Recent Progresses in Organic-Inorganic Nano Technological Platforms for Cancer Therapeutics

2020 ◽  
Vol 27 (35) ◽  
pp. 6015-6056 ◽  
Author(s):  
Sanjay Kumar ◽  
Anchal Singhal ◽  
Uma Narang ◽  
Sweta Mishra ◽  
Pratibha Kumari
Keyword(s):  
Cancer Therapeutics ◽  
Therapeutic Action ◽  
Research Areas ◽  
Current Review ◽  
Bio Imaging ◽  
Inorganic Nanomaterials ◽  
Technological Platform ◽  
Organic Nanomaterials ◽  
Technological Platforms ◽  
Combinational Therapies

Nanotechnology offers promising tools in interdisciplinary research areas and getting an upsurge of interest in cancer therapeutics. Organic nanomaterials and inorganic nanomaterials bring revolutionary advancement in cancer eradication process. Oncology is achieving new heights under nano technological platform by expediting chemotherapy, radiotherapy, photo thermodynamic therapy, bio imaging and gene therapy. Various nanovectors have been developed for targeted therapy which acts as “Nano-bullets” for tumor cells selectively. Recently combinational therapies are catching more attention due to their enhanced effect leading towards the use of combined organicinorganic nano platforms. The current review covers organic, inorganic and their hybrid nanomaterials for various therapeutic action. The technological aspect of this review emphasizes on the use of inorganic-organic hybrids and combinational therapies for better results and also explores the future opportunities in this field.

Innovatory role of nanomaterials as bio-tools for treatment of cancer

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Khuram Shahzad Ahmad ◽  
Muntaha Talat ◽  
Shaan Bibi Jaffri ◽  
Neelofer Shaheen
Keyword(s):  
Cancer Treatment ◽  
Cancer Therapeutics ◽  
Physicochemical Characteristics ◽  
Global Scale ◽  
Current Review ◽  
Anti Cancer ◽  
Different Types ◽  
Cancerous Cells

AbstractConventional treatment modes like chemotherapy, thermal and radiations aimed at cancerous cells eradication are marked by destruction pointing the employment of nanomaterials as sustainable and auspicious materials for saving human lives. Cancer has been deemed as the second leading cause of death on a global scale. Nanomaterials employment in cancer treatment is based on the utilization of their inherent physicochemical characteristics in addition to their modification for using as nano-carriers and nano-vehicles eluted with anti-cancer drugs. Current work has reviewed the significant role of different types of nanomaterials in cancer therapeutics and diagnostics in a systematic way. Compilation of review has been done by analyzing voluminous investigations employing ERIC, MEDLINE, NHS Evidence and Web of Science databases. Search engines used were Google scholar, Jstore and PubMed. Current review is suggestive of the remarkable performance of nanomaterials making them candidates for cancer treatment for substitution of destructive treatment modes through investigation of their physicochemical characteristics, utilization outputs and long term impacts in patients.

scholarly journals Mechanisms of Reactive Oxygen Species Generated by Inorganic Nanomaterials for Cancer Therapeutics

2021 ◽  
Vol 9 ◽  
Author(s):  
Lizhen Zhang ◽  
Chengyuan Zhu ◽  
Rongtao Huang ◽  
Yanwen Ding ◽  
Changping Ruan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Biomedical Applications ◽  
Reactive Oxygen ◽  
Cancer Therapeutics ◽  
Surface Characteristics ◽  
Oxygen Species ◽  
Sonodynamic Therapy ◽  
Dynamic Therapy ◽  
Inorganic Nanomaterials ◽  
Generation Mechanisms

Recently, inorganic nanomaterials have received considerable attention for use in biomedical applications owing to their unique physicochemical properties based on their shapes, sizes, and surface characteristics. Photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemical dynamic therapy (CDT), which are cancer therapeutics mediated by reactive oxygen species (ROS), have the potential to significantly enhance the therapeutic precision and efficacy for cancer. To facilitate cancer therapeutics, numerous inorganic nanomaterials have been developed to generate ROS. This mini review provides an overview of the generation mechanisms of ROS by representative inorganic nanomaterials for cancer therapeutics, including the structures of engineered inorganic nanomaterials, ROS production conditions, ROS types, and the applications of the inorganic nanomaterials in cancer PDT, SDT, and CDT.

scholarly journals IMPROVING INFORMATION SUPPORT OF CRISIS MANAGEMENT BY ENTERPRISES ON THE BASIS OF USING COMMUNICATION TOOLS OF THE TECHNOLOGICAL PLATFORM

2019 ◽  
pp. 13-19
Author(s):  
M. N. Belousova ◽  
V. A. Belousov
Keyword(s):  
Crisis Management ◽  
Information Support ◽  
Enterprise Management ◽  
Information Component ◽  
Communication Tools ◽  
Enterprise Management System ◽  
Technological Platform ◽  
New Research ◽  
Innovation Clusters ◽  
Technological Platforms

