scholarly journals The Effect of Immobilization Stress on Gastric Mucosal Histopathology in White Mice (Mus musculus) Male Swiss Webster Strain

2020 ◽  
Vol 4 (1) ◽  
pp. 34
Author(s):  
Rizki Bunaya ◽  
Ilhami Romus ◽  
Fajri Marindra Siregar ◽  
Desby Juananda
Keyword(s):  
Mus Musculus ◽  
Immobilization Stress ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Control Group ◽  
Histological Structure ◽  
Control Group Design ◽  
Experimental Animals ◽  
Structure Damage ◽  
Significant Difference

Background: Immobilization stress is one method of stress induction on experimental animals. It affects the psychology and physical of experimental animals and is the recommended method for assessing changes in histological structure damage. The purpose of research was to analyze the effect of immobilization stress on gastric mucosal in mice.Materials and Methods: This research was experimental with post-test-only control group design. Twenty white mice (Mus musculus) male Swiss Webster strains were used in this study and divided into 4 groups: control, immobilization stress 14 days, immobilization stress 21 days, immobilization stress 28 days. Mice were given immobilization stress using 50 cc syringes for 2 hours every day for 14 days, 21 days and 28 days. Gastric mucosal damage in mice was analyzed under a microscope with of 10 fields of view in each sample. Data were analyzed using the Kruskal Wallis test and Mann Whitney test.Results: Gastric mucosal damage score were 0 in control, 1.42±0.265 in 14 days, 1.82±0.265 in 21 days, and 2.54±0.05 in 28 days. There was significant difference between each group (p<0.05), while the greatest damage was found in the 28 days group.Conclusion: These result indicated that immobilization stress caused gastric mucosal damage and the degree of damage is in accordance with duration of stress.Keywords: gastric mucosal, immobilization, stress

scholarly journals EFFECT OF ASIATIC MANGROVE (RHIZOPHORA MICRONATA) LEAVES EXTRACT AS ANALGESIC IN MALE ALBINO DDW MICE (MUS MUSCULUS L.) INDUCED BY 0,7% ACETIC ACID

2021 ◽  
Vol 5 (2) ◽  
pp. 1-8
Author(s):  
Erika Widianingsih Nanuru ◽  
Lestari Dewi ◽  
Prajogo Wibowo
Keyword(s):  
Acetic Acid ◽  
Emotional Experience ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Control Group ◽  
Rhizophora Mucronata ◽  
Control Group Design ◽  
Significant Difference ◽  
Post Test ◽  
The Difference

Background : Pain is an unpleasant emotional experience that illustrates ongoing tissue damage. Excessive use of non-steroidal anti-inflammatory drugs can cause peptic ulcer to gastric mucosal damage and perforation. Indonesia contains the largest area of mangrove forest in the world. There are 45 species of mangrove found and one of them is Asiatic Mangrove (Rhizophora mucronata). This type is easy to find and rich of alkaloids and flavonoids which can be used as analgesics. Method:  This study used post-test only control group design. The number of mice that used was 25 mice, divided into 5 groups. Which were given different therapies aquadest 10mL/KgBW, acetosal 150 mg/KgBW, extract of Rhizophora mucronata 250 mg/KgBW, 500 mg/KgBW, and 1000 mg/kg bw. The pain was induced by 0,7% glacial acetic acid at a dose of 10 mL/KgBW.  The writhes of the mice was being calculated with an interval of 10 minutes in 30 minutes. Result:  The results of the analysis showed the decrease in writhes of mice  in acetosal group dose 150 mg/kg bw, Rhizophora mucronata leaves extract dose 250 mg/kg bw, 500 mg/kg bw, and 1000 mg/kg bw. There was a significant difference in the results of the Mann-Whitney U test with p<0,05 in the aquadest group and the acetosal group with the Rhizophora mucronata leaves extract group dose 500 mg/kg bw, the difference between the acetosal group and the Rhizophora mucronata leaves extract group dose 250 mg/kg bw, and the difference between the Rhizophora mucronata leaves extract group dose 500 mg/kg bw and the Rhizophora mucronata leaves extract group dose 1000 mg/kg bw. Conclusion: Rhizophora mucronata leaves extract dose 500 mg/kg bw can provide analgesic effect and can reduce the writhing frequency in mice much better than acetosal group.

