Third dose vaccine With BNT162b2 and its response on Long COVID after Breakthrough infections

Abstract Background: Breakthrough events are not rare after emerging of Delta variant. On the other hand, long COVID is an unsolved issue where sufferers suffer a lot. Some study has shown that COVID-19 vaccine has improved some clinical and libratory parameters in long COVID. But what will be the possible measures against long COVID after the breakthrough event is still a burning question. Method: We have observed the third dose by BNT162b2 in a small group(n=20) who were diagnosed as long COVID after breakthrough infections, in Sheikh Hasina National Institute of Burn & Plastic Surgery Institute, Dhaka, Bangladesh. CRP(C-reactive protein) and Anti S1 RBD IgG responses were measured. Result: All 20 participants in the study received both dosage of ―ChAdOx1-nCoV-19‖ in between February 2021 to April 2021 and had breakthrough infection in the same or following month which led to long COVID syndrome. They all received a third dose of ―BNT162b2‖. A before and after 3rd dose (14 days after) CRP from participants serum was measured. A Wilcoxon matched paired signed rank test revealed significant (P value <0.05) reduction of inflammatory marker (CRP) after receiving the 3rd vaccine dose. Pre and post 3rd dose quantitative anti S1-RBD IgG response was measured and compared that revealed significant boosting effect that clearly correlates with the CRP response. Conclusion: Coverage of vaccines all over the world is still not expected level to control this pandemic. WHO has not recommended the use of a third/booster Background: Breakthrough events are not rare after emerging of Delta variant. On the other hand, long COVID is an unsolved issue where sufferers suffer a lot. Some study has shown that COVID-19 vaccine has improved some clinical and libratory parameters in long COVID. But what will be the possible measures against long COVID after the breakthrough event is still a burning question. Method: We have observed the third dose by BNT162b2 in a small group(n=20) who were diagnosed as long COVID after breakthrough infections, in Sheikh Hasina National Institute of Burn & Plastic Surgery Institute, Dhaka, Bangladesh. CRP(C-reactive protein) and Anti S1 RBD IgG responses were measured. Result: All 20 participants in the study received both dosage of ―ChAdOx1-nCoV-19‖ in between February 2021 to April 2021 and had breakthrough infection in the same or following month which led to long COVID syndrome. They all received a third dose of ―BNT162b2‖. A before and after 3rd dose (14 days after) CRP from participants serum was measured. A Wilcoxon matched paired signed rank test revealed significant (P value <0.05) reduction of inflammatory marker (CRP) after receiving the 3rd vaccine dose. Pre and post 3rd dose quantitative anti S1-RBD IgG response was measured and compared that revealed significant boosting effect that clearly correlates with the CRP response. Conclusion: Coverage of vaccines all over the world is still not expected level to control this pandemic. WHO has not recommended the use of a third/booster

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Third dose vaccine With BNT162b2 and its response on Long COVID after Breakthrough infections

10.1101/2021.11.08.21266037 ◽

2021 ◽

Author(s):

ashraful hoque ◽

Marufur Rahman ◽

Hossain Imam ◽

Nurun Nahar ◽

Forhad Uddin Hasan Chowdhury

Keyword(s):

Inflammatory Marker ◽

Vaccine Dose ◽

Rank Test ◽

P Value ◽

Reactive Protein ◽

The Third ◽

Signed Rank ◽

Before And After ◽

Signed Rank Test ◽

Dose Vaccine

Background: Breakthrough events are not rare after emerging of the Delta variant. On the other hand, long COVID is an unsolved issue where sufferers suffer a lot. Some study has shown that the COVID-19 vaccine has improved some clinical and libratory parameters in long COVID. But what will be the possible measures against long COVID after the breakthrough event is still a burning question. Method: We have observed the third dose by BNT162b2 in a small group(n=20) who were diagnosed as long COVID after breakthrough infections, in Sheikh Hasina National Institute of Burn & Plastic Surgery Institute, Dhaka, Bangladesh. CRP(C-reactive protein) and Anti S1 RBD IgG responses were measured. Result: All 20 participants in the study received both dosages of ChAdOx1-nCoV-19 between February 2021 to April 2021 and had breakthrough infections in the same or following month which led to long COVID syndrome. They all received a third dose of BNT162b2. A before and after 3rd dose (14 days after) CRP from participants' serum was measured. A Wilcoxon matched paired signed-rank test revealed a significant (P-value <0.05) reduction of inflammatory marker (CRP) after receiving the 3rd vaccine dose. Pre and post 3rd dose quantitative anti-S1-RBD IgG response was measured and compared that revealed a significant boosting effect that clearly correlates with the CRP response. Conclusion: Coverage of vaccines all over the world is still not expected level to control this pandemic. WHO has not recommended the use of a third/booster dose of COVID vaccines. Though our results show some sort of hope for the long COVID in breakthrough events after getting the third dose more study is needed to conclude this issue.

