Vitamin D Status in Egyptian Adolescent Females with Iron Deficiency Anemia and Its Correlation with Serum Iron Indices

2019 ◽  
Vol 19 (4) ◽  
pp. 519-525
Author(s):  
Eman H. EL-Adawy ◽  
Fawkia E. Zahran ◽  
Gehan A. Shaker ◽  
Amal Seleem
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Adolescent Girls ◽  
Serum Iron ◽  
Adolescent Females ◽  
Dietary Factors ◽  
Deficiency Anemia ◽  
Control Group ◽  
Healthy Control

Background: In Egypt, it seems that adolescent girls are a candidate for Vitamin D Deficiency (VDD), mostly due to inadequate sun exposure as a result of the culture and social dress codes and dietary factors. Currently, there is growing evidence that VDD is associated with Iron Deficiency Anemia (IDA). Aim: To investigate the frequency of VDD in adolescent females with IDA in comparison to healthy control and demonstrate whether VD level was correlated with serum iron indices. Subjects and Methods: Forty adolescent females with known cases of IDA (group 1) and 30 healthy females matched for age as a control (group 2) were selected. We compared the differences between the two groups to determine the degree of VD level; where VDD was defined as 25-hydroxyvitamin D [25(OH)D] ≤20 ng/mL, vitamin D insufficiency (VDI) as 25(OH) D of 20-30 ng/mL, and vitamin D sufficiency (VDS) as 25(OH)D >30 ng/mL. Body mass index (BMI), complete blood count (CBC), serum iron, total iron binding capacity (TIBC), serum ferritin, serum creatinine, ionized calcium and 25(OH)D were measured for all participants. Results: We found that subnormal vitamin D (VDD and VDI) was more frequent in the IDA group (75%) than control (40%), (p = 0.025); where 19 adolescent female patients (47.5%) were VDD, 11 (27.5%) were VDI and 10 (25%) were VDS, while in the control group, VDD was present in 4 (20%), VDI in 4 (20%) and VDS in 12 (60%) respectively. There was not any significant correlation between serum VD and serum iron indices (r =0.168, p < 0.05) and Hb (r = 0.360, p < 0.001). There was no significant difference in serum hemoglobin level between IDA patients with subnormal VD and those with VDS. The mean level of serum 25(OH) D was significantly lower in winter months than summer in both groups; (16.87 vs. 31.57 mg/dL, p < 0.001) and (31.9 vs. 35.04 mg/dL, p < 0.001) respectively. BMI, Iron, TIBC and seasonal variation were not predictors of 25(OH) D levels in adolescent girls with IDA. Conclusion: VDD has a higher frequency in Egyptian adolescent females with IDA than healthy control. However, vitamin D levels were not significantly correlated with iron indices. Our result might direct the attention for measuring vitamin D level in patients with IDA with the possibility of VD supplementation with iron.

scholarly journals Relations between Iron Deficiency Anemia and Anemia from Hookworms Parasites

2015 ◽  
Vol 39 (2) ◽  
pp. 66-71
Author(s):  
Jamal A. AL Jabbar Attawi
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Control Group ◽  
Blood Samples ◽  
Male And Female ◽  
Female Patients ◽  
Parasitic Worms

     This research aimed at identifying the relationship of iron-deficiency anemia caused by insufficient dietary intake and the iron-deficiency anemia caused by parasitic worms such as hookworms. Whole blood was drawn from 40 specimens; 20 males and 20 females, normal healthy controls with age ranges 8-50 year. Blood samples were collected from 80 patients with symptoms of anemia, with age range from 10-50 year. After fecal examination, they were divided into two groups: Group one, iron-deficiency anemia with non-parasitic; and group two, iron-deficiency anemia with parasitic. Blood samples were divided into two container, one for the hemoglobin, other for serum ferritin and elements of iron, zinc in tubes without anticoagulants. Results demonstrated a significant decrease in the levels of serum iron, serum ferritin, and hemoglobin in male and female patients (in group one without parasitic worms) as compared with control groups. Furthermore (in two groups with and without parasitic worms), a significant decrease in the level of serum zinc in male and female patients as compared with control group. A significant decrease in the levels of serum iron, ferritin and hemoglobin were observed in male and female patients with iron-deficiency anemia caused by parasitic hookworms compared with control group. The worm burden was classified as light, moderate and heavy as estimated by egg counts per gram of faeces, so results showed the median increase with developing of iron deficiency anemia from parasitic hookworms.