scholarly journals PENGARUH DOSIS EKSTRAK JAMBU BIJI (PSIDIUM GUAJAVA. L) DAN TABLET Fe TERHADAP PERUBAHAN KADAR HEMOGLOBIN PADA MENCIT (MUS MUSCULUS)

2018 ◽  
Vol 10 (3) ◽  
pp. 102-107
Author(s):  
Yusnaini Yusnaini
Keyword(s):  
Mus Musculus ◽  
Experimental Studies ◽  
Psidium Guajava ◽  
Control Group ◽  
Control Group Design ◽  
Laboratory Design ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Post Hoc

According to the WHO 40% of maternal deaths in developing countries related to anemia in pregnancy and is most commonly caused by iron deficiency and acute bleeding, even less so the two interact. This study aims to determine the effect of doses of extracts of Guava (Psidium Guajava. L) and Tablet Fe to changes in hemoglobin levels in mice (Mus musculus). Type True Experimental studies in laboratory design nonrandomized design Pretest-Posttest Control Group Design. Samples were mice (Mus musculus) as many as 20 birds were divided into four groups with each group number as many as five tails. Group A was given a tablet Fe as much as 0.126 mg / kg / day, group B was given a tablet Fe as much as 0.126 mg / KgBW / day coupled with extracts of Guava as much as 10 mg / kg / day, group C was given tablets Fe as much as 0.126 mg / kg / day coupled with guava extract as much as 20 mg / kg / day, group D was given tablets as much as 0.126 mg Fe / KgBW / day plus guava extract as much as 30 mg / kg / day. The data collection was conducted from June 5 s / d July 20, 2015. Data were analyzed using Paired T-Test continued with Test and One Way ANOVA Post Hoc Test namely LSD test. Results showed that there was no significant difference in hemoglobin levels between the groups in which the value of P = 0634> 0.05.. Based on the results of this study concluded that there was no effect of dose of extract of guava (Psidium Guajava. L) and Tablet Fe to changes in hemoglobin levels in mice (Mus musculus), but the effect on the number of erythrocytes of mice (Mus musculus)

scholarly journals Effect of Caulerpa Cylindracea Extract on Histopathology Depiction of Male Rattus Norvegicus Gaster Mucosa Induced by Indomethacin

2021 ◽  
Vol 5 (1) ◽  
pp. 1-6
Author(s):  
FITRI HANDAJANI ◽  
Adya Hidayatullah ◽  
Nita Pranitasari
Keyword(s):  
Rattus Norvegicus ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Male Rats ◽  
Gastric Ulcers ◽  
Gastric Lesions ◽  
Flavonoid Content ◽  
Experimental Animals ◽  
Significant Difference ◽  
Group 2

ABSTRACT Background: A lot of food can repair gastric mucosal damage. For example, sea grapes or the Caulerpa cylindracea with its flavonoid content. Anti-inflammatory and anti-ulcer effect can reduce gastric lesions due to ulcerogenic agents. Indomethacin is used to induce gastric ulcers in experimental animals. Based on this background, this study was conducted to analyze the effect of Caulerpa cylindracea extract, on the histopathological picture of gastric mucosal damage of Rattus norvegicus male rats.   Method: 32 male Rattus norvegicus rats were divided into 4 groups, (1) Group K(-), the untreated group, (2) Group K(+) induced by indomethacin 30mg/kgBB per head (3) Group P1 induced by indomethacin 30 mg/kgBB and Caulerpa cylindracea extract 1gr/100grBB per head, (4) Group P2, induced by indometacin 30mg/kgBB and 2gr/100grBB of Caulerpa cylindracea extract per head.   Result: There was a significant difference (p = 0.001) between the degree of gastric mucosal damage in group K(+) given only indomethacin and group P1 given Indomethacin and 1gr/100grBB Caulerpa cylindracea extract. There was a significant difference (p = 0.001) between group K(+) and group P2 that given Indomethacin and 2g/100grBB Caulerpa cylindracea extract. There was a significant difference (p = 0.004) between group P1 and group P2. Data revealed on group K(-) without any treatment did not obtain significant results (p = 0.060) with group P2.    Conclusion: Giving Caulerpa cylindracea extract with 1 gr/100grBB dose and 2gr/100grBB dose can repair mucosal damage in Rattus norvegicus male rats induced by indomethacin.   

