scholarly journals The association of Coronavirus Disease-19 mortality and prior bacille Calmette-Guerin vaccination: a robust ecological evaluation using unsupervised machine learning

2020 ◽  
Author(s):  
Nathan A Brooks ◽  
Ankur Puri ◽  
Sanya Garg ◽  
Swapnika Nag ◽  
Noshir Kaka ◽  
...  

Abstract Population-level data have suggested that bacille Calmette-Guerin (BCG) vaccination may lessen the severity of Coronavirus Disease-19 (COVID-19) prompting clinical trials in this area. Some reports have demonstrated conflicting results. We performed a robust, ecologic analysis comparing COVID-19 related mortality (CSM) between strictly selected countries based on BCG vaccination program status utilizing publicly available databases and machine learning to define the association between active BCG vaccination programs and CSM. Validation was performed using linear regression and country-specific modeling. CSM was lower for 80% of similarly clustered countries with a BCG vaccination policy for at least the preceding 15 years (BCG15). CSM increased significantly for each increase in the percent population over age 65. The total population of a country and BCG15 were significantly associated with improved CSM. There was a consistent association between countries with a BCG vaccination for the preceding 15 years, but not other vaccination programs, and CSM.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nathan A. Brooks ◽  
Ankur Puri ◽  
Sanya Garg ◽  
Swapnika Nag ◽  
Jacomo Corbo ◽  
...  

AbstractPopulation-level data have suggested that bacille Calmette-Guerin (BCG) vaccination may lessen the severity of Coronavirus Disease-19 (COVID-19) prompting clinical trials in this area. Some reports have demonstrated conflicting results. We performed a robust, ecologic analysis comparing COVID-19 related mortality (CRM) between strictly selected countries based on BCG vaccination program status utilizing publicly available databases and machine learning methods to define the association between active BCG vaccination programs and CRM. Validation was performed using linear regression and country-specific modeling. CRM was lower for the majority of countries with a BCG vaccination policy for at least the preceding 15 years (BCG15). CRM increased significantly for each increase in the percent population over age 65. A higher total population of a country and BCG15 were significantly associated with improved CRM. There was a consistent association between countries with a BCG vaccination for the preceding 15 years, but not other vaccination programs, and CRM. BCG vaccination programs continued to be associated with decreased CRM even for populations < 40 years old where CRM events are less frequent.


2020 ◽  
Author(s):  
Nathan A. Brooks ◽  
Ankur Puri ◽  
Sanya Garg ◽  
Swapnika Nag ◽  
Jacomo Corbo ◽  
...  

Abstract Population-level data have suggested that bacille Calmette-Guerin (BCG) vaccination may lessen the severity of COVID-19; prior reports have demonstrated conflicting results. We leveraged publicly available databases and unsupervised machine learning, adjusting for established confounders designated a priori, to assign countries into similar clusters. The primary outcome was the association of deaths per million related to COVID-19 (CSM) 30 days after each included country reported 100 cases with several factors including vaccination. Validation was performed using linear regression and country-specific modeling. This protocol details the statistical analyses used to establish an association between BCG vaccination and CSM, which includes : Definition of the target function, data processing, exploratory factor analysis for variable selection, k-means clustering and step wise linear regression for validation. This protocol is differentiated from previous works on the same subject by its' comprehensive nature which considers the effect of several confounding variables while studying the association between BCG vaccination and CSM. There are still several potential measured and unmeasured confounding variables which could not be included in this study. It is also unclear if the protection from neonatal vaccination with BCG is transferable to those receiving vaccination as an adult and how long such protection lasts. The authors advise caution against routine BCG vaccination for the prevention of COVID-19 until prospective trials are completed.


2020 ◽  
Author(s):  
Norifumi Kuratani

A possible association between national Bacille Calmette-Guérin (BCG) vaccination policy and lower COVID-19 incidence has been suggested in some preprint papers. Using publicly accessible databases, I explored associations of national BCG vaccination policy with COVID-19 epidemiology in 78 countries. Data collection was conducted from April 25 to May 5, 2020. I compared countries that have a current universal BCG vaccination policy (BCG countries), with countries that currently lack such a policy (non-BCG countries). The mixed effect model revealed national BCG policy decreases in the country-specific risk of death by COVID-19, correspond to odds ratio of 0.446 (95% confidence intervals 0.323 - 0.614, P =1×10-5). In BCG countries, the case increase rate was attenuated marginally by 25.4% (95% CI 3.0 to 42.7, P=0.029) as compared with those of the non-BCG countries. Although the protective mechanism of BCG vaccination against COVID-19 remains unknown, further laboratory and clinical research should be warranted.


