Exploring the Potential of Aromatherapy as an Adjuvant Therapy in Cancer and its Complications: A Comprehensive Update

2021 ◽  
Vol 21 ◽  
Author(s):  
Madhuri Grover ◽  
Tapan Behl ◽  
Mohit Sanduja ◽  
Md. Habibur Rahman ◽  
Amirhossein Ahmadi
Keyword(s):  
Adjuvant Therapy ◽  
Essential Oil ◽  
Essential Oils ◽  
Chemical Constituents ◽  
Chemical Components ◽  
Traditional Practice ◽  
Mutagenic Potential ◽  
Potential Health ◽  
Anti Cancer ◽  
Authentic Data

Background: Aromatherapy is a traditional practice of employing essential oils for the therapeutic purposes, currently headed under the category of complementary and adjuvant medicine. Objective: The aim of this review article is to summarize the potential health benefits of aromatic essential oil from traditional times till the present. It also proposed some mechanisms which can be utilized as basis for using aromatherapy in cancer and cancer linked complications. Methods: To find out the relevant and authentic data, several search engines like Science direct, Pubmed, research gate, etc. were thoroughly checked by inserting key words like aromatherapy, complementary, adjuvant therapy etc. to collect the relevant material in context of article. Also, the chemical components of essential oil were classified based on the presence of functional groups, which are further explored for their cytotoxic potential. Results: The result depicted the anti-cancer potential of chemical constituents of essential oil against different types of cancer. Moreover, the essential oils show promising anti-inflammatory, anti-microbial, anti-oxidant and anti-mutagenic potential in several studies, which collectively can form the basis for initiation of its anti-cancer utility. Conclusion: Aromatherapy can serve as adjuvant economic therapy in cancer after the standardization of protocol.

scholarly journals Chemical Characterization and Antidiabetic Activity of Essential Oils from Pelargonium graveolens Leaves

2021 ◽  
Vol 9 (1) ◽  
pp. 109-113
Author(s):  
Javed Ahamad ◽  
Subasini Uthirapathy
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Chemical Constituents ◽  
Chemical Characterization ◽  
Study Finding ◽  
Antidiabetic Activity ◽  
Chemical Components ◽  
Diabetic Patients ◽  
Pelargonium Graveolens

Pelargonium graveolens (Geranium) is a source of the finest quality of fragrance and its essential oils are used as antibacterial, and antifungal agents. The aim of the current research is to determine chemical constituents in the essential oil of P. graveolens by GC-MS and evaluate its antidiabetic activity via α-glucosidase inhibition assay. The chemical composition of P. graveolens essential oil was determined by GC/MS and its antidiabetic activity was assessed through inhibition of α-glucosidase enzyme in in-vitro models. GC-MS analysis determines 36 chemical components in the essential oil of P. graveolens leaves, and citronellyl isovalerate (10.41 %), menthol (9.61 %), linalool (8.63 %), p-menthone (6.31 %), and geranyl tiglate (4.99 %) were recorded as major constituents. The essential oil of P. graveolens leaves showed concentration dependant inhibition of α-glucosidase enzyme ranging from 28.13±1.41 to 74.24±2.53 µg/mL for concentration ranging from 31.25 to 1000 µg/mL. The IC50 values for of P. graveolens and acarbose were found as 93.72±4.76 and 80.4±2.17 µg/mL, respectively against the α-glucosidase enzyme. The study finding explores the chemical components of P. graveolens growing in the Iraqi Kurdistan region and scientifically supported its possible use in diabetic patients for controlling postprandial hyperglycemia.

scholarly journals Chemical Composition of Essential Oils Obtained from Heteromorpha arborescens (Spreng.) Cham. and Schltdl Leaves Using Two Extraction Methods