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Aromaterapi Lavender dapat Menurunkan Intensitas Nyeri Perineum pada Ibu Post Partum

Jurnal Ners dan Kebidanan Indonesia ◽

10.21927/jnki.2016.4(3).123-128 ◽

2017 ◽

Vol 4 (3) ◽

pp. 123

Author(s):

Wiwin Widayani

Keyword(s):

Post Partum ◽

Sampling Technique ◽

Complementary Therapy ◽

Perineal Pain ◽

Rank Test ◽

P Value ◽

Relieve Pain ◽

Signed Rank ◽

Before And After ◽

Signed Rank Test

Perineals pain affects woman ability to mobilize so that it can cause complications such as post-partum haemoragik. Trauma to the perineum also cause discomfort and dyspareunia, therefore, perineal pain management is important. Currently the handling used to relieve pain is complementary therapy aromatherapy with essential oils of lavender, because lavender has the properties of anticonvulsant, antidepressant, anxiolytic, and also soothing. Aromatherapy stimulates the hypothalamus to secrete chemical mediators that serve as pain relievers and give rise to feelings of happiness. The purpose of this study was to determine the effect of lavender aromatherapy to the perineal pain intensity in post partum women. This study is a quasy experiment pre and post non random control in postpartum women at Bidan Praktik Mandiri in Bandung. Sampling this study using consecutive sampling technique. The data taken using the instrument in the adaptation of a Visual Analog Scale (VAS) and analyzed by using the wilcoxon signed rank test. The result is there was a decrease in pain intensity before and after the administration of inhaled lavender aromatherapy (Z=-3.77) with p-value 0.001. Lavender aromatherapy can be a complementary alternative therapy to reduce pain in postpartum women but more research necessary is needed with more respondents.

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Pengaruh Pelatihan terhadap Peningkatan Pengetahuan Kader Posyandu tentang Deteksi Dini TBC Anak di Kelurahan Tanjung Mas Semarang

ABDIMASKU : JURNAL PENGABDIAN MASYARAKAT ◽

10.33633/ja.v4i3.188 ◽

2021 ◽

Vol 4 (3) ◽

pp. 222

Author(s):

Eti Rimawati ◽

Sri Handayani ◽

Catur Yuantari

Keyword(s):

Early Detection ◽

Junior High School ◽

Rank Test ◽

P Value ◽

Test Analysis ◽

Signed Rank ◽

Before And After ◽

Signed Rank Test ◽

The Difference ◽

Tuberculosis In Children

Introduction: Symptoms of tuberculosis in children that are not specific require early detection efforts. One of the efforts to carry out early detection is to monitor children's growth and development in posyandu activities. Posyandu cadres have an important role in this. The purpose of this training activity is to increase the knowledge of posyandu cadres in early detection of tuberculosis in children. Method: The target of the training was 21 posyandu cadres who were selected by purposive sampling. Training activities as a form of community service are carried out with the stages of giving a pretest, presentation of material and case and posttest questions. The Wilcoxon Signed Rank Test analysis is used to determine differences in knowledge before and after training.Result Recommendation: All cadres were female, with the lowest education was junior high school (9.8%), the youngest was 38 years old and the oldest was 65 years old. The results of the difference test showed that there was a difference between before and after training (p value 0.0006), indicating that the training method was effective in increasing the knowledge of the cadres

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PENAMBAHAN LATIHAN CORE STABILITY PADA PROGRAM PELATIHAN ATLET DAYUNG UNTUK PENINGKATAN KECEPATAN MENDAYUNG

Sport and Fitness Journal ◽

10.24843/spj.2017.v05.i03.p06 ◽

2017 ◽

Author(s):

Dyno Aryo Christanto ◽

N. Adiputra ◽

S. Indra Lesmana ◽

Dw P. Sutjana ◽

Made Muliarta ◽

...