2019 ◽  
Author(s):  
Suranga N Kasthurirathne ◽  
Shaun Grannis ◽  
Paul K Halverson ◽  
Justin Morea ◽  
Nir Menachemi ◽  
...  

BACKGROUND Emerging interest in precision health and the increasing availability of patient- and population-level data sets present considerable potential to enable analytical approaches to identify and mitigate the negative effects of social factors on health. These issues are not satisfactorily addressed in typical medical care encounters, and thus, opportunities to improve health outcomes, reduce costs, and improve coordination of care are not realized. Furthermore, methodological expertise on the use of varied patient- and population-level data sets and machine learning to predict need for supplemental services is limited. OBJECTIVE The objective of this study was to leverage a comprehensive range of clinical, behavioral, social risk, and social determinants of health factors in order to develop decision models capable of identifying patients in need of various wraparound social services. METHODS We used comprehensive patient- and population-level data sets to build decision models capable of predicting need for behavioral health, dietitian, social work, or other social service referrals within a safety-net health system using area under the receiver operating characteristic curve (AUROC), sensitivity, precision, F1 score, and specificity. We also evaluated the value of population-level social determinants of health data sets in improving machine learning performance of the models. RESULTS Decision models for each wraparound service demonstrated performance measures ranging between 59.2%% and 99.3%. These results were statistically superior to the performance measures demonstrated by our previous models which used a limited data set and whose performance measures ranged from 38.2% to 88.3% (behavioural health: F1 score <i>P</i>&lt;.001, AUROC <i>P</i>=.01; social work: F1 score <i>P</i>&lt;.001, AUROC <i>P</i>=.03; dietitian: F1 score <i>P</i>=.001, AUROC <i>P</i>=.001; other: F1 score <i>P</i>=.01, AUROC <i>P</i>=.02); however, inclusion of additional population-level social determinants of health did not contribute to any performance improvements (behavioural health: F1 score <i>P</i>=.08, AUROC <i>P</i>=.09; social work: F1 score <i>P</i>=.16, AUROC <i>P</i>=.09; dietitian: F1 score <i>P</i>=.08, AUROC <i>P</i>=.14; other: F1 score <i>P</i>=.33, AUROC <i>P</i>=.21) in predicting the need for referral in our population of vulnerable patients seeking care at a safety-net provider. CONCLUSIONS Precision health–enabled decision models that leverage a wide range of patient- and population-level data sets and advanced machine learning methods are capable of predicting need for various wraparound social services with good performance.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
László Németh ◽  
Domantas Jasilionis ◽  
Henrik Brønnum-Hansen ◽  
Dmitri A. Jdanov

Abstract Background The lack of classification by educational attainment in death and population exposure data at older ages is an important constraint for studying changes and patterns of mortality disparities by education in Denmark and Sweden. The missing educational distribution of population also restricts analyses aiming at estimating contributions of compositional change to the improvements in national longevity. This study proposes a transparent approach to solve the two methodological issues allowing to obtain robust education-specific mortality estimates and population weights. Methods Using nonparametric approach, we redistribute the unknown cases and extrapolate the mortality curves of these sub-populations with the help of population-level data on an aggregate level from the Human Mortality Database. Results We present reconstructed and harmonized education-specific abridged and complete life tables for Sweden and Denmark covering 5-year-long periods from 1991–1995 to 2011–2015. The newly estimated life tables are in good agreement with the national life tables and show plausible age- and education-specific patterns. The observed changes in life expectancy by education suggest about the widening longevity gap between the highest and lowest educated for males and females in both countries. Conclusions The proposed simple and transparent method can be applied in similar country-specific cases showing large proportions of missing education or other socio-economic characteristics at older ages.


