy (STT) with proton pump inhibitors (PPI), amoxicillin and clarithromycin (CLA) has been the standard in Latin America. However, CLA resistance is a rising problem affecting eradication rates. Genetic polymorphisms of CYP2C19, a PPI metabolizer may also affect eradication. The primary aims of this study were to evaluate the effect of clarithromycin resistance on H. pylori eradication in a population from Santiago, and to establish the pooled clarithromycin resistance in Santiago, Chile. Symptomatic adult patients attending a tertiary hospital in Santiago were recruited for this study. CLA resistance and the polymorphisms of CYP2C19 were determined on DNA extracted from gastric biopsies, using PCR. The STT was indicated for 14 days and eradication was determined by a urea breath test 4–6 weeks after therapy. A meta-analysis of CLA resistance studies among adult residents in Santiago was performed. Seventy-three out of 121 consecutive patients had positive rapid urease test (RUT) and received STT. Sixty-nine patients (95%) completed the study. The H. pylori eradication rate was 63% and the prevalence of CLA resistance was 26%. According to the CYP2C19 polymorphisms, 79.5% of the RUT-positive patients were extensive metabolizers. Multivariable analyses showed that only CLA resistance was significantly and inversely associated with failure of eradication (OR: 0.13; 95% confidence interval [95% CI], 0.04–0.49). A meta-analysis of two previous studies and our sample set (combined n = 194) yielded to a pooled prevalence of CLA resistance of 31.3% (95% CI 23.9–38.7). Our study shows that CLA resistance is associated with failure of H. pylori eradication. Given the high pooled prevalence of CLA resistance, consideration of CLA free therapies in Santiago is warranted. We could recommend bismuth quadruple therapy or high-dose dual therapy, according to bismuth availability. Further studies need to evaluate the best therapy.

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