scholarly journals An Exploratory Cohort Study of the Association Between the Level of Testosterone and Suicidal Ideation in the Hospitalized Adolescent Female With Depression in China

Author(s):  
Yan Liu ◽  
Shaohua Wang ◽  
Chuang Xue ◽  
Xiwen Hu ◽  
Guoling Zhou ◽  
...  

Abstract BackgroundTo date, around 4 per 100, 000 adolescent committed suicide within the 29 OECD countries. The suicidal behavior is related to psychological factors, genetics, neurobiology, and other biomarkers. We aimed to investigate the risk factors for the suicidal ideation, especially the association between suicide ideation and different levels of testosterone in the adolescent female with depression. The goal of this study is to aid the development of strategies to intervene the suicidal behavior for the depressed female adolescent. MethodIn this single center, prospective cohort study, we enrolled adolescent female with depression. We collected baseline demographic data, age adjusted level of testosterone, Symptom Self-rating Scale, and information about the suicidal ideation, non-suicidal self-injury (NSSI), and suicide attempt. We used multivariate logistic regression to determine the risk factors for the suicidal ideation. ResultsTotal 113 hospitalized adolescent female enrolled with a mean age of 13.5 (1.20). Among these patients, there were 86 (76.1%) subjects suffered from the suicidal ideation, while 59 (52.2%) of them had NSSI and 23 (20.4%) had suicide attempt behavior. In the final model, higher level of testosterone (p = 0.04) and higher age (p = 0.02) were associated with the higher odds of having suicidal ideation.ConclusionIn this exploratory cohort study, suicidal ideation was prevalent. It is important to assess the level of testosterone in the adolescent female with depression. This study is consistent with the other studies. It shows the age is a potential predictor for the suicidal ideation in the hospitalized adolescent female with depression.

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yan Liu ◽  
Shaohua Wang ◽  
Chuang Xue ◽  
Xiwen Hu ◽  
Guoling Zhou ◽  
...  

Background. To date, around 4 per 100,000 adolescents committed suicide within the 29 OECD countries. The suicidal behavior is related to psychological factors, genetics, neurobiology, and other biomarkers. The aim of this study was to examine risk factors for the development of suicidal ideation in adolescent females with depression, focusing on the relationship between different testosterone levels and suicidal ideation, in order to help develop strategies to intervene in suicidal behavior in female adolescents with depression. Method. In this single-center prospective cohort study, we enrolled adolescent females with depression. We collected information on their baseline data, testosterone levels, symptom self-rating scale scores, suicidal ideation, non-suicidal self-injurious (NSSI) behaviours, and suicide attempts. We used multivariate logistic regression to identify risk factors for the development of suicidal ideation in adolescent females with depression. Results. A total of 113 hospitalized adolescent females were enrolled with a mean age of 13.5 (1.20). Among these patients, there were 86 (76.11%) subjects who suffered from suicidal ideation, 59 (52.21%) had NSSI and 23 (20.35%) had suicide attempt behavior. In the final model, higher level of testosterone ( p = 0.04 ) and higher age ( p = 0.02 ) were associated with the higher odds of having suicidal ideation. Conclusion. In this exploratory cohort study, the emergence of suicidal ideation was common among adolescent females with depression. This study is consistent with the other studies. It shows that the age is a potential predictor for suicidal ideation in hospitalized adolescent females with depression.


Crisis ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Amanda Venta ◽  
Carla Sharp

Background: Identifying risk factors for suicide-related thoughts and behaviors (SRTB) is essential among adolescents in whom SRTB remain a leading cause of death. Although many risk factors have already been identified, influential theories now suggest that the domain of interpersonal relationships may play a critical role in the emergence of SRTB. Because attachment has long been seen as the foundation of interpersonal functioning, we suggest that attachment insecurity warrants attention as a risk factor for SRTB. Aims: This study sought to explore relations between attachment organization and suicidal ideation, suicide attempts, and self-harm in an inpatient adolescent sample, controlling for demographic and psychopathological covariates. Method: We recruited 194 adolescents from an inpatient unit and assigned them to one of four attachment groups (secure, preoccupied, dismissing, or disorganized attachment). Interview and self-report measures were used to create four variables reflecting the presence or absence of suicidal ideation in the last year, single lifetime suicide attempt, multiple lifetime suicide attempts, and lifetime self-harm. Results: Chi-square and regression analyses did not reveal significant relations between attachment organization and SRTB, although findings did confirm previously established relations between psychopathology and SRTB, such that internalizing disorder was associated with increased self-harm, suicide ideation, and suicide attempt and externalizing disorder was associated with increased self-harm. Conclusion: The severity of this sample and methodological differences from previous studies may explain the nonsignificant findings. Nonsignificant findings may indicate that the relation between attachment organization and SRTB is moderated by other factors that should be explored in future research.


