Can Wogonin be Used in Controlling Diabetic Cardiomyopathy?

2019 ◽  
Vol 25 (19) ◽  
pp. 2171-2177 ◽  
Author(s):  
Shahzad Khan ◽  
Mohammad A. Kamal
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Therapeutic Potential ◽  
Heart Diseases ◽  
Cardiovascular Complications ◽  
Cancer Drug ◽  
Scutellaria Baicalensis Georgi ◽  
Yellow Color ◽  
Anti Oxidant ◽  
Margin Of Safety ◽  
Anti Inflammatory

<P>Diabetes Mellitus (DM) is now a well-known factor which initiates many metabolic derangements in various tissues and organs including liver, muscle, pancreas, adipose tissue, cardiovascular and nervous system. Cardiovascular complications are the most crucial , and their effects are so intensive that their derangement leads to cardiac failure even in the absence of ischemic heart diseases. This entity of cardiac pathology in DM is often regarded as diabetic cardiomyopathy (DCM). Recently, many plant-derived drugs have been tested to control and alleviate DCM. Wogonin is one of the drugs the characteristics of which have been deeply studied. Wogonin is a flavonoid having yellow color pigment in their leaves and is obtained from the roots of plant Scutellaria Baicalensis Georgi. Wogonin has long been used as an active anti-cancer drug in Chinese medicine practice. In recent past wogonin has shown to possess notable anti-inflammatory, and anti-allergic properties. Wogonin has demonstrated to possess anti-oxidant, anti-viral, anti-inflammatory and also anti-thrombotic properties. </P><P> Wogonin has shown to alleviate apoptosis, and ER stress in the cells and this property can also be used in the treatment of cardiovascular diseases. Notably, wogonin has been documented to have an extensive margin of safety as well as displays little or no organ toxicity following extended intravenous administration. In this review, we discuss recently discovered therapeutic potential of wogonin in the treatment of DCM.</P>

scholarly journals Processed Scutellaria baicalensis Georgi Extract Alleviates LPS-Induced Inflammatory and Oxidative Stress through a Crosstalk between NF-κB and KEAP1/NRF2 Signaling in Macrophage Cells

2021 ◽  
Vol 11 (13) ◽  
pp. 6055
Author(s):  
Akhtar Ali ◽  
En-Hyung Kim ◽  
Jong-Hyun Lee ◽  
Kang-Hyun Leem ◽  
Shin Seong ◽  
...  
Keyword(s):  
Scutellaria Baicalensis ◽  
Raw 264.7 Cells ◽  
Prostaglandin E ◽  
Scutellaria Baicalensis Georgi ◽  
Anticancer Effects ◽  
Tnf Α ◽  
Clinical Benefits ◽  
Anti Oxidant ◽  
Cox 2 ◽  
Anti Inflammatory

Prolonged inflammation results in chronic diseases that can be associated with a range of factors. Medicinal plants and herbs provide synergistic benefits based on the interaction of multiple phytochemicals. The dried root of Scutellaria baicalensis Georgi and its compounds possess anti-inflammatory, anti-oxidative, and anticancer effects. Processing is a traditional method to achieve clinical benefits by improving therapeutic efficacy and lowering toxicity. In this study, we investigated the anti-inflammatory and anti-oxidant effect of processed Scutellaria baicalensis Georgi extract (PSGE) against lipopolysaccharide (LPS) stimulated RAW 264.7 cells. Data using Griess assay and ELISA showed that PSGE decreased nitric oxide and prostaglandin E2 (PGE2) levels against LPS. PSGE treatment up-regulated 15-hydroxyprostaglandin dehydrogenase (PGDH), while cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 expression did not change. Interestingly, PGE2 inhibition was regulated by prostaglandin catabolic enzyme 15-PGDH rather than COX-2/mPGES-1, enzymes essential for PGE2 synthesis. Additionally, PSGE-suppressed LPS-induced IL-6 and TNF-α production through NF-κB signaling. NF-κB release from an inactive complex was inhibited by HO-1 which blocked IκBα phosphorylation. The ROS levels lowered by PSGE were measured with the H2DCFDA probe. PSGE activated NRF2 signaling and increased antioxidant Hmox1, Nqo1, and Txn1 gene expression, while reducing KEAP1 expression. In addition, pharmacological inhibition of HO-1 confirmed that the antioxidant enzyme induction by PSGE was responsible for ROS reduction. In conclusion, PSGE demonstrated anti-inflammatory and anti-oxidant effects due to NRF2/HO-1-mediated NF-κB and ROS inhibition.