Information support of crisis management requires the creation of a communication infrastructure, based on the program-target method, within which technological standards and profiles are formed – technological platforms. The information support of the crisis management of enterprises, based on the use of communication tools of the technological platform, as an interface of the innovative infrastructure, allowing increase the efficiency of the information component of the enterprise management system, has been improved in the paper. Based on the technological platform, new research and production cooperations, innovation clusters will be formed, which will allow overcome the crisis state of enterprises.

scholarly journals Medication Related Osteonecrosis of Jaw: A Medical Oncologist’s Perspective

2018 ◽  
Vol 1 (1) ◽  
pp. 10-17
Author(s):  
Harry S Darling
Keyword(s):  
Quality Of Life ◽  
Medical Oncology ◽  
Cancer Therapeutics ◽  
Therapeutic Action ◽  
Treatment Of Osteoporosis ◽  
Medical Oncologists ◽  
Osteonecrosis Of Jaw ◽  
High Index Of Suspicion ◽  
Major Emphasis

Medication related osteonecrosis of jaw (MRONJ) is a rare iatrogenic disease. Cancer therapeutics is advancing exponentially and apart from a major emphasis on quality of life (QoL) in metastatic patients, now we are foreseeing increased longevity. This necessitates the rising need of betterment of supportive care modalities and looking into the rare complications of therapy. Bisphosphonates (BPs) and Denosumab, the anti-resorptive agents (ARAs) used commonly by medical oncologists in cancers with bone metastases and less commonly in prevention or treatment of osteoporosis, are implicated in the etiology of MRONJ. Many a times, it goes undetected, underdiagnosed and untreated due to lack of awareness, low index of suspicion and paucity of understanding of this disorder amongst medical oncology fraternity. A high index of suspicion is a cornerstone of timely diagnosis and therapeutic action. A regular collaboration between treating oncologist and dentist is of utmost importance.

Technological Platform as a Tool for the Implementation of the Subjectivity Right in the Mechanism of Public-Private Partnership

2019 ◽  
pp. 69-80
Author(s):  
A.A. Chekushov ◽  
M.A. Chirkov ◽  
M.S. Chistyakov
Keyword(s):  
Industrial Relations ◽  
Innovation System ◽  
Public Private Partnership ◽  
National Innovation System ◽  
Activation Mechanism ◽  
High Tech ◽  
Private Partnership ◽  
Technological Platform ◽  
Technological Platforms

The formation of technological platforms, using the advantages of public-private partnership, can be considered as an effective cooperation and partnership tool for the mechanism of implementation of national priorities of high-tech development, including the formation of a sustainable balance of scientific and industrial relations. The functioning of technological platforms in this strategic algorithm will clarify and adjust the priorities of innovative high-tech development and consistent development of the national innovation system. The activation mechanism of the innovative component of the implementation of various projects using public-private partnership could be a policy of consistent motivation of competition in innovation.

scholarly journals Nanostructured Materials for Artificial Tissue Replacements

2020 ◽  
Vol 21 (7) ◽  
pp. 2521 ◽  
Author(s):  
Jana Pryjmaková ◽  
Markéta Kaimlová ◽  
Tomáš Hubáček ◽  
Václav Švorčík ◽  
Jakub Siegel
Keyword(s):  
Tissue Regeneration ◽  
Nano Particles ◽  
Porous Scaffolds ◽  
Current Trends ◽  
Organic Matrices ◽  
Application Potential ◽  
Inorganic Nanomaterials ◽  
High Level ◽  
Almost All ◽  
Organic Nanomaterials

This paper review current trends in applications of nanomaterials in tissue engineering. Nanomaterials applicable in this area can be divided into two groups: organic and inorganic. Organic nanomaterials are especially used for the preparation of highly porous scaffolds for cell cultivation and are represented by polymeric nanofibers. Inorganic nanomaterials are implemented as they stand or dispersed in matrices promoting their functional properties while preserving high level of biocompatibility. They are used in various forms (e.g., nano- particles, -tubes and -fibers)—and when forming the composites with organic matrices—are able to enhance many resulting properties (biologic, mechanical, electrical and/or antibacterial). For this reason, this contribution points especially to such type of composite nanomaterials. Basic information on classification, properties and application potential of single nanostructures, as well as complex scaffolds suitable for 3D tissues reconstruction is provided. Examples of practical usage of these structures are demonstrated on cartilage, bone, neural, cardiac and skin tissue regeneration and replacements. Nanomaterials open up new ways of treatments in almost all areas of current tissue regeneration, especially in tissue support or cell proliferation and growth. They significantly promote tissue rebuilding by direct replacement of damaged tissues.