Effectiveness Of Toilet Training Education On Mother's Behavior And Toddler Age Toilet Training Ability (18-36 Months)

2020 ◽  
Vol 5 (2) ◽  
pp. 49-55
Author(s):  
Hafiko Andresni ◽  
Zahtamal Zahtamal ◽  
Winda Septiani ◽  
Mitra Mitra ◽  
Lita Lita
Keyword(s):  
Sampling Technique ◽  
T Test ◽  
The Body ◽  
Toilet Training ◽  
Wilcoxon Test ◽  
Control Group ◽  
Maternal Knowledge ◽  
Control Group Design ◽  
Significant Difference

ABSTRACT Toilet training is an effort to train children to be able to control and urinate (BAK) and defecate (BAB). Toilet training is one of the main tasks of children at toddler age. Toilet training is one of the main tasks of children in toddler age which is very important to be done to create independence in children in controlling BAK and BAB and children know the parts of the body and their functions. Data in 2012 shows that ± 60% of parents do not teach toilet training to children from an early age. The aim of the study was to find out the effectiveness of toilet training education on maternal behavior and toilet skills in toddler age training (18-36 months). The study was conducted in July-August 2018. This type of quantitative research used the design of the Quasy pretest and posttest experiment with non-equivalent control group design. Samples were 36 mothers and 36 children with purposive sampling technique. Data analysis used Paired t test, Wilcoxon test, Man-Whitney test an Independent t test. The results showed that toilet training education through lecture methods, modules and maze games was more effective than toilet training education through lecture and leaflet methods on children's knowledge and abilities. Conversely, for the role of mothers in supervision there is no significant difference in effectiveness. Health education is recommended in health promotion programs to increase maternal knowledge, the role of mothers and the ability of toilet training children independently. Keywords: Toilet training, Lecture method, Module, Maze game, Leaflet, Knowledge, Role of mother, Children's ability.

PERBANDINGAN KEMAMPUAN KOMUNIKASI MATEMATIS SISWA YANG MENGGUNAKAN METODE SILIH TANYA BERBANTUAN KARTU MODEL DAN METODE MAKE A MATCH

2020 ◽  
Vol 2 (1) ◽  
pp. 32
Author(s):  
Ahmad Farham Majid ◽  
Ismail Ismail ◽  
Mardhiah Mardhiah ◽  
Fitriani Nur
Keyword(s):  
Total Sample ◽  
Control Group ◽  
Match Method ◽  
Mathematical Communication ◽  
Control Group Design ◽  
Purposive Sampling ◽  
Group Design ◽  
Significant Difference ◽  
Post Test ◽  
Quasi Experimental

AbstrakPenelitian ini bertujuan untuk mengetahui kemampuan komunikasi matematis siswa yang menggunakan metode silih tanya berbantuan kartu model dan metode make a match. Jenis penelitian ini adalah quasi eksperimen dengan desain penelitian non equivalent pretest-posttest control group design. Populasi dalam penelitian ini adalah seluruh siswa kelas VII SMPN 4 Sungguminasa Kab. Gowa berjumlah 351 siswa dan total sampel berjumlah 64 siswa dengan teknik pengambilan sampel purposive sampling. Instrumen yang digunakan dalam penelitian ini adalah tes yang terdiri dari pretest dan posttest dan non tes berupa lembar observasi. Berdasarkan hasil analisis data nilai siswa menggunakan statistik deskriptif rata-rata nilai kemampuan komunikasi matematis siswa yang diajar menggunakan metode silih tanya berbantuan kartu model adalah 86,84 dengan kategori sedang dan yang diajar menggunakan metode make a match adalah 77,78 dengan kategori sedang. Berdasarkan analisis statistik inferensial bahwa terdapat perbedaan yang signifikan antara kemampuan komunikasi matematis siswa yang menggunakan metode silih tanya berbantuan kartu model dengan yang menggunakan metode make a match pada kelas VII SMPN 4 Sungguminasa Kab. Gowa. AbstractThis study aims to determine the mathematical communication ability of students who use card-assisted questions method and make a match method. This type of research is a quasi-experimental research with nonequivalent pretest-posttest control group design. The population in this study were all VII grade students of SMPN 4 Sungguminasa, Gowa Regency with 351 students and a total sample of 64 students with purposive sampling techniques. The instrument used in this study was a test consisting of pre-test and post-test and non-test that is observation sheet. Based on the data analysis results that average the value of students’ mathematical communication skills who were taught using the card-assisted questions was 86.84 in the medium category and those who taught using make a match method were 77.78 in the medium category. The results of inferential statistical analysis that there is a significant difference between the mathematical communication abilities of students who use card-assisted questions and using the make a match method in class VII of SMPN 4 Sungguminasa, Gowa Regency.