Pharmacological activities and Therapeutic potential of kaempferitrin in medicine for the treatment of human disorders: A review of medicinal importance and health benefits

2021 ◽  
Vol 21 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Broiler Chickens ◽  
Therapeutic Potential ◽  
Scientific Information ◽  
Aloe Vera ◽  
Crocus Sativus ◽  
Related Complication ◽  
Food Material ◽  
Biological Potential ◽  
Anti Oxidant ◽  
Anti Inflammatory

Background: Herbal drugs and their derived phytochemicals are valuable for human being as a source of vital component of food material and drugs. Flavonoids are naturally occurring phytochemical produced in plants through metabolisms and they are having anti-hyperlipidemia, anti-inflammatory, anti-oxidant and anti-apoptotic activity. Flavonoids have been identified in the fruits, nuts, vegetables, seeds, stem, flowers and tea. Kaempferol is a natural flavonoidal compound present in edible plants such as apples, broccoli, strawberries, beans, grapefruit, propolis and medicinal plants such as Aloe vera, Ginkgo biloba, Rosmarinus officinalis, Crocus sativus L., Hypericum perforatum L. Kaempferol have anti-oxidant, anti-inflammatory, anti-apoptotic, pro-apoptotic, cardio-protective and anti-cancer activities. Methods: Glycosides of kaempferol such as kaempferitrin also called kaempferol 3,7-dirhamnoside are known to be more abundant than their flavonoid monomers in plants. Various literature databases have been searched to collect all the scientific information of kaempferitrin in the present investigation and analyzed in order to know the therapeutic benefit and biological potential of kaempferitrin. Moreover all the information has been presented here in two broad sections i.e. pharmacological and analytical. Results: From the analysis of all the collected and presented information, it was found that kaempferitrin has potent insulin-mimetic potential and could be used for the treatment of diabetes and related complication. However, it has also shown anti-oxidant, anti-inflammatory, anti-convulsant, anti-osteoporotic, anti-depressant, anthelmintic, immunostimulatory and natriuretic properties and inhibits cell proliferation and apoptosis. Kaempferitrin also improves meat quality of broiler chickens. Conclusions: The presented information in this work will be valuable to justify the biological importance and therapeutic potential of kaempferitrin in the scientific field.

scholarly journals Observing the Anti-oxidant and Anti-inflammatory Effect of Nigella Sativa Combined With Silybum Marianum Extracts on the Acute Peritonitis Mouse Model

2021 ◽  
Vol 24 (3) ◽  
pp. 372-385
Author(s):  
Maryam Bahrami ◽  
◽  
Ali Ghazavi ◽  
Ali Ganji ◽  
Ghasem Mosayebi ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Therapeutic Potential ◽  
Inflammatory Diseases ◽  
Nigella Sativa ◽  
Control Group ◽  
Silybum Marianum ◽  
Acute Peritonitis ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Background and Aim: In addition to free radicals such as Nitric Oxide (NO), inflammation is one of the most important pathophysiological causes of peritonitis. Over thousands of years, Nigella Sativa (NS) and Silybum Marianum (SM) are two plants known for their anti-oxidant and anti-inflammatory properties. However, the effect of its compound is unclear. Thus, in this study, we evaluated the anti-inflammatory effect of NS and SM extracts and their combination on inflammatory diseases like thioglycollate peritoneal. Methods & Materials: Alcoholic extracts of SM and NS were obtained by the soxhlet method. Male Balb/C mice were divided into 5 groups and gavage orally for 14 days with SM, NS, the mixture of extracts of these two, DMSO 30% as the control group, and dexamethasone as the positive control group. The safety profile and acute toxicity in mice were assessed. On day 10, acute peritonitis was induced by thioglycollate 3%. Finally, the total anti-oxidant power and NO concentration were measured by FRAP and Griess method, respectively, in the serum of treated mice. Ethical Considerations: All experimental process was performed following the guidelines according to the Animal Ethics Committee of Arak University of Medical Sciences (IR.ARAKMU.REC.1397.359). Results: Acute toxicity test showed no significant changes in weight and physical appearance of the mice. However, the extract and their mixture decreased NO level significantly (P=0.000) in serum. Also, the mixture significantly increased total anti-oxidant power (P=0.015). Conclusion: Results showed that the SM and NS extract mixture demonstrated anti-inflammatory activity, inhibiting inflammatory mediators such as NO and increasing anti-oxidant power, thus supporting its therapeutic potential in slowing down inflammatory processes in inflammation disorders.