Design and Synthesis of a Multifunctional Probe for Bio-Imaging and Therapeutics

2006 ◽  
Vol 943 ◽  
Author(s):  
Yu-San Liu ◽  
Chi Hui Liang ◽  
P. Thomas Vernier ◽  
Yinghua Sun ◽  
Martin A. Gundersen
Keyword(s):  
Quantum Dots ◽  
Fluorescent Protein ◽  
Fluorescence Probe ◽  
Cancer Therapeutics ◽  
Medical Diagnostics ◽  
Egfp Gene ◽  
Design And Synthesis ◽  
Potential Applications ◽  
Bio Imaging ◽  
Green Fluorescent

ABSTRACTWe report the synthesis of CdSe/ZnSe/ZnS (core/shell/shell) quantum dots (QDs) as a fluorescence probe for biological cells, and their functionalization with carbon nanotube (CNT)-retrovirus complexes (labeled with the QDs) to form multi-functional tool with potential applications for cancer therapeutics. A mild method for preparing this QD-CNT-retrovirus complex, which preserves viral function, is reported. Observations and imaging under fluorescence confocal microscope show the expression of enhanced green fluorescent protein (EGFP) gene and QD uptake in viable cells, indicating that this novel probe is able to enter cells, crossing the natural barrier of the cell membranes. Such multi-functional probes have potential as medical diagnostics and for therapeutics for diseases including cancer. The multifunctional probe is of interest for potentially broad applications – with the quantum dots as the visualization aid, carbon nanotubes as an efficient opto-thermo converter for selective extermination of cells with the help of light irradiation at near-IR range, and the retrovirus as a vehicle for genetic therapy.

scholarly journals Integrating Blogs in Student teachers’ Practical Work

2020 ◽  
pp. 99-108
Author(s):  
Liat Biberman-Shalev ◽  
Keyword(s):  
Teacher Education ◽  
Student Teachers ◽  
Teacher Educators ◽  
Final Section ◽  
Practical Work ◽  
Current Review ◽  
The World ◽  
Technological Platforms

A variety of technological platforms can help advance teacher education. The current review focuses on the contributions of blogs and blogging in teacher education. The introduction will begin with an explanation of the blog platform, a description of its generic characteristics, and a review of the variety of blog functions. This will be followed by a review of research from various parts of the world that examined the practical uses and the benefits of the blog in the context of teacher education. The final section will present a summary of the benefits of blogging in teacher education and some implications for teacher educators.

scholarly journals Recent Development of Ruminant Vaccine Against Viral Diseases

2021 ◽  
Vol 8 ◽  
Author(s):  
Sk Mohiuddin Choudhury ◽  
XuSheng Ma ◽  
Wen Dang ◽  
YuanYuan Li ◽  
HaiXue Zheng
Keyword(s):  
Molecular Biology ◽  
Infectious Diseases ◽  
Animal Husbandry ◽  
Recombinant Vaccines ◽  
Public Attention ◽  
Viral Origin ◽  
Subunit Vaccines ◽  
Current Review ◽  
Animal Care ◽  
Technological Platforms

Pathogens of viral origin produce a large variety of infectious diseases in livestock. It is essential to establish the best practices in animal care and an efficient way to stop and prevent infectious diseases that impact animal husbandry. So far, the greatest way to combat the disease is to adopt a vaccine policy. In the fight against infectious diseases, vaccines are very popular. Vaccination's fundamental concept is to utilize particular antigens, either endogenous or exogenous to induce immunity against the antigens or cells. In light of how past emerging and reemerging infectious diseases and pandemics were handled, examining the vaccination methods and technological platforms utilized for the animals may provide some useful insights. New vaccine manufacturing methods have evolved because of developments in technology and medicine and our broad knowledge of immunology, molecular biology, microbiology, and biochemistry, among other basic science disciplines. Genetic engineering, proteomics, and other advanced technologies have aided in implementing novel vaccine theories, resulting in the discovery of new ruminant vaccines and the improvement of existing ones. Subunit vaccines, recombinant vaccines, DNA vaccines, and vectored vaccines are increasingly gaining scientific and public attention as the next generation of vaccines and are being seen as viable replacements to conventional vaccines. The current review looks at the effects and implications of recent ruminant vaccine advances in terms of evolving microbiology, immunology, and molecular biology.

Program Approach in Energy Sector’s Technological Platforms Development (by the Example of " Russian Intellectual Power System" Technological Platform)

2015 ◽  
Vol 4 (4) ◽  
pp. 3-11
Author(s):  
Яковлева ◽  
Anna Yakovleva ◽  
Яремчук ◽  
R. Yaremchuk
Keyword(s):  
Power System ◽  
Program Implementation ◽  
Development Program ◽  
Program Approach ◽  
Platform Development ◽  
Technological Platform ◽  
Intellectual Power ◽  
Technological Platforms

The analysis of features related to implementation of "Intellectual Power System of Russia" technological platform development program is presented in this paper. Possibilities for adaptation of program approach for technological platform development have been investigated. Specific conditions of context and relationship inside the program have been considered. Recommendations on program implementation directions have been offered.

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