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Taiwo Oluwafunmilola Abifarin ◽  
Gloria Aderonke Otunola ◽  
Anthony Jide Afolayan
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Co2 Emission ◽  
Chemical Constituents ◽  
Solvent Free ◽  
Oil Yield ◽  
Chemical Components ◽  
Chemical Compositions ◽  
Microwave Extraction ◽  
Oxygenated Compounds

This study was aimed at comparing the essential oils obtained from Heteromorpha arborescens leaves by Solvent-Free Microwave Extraction (SFME) and Hydrodistillation (HD) methods in terms of their chemical compositions, yield, CO2 emission, and energy consumption. The solvent-free microwave extraction method indicated a higher oil yield of 0.7 mL/200 g (0.35%) as compared to 0.59 mL/200 g (0.295%) obtained through hydrodistillation. GC-MS analysis of the oils revealed a total of 52 chemical components from both methods with the presence of 35 (96.52%) and 30 (71.15%) chemical constituents for HD and SFME, respectively. The major constituents observed in the essential oil extracted by SFME methods include α-pinene (6%), D-limonene (11.27%), β-ocimene (9.09%), β-phellandrene (6.33%), β-mycene (8.49%), caryophyllene (5.96%), and camphene (4.28%). However, in the hydrodistillation method, the oil was majorly composed of a-pinene (4.41%), β-pinene (10.68%), β-ocimene (6.30%), germacrene-D (5.09%), humulene (5.55%), and α-elemene (6.18%). The SFME method was better in terms of saving energy (0.25 kWh against 4.2 kWh of energy consumed), reduced CO2 emission (200 g against 3360 g of CO2), a higher yield, and better quality of essential oil due to the presence of higher valuable oxygenated compounds (8.52%) against that of the hydrodistillation method (2.96%). The SFME method is, therefore, a good alternative for extracting the oils of H. arborescens leaves since the essential oil yield is higher with more oxygenated compounds, considerable energy savings, lower cost, and reduced environmental burden at substantially reduced extraction time (30 min as opposed to 180 min).

scholarly journals Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yu Zhong ◽  
Qin Zheng ◽  
Pengyi Hu ◽  
Xiaoying Huang ◽  
Ming Yang ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Mouse Brain ◽  
Chemical Constituents ◽  
Sleep Time ◽  
Gas Chromatography Mass Spectrometry ◽  
Chemical Components ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sleeping Time ◽  
Psychotropic Substances

Abstract Backgrounds The chemical composition of many essential oils indicates that they have sedative and hypnotic effects, but there is still a lack of systematic studies on the sedative and hypnotic effects of essential oils. In addition, aromatherapy does not seem to have the side effects of many traditional psychotropic substances, which is clearly worthwhile for further clinical and scientific research. The clinical application of essential oils in aromatherapy has received increasing attention, and detailed studies on the pharmacological activities of inhaled essential oils are increasingly needed. Hypothesis/purpose As insomniacs are usually accompanied by symptoms of depression and anxiety of varying degrees, based on the theory of aromatherapy of Traditional Chinese Medicine, this experiment is to study a Compound Anshen essential oil that is compatible with Lavender essential oil, Sweet Orange essential oil, Sandalwood essential oil and other aromatic medicine essential oils with sedative and hypnotic effects, anti-anxiety and anti-depression effects. To study the sedative and hypnotic effects of Compound Anshen essential oil inhaled and the main chemical components of Compound Anshen essential oil, and to compare and analyze the pharmacodynamics of diazepam, a commonly used drug for insomnia. Methods The Open field test and Pentobarbital-induced sleep latency and sleep time experiments were used to analyze and compare the sedative and hypnotic effects of inhaling Compound Anshen essential oil and the administration of diazepam on mice. The changes of 5-HT and GABA in mouse brain were analyzed by Elisa. The main volatile constituents of Compound Anshen essential oil were analyzed by gas chromatography-mass spectrometry (GC-MS). Results Inhalation of Compound Anshen essential oil can significantly reduce the spontaneous activity of mice, reduce latency of sleeping time and prolong duration of sleeping time. The results of enzyme-linked immunosorbent assay showed that Compound Anshen essential oil can increase the content of 5-HT and GABA in mouse brain. The main volatile chemical constituents of the Compound Anshen essential oil are D-limonene (24.07%), Linalool (21.98%), Linalyl acetate (15.37%), α-Pinene (5.39%), and α-Santalol (4.8%). Conclusion The study found that the inhalation of Compound Anshen essential oil has sedative and hypnotic effect. This study provides a theoretical basis for further research and development of the sedative and hypnotic effects of Compound Anshen essential oil based on the theory of aromatherapy.