Particular Matter of Motor Vehicle Exposure and High-Fat Diet Effects on Kidney Histopathology, Creatinine, and Malondialdehyde (MDA) Levels in Wistar Rats

2021 ◽  
Vol 5 (3) ◽  
pp. 124-128
Author(s):  
Rizka Veni ◽  
Awal Prasetyo ◽  
Muflihatul Muniroh
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Motor Vehicle ◽  
Histopathological Change ◽  
Normal Diet ◽  
Control Group ◽  
High Fat ◽  
Control Group Design ◽  
Treatment Groups ◽  
Significant Difference

This study aims to analyze the effect of combination of motor vehicle particular matter exposure and high-fat diet in kidney histopathology, creatinine levels, and MDA levels in Wistar rats. This study used a posttest-only control group design. Eighteen healthy male Wistar rats were divided into three groups. The intervention groups received motor vehicle fume exposure for 100 s with normal diet (X1) or high-fat diet (X2), and the control group received no exposure (C). Data analysis was processed with a SPSS 25.0 computer program by using the one-way ANOVA test followed by post hoc LSD. The degree of kidney histopathological damage showed significant differences between the X1 and X2 groups when compared with the control group (p < 0.05). The results of the creatinine level examination found a significant difference between the X2 and C groups (p < 0.05) and the treatment groups X1 and X2 (p < 0.05). The results of kidney MDA level examination showed a significant difference between the treatment groups (X1 and X2) and the control group (p < 0.05). The combination of particular matter of motor vehicle fumes exposure and high-fat diet could induce kidney damage through histopathological change and increased creatinine levels and kidney MDA levels in Wistar rats.

The effect of patience training on university students’ patience and life satisfaction levels

2021 ◽  
Vol 9 (3) ◽  
pp. 712-719
Author(s):  
Ayşe Eliüşük Bülbül ◽  
Keyword(s):  
Life Satisfaction ◽  
University Students ◽  
Wilcoxon Test ◽  
Control Group ◽  
Control Group Design ◽  
Satisfaction Scale ◽  
Significant Difference ◽  
Post Test ◽  
And Control ◽  
Experimental Group

The purpose of this study is to determine the effect of the "patience training program" on the patience and life satisfaction levels of university students. The study was organized as a pre-test, post-test experiment and control group design. For a total of 30 students from which were 17 in the control group and 17 in the experimental group, patience training was given for 5 weeks. The "Patient Scale" developed by Schnitker (2010) and adapted to Turkish by Eliüşük and Arslan (2016) and the "Life Satisfaction Scale" developed by Diener, Emmons, Larsen and Griffin (1985) and adapted to Turkish by Dağlı and Baysal (2016) were used as a data collection tool in the study. The "Wilcoxon" test was used for the comparison of in-group differences in the analysis of obtained data and the "Mann-Whitney U" test was used in examining the differences between the two groups. As a result of the study, it was observed that the patience and life satisfaction average scores of students in the experimental group receiving "patience training" increased significantly, while there was no significant difference in the patience and life satisfaction averages scores of the control group students.

scholarly journals Mathematical Critical Thinking and Curiosity Attitude in Problem Based Learning and Cognitive Conflict Strategy: A Study in Number Theory course

2017 ◽  
Vol 10 (7) ◽  
pp. 65 ◽  
Author(s):  
Zetriuslita Zetriuslita ◽  
Wahyudin Wahyudin ◽  
Jarnawi Jarnawi
Keyword(s):  
Number Theory ◽  
Critical Thinking ◽  
Undergraduate Students ◽  
Problem Based Learning ◽  
Cognitive Conflict ◽  
Thinking Skills ◽  
Control Group ◽  
Control Group Design ◽  
Significant Difference ◽  
Conflict Strategy

