scholarly journals Recombinant interleukin-2 stimulates lymphocyte recovery in severe patients with COVID-19

2020 ◽  
Author(s):  
Meng‘en Zhu ◽  
Qian Wang ◽  
Shaoqiong Zhou ◽  
Bin Wang ◽  
Li Ke ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Laboratory Data ◽  
Control Group ◽  
Regular Treatment ◽  
Reactive Protein ◽  
Significant Difference ◽  
Before And After ◽  
Recombinant Interleukin 2 ◽  
The Difference ◽  
Control Study

Abstract Object: A recently developing pneumonia called COVID-19 which caused by SARS-CoV-2 has quickly spread across the world. Lymphopenia and a proinflammatory cytokine storm frequently happened in severe COVID-19 patients. But no specific immunomodulate therapy on COVID-19 had been reported. In this retrospect case control study, we observed the potential therapeutic effect of recombinant human interleukin-2 (rIL-2) on severe COVID-19 patients in a hospital in Wuhan, China. Methods: Fifty nine severe cases with COVID-19 admitted in hospital from January 29, 2020 to February 29, 2020 were included in this study. Twenty patients received a one-week to 10 days subcutaneous injection of the recombinant human interleulin-2 1 million IU per day other than regular treatment were classified as rIL-2 group. Twenty from thirty nine patients with regular treatment without intervention of rIL-2 were matched as the control group. Clinical characteristic such as age, gender, symptoms, signs, laboratory data and comorbidities were paired in these two groups. Changes of lymphocytes counts, IL-6 and C- reactive protein (CRP) before and after rIL-2 treatment and differences between rIL-2 group and non-rIL-2 group were analyzed.Results: There were a clearly visible increasing in lymphocyte counts and a decreasing in CRP level in non rIL-2 group and rIL-2 group. The difference of the change of lymphocyte counts were significant in rIL-2 group and non-rIL-2 group (p<0.01). Though CRP decreased more in rIL-2 group, it did not show a significant difference between the two groups (p>0.05).Conclusion: RIL-2 might be a prospective adjuvant therapy for severe COVID-19 patients by increasing lymphocytes number.

scholarly journals The difference in saliva pH before and after brushing with fluoride containing toothpaste and without toothpaste

2008 ◽  
Vol 20 (3) ◽  
Author(s):  
Samuel Setiawan ◽  
Edeh Rolleta Haroen ◽  
Dede Hadidjah
Keyword(s):  
Drinking Water ◽  
Research Method ◽  
Control Group ◽  
Research Subjects ◽  
Male And Female ◽  
Significant Difference ◽  
Salivary Ph ◽  
Before And After ◽  
Quasi Experimental ◽  
The Difference

In administering fluoride through drinking water there is the risk of overdose, higher cost and inadequate availability of drinking water containing fluoride in developing countries like Indonesia. A safe fluoride source is contained in toothpaste. The purpose of this research was to obtain data concerning difference in saliva pH before and after brushing with toothpaste containing fluoride and without toothpaste. The research method used was the quasi-experimental method. Samples were collected by the way of purposive sampling, conducted on 43 male and female research subjects. The data were analyzed by statistical analysis using the t test at 95% confidence level. In this research a control group consisting of 43 people was used. Research results indicated that the average saliva pH before brushing was 7.174; after brushing with fluoride containing toothpaste salivary pH was 7.593. Result research of brushing without toothpaste showed an average saliva of 7.163 before brushing and 7.379 after brushing without toothpaste. The average changes in saliva pH before and after brushing using fluoride containing toothpaste was 0.216. The conclusion of this research was that there was significant difference in saliva pH before and after brushing with toothpaste containing fluoride; there was significant difference in saliva pH before and after brushing without toothpaste, and there was significant difference in saliva pH before and after brushing with toothpaste containing fluoride and without toothpaste.

scholarly journals OHIS Differences on Primary School Students in Relation to Little Dentist Training

2021 ◽  
Author(s):  
Asep Arifin Senjaya ◽  
Ni Made Sirat ◽  
I Nyoman Wirata ◽  
Ni Ketut Ratmini
Keyword(s):  
Treatment Group ◽  
Primary School ◽  
Oral Hygiene ◽  
Dental Health ◽  
Control Group ◽  
Primary School Students ◽  
School Students ◽  
Significant Difference ◽  
Before And After ◽  
The Difference