Author(s):  
Leah Shelef ◽  
Jessica M Rabbany ◽  
Peter M Gutierrez ◽  
Ron Kedem ◽  
Ariel Ben Yehuda ◽  
...  

Past suicide attempts are a significant risk factor for future suicidality. Therefore, the present military-based study examined the past suicidal behavior of soldiers who recently made a severe suicide attempt. Our sample consisted of 65 active-duty soldiers (61.5% males), between the ages of 18 and 28 years old (M = 20.4, SD ± 1.3). The inclusion criterion was a recent severe suicide attempt, requiring at least a 24 h hospitalization. This sample was divided into two groups, according to previous suicidal behavior, namely whether their first suicide attempt was before or after enlistment (n = 25; 38.5% and n = 40; 61.5%, respectively). We then examined the lethality and intent of the recent event in regard to this division. Four measures were used to assess the subjects’ suicidal characteristics: the Columbia Suicide Severity Rating Scale, the Self-Harm Behavior Questionnaire, the Suicidal Behaviors Questionnaire-Revised, and the Beck Scale for Suicide Ideation. No significant difference in the severity of the suicide attempts (either actual or potential severity) were found between those who had suicide attempts before enlistment and those who had their first attempt in the service. As a matter of fact, most of the suicide attempts that occurred for the first time during military service had used a violent method (58.3%, n = 21). Finally, using multivariate analyses, we found that current thoughts and behavior, rather than past suicidality, was the strongest predictor for the lethality of suicide attempts.


2021 ◽  
Vol 4 (6) ◽  
pp. 29-42
Author(s):  
Johnson F.A. ◽  
Ogunsanmi L. ◽  
Ayokanmi I.

Background: Today, the most prevalent and the leading cause of death among young people is suicide. Worldwide, suicide accounts for an estimated 6% of all deaths among young people. The study examined the various risk factors for suicidal ideation and self-harm amongst Babcock University undergraduates. Method: Descriptive survey research design was utilized with a multistage sampling technique to select 398 undergraduates. The instrument for data collection was a semi-structured questionnaire that sought information on the environmental, social, and intrapersonal factors influencing suicide ideation and self-harm. Results were presented via means and percentages for descriptive statistics; correlation and regression were used to determine the associations between suicidal ideation and the risk factors. Ethical clearance was sought from Babcock University Health Research Ethics Committee. Results: The distribution of participants showed that 46.0% (183) were males while 54.0% (215) were females. Environmental factors influencing suicidal ideation were computed and measured on a 21-point rating scale with a mean ± SD of 13.38±3.458. The respondents' mean ± SD for the social factors measured on a 27-point rating scale was 17.15±5.772. Correlation analysis showed that suicide ideation had a statistically significant relationship with gender (p<0.01), parents' spousal relationship (p<0.01), environmental (p<0.01), social (p<0.01), and intrapersonal factors (p<0.01). Self-harm had a significant relationship with parents' relationship (p<0.01), environmental (p<0.01), social (p<0.01) and intrapersonal factors (p<0.01). However, the practice of self-harm was not different across the two genders (p = 0.170). Conclusion: Suicidal behaviors have been seen to be a serious public health concern. The prevention and intervention programs of suicide and self-harm should consider the particular characteristics of adolescent suicide and self-harm. This should include social transmission and recognition of mental health disorders.


CNS Spectrums ◽  
2007 ◽  
Vol 12 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Kelly Posner ◽  
Glenn A. Melvin ◽  
Barbara Stanley ◽  
Maria A. Oquendo ◽  
Madelyn Gould

ABSTRACTSuicide remains a leading cause of death among youth, and suicide ideation and behavior are relatively common in both normal and clinical populations. Clinicians working with young people must assess for the presence of suicidal ideation, suicidal behavior, and other risk factors, in order to determine the level of risk. This paper provides the clinician with a summary of risk factors for youth suicide, as well as providing standardized terminology to enhance assessment of suicidal ideation and behavior.


Neurology ◽  
2019 ◽  
Vol 92 (14) ◽  
pp. e1643-e1651 ◽  
Author(s):  
Andrew McGarry ◽  
Michael P. McDermott ◽  
Karl Kieburtz ◽  
Wai Lun Alan Fung ◽  
Elizabeth McCusker ◽  
...  