Keyword(s):

Training Program ◽

Core Stability ◽

Rank Test ◽

P Value ◽

Signed Rank ◽

Wilcoxon Signed Rank Test ◽

Before And After ◽

Post Test ◽

Signed Rank Test ◽

The Difference

Introduction: Generally, core stability exercise as a training program is needed in almost kind of sport including paddle, analysis of movement in any kind of paddle sport such as kayak, canoe, or even rowing have been showed that the activity of core stability muscles are really needed. Purpose: purpose of this research is to know the effectivity of core stability exercise replenishment to increase sculling speed in paddle training program. Methods: This research is experimental with treatment by subject design project, involving 15 paddle athletes which divided into two groups and consists of II periods which are, Period I and Period II. In the 1st period, the athletes were given extra core stability exercise along with their normal paddling routine mean while in the 2nd period, the athletes only doing their normal paddling routine. Each period do the trial in 6 weeks, so this reseach took 12 weeks. In 1st period, the subjects were given extra core stability training 3 times a week along with their normal paddling routine where as subjects in period II only do their normal paddling routine. Results: The used of parametric paired t test is to know the difference of sculling speed before and after the trials were given. To period I pre test value is 3.80 ± 0.26 meters/second while the post test value is 4.06 ± 0.41 meters/second and the value 0.001 (p<0.05)mean while the 2nd period use Wilcoxon signed rank test to know the difference of sculling speed between before and after the trial were given resulting pre test value 3.80 ± 0.22 meters/second and post test value 3.91 ± 0.27 meters/second while the p value is 0.004 (p<0.05). After 12 weeks of sculling speed test between both period using Wilcoxon signed rank test and resulting obvions with period I value 0.26 ± 0.20 meters/second and period II value is 0.11 ± 0.12 meters/second along with p value 0.001 (p<0.05). Conclusion: Therefore, based on the result of my research test, we can concluded that the addition of core stability exercise in paddle training program is more effective to increase sculling speed.

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The Effectiveness of Dark Chocolate Consumption toward Anxienty of Post Sectio Caesaraea Mother

Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) ◽

10.26699/jnk.v3i2.art.p131-135 ◽

2016 ◽

Vol 3 (2) ◽

pp. 131-135

Author(s):

Laily Wahidatul Oktavia ◽

Maria Ulfa

Keyword(s):

Anxiety Scale ◽

Dark Chocolate ◽

Sectio Caesarea ◽

Rank Test ◽

P Value ◽

Post Surgery ◽

Signed Rank ◽

Before And After ◽

Signed Rank Test ◽

Wilcoxon Rank Test

The consumption of dark chocolate on the second day of mother post section caesarea canreduce anxiety, since the asetosal substance can stimulate the limbic system of hypothalamus to suppressthe anxiety. Method: The research design was a Quasy experimental. The research sample was 8mother post sectio caesarea in Ngudi Waluyo Hospital Cempaka Wlingi at August 14th, up to September14th, 2015, it was chosen using accidental sampling. The data analyzed by Wilcoxon rank test. Result:showed a decrease in the percentage of anxiety scale before and after eating dark chocolate in whichthe anxiety scale of 87.5% to 20%. Based on statistical analysis showed Wlicoxon Signed Rank Test pvalue = 0,008, so p value = 0.008 < = 0.05. Discussion: relaxed condition was needed in the processof recovery condition after partum mothers, especially post surgery. Psychological factors like familysupport also needed to optimize all of the action taken.