Modern view on the problem of iron deficiency in girls at pubertal age

2018 ◽  
pp. 86-92
Author(s):  
E.V. Kucher ◽  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Adolescent Girls ◽  
Ferritin Level ◽  
Reproductive Period ◽  
Laboratory Research ◽  
Deficiency Anemia ◽  
Control Group ◽  
Good Tolerability ◽  
Teenage Girls

Iron deficiency is one of the most urgent problems of adolescence. In the genesis of iron deficiency, a number of factors characteristic of the pubertal period are involved: accelerated rates of development, the formation of the ovarian-menstrual cycle, endocrine and metabolic dysfunctions. Prolonged iron deficiency to a decrease in the effectiveness of erythropoiesis, a violation of the differentiation of erythroid cells. In the case of an unresolved problem in girls in adolescence, iron deficiency in the reproductive period may have an adverse effect on the course of the gestational process, delivery, fetus and newborn condition in the future mother. The complex approach to the treatment and prevention of iron deficiency conditions in adolescent girls, the use of iron-containing preparations enriched with vitamins and microelements is topical. The objective: to study the effectiveness of correction of iron deficiency anemia in adolescent girls with the drug Fursinol-3, which represents a unique therapeutic complex of ferrous sulfate, zinc sulfate, vitamins of group B1, B2, B6, B9, C and PP. Materials and methods. Under outpatient observation, 62 patients aged 12–17 years were diagnosed with iron deficiency anemia (main group). The diagnosis was established on the basis of clinical (the presence of anemic and sideropenic syndromes) and laboratory research methods. The control group consisted of 30 teenage girls of similar age without anemic syndrome. Results. Results of clinical symptomatology evaluation after 6 weeks of drug administration showed that all women with IDA had no skin pallor, asthenoneurotic syndrome was curative, and epithelial syndrome was reduced. After 3 weeks of taking the drug, the Hb level was significantly higher than the baseline data (119.02±1.27 g/L compared to 99.89±1.08 g/L; p<0.001), and after 6 weeks of administration the drug reached the age norms. The increase in hemoglobin for 6 weeks of taking the drug was 21.16±0.99 g/L. After 6 weeks of administration of the Fernistol-3 preparation, patients with IDA showed a positive dynamics of serum ferritin level in comparison with the initial level (28.36±0.52 g/L versus 10.02±0.28 g/L; p<0.001). When using the drug “Fursinol-3” no side effects were noted. All patients noted good tolerability of the drug. Conclusions. The conducted studies showed high therapeutic effectiveness, good tolerability and safety of the drug Fersinol-Z, which gives reason to use it widely for correcting iron deficiency states in girls of pubertal age. The use of the drug Fessinol-3 in pediatric practice will promote along with iron deficiency, restoration of the balance of vitally important microelements and vitamins, contributing to the normalization of physiological processes in various organs and systems of a growing organism. Key words: iron-deficiency anemia, teenage girls, hemoglobin, MCV, MCH, ferritin, efficacy of therapy, Fersinol-Z.

scholarly journals Determining the Predictive Power of Vitamin D Levels in Iron Deficiency Anemia

2019 ◽  
Vol 1 (1) ◽  
pp. 29-35
Author(s):  
Sorush Niknamian
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Levels ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Roc Curve Analysis ◽  
Vitamin D Levels