ObjectiveMost suicidality literature in Huntington disease (HD) is based on natural history studies or retrospective reviews, but reports on risk factors from clinical trials are limited.MethodsWe analyzed 609 participants from 2CARE, a randomized, double-blind, placebo-controlled clinical trial with up to 5 years of follow-up, for risk factors related to suicidality. The primary outcome variable was the time from randomization until the first occurrence of either suicidal ideation or attempt. We also considered time from randomization until the first suicide attempt as a secondary outcome variable.ResultsDepression, anxiety, bipolar disorder, antidepressant or anxiolytic use, and prior suicide attempt at baseline were associated with time to ideation or attempt. Baseline employment status, marital status, CAG repeat length, tetrabenazine use, and treatment assignment (coenzyme Q10 or placebo) were not associated with suicidality. Time-dependent variables from the Unified Huntington's Disease Rating Scale Behavioral Assessment were associated with time to suicidal ideation or attempt, driven mainly by items related to depressed mood, low self-esteem/guilt, anxiety, suicidal thoughts, irritability, and compulsions. Variables associated with time to suicide attempt alone were generally similar.ConclusionThese data suggest psychiatric comorbidities in HD are predictive of suicidal behavior while participating in clinical trials, reinforcing the importance of clinical surveillance and treatment towards lessening risk during participation and perhaps beyond. Designing a composite algorithm for early prediction of suicide attempts in HD may be of value, particularly given anticipated trials aimed at disease modification are likely to be long-term.Clinicaltrials.gov identifierNCT00608881.


2009 ◽  
Vol 31 (3) ◽  
pp. 271-280 ◽  
Author(s):  
Lena Nabuco de Abreu ◽  
Beny Lafer ◽  
Enrique Baca-Garcia ◽  
Maria A. Oquendo

OBJECTIVE: This article reviews the evidence for the major risk factors associated with suicidal behavior in bipolar disorder. METHOD: Review of the literature studies on bipolar disorder, suicidal behavior and suicidal ideation. RESULTS: Bipolar disorder is strongly associated with suicide ideation and suicide attempts. In clinical samples between 14-59% of the patients have suicide ideation and 25-56% present at least one suicide attempt during lifetime. Approximately 15% to 19% of patients with bipolar disorder die from suicide. The causes of suicidal behavior are multiple and complex. Some strong predictors of suicidal behavior have emerged in the literature such as current mood state, severity of depression, anxiety, aggressiveness, hostility, hopelessness, comorbidity with others Axis I and Axis II disorders, lifetime history of mixed states, and history of physical or sexual abuse. CONCLUSION: Bipolar disorder is the psychiatric condition associated with highest lifetime risk for suicide attempts and suicide completion. Thus it is important to clinicians to understand the major risk factors for suicidal behavior in order to choose better strategies to deal with this complex behavior.


Crisis ◽  
2011 ◽  
Vol 32 (5) ◽  
pp. 283-287 ◽  
Author(s):  
L. F. Chan ◽  
T. Maniam ◽  
A. S. Shamsul

Background: Depressed inpatients constitute a high-risk population for suicide attempts. Aims: To describe the interactions of clinical and psychosocial risk factors influencing suicide attempts among a Malaysian sample of depressed inpatients. Methods: Seventy-five subjects were diagnosed with a depressive disorder according to the Structured Clinical Interview for DSM-IV Axis I Disorders-Clinical Version (SCID-CV). Data on suicide attempts, suicidal ideation (Scale for Suicidal Ideation, SSI), depression severity (Beck’s Depression Inventory, BDI), recent life-event changes (Social Readjustment Rating Scale, SRRS), sociodemographic and other relevant clinical factors were collected. Results: A third of the subjects presented after a current suicide attempt. Significant factors for a current suicide attempt were race, religion, recent life-event changes, suicidal ideation, and alcohol use disorder. Independent predictive risk factors for a current suicide attempt were Chinese race, recent marital separation, major mortgage or loans, and being newly diagnosed with depression. Any recent change in personal habits was shown to be a protective factor against current suicide attempt. Age and gender were nonsignificant factors. Conclusions: The findings are generally consistent with existing studies and highlight the role of psychosocial risk factors.


2018 ◽  
Vol 69 (9) ◽  
pp. 2465-2466
Author(s):  
Iustin Olariu ◽  
Roxana Radu ◽  
Teodora Olariu ◽  
Andrada Christine Serafim ◽  
Ramona Amina Popovici ◽  
...  

Osseointegration of a dental implant may encounter a variety of problems caused by various factors, as prior health-related problems, patients� habits and the technique of the implant inserting. Retrospective cohort study of 70 patients who received implants between January 2011- April 2016 in one dental unit, with Kaplan-Meier method to calculate the probability of implants�s survival at 60 months. The analysis included demographic data, age, gender, medical history, behavior risk factors, type and location of the implant. For this cohort the implants�survival for the first 6 months was 92.86% compared to the number of patients and 97.56% compared to the number of total implants performed, with a cumulative failure rate of 2.43% after 60 months. Failures were focused exclusively on posterior mandible implants, on the percentage of 6.17%, odds ratio (OR) for these failures being 16.76 (P = 0.05) compared with other localisations of implants, exclusively in men with median age of 42 years.


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