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UJI BEDA PREFERENSI BELANJA IMPOR BARANG KIRIMAN ATAS PERUBAHAN BATAS PEMBEBASAN BEA MASUK

JURNAL PERSPEKTIF BEA DAN CUKAI ◽

10.31092/jpbc.v4i1.748 ◽

2020 ◽

Vol 4 (1) ◽

Author(s):

Himawan Yusuf

Keyword(s):

Consumer Preferences ◽

T Test ◽

Rank Test ◽

P Value ◽

Average Value ◽

Signed Rank ◽

Wilcoxon Signed Rank Test ◽

Before And After ◽

Initial Hypothesis ◽

Signed Rank Test

ABSTRACT: Modification of threshold exemption from import duties was tested whether changing consumer preferences in shopping from abroad. This study uses a paired test with the initial hypothesis that there is no difference in the daily average value of imports before and after the policy is applied. The research data is only from the Customs offices which have services for shipment items (32 offices) on October 1, 2019, to March 2, 2020. Descriptive statistical results show that the average was USD135,065, then dropped to USD127,430. Based on the results, both the Paired Sample T Test and The Wilcoxon Signed Rank Test obtained a p-value of 0,000, meaning that the initial hypothesis was rejected. The adoption of this policy has changed the preferences of consumers shopping from abroad. The Government's aim to reduce the trade balance deficit and protect domestic businesses appears to be successful, however, if there are no substitute goods available in the country, the import will only move from importing consignment goods to general imports. The novelty is the variable of import duty on shopping preferences is not widely used. The limitation of this study only measures changes in spending preferences, do not in state revenue.Keywords: shopping preference, consignment, tax exemption, difference test ABSTRAK:Perubahan kebijakan batas pembebasan terhadap bea masuk dan pajak atas impor barang kiriman diuji apakah merubah preferensi konsumen dalam berbelanja barang yang dikirim langsung dari luar negeri melalui mekanisme impor barang kiriman. Penelitian ini menggunakan metode kuantitatif melalui uji berpasangan dengan hipotesis awal tidak adanya perbedaan nilai rerata impor harian baik sebelum maupun setelah kebijakan berlaku. Data penelitian hanya kantor-kantor Bea Cukai yang memiliki pelayanan atas barang kiriman (32 kantor) pada 1 Oktober 2019 sampai dengan 2 Maret 2020. Hasil statistik deskriptif menunjukkan bahwa rerata harian impor sebelum kebijakan tersebut berlaku sebesar USD135.065, kemudian turun menjadi USD127.430. Berdasarkan pengujian, baik pada Paired Sampel T Test maupun pada Wilcoxon Signed Rank Test diperoleh nilai p sebesar 0.000 (hipotesis awal ditolak). Hal ini berarti penerapan kebijakan tersebut telah merubah preferensi belanja dari luar negeri melalui impor barang kiriman. Tujuan Pemerintah untuk mengurangi defisit neraca perdagangan dan melindungi usaha dalam negeri tampaknya berhasil, namun apabila belum tersedia barang subtitusi di dalam negeri, importasi tersebut hanya akan berpindah dari impor barang kiriman menjadi impor umum. Keterbaruan pada penelitian ini adalah variabel bea masuk pada preferensi belanja belum banyak digunakan. Keterbatasan penelitian ini hanya mengukur perubahan preferensi belanja, tidak mengukur perubahan penerimaan negara.Kata Kunci: preferensi belanja, impor barang kiriman, pembebasan pajak, uji beda

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The Effect of Heart Exercise to Blood Pressure on Elderly with Hypertension at PSTW Pagar Dewa Bengkulu City

Jurnal Sains Kesehatan ◽

10.37638/jsk.26.3.18-27 ◽

2019 ◽

Vol 26 (3) ◽

pp. 18-27

Author(s):

Devi Listiana ◽

Buyung Keraman ◽

Kurnia Esti

Keyword(s):

Blood Pressure ◽

Test Group ◽

The Elderly ◽

Pharmacological Therapy ◽

Rank Test ◽

P Value ◽

Signed Rank ◽

Before And After ◽

Post Test ◽

Signed Rank Test

Healthy heart exercises can be used as non-pharmacological therapy in the treatment of hypertension. The aims of this study to determine Effect of Heart Exercise to Blood Pressure on Elderly with Hypertension at PSTW Pagar Dewa Bengkulu City. Design of this study was Pre-Experimental Design with Pre-Test and Post-Test Group Design, observation design which was conducted twice, that were before and after the experiment. Aneroid sphgmomanometer measuring devices, stethoscopes and digital tension and measuring methods by measuring blood pressure elderly. Population in this study were all the elderly who had hypertension were in PSTW Pagar Dewa Bengkulu City, with the amounted of 44 people and the sample used according to criteria was 26 people. Data analysis used the Wilcoxon Signed-Rank Test. The results of this study have an influence, obtained Systolic Blood Pressure values in the Elderly before and after Healthy Heart exercised Z = -4,282 with p = value = 0,000 0.05 means significant diastolic Blood Pressure in the Elderly before and after Healthy Heart exercised Z = - 4,314 with p = value = 0,000 0.05 means significant. Suggestions elderly who suffer from hypertension can used healthy heart exercises as non-pharmacological therapy. Keywords: elderly, heart exercises, hypertension