Research Progress of Essential Oil as a New Complementary Therapy in the Treatment of Depression

2021 ◽  
Vol 21 ◽  
Author(s):  
Xinli Liang ◽  
Xinli Wang ◽  
Guowei Zhao ◽  
Xiaoying Huang ◽  
Xiqiang Xu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Mental Disease ◽  
Complementary Therapy ◽  
Scientific Basis ◽  
Research Progress ◽  
Chemical Components ◽  
Physical And Mental Health ◽  
Plant Essential Oils ◽  
Treatment Of Depression

: Depression is a mood disorder or affective disorder disease with depression as the main symptom. It has become a kind of mental disease that cannot be ignored in the world that seriously endangers human physical and mental health. Antidepressants commonly used in clinics generally have some defects including slow action, unremarkable effects and large side-effects. Therefore, there has a huge developing space for the research of new and effective therapeutic drugs to supplement or replace traditional drugs. Essential oil has obvious advantages in the treatment of depression and other emotional diseases, its aromatic odor can directly stimulate the olfactory nerves, and the lipophilic small- molecular compounds can cross the blood-brain barrier easily, to play its regulatory role of releasing of neurotransmitters and hormones related to depression, or adjusting the expression of brain-derived neurotrophic factor and proinflammatory cytokines. The pathogenesis of depression and the problems in traditional medication was illustrated, the research on the antidepressant effects and mechanism of essential oils in recent years was summarized and the antidepressant chemical components in plant essential oils were reviewed in this article. It could provide scientific basis for essential oil to be a new choice for relieving depression and treating depression.

scholarly journals Constituents of Peel and Leaf Essential Oils of Citrus Medica L

2009 ◽  
Vol 1 (2) ◽  
pp. 387-392 ◽  
Author(s):  
M. N. I. Bhuiyan ◽  
J. Begum ◽  
P. K. Sardar ◽  
M. S. Rahman
Keyword(s):  
Gas Chromatography ◽  
Essential Oil ◽  
Essential Oils ◽  
Mass Spectroscopy ◽  
Chemical Constituents ◽  
Citrus Medica ◽  
Leaf Oil ◽  
Gas Chromatography Mass Spectroscopy ◽  
Total Oil ◽  
Peel Oil

The chemical constituents of leaf and peel essential oil of Citrus medica L. were analysed by gas chromatography mass spectroscopy (GC-MS). Nineteen components accounting for 99.9% of the oil were identified in leaf oil. The major constituents are erucylamide (28.43%), limonene (18.36%) and citral (12.95%). The peel oil contains forty three components accounting for 99.8% of the total oil and the major components are isolimonene (39.37%), citral (23.12%) and limonene (21.78%). Keywords: Citrus medica; Essential oils; GC-MS; Erucylamide; Isolimonene. © 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.DOI: 10.3329/jsr.v1i2.1760   

scholarly journals Chemical constituents of essential oil of Dracocephalum moldavica L. and Dracocephalum kotschyi Boiss. from Iran