Dental healthcare is very important since dental and oral hygiene should be maintained. Statistics showed that more than 80% of children in developed and developing countries suffer from dental disease. This study aimed to see the safety of OHIS (Oral Hygiene Index Simplified) in primary school students who got and did not get little dentist cadre training in Bangli Regency in 2019. The study was done in an experimental design: pre and post-test with control design, which was conducted in August-September 2019. The sample in this study is 366 students. The difference in OHIS scores before and after treatment in the control group and treatment group was carried out by the bivariate Mann Whitney U Test. The results of the study showed that before dental health training was conducted, there were 54.3% of primary school students in the treatment group with good OHIS score criteria, and after the training was carried out as many as 98.4% of the students in the treatment group had a good OHIS. Additionally, prior to the training, 57.5% of the control group had fair OHIS criteria score. Then, after the training was carried out, 73.7% of the control group had good OHIS score. Hence, the study concluded that there was a significant difference in the OHIS of primary school students who got little doctor training prior to and after the training. Also, there was a significant difference in the OHIS of the students who did not get such treatment before and after the training.

Is There a Relationship between Patellofemoral Alignment and Osgood–Schlatter Disease? A Case-Control Study

2018 ◽  
Vol 33 (01) ◽  
pp. 067-072 ◽  
Author(s):  
Fırat Seyfettinoğlu ◽  
Özkan Köse ◽  
Hasan Ulaş Oğur ◽  
Ümit Tuhanioğlu ◽  
Hakan Çiçek ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Radiographic Examination ◽  
Control Group ◽  
Etiologic Factor ◽  
Full Extension ◽  
Significant Difference ◽  
Patellofemoral Alignment ◽  
The Difference ◽  
Control Study

AbstractThis study was aimed to investigate the role of anatomic variations in patellofemoral alignment in patients with or without Osgood-Schlatter disease (OSD) and to determine the potential anatomic risk factors that may play role in the etiology. This prospective observational case-control study was conducted on two groups of adolescent patients. Group 1 comprised patients who were diagnosed as having OSD and group 2 consisted of an equal number of age-matched patients who presented to the outpatient clinic with traumatic knee injury and underwent knee radiographic examination but without a diagnosis of OSD. Age, height, weight, body mass index (BMI), dominant side, and level of sporting activity were recorded. Quadriceps (Q) angles were measured using a long-arm goniometer with patients lying in the supine position with their knees in full extension and contracting the Q muscles. On anteroposterior, lateral knee, and tangential patella (Merchant and Laurin views) radiographs, the following measurements were performed: Insall–Salvati (IS), Caton–Deschamps (CD), and Blackburne–Peel (BP) indexes, congruence angles, lateral patellofemoral angles, sulcus angles, and patella type according to Grelsamer's morphology classification. Both groups were similar in respect of age (p = 0.160), sex (p = 0.311), height (p = 0.326), weight (p = 0.596), BMI (p = 0.153), and dominancy (p = 0.500). The rate of patients engaged in sports activities was significantly greater in the OSD group (p = 0.003). No significant difference was determined between the groups in respect to IS index, CD index, BP index, sulcus angle, lateral patellofemoral angle, and congruence angle (p–values: 0.358, 0.995, 0.912, 0.802, 1.000, and 0.907, respectively). The mean Q angle was measured as 15.6 ± 2.2 degrees in the OSD group and 14.3 ± 2.5 degrees in the control group (p = 0.014). Despite the difference being statistically significant, it was clinically insignificant because the difference was only 1.3 degrees. The principle etiologic factor seems to be increased physical activity rather than subtle variations is patellofemoral anatomy and alignment of extensor mechanism.

scholarly journals A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement

2021 ◽  
Author(s):  
Zahra Alizadeh ◽  
Nastaran Keyhanian ◽  
Sara Ghaderkhani ◽  
Simin Dashti-Khavidaki ◽  
Raheleh Shokouhi Shoormasti ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Intervention Group ◽  
Control Group ◽  
Low Light ◽  
Reactive Protein ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
To Receive ◽  
Chest Ct Scan