This research aims to describe and analyze result of applying Problem-Based Learning and Cognitive Conflict Strategy (PBLCCS) in increasing students’ Mathematical Critical Thinking (MCT) ability and Mathematical Curiosity Attitude (MCA). Adopting a quasi-experimental method with pretest-posttest control group design and using mixed method with sequential explanatory strategy, the study involves undergraduate students of Mathematics Education Program at a private university in Riau, Indonesia, academic year 2015/2016 enrolled in Number Theory course. Quantitative data were obtained from essay test and questionnaire whereas qualitative data were from interview and observation. The findings show that; (1) there is a difference between MCT ability taught by PBLCCS and Explicit Direct Instruction (EDI), (2) there is no significant difference between MCA taught by PBLCCS and EDI, (3) students still face obstacles in developing their critical thinking skills when solving matematical problems.

scholarly journals Optimalisasi Pertumbuhan Bayi dengan Baby Massage and Spa

2019 ◽  
Vol 10 (2) ◽  
pp. 276
Author(s):  
Yusari Asih ◽  
I Gusti Ayu Mirah WS
Keyword(s):  
Body Length ◽  
Head Circumference ◽  
Intervention Group ◽  
Sampling Technique ◽  
Holistic Approach ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference

<p><span>Baby Massage and Spa was a traditional effort that uses a holistic approach through comprehensive care using a combination of massage and water therapy methods that are carried out in an integrated manner to balance the body, mind, and feelings. Age 3-6 months is the right time for babies to do massage and spa. The purpose of this study was to determine the effect of baby massage and spa on the growth of infants aged 3-5 months in Pringsewu District in 2018. This study uses a quasi-experimental approach with research design pre and post-test with control group design. The purposive sampling technique was taken with a sample of 30 infants as the intervention group and 30 infants as the control group. Data were processed using computerization and analyzed using the T-Test. The results showed that there were significant differences between body weight, body length and baby head circumference in the pre and post-treatment. There was no significant difference in the average increase in infant weight between babies who were carried out by baby massage and spa with babies who were not carried out by baby massage and spa with p-value 0.116. There is a significant difference in the baby's body length and head circumference performed by baby massage and spa with those not carried out by baby massage and spa with p-value 0.000. Baby Massage and Spa has a significant effect on increasing the growth of babies aged 3-5 months.</span></p><p><span> </span></p>

scholarly journals EFFECT OF MINDFULNESS INTERVENTION ON THE INTENSITY OF PAIN IN NASOPHARINGEAL CANCER PATIENTS UNDERGOING RADIATION TREATMENT

2018 ◽  
Vol 4 (2) ◽  
pp. 195-201
Author(s):  
Anna Jumatul Laely ◽  
Awal Prasetyo ◽  
Chandra Bagus Ropyanto
Keyword(s):  
Cancer Patients ◽  
Radiation Treatment ◽  
Nasopharyngeal Cancer ◽  
Psychological Trauma ◽  
Control Group ◽  
Intensity Level ◽  
Control Group Design ◽  
Mindfulness Intervention ◽  
Significant Difference ◽  
Before And After

Background: Physical responses that occur in patients with nasopharyngeal cancer are the emergence of pain due to the effects of treatment. The problem of pain in these patients at the stage of treatment remains critical to solve because it can cause comorbidity, psychological trauma and mortality. Mindfulness intervention is considered useful in transforming consciousness into the stage of acceptance.Objective: This study aims to determine the effect of mindfulness intervention on the intensity of pain in nasopharyngeal cancer patients undergoing radiation treatment.Methods: This was a quasy-experimental study with pretest posttest control group design. Thirty patients were selected using consecutive sampling, which divided into experiment and control group. Visual Analogue Scale (VAS) was used to measure pain. Each respondent received mindfulness intervention for 6 sessions, divided into 3 meetings. Paired t-test was used for data analysis.Results: The results showed a significant reduction of pain from 4.12 (moderate pain) to 3.06 (mild pain) in the experiment group. There was a significant difference in pain level before and after mindfulness intervention (p= 0.001).Conclusion: Mindfulness is effective in reducing pain intensity level in nasopharyngeal cancer patients undergoing radiation therapy.

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