2016 ◽  
Vol 107 (1) ◽  
pp. 25 ◽  
Author(s):  
Ahmad Reza GOLPARVAR ◽  
Amin HADIPANAH ◽  
Mohammad Mehdi GHEISARI ◽  
Reza KHALILIAZAR
Keyword(s):  
Essential Oil ◽  
Chemical Constituents ◽  
Geranyl Acetate ◽  
Chemical Components ◽  
Aromatic Plants ◽  
Mazandaran Province ◽  
Isfahan Province ◽  
Aerial Parts ◽  
Dracocephalum Kotschyi ◽  
North Of Iran

<em>Dracocephalum moldavica </em>L. and <em>Dracocephalum kotschyi </em>Boiss. are aromatic plants belonging to Lamiaceae family.<strong> </strong>The aim of this study was to identify the chemical components of <em>D. kotschyi<strong> </strong></em>and <em>D. moldavica</em> from Iran.<strong> </strong>The aerial parts of <em>D. kotschyi </em>were collected from (Kamu Mountain) Isfahan province and the aerial parts of <em>D. moldavica</em> were collected from Sari (Mazandaran province) North of Iran, during 2014. The essential oil was extracted by a Clevenger approach and analyzed using GC/MS. In total, 32 and 24 compounds were identified in the essential oil from the aerial parts <em>D. kotschyi<strong> </strong></em>and <em>D. moldavica</em>, respectively. The results obtained in our study indicated that the major components in the oil <em>D. kotschyi<strong> </strong></em>were limonene (23.56 %), carvacrol (14.65 %), γ-terpinene (12.99 %), α -pinene (12.62 %), 2-methyl-1-octen-3-yne (9.73 %), camphene (4.66 %), myrcene (3.65 %) and α -terpinene (3.12 %). The major constituents of the oil <em>D. moldavica</em> were geranyl acetate (36.62 %), geraniol (24.31 %), neral (16.25 %) and geranial (11.21 %). <em>D. kotschyi </em>is one of the important sources of limonene and<em> D. moldavica </em>is one of the important sources of geranyl acetate.

scholarly journals Extraction, Radical Scavenging and Antimicrobial Activity of Essential Oils of Root of Dryopteris marginalis

2019 ◽  
Vol 31 (11) ◽  
pp. 2512-2516 ◽  
Author(s):  
Md. Zahidul Islam ◽  
Jannat Al Foisal ◽  
Mahbubur Rahman ◽  
Mst. Afsana Mimi ◽  
Faridul Islam ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Antioxidant Activities ◽  
Chemical Constituents ◽  
Total Concentration ◽  
Petroleum Ether Extract ◽  
Radical Scavenging ◽  
Organic Extracts ◽  
Zones Of Inhibition ◽  
Essential Oil Yield

The aim of the study was to characterize the chemical constituents and determine antibacterial and antioxidant activities of essential oils and three different extracts of Dryopteris marginalis. The root had essential oil yield of 0.36 % (w/w) in which 12 organic compounds representing 97.22% of the root oils were identified. Tyranton was found as the most abundant component with 77.571 % of the total concentration in the essential oil. The zones of inhibition of different organic extracts against the tested bacteria were found in the range of 6.5-15 mm. Pseudomonas was the most vulnerable with MICs of 15.62 μg/mL by both ethyl acetate and petroleum ether extract producing 3.8 mm zone of inhibition. The essential oils extracted from roots of Dryopteris marginalis showed maximum 85.29 % inhibition of radical scavenging at 2 mg/mL concentration. Among all root extracts, methanol extract exhibited 41.11 % inhibition at 2 mg/mL concentration.

scholarly journals Evaluation of volatile constituents, exudation of resin and occurrence of galls of Protium aracouchini (Aubl.) Marchand

2021 ◽  
Vol 5 (3) ◽  
pp. 88
Author(s):  
Thiago Augusto Araujo Correia Lima (in memorian) ◽  
Leonardo Pinto Cunha ◽  
José Eduardo Lahoz da Silva Ribeiro ◽  
Marcia Ortiz Mayo Marques ◽  
Maria da Paz Lima
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Chemical Constituents ◽  
Brazilian Amazon ◽  
High Concentration ◽  
Forest Reserve ◽  
Volatile Constituents ◽  
Aerial Parts ◽  
First Time ◽  
Time Information