No effective antiviral drugs and vaccines are available for the treatment of patients with severe coronavirus 2019 (COVID-19). Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation. We did a randomized, single-blind study in Imam Khomeini Hospital between June 30, 2020, and August 5, 2020. Mild to moderate COVID-19 patients aged 25-65 years were eligible to enter the study based on chest CT scan, clinical symptoms, and physician diagnosis. The intervention group was prescribed 6 mg of oral melatonin for 2 weeks, which consumed half an hour before bedtime every night in low light conditions. Clinical symptoms and C-reactive protein (CRP) were measured before and after treatment in the melatonin received and control (regular medications) groups. Among screened patients with COVID-19, 14 patients were assigned to receive melatonin, and 17 patients were considered as controls. A significant difference (p=0.005) between CRP 1 and CRP 2 levels (before and after using melatonin) was found in the melatonin group while this difference (p=0.069) was not significant in the control group. Also, the percentage of recovery (based on symptoms) in patients who took melatonin was higher than that of patients in the control group (85.7% VS 47.1%).  The result of this study confirmed the effectiveness of melatonin in mild to moderate outpatients with COVID-19. More clinical trials on elderly, diabetic, obese patients and severe cases are suggested in future studies.   

scholarly journals Comparative Therapeutic Efficacy and Safety of Remdesivir monotherapy and its Combination of Lopinavir/Ritonavir in COVID-19 Patients

2021 ◽  
Author(s):  
Marian Boshra ◽  
haitham saeed ◽  
Ahmed E. Abou Warda ◽  
Rania Sarhan
Keyword(s):  
Therapeutic Efficacy ◽  
Laboratory Data ◽  
Efficacy And Safety ◽  
Once Daily ◽  
Infection Treatment ◽  
Significant Difference ◽  
Before And After ◽  
The Difference ◽  
Severity Of The Disease ◽  
Enzyme Elevation

Objectives: The treatment of COVID-19 infection remains a challenge because till now, there is no approved therapy for it. This study aimed to estimate the difference in the therapeutic efficacy and safety between remdesivir as monotherapy and its use in combination with lopinavir/ritonavir provided with standard supportive care. Methods: This is a prospective randomized cohort study included 1043 adult patients with confirmed moderate and severe COVID-19 infection. Treatment of all patients followed Egyptian Ministry of Health COVID-19 protocol as the first group received IV remdesivir 200 mg on day 1, followed by 100 mg once daily, for 5 days while the second group received lopinavir/ritonavir 400/100 mg twice daily, for 5 days with the same remdesivir regimen in the first group. All laboratory and clinical parameters were assessed before and after treatment duration. Results: There was no significant difference related to improvement parameters such as laboratory data and improvement time between the two groups. On the other hand, hepatotoxicity of the second group (combination) was significantly higher compared with that of the first one. The elevation on liver enzymes was affected by the severity of the disease, the severe cases showed a high enzyme elevation rate. Conclusion: Remdesivir as monotherapy and its use in combination with lopinavir/ritonavir is effective in the management of moderate COVID 19 subjects than severe cases. The combination of remdesivir with lopinavir/ritonavir is not recommended due to the increased hepatotoxicity effect.

scholarly journals Dialyzable Leukocyte Extract (Transferon™) Administration in Sepsis: Experience from a Single Referral Pediatric Intensive Care Unit

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Maria Isabel Castrejón Vázquez ◽  
Aldo Arturo Reséndiz-Albor ◽  
Mario A. Ynga-Durand ◽  
Ivonne Maciel Arciniega Martínez ◽  
Vanessa Ivonne Orellana-Villazon ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pediatric Intensive Care Unit ◽  
Laboratory Data ◽  
Pediatric Intensive Care ◽  
Control Group ◽  
Immunomodulatory Agents ◽  
Reactive Protein ◽  
Significant Difference ◽  
Pediatric Sepsis

Immunomodulatory agents have been proposed as therapeutic candidates to improve outcomes in sepsis. Transferon™, a dialyzable leukocyte extract (DLE), has been supported in Mexico as an immunomodulatory adjuvant in anti-infectious therapy. Here we present a retrospective study describing the experience of a referral pediatric intensive care unit (PICU) with Transferon™ in sepsis. We studied clinical and laboratory data from 123 patients with sepsis (15 in the DLE group and 108 in the control group) that were admitted to PICU during the period between January 2010 and December 2016. Transferon™ DLE use was associated with lower C reactive protein (CRP), increase in total lymphocyte counts (TLC), and decrease in total neutrophil count (TNC) 72 hours after Transferon™ DLE administration. The control group did not present any significant difference in CRP values and had lower TLC after 72 hours of admission. There was no difference in PICU length of stay between control and Transferon™ DLE group. Transferon™ DLE administration was associated with a higher survival rate at the end of PICU stay. This study shows a possible immunomodulatory effect of Transferon™ on pediatric sepsis patients.