10.2196/16129 ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. e16129 ◽  
Author(s):  
Suranga N Kasthurirathne ◽  
Shaun Grannis ◽  
Paul K Halverson ◽  
Justin Morea ◽  
Nir Menachemi ◽  
...  

Background Emerging interest in precision health and the increasing availability of patient- and population-level data sets present considerable potential to enable analytical approaches to identify and mitigate the negative effects of social factors on health. These issues are not satisfactorily addressed in typical medical care encounters, and thus, opportunities to improve health outcomes, reduce costs, and improve coordination of care are not realized. Furthermore, methodological expertise on the use of varied patient- and population-level data sets and machine learning to predict need for supplemental services is limited. Objective The objective of this study was to leverage a comprehensive range of clinical, behavioral, social risk, and social determinants of health factors in order to develop decision models capable of identifying patients in need of various wraparound social services. Methods We used comprehensive patient- and population-level data sets to build decision models capable of predicting need for behavioral health, dietitian, social work, or other social service referrals within a safety-net health system using area under the receiver operating characteristic curve (AUROC), sensitivity, precision, F1 score, and specificity. We also evaluated the value of population-level social determinants of health data sets in improving machine learning performance of the models. Results Decision models for each wraparound service demonstrated performance measures ranging between 59.2%% and 99.3%. These results were statistically superior to the performance measures demonstrated by our previous models which used a limited data set and whose performance measures ranged from 38.2% to 88.3% (behavioural health: F1 score P<.001, AUROC P=.01; social work: F1 score P<.001, AUROC P=.03; dietitian: F1 score P=.001, AUROC P=.001; other: F1 score P=.01, AUROC P=.02); however, inclusion of additional population-level social determinants of health did not contribute to any performance improvements (behavioural health: F1 score P=.08, AUROC P=.09; social work: F1 score P=.16, AUROC P=.09; dietitian: F1 score P=.08, AUROC P=.14; other: F1 score P=.33, AUROC P=.21) in predicting the need for referral in our population of vulnerable patients seeking care at a safety-net provider. Conclusions Precision health–enabled decision models that leverage a wide range of patient- and population-level data sets and advanced machine learning methods are capable of predicting need for various wraparound social services with good performance.


Author(s):  
Jan A. Paredes ◽  
Valeria Garduño ◽  
Julian Torres

AbstractThe coronavirus disease 2019 (COVID-19) pandemic has become a worldwide emergency. In the attempt to search for interventions that would improve outcomes, some studies have looked at the potential benefit of BCG vaccination. These past studies have found a statistically significant reduction in COVID-19 related mortality in countries with a current universal bacille Calmette-Guérin (BCG) vaccination policy. However, just as the authors themselves noted, the nature of ecological studies make them very prone to the presence of several confounders. This paper took into account demographic differences, economic differences and the different stages of the pandemic in each country; gathering data from publicly available sources. It was found that no statistically significant difference exists in mortality rates between countries with a current or prior BCG vaccination policy when compared to those that never had such a program. Nevertheless, the immunostimulatory potential of the BCG vaccine might still prove useful in the development of future vaccines or other prophylactic measures.


2020 ◽  
Author(s):  
Yue-Cune Chang

BACKGROUND The Coronavirus Disease-19 (COVID-19) is the new form of an acute infectious respiratory disease and has quickly spread over most continents in the world. Recently, it has been shown that Bacille Calmette-Guerin (BCG) might protect against COVID-19. This study aims to investigate the possible correlation between BCG vaccination and morbidity/mortality/recovery rate associated with COVID-19 infection. OBJECTIVE Our findings confirm that the BCG vaccination might protect against COVID-19 virus infection. METHODS Data of COVID-19 confirmed cases, deaths, recoveries, and population were obtained from https://www.worldometers.info/coronavirus/ (Accessed on 12 June, 2020). To have meaningful comparisons among countries’ mortality and recovery rates, we only choose those countries with COVID-19 infected cases at least 200. The Poisson regression and logistic regression were used to explore the relationship between BCG vaccination and morbidity, mortality and recovery rates. RESULTS Among those 158 countries with at least 200 COVID-19 infected cases, there were 141 countries with BCG vaccination information available. The adjusted rates ratio of COVID-19 confirmed cases for Current BCG vaccination vs. non-Current BCG vaccination was 0.339 (with 95% CI= (0.338,0.340)). Moreover, the adjusted odds ratio (OR) of death and recovery after coronavirus infected for Current BCG vaccination vs. non-Current BCG vaccination were 0.258 (with 95% CI= (0.254,0.261)) and 2.151 (with 95% CI= (2.140,2.163)), respectively. CONCLUSIONS That data in this study show the BCG might provide the protection against COVID-19, with consequent less COVID-19 infection and deaths and more rapid recovery. BCG vaccine might bridge the gap before the disease-specific vaccine is developed, but this hypothesis needs to be further tested in rigorous randomized clinical trials. INTERNATIONAL REGISTERED REPORT RR2-https://doi.org/10.1101/2020.06.14.20131268