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PERBEDAAN KEMAMPUAN MANAJERIAL KEPALA RUANG SEBELUM DAN SESUDAH PELATIHAN MANAJEMEN BANGSAL

Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal ◽

10.32583/pskm.9.2.2019.79-84 ◽

2019 ◽

Vol 9 (2) ◽

pp. 79-84

Author(s):

Priyanto Priyanto ◽

Sakbani Sakbani

Keyword(s):

General Hospital ◽

Management Training ◽

Rank Test ◽

P Value ◽

Signed Rank ◽

Wilcoxon Signed Rank Test ◽

Before And After ◽

Post Test ◽

Signed Rank Test ◽

Managerial Capabilities

Kemampuan manajerial kepala ruang merupakan kemampuan untuk memimpin, mengelola, menggerakkan dan mengarahkan bawahan agar mencapai tujuan bersama dalam organisasi. Penelitian bertujuan untuk mengetahui kemampuan manajerial kepala ruang di RSUD Kabupaten Temanggung dengan intervensi pelatihan manajemen. Penelitian ini menggunakan desain pre eksperimental dengan pendekatan one group pre post test. Populasi penelitian adalah kepala ruang dan staf perawat di RSUD Kabupaten Temanggung, dengan jumlah sampel 15 responden kepala ruang.Hasil penelitian menggunakan uji wilcoxon signed rank test (α =5%) menunjukkan perbedaan yang bermakna antara kemampuan manajerial kepala ruang sebelum dan sesudah pelatihan manajemen bangsal (p value = 0,001). Pelatihan manajemen bangsal dapat meningkatkan kemampuan manajerial kepala ruang. Perlu dilakukan tindak lanjut pelatihan tentang kemampuan manajerial kepala ruang berupa implementasi hasil pelatihan. Kata kunci : Kemampuan manajerial kepala ruang, pelatihan manajemen bangsal. DIFFERENCE OF MANAGERIAL CAPABILITIES IN THE ROOM BEFORE AND AFTER AFTER BANGSAL MANAGEMENT TRAINING . ABSTRACT Managerial capability of head nurses is the ability to lead in mobilizing and directing subordinates to achieve common goals in an organization. The study aimed to determine the managerial capability of head nurses at Temanggung General Hospital with the managerial intervention. This study used pre experimental design with one group pre post test. The study population were the head nurses at Temanggung general hospital, the number of samples of head nurses were 15 samples. The results of the Wilcoxon signed rank test (α = 5%) show significant differences between managerial capability of head nurses before and after the training of ward management (p value = 0.001). The training of ward management can improve the head nurses’ managerial capability. It is necessary to follow up the training of the head nurses managerial capability in the form of the implementation of training result. Keywords: Managerial capability of head nurses, the training of ward management

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The interventions of nutritional education on malnutrition infants mothers in Wonokromo Surabaya

Journal of Health Sciences ◽

10.33086/jhs.v5i2.16 ◽

2015 ◽

Vol 5 (2) ◽

Author(s):

Wiwik Afridah

Keyword(s):