Comparing the effects of cold compress and Xyla-p cream on hemodynamic changes in hemodialysis patients during venipuncture

2019 ◽  
Vol 17 (2) ◽  
Author(s):  
Ziba Ghoreyshi ◽  
Monireh Amerian ◽  
Farzaneh Amanpour ◽  
Reza Mohammadpourhodki ◽  
Hossein Ebrahimi
Keyword(s):  
Blood Pressure ◽  
Physiological State ◽  
Vital Signs ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Intermittent Hemodialysis ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
The Difference

AbstractBackgroundThe vital signs reflect the physiological state of patients in various clinical conditions. The purpose of this study was to compare the effects of cold compress and Xyla-P cream on hemodynamical changes during venipuncture in hemodialysis patients.Methods and MaterialIn this clinical trial study, 50 patients under hemodialysis were selected by simple random sampling. The patients were then randomly assigned to either Xyla-P cream, cold compress or placebo groups. The vital signs (blood pressure and pulse) were measured upon two intermittent hemodialysis sessions before and after venipuncture. Data were analyzed using repeated measures analysis of variance.ResultsThe mean alternation in systolic blood pressure was significantly different comparing the placebo and cold compress groups before and after intervention (p<0.001). However, the difference was not significant between the Xyla-P cream group and either placebo (p=0.402) or ice compress (p=0.698) groups. The difference of the mean diastolic blood pressure was significant comparing the placebo group with either the Xyla-P cream group (p=0.003) or cold compress group (p<0.001) before and after intervention. In addition, there was a significant difference in the mean number of heartbeats comparing the control group with either the Xyla-P cream group (p<0.001) or cold compress group (p<0.001) before and after the intervention.ConclusionsConsidering the beneficial effects of ice compress and the Xyla-P cream on reduction of cardiovascular parameters, it is recommended to use these methods in hemodialysis patients during venipuncture.

scholarly journals Cephalometric Changes Following Maxillary Expansion with Ni-Ti Leaf Springs Palatal Expander and Rapid Maxillary Expander: A Retrospective Study

2021 ◽  
Vol 11 (12) ◽  
pp. 5748
Author(s):  
Valentina Lanteri ◽  
Andrea Abate ◽  
Davide Cavagnetto ◽  
Alessandro Ugolini ◽  
Francesca Gaffuri ◽  
...  
Keyword(s):  
Los Angeles ◽  
Leaf Spring ◽  
Control Group ◽  
Maxillary Expansion ◽  
Average Decrease ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
Before And After ◽  
The Difference ◽  
One Way Anova

Background: The aim of this study is to evaluate and compare, through bidimensional cephalometry, skeletal and dental changes obtained from a rapid maxillary expander (RME) and a Ni-Ti leaf spring expander (Leaf) and compare them with an untreated control group. Methods: Records consisted of lateral cephalograms obtained before and after maxillary expansion of patients that underwent orthodontic treatment at the Department of Biomedical, Surgical and Dental Sciences. The Leaf expander group consisted of 9 males (mean age = 7.5 ± 0.9 years old) and 11 females (mean age = 8.2 ± 0.6 years old). The RME group of the present study was composed of 11 males (mean age = 7.8 ± 0.6 years old) and 12 females (mean age = 8.1 ± 0.5 years old). Digital cephalograms were traced using Dolphin Imaging software v.11.1 (Dolphin Imaging and Management Solutions; Los Angeles, CA, USA), which calculated all reported measurements. Each subject was assigned a random identification number, and the examiner was blinded to the subject when measuring. The difference between the two experimental times in all groups was evaluated using the Student’s t-test for dependent variables. The difference between the two evaluation times in each group for all the variables was used to perform a one-way ANOVA test between the three groups. Results: No statistically significant difference was noted, apart from the angle between the upper incisor and the SN and PP planes, which showed an average decrease of 3.25 and 2.55, respectively, and the angle between the lower incisors and the mandibular plane, which showed an average increase of 2.85 degrees. The one-way ANOVA showed no statistically significant difference between the three groups. Conclusions: It appears that the leaf expander and the RME present similar effects such as dental and skeletal changes.