2020 ◽  
Author(s):  
Carson Lam ◽  
Jacob Calvert ◽  
Gina Barnes ◽  
Emily Pellegrini ◽  
Anna Lynn-Palevsky ◽  
...  

BACKGROUND In the wake of COVID-19, the United States has developed a three stage plan to outline the parameters to determine when states may reopen businesses and ease travel restrictions. The guidelines also identify subpopulations of Americans that should continue to stay at home due to being at high risk for severe disease should they contract COVID-19. These guidelines were based on population level demographics, rather than individual-level risk factors. As such, they may misidentify individuals at high risk for severe illness and who should therefore not return to work until vaccination or widespread serological testing is available. OBJECTIVE This study evaluated a machine learning algorithm for the prediction of serious illness due to COVID-19 using inpatient data collected from electronic health records. METHODS The algorithm was trained to identify patients for whom a diagnosis of COVID-19 was likely to result in hospitalization, and compared against four U.S policy-based criteria: age over 65, having a serious underlying health condition, age over 65 or having a serious underlying health condition, and age over 65 and having a serious underlying health condition. RESULTS This algorithm identified 80% of patients at risk for hospitalization due to COVID-19, versus at most 62% that are identified by government guidelines. The algorithm also achieved a high specificity of 95%, outperforming government guidelines. CONCLUSIONS This algorithm may help to enable a broad reopening of the American economy while ensuring that patients at high risk for serious disease remain home until vaccination and testing become available.


2021 ◽  
Vol 10 (11) ◽  
pp. 2314
Author(s):  
Mikolaj Przydacz ◽  
Marcin Chlosta ◽  
Piotr Chlosta

Objectives: Population-level data are lacking for urinary incontinence (UI) in Central and Eastern European countries. Therefore, the objective of this study was to estimate the prevalence, bother, and behavior regarding treatment for UI in a population-representative group of Polish adults aged ≥ 40 years. Methods: Data for this epidemiological study were derived from the larger LUTS POLAND project, in which a group of adults that typified the Polish population were surveyed, by telephone, about lower urinary tract symptoms. Respondents were classified by age, sex, and place of residence. UI was assessed with a standard protocol and established International Continence Society definitions. Results: The LUTS POLAND survey included 6005 completed interviews. The prevalence of UI was 14.6–25.4%; women reported a greater occurrence compared with men (p < 0.001). For both sexes, UI prevalence increased with age. Stress UI was the most common type of UI in women, and urgency UI was the most prevalent in men. We did not find a difference in prevalence between urban and rural areas. Individuals were greatly bothered by UI. For women, mixed UI was the most bothersome, whereas for men, leak for no reason was most annoying. More than half of respondents (51.4–62.3%) who reported UI expressed anxiety about the effect of UI on their quality of life. Nevertheless, only around one third (29.2–38.1%) of respondents with UI sought treatment, most of whom received treatment. Persons from urban and rural areas did not differ in the degrees of treatment seeking and treatment receiving. Conclusion: Urinary incontinence was prevalent and greatly bothersome among Polish adults aged ≥ 40 years. Consequently, UI had detrimental effects on quality of life. Nonetheless, most affected persons did not seek treatment. Therefore, we need to increase population awareness in Poland about UI and available treatment methods, and we need to ensure adequate allocation of government and healthcare system resources.


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