Nutrition Education ◽

T Test ◽

Rank Test ◽

P Value ◽

Education Intervention ◽

Signed Rank ◽

The Family ◽

Before And After ◽

Signed Rank Test ◽

Paired T Test

Mother’s knowledge has great affect to the nutritional status of the infants, because mother has a big role in providing the food in the family. That Knowledge was heavily influenced by social circumstances of the family's such as lack of family income that may affect the mother's in providing the food in the family. The research objective is to examine the effect of nutrition education intervention on body weight of malnutrition infants in RW 07 Wonokromo, Surabaya. This study uses a pre-experimental study design with pre-post test type approach. The subjects were children aged six months to five years who are malnutrition and poor nutrition, with indexes BW/U is less than Z score, located in Wonokromo Village, Surabaya. Sampling techniques in a study conducted by simple random sampling. Analysis of differences nutritional status of children before and after giving of nutrition education were tested by paired t test (paired t test) and differences of mother’s knowledge before and after giving of nutrition education were tested by Wilcoxon signed rank test. Results of statistically tests by using a paired t-test obtained P Value (0.108) > α (0.05) means there is no different on giving of nutrition education intervention on weight infants in the RW. 07 Wonokromo Village, Surabaya. Results of statistically tests by using the Wilcoxon signed rank test obtained P Value (0.157) > α (0.05) means there is no different on giving of nutrition education intervention on parent’s knowledge level of a toddler in the RW. 07 Wonokromo Village Surabaya. Required planning and strategies to change behavior and awareness of nutrition and health. Using 4P concept for viewpoint of trainers/educators and 4C for viewpoint of participants or trained, and performed by ABC approach (Advocacy, Situation control and the Movement Atmosphere/mobilization).

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Reduksi Tingkat Stress pada Komunitas Purbalingga Street Art melalui Graffiti dan Mural

Jurnal Ilmu Dakwah ◽

10.21580/jid.v39.2.3997 ◽

2019 ◽

Vol 39 (2) ◽

pp. 112

Author(s):

Eti Khusnul Khotimah ◽

Alief Budiyono

Keyword(s):

Street Art ◽

Rank Test ◽

P Value ◽

Depression Anxiety Stress Scale ◽

Stress Scale ◽

Signed Rank ◽

Significant Difference ◽

Stress Levels ◽

Before And After ◽

Signed Rank Test

Many things can be done to reduce stress, one of them is through Graffiti and Mural. Both are recognized to reduce stress levels in a person. The purpose of this study is to find out how to reduce stress levels and differences in stress levels before and after treatment in the form of drawing graffiti and murals in the Purbalingga Street Art (PUSAR) community. This type of research is a quantitative quasi experiment. To measure stress levels, the instrument used is the Depression Anxiety Stress Scale (DASS). The stress difference was analyzed using the Wilcoxon signed rank test. The results of the study stated that graffiti and murals can cause a sense of fun and calm when the artist holds a pilox (spray paint) on the object of the wall. Then, there is a point in making graffiti that makes a graffiti artist feel satisfied to express and express emotions from within himself. So that what makes graffiti and murals can overcome problems and cause pleasure is when all emotions can be overflowed into his work. Furthermore, every member of the Purbalingga Street Art (PUSAR) community with different stress levels get different results. Statistical test results show a significant difference or decrease in stress levels in the study subjects with the results of p value = 0.011 (p value <0.05), so the hypothesis is accepted. Banyak hal yang dapat dilakukan untuk mereduksi stress, salah satunya melalui Graffiti dan Mural. Keduanya diakui dapat mengurangi tingkat stress pada seseorang. Tujuan dari penelitian ini adalah mengetahui cara mereduksi tingkat stress dan perbedaan tingkat stress sebelum dan sesudah dilakukannya perlakuan berupa menggambar graffiti dan mural pada komunitas Purbalingga Street Art (PUSAR). Jenis penelitian ini adalah kuantitatif quasi eksperimen. Untuk mengukur tingkat stress, instrumen yang digunakan adalah skala Depression Anxiety Stress Scale (DASS). Perbedaan stress tersebut dianalisis menggunakan uji wilcoxon signed rank. Hasil penelitian menyatakan bahwa graffiti dan mural dapat menimbulkan rasa senang serta ketenangan ketika artist memegang pilox (cat semprot) pada obyek tembok. Kemudian, ada sebuah titik dalam pembuatan graffiti yang membuat seorang artist graffiti merasa puas untuk mengungkapkan dan mengekspresikan emosi dari dalam dirinya. Sehingga yang membuat graffiti dan mural dapat mengatasi masalah dan menimbulkan rasa senang adalah saat semua emosi dapat diluapkan ke karyanya. Selanjutnya, setiap anggotakomunitas Purbalingga Street Art (PUSAR) dengan tingkat stress yang berbeda mendapatkan hasil yang berbeda pula. Hasil uji statistik menunjukan perbedaan atau penurunan tingkat stress yang signifikan pada subjek penelitian dengan hasil p value = 0,011 (p value < 0,05), sehingga hipotesis diterima.

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