Potential Role of Curcumin in Amelioration of Skin Diseases: A Comprehensive Review

2020 ◽  
Vol 06 ◽  
Author(s):  
Bhumika Kumar ◽  
Rohan Aggarwal ◽  
Udai Prakash ◽  
P. K. Sahoo
Keyword(s):  
Skin Diseases ◽  
Therapeutic Potential ◽  
Curcuma Longa ◽  
Antibacterial Properties ◽  
Skin Inflammation ◽  
Skin Aging ◽  
Ultraviolet B ◽  
Skin Cancers ◽  
Yellow Color ◽  
Anti Inflammatory

Abstract:: Curcumin is a natural polyphenol with bright yellow color, obtained from the spice turmeric (curcuma Longa) which is used since ancient times in various Asian countries including China and India for its anti‐inflammatory, antioxidative, and antibacterial properties. It possesses various other beneficial medicinal properties like anticarcinogenic, antimutagenic, antifungal, antiviral, antibacterial, antiulcer and hypocholesteremic which makes it an ideal multipurpose moiety for treating different diseases. Due to curcumin’s anti‐inflammatory, antioxidative, and antibacterial properties it is used in averting and treating several skin diseases like psoriasis, acne, skin inflammation, skin cancers and premature skin aging. Curcumin protects the skin against the damage caused by ultraviolet B radiations. Curcumin falls in the BCS class IV drug, with poor solubility and poor permeability which makes it very challenging in utilizing the maximum therapeutic potential of this moiety. The review aims at providing a broad updated view of curcumin and its efficacious role in treating various skin diseases.

scholarly journals Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

2020 ◽  
Vol 245 (5) ◽  
pp. 486-497 ◽  
Author(s):  
Vaishali Aggarwal ◽  
Hardeep S Tuli ◽  
Falak Thakral ◽  
Paavan Singhal ◽  
Diwakar Aggarwal ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Drug Targets ◽  
Molecular Mechanisms ◽  
Cancer Drug ◽  
Nano Technology ◽  
Anticancer Effects ◽  
Cell Metastasis ◽  
Tumor Cell Metastasis ◽  
Anti Oxidant ◽  
Anti Inflammatory

Hesperidin belongs to flavanones class of flavonoids and is known to possess broad-spectrum applicability to prevent dreadful diseases such as cardiovascular disease, neurodegeneration, and cancer. The reported anticancer effects of hesperidin have been found to be associated with its anti-oxidant and anti-inflammatory activities. Hesperidin interacts with numerous recognized cellular targets and inhibits cancer cell proliferation by inducing apoptosis and cell cycle arrest. In addition, evidence has suggested its promising role in inhibiting tumor cell metastasis, angiogenesis, and chemoresistance. The present mini-review highlights the ongoing development to identify hesperidin targets in cancer. Furthermore, the potential of nano technology-based hesperidin combinations and delivery systems will also be discussed. Overall, this review highlights all the possible molecular targets affected by hesperidin in tumor cells on a single platform. Impact statement Experimental findings from numerous studies have demonstrated the anticancer effects of hesperidin (Hesp) to be associated with anti-oxidant and anti-inflammatory activities along with its potential role in inhibiting the tumor cell metastasis and angiogenesis. Additionally, Hesp can also reverse drug resistance of cancer cells, which make it a promising candidate to be used in combination with existing anti-cancer drugs. This review will be helpful for upcoming researchers and scientific community to find out complete capsular package about cancer drug targets of Hesp and its role in modulating various important hallmarks of cancer.

scholarly journals Evaluation of Anti Inflammatory and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Seed Extract of Mucuna pruriens

2021 ◽  
pp. 816-824
Author(s):  
P. Anushya ◽  
R. V. Geetha ◽  
S. Rajesh Kumar
Keyword(s):  
Copper Nanoparticles ◽  
Cytotoxic Effect ◽  
Seed Extract ◽  
Inflammatory Activity ◽  
Mucuna Pruriens ◽  
Cancer Drug ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Effect Of Copper