scholarly journals THE IMPACT OF GREAT MOM GREAT CHILDREN TRAINING TO IMPROVE YOUNG STREET MOTHER STIMULATION SKILL

2018 ◽  
Author(s):  
Dessy Pranungsari ◽  
Nissa Tarnoto ◽  
Fatwa Tentama
Keyword(s):  
Unwanted Pregnancy ◽  
Test Sample ◽  
Wilcoxon Test ◽  
Control Group ◽  
Control Group Design ◽  
Group Participant ◽  
Significant Difference ◽  
Before And After ◽  
The Difference ◽  
The Impact

The objective of this research is to examine the impact of “Great Mom Great Children” training to improve young street mother stimulation skill. The subjects of the research are from Yogyakarta. They are young homeless mothers who are commonly referred to as a street mother, young mothers who are less than 18 years old, mothers for unwanted pregnancy, mothers who have 0 to 5 years old children and mothers who are upbringing their children themselves. The experiment design used in this research is untreated control group design with dependent pretest and post-test sample. The data is collected by using Children Stimulation Skill Development Scale. The researchers perform Wilcoxon Test to examine the difference between stimulation skill level before and after the test. The result suggested that there was a significant difference before and after the treatment was given. It can be seen from Z=-1,755 and p=0,079) (2-tailed)/0, 0395 (1-tailed) with p&lt;0.05. Also, the result of Mann Whitney U-test showed that the average level of stimulation skill in experiment group participant was higher than that of control group participant with the result of pretest-posttest (p= 0,074 (2-tailed)/ p= 0.037 (1-tailed) where p&lt;0.05 which meant significant. In conclusion,“Great Mom Great Children” training is an effective method to improve children’ stimulation skill for young street mothers.

scholarly journals Intravenous Immunoglobulin for Treatment of Patients with COVID-19: A Case-control Study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Rozita Khodashahi ◽  
HamidReza Naderi ◽  
Alireza Sedaghat ◽  
Abolghasem Allahyari ◽  
Soroush Sarjamee ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Case Control Study ◽  
Case Control ◽  
Therapeutic Effects ◽  
C Reactive Protein ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Significant Difference ◽  
Before And After ◽  
Control Study

Background: It seems that the risk of developing complications associated with coronavirus disease 2019 (COVID-19) is higher among individuals with weakened immune systems. Objectives: Therefore, this study was carried out to determine the effectiveness of intravenous immunoglobulin (IVIG) for the treatment of patients not entering the intubation phase compared to those entering the intubation phase. Methods: This descriptive case-control study was performed on 26 patients with COVID-19 referring to Imam Reza hospital in Mashhad, Iran, in March 2020. For subjects with COVID-19 not responding to the standard three-drug protocol (i.e., ribavirin, hydroxychloroquine, and lopinavir/ritonavir), three doses of IVIG (0.4 g/kg/day) were added to the protocol. The patients were divided into two groups of subjects not entering the intubation phase and those entering the intubation phase and compared in terms of different variables. Results: The comparison of laboratory findings showed a significant difference before and after receiving IVIG regarding oxygen saturation (P < 0.005), white blood cell (P = 0.001), hemoglobin level (P = 0.0002), lymphocyte count (P = 0.03), and C-reactive protein (P = 0.001). In general, 53.8% and 46.2% of the patients were discharged and expired, respectively. All the subjects not entering the intubation phase were recovered; nevertheless, only one case entering the intubation phase was recovered, and 92.3% of the patients expired. A significant difference was observed between the patients not entering the intubation phase and those entering the intubation phase in terms of mortality (χ2 = 22.28; P < 0.005). Conclusions: In summary, the obtained results of the current study confirmed the therapeutic effects of IVIG on patients with COVID-19. Moreover, better treatment results, shorter hospital stay, and lower mortality rates were observed among COVID-19 patients who did not enter the intubation phase in comparison with those entering the intubation phase.

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