Protium aracouchini (Aubl.) Marchand [sin Icica aracouchini Aubl.], which occurs in the Adolpho Ducke Forest Reserve, in the Brazilian Amazon, was evaluated for the presence of galls, for resin exudation and the composition of the essential oils from the aerial parts and the resin. The experiment to stimulate the exudation of resin from the trunk was conducted using a 2-chloroethylphosphonic acid solution. The resin produced after 40 days and the aerial parts had their essential oils extracted in a Clevenger apparatus and the volatile chemical constituents were analyzed using GC/MS. The non-oxygenated sesquiterpenes α-copaene (21.15%) and α-gurjunene (13.69%), in addition to the oxygenated sesquiterpene spathulenol (10.32%), were detected as the majority constituents of the essential oil of the leaves, and a concentration similar to that of α-gurjunene was found in the branches (13.28%). The resin essential oil showed a high concentration of hydrocarbon monoterpenes (76.49%) with a predominance of α-pinene (17.57%) and limonene (46.11%). Four gall morphotypes were found associated with this species. The present study reports for the first time information on the volatile constituents and the resinous potential of P. aracouchini, and registers the morphotypes of the galls that help in the taxonomy of the species.

scholarly journals COMPARATIVE STUDY OF DIFFERENT ROSEMARY ESSENTIAL OIL

1970 ◽  
Vol 63 ◽  
Author(s):  
Sonia A. Socaci ◽  
Maria Tofana ◽  
Carmen Socaciu ◽  
D. Varban ◽  
Sevastita Muste
Keyword(s):  
Essential Oil ◽  
Comparative Study ◽  
Essential Oils ◽  
Plant Material ◽  
Chemical Constituents ◽  
Rosemary Essential Oil

The present study includes researches regarding the composition of different varieties of rosemary essential oil. The essential oils were extracted from the plant material using the hydrodistillation technique. The analyses of the composition of essential oils were carried out by using a GC-MS system. The chemical constituents of the essential oil were separated and identified using the GC-MS NIST libraries.

scholarly journals Comparative Evaluation of the Inhibitory Effect of Some Essential Oils with Antibiotics against Pseudomonas aeruginosa

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Lobna El-Hosseiny ◽  
Moustafa El-Shenawy ◽  
Medhat Haroun ◽  
Fadhil Abdullah
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Inhibitory Effect ◽  
Chemical Components ◽  
Spectroscopy Analysis ◽  
Thyme Oil ◽  
Bioactive Agents ◽  
Gas Chromatography Mass Spectroscopy

Gas chromatography/mass spectroscopy analysis was performed to identify the chemical components of three extracted essential oils including thyme, marjoram, and sage. The antibacterial activity of the extracted essential oils against Pseudomonas aeruginosa (ATCC 9027) was investigated using disc diffusion assay, either alone or in combination with standard antibiotics (piperacillin, cefepime, meropenem, gentamicin, and norfloxacin). Results showed that the studied oils exhibited a variety of activities against the tested bacterium. Thyme oil was the most active followed by marjoram oil, whereas sage displayed no activity towards the tested organism. Thyme oil enhanced the antibacterial activity of cell wall targeting antibiotics (piperacillin, cefepime, and meropenem) by more than twofold. Marjoram oil potentiated the activity of all the tested antibiotics except norfloxacin. Sage, despite its inactivity against pseudomonas, synergistically enhanced the activity of piperacillin, meropenem, and gentamicin. Thyme essential oil, containing thymol as a major component (33.6%), exhibited higher activity alone or in combination with antibiotics than marjoram which contained alcoholic terpenes or sage essential oil that contained 1,8-cineole as its major component (29%). The investigated oils, as natural bioactive agents, may be used to enhance the activity of antibiotics towards pseudomonas.

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