Introduction:  Nanotechnology is a rapidly developing interdisciplinary area that has brought enormous changes in dentistry. Copper nanoparticle made from plant extract would be an environmental friendly, convenient and dependable way for providing therapeutic agents that are safe, free of side effects and useful for a wide range of diseases. Mucuna pruriens seed extract was selected for our study, due to its due to its anti- bacterial, anti-diabetic, anti- Parkinson, anti-cholesterol and anti- oxidant properties. Aim: To evaluate the anti-inflammatory properties of Mucuna pruriens, the green synthesis, characterization of CuNPs, and screening of their cytotoxic activity. Materials and methods: The collection and preparation of Mucuna pruriens extract was done and stored for further use. Synthesis of Cu nanoparticles was done with 30 milli molar of copper (II) sulfate. Centrifugation was done and characterisation of Copper nanoparticles using ultraviolet (UV)-visual spectrophotometer.  Cytotoxic effect and anti-inflammatory activity of copper nanoparticles with Mucuna pruriens seed extract were assessed using Brine Shrimp Assay at 5µL, 10µL, 20µL, 40µL and 80 µL and Bovine Serum Albumin (BSA) at 5 µL, 10 µL, 20 µL, 30 µL, 50 µL. Results: The anti inflammatory activity of Copper Nanoparticles with Mucuna pruriens, increased with increase in concentrations. Percentage of inhibition was 17% at 10 µL concentration, 24% at 20 µL, 43% at 30 µL and 54% at 40 µL and highest at 50 µL (71%). Cytotoxicity of Copper Nanoparticles with Mucuna pruriens, at 5 µL concentration there was a death of 10% of nauplii, at 10 µL there was a death of 20% of nauplii, at 20 µL and 40 µL there was a death of 30% of nauplii and at 80 µL there was a death of 40% of nauplii. As the concentration increased, the cytotoxicity of the nanoparticles increased. Conclusion: Based on the results of the current study, it is concluded that Mucuna pruriens mediated Cu Nps can be used as a potential source of anti inflammatory agent and also as an anti cancer drug for the treatment of tumours and cancers.

scholarly journals Effects of Piper sarmentosum on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

2021 ◽  
Vol 11 (21) ◽  
pp. 9860
Author(s):  
Sophia Ogechi Ekeuku ◽  
Mohd Fahami Nur Azlina ◽  
Kok-Yong Chin
Keyword(s):  
Metabolic Syndrome ◽  
Principal Components ◽  
Therapeutic Potential ◽  
Cardiovascular Complications ◽  
Infectious Agents ◽  
Research Gaps ◽  
East Asians ◽  
Future Studies ◽  
Anti Inflammatory ◽  
Randomised Controlled

Piper sarmentosum (PS) is a traditional medicinal herb used by South East Asians. It demonstrates promising properties against various non-communicable diseases and infectious agents due to its antioxidant and anti-inflammatory properties. Given that oxidative stress and inflammation are involved in developing and exacerbating metabolic syndrome (MetS) and its principal components (central obesity, hyperglycaemia, hypertension, and dyslipidaemia), PS could manage MetS and its complications. This review summarises the available literature on the effects of PS on principal components of MetS and their complications. The accumulated evidence suggests that PS prevented adiposity, hyperglycaemia, hypertension, and dyslipidaemia in preclinical studies mainly through its antioxidant and anti-inflammatory properties. It also protected against MetS-associated cardiovascular complications. This review has identified research gaps in this field and suggested future studies to guide interested researchers to explore further or affirm the therapeutic potential of PS. One of the most significant challenges to the medical use of PS is the absence of randomised controlled trials in humans. This study gap must be bridged before PS supplementation could be used to manage MetS in humans.

Hydrogen sulfide: an old gas with new cardioprotective effects

2014 ◽  
Vol 128 (5) ◽  
pp. 321-323 ◽  
Author(s):  
Vaibhav B. Patel ◽  
Brent A. McLean ◽  
Xueyi Chen ◽  
Gavin Y. Oudit
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Hydrogen Sulfide ◽  
Diabetic Cardiomyopathy ◽  
Therapeutic Potential ◽  
Cardiovascular Complications ◽  
Signalling Pathways ◽  
Intracellular Signalling Pathways ◽  
Signalling Molecule ◽  
Cardioprotective Effects

Diabetic cardiovascular complications are reaching epidemic proportions and the risk of HF (heart failure) is increased 2–3-fold by diabetes mellitus. H2S (hydrogen sulfide) is emerging as a new gaseous signalling molecule in the cardiovascular system which possesses multifactorial effects on various intracellular signalling pathways. The proven cardioprotective and vasodilator activities of H2S warrant a detailed investigation into its role in diabetic cardiomyopathy. In the present issue of Clinical Science, Zhou et al. demonstrate an important therapeutic potential of the H2S pathway in diabetic cardiomyopathy.

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

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