Background:Iron deficiency anemia is one of the most common hypochromic microcytic anemias and nutritional disorders in today’s world. Vitamin D is an important steroid hormone for the metabolism of serum calcium and phosphorus and plays a major role in the function of various body systems. Evidence suggests that vitamin D deficiency is associated with iron deficiency anemia. We aimed to compare the serum level of vitamin D between children with iron deficiency anemia and healthy ones. Methods: This case-control study was conducted on 60 patients with iron deficiency anemia and 60 healthy ones who did not suffer from iron deficiency anemia. Patients participated in the study voluntarily. Vitamin D levels were measured using HPLC and ferritin by RIA method. To estimate the predictive value of vitamin D levels in iron deficiency anemia, ROC curve analysis was used.  Results: In this study, 120 children aged 6-144 months with mean age of 30.2±31.4 months were analyzed; 49.2% of them were boys and 50.8% were girls. Vitamin D levels varied from 4.8 to 63.2 ng/ml with a mean of 23.87±12.57 ng/ml in all patients (19.25±9.15 ng/ml in the case group and 28.48±13.84 ng/ml in the control group (P<0.001). In other words, patients with a vitamin D level <23.6 ng/ml should be investigated for iron deficiency anemia, and sufficient vitamin D had a protective effect on iron deficiency anemia and each unit increase in vitamin D decreased the chance of iron deficiency anemia by 7.8%. Conclusion: The prevalence of simultaneous iron deficiency anemia and vitamin D deficiency is very high in children and there is a significant relationship between serum levels of 25(OH)D and hemoglobin.

Influence of Artistic Gymnastics on Iron Nutritional Status and Exercise-Induced Hemolysis in Female Athletes

2012 ◽  
Vol 22 (4) ◽  
pp. 243-250 ◽  
Author(s):  
Thaiz Mattos Sureira ◽  
Olga Silverio Amancio ◽  
Josefina Aparecida Pellegrini Braga
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Female Athletes ◽  
Deficiency Anemia ◽  
Control Group ◽  
Type I ◽  
Iron Intake ◽  
Hematological Profile ◽  
Exercise Induced

This study evaluates the relationship between body iron losses and gains in artistic gymnastics female athletes. It shows that despite the low iron intake and exercise-induced hemolysis, iron deficiency or iron-deficiency anemia does not occur, but partial changes in the hematological profile do. The hypothesis that gymnasts’ nutritional behavior contributes to anemia, which may be aggravated by exercise-induced hemolysis, led to this cross-sectional study, conducted with 43 female artistic gymnasts 6–16 yr old. The control group was formed by 40 nontraining girls, paired by age. Hemogram, serum iron, ferritin, soluble transferrin receptor, haptoglobin, total and fractional bilirubin, Type I urine, and parasitologic and occult fecal blood tests were evaluated. The athletes presented mean hematimetric and serum iron values (p = .020) higher than those of the control group. The bilirubin result discarded any hemolytic alteration in both groups. The haptoglobin results were lower in the athlete group (p = .002), confirming the incidence of exercise-induced hemolysis. Both groups presented low iron intake. The results suggest that artistic gymnastics practice leads to exerciseinduced hemolysis and partially changes the hematological profile, although not causing iron deficiency or iron-deficiency anemia, even in the presence of low iron intake.

scholarly journals SALIVA IRON AND FERRITIN LEVELS IN PATIENTS WITH THALASSEMIA AND IRON DEFICIENCY ANEMIA

2012 ◽  
Vol 4 (1) ◽  
pp. e2012051 ◽  
Author(s):  
Duran Canatan ◽  
Sevgi Kosaci Akdeniz
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Iron Concentration ◽  
Thalassemia Major ◽  
The Body ◽  
Deficiency Anemia ◽  
Control Group ◽  
Healthy Children ◽  
Positive Correlation

Most of the  techniques for measuring iron accumulation such as serum iron concentration, iron binding capacity, serum ferritin level, liver biopsy are invasive and hard methods for patients. The changes in trace element concentrations in saliva at different systemic diseases shows the quantity of the element at the body. The aim of this study was to compare the levels of iron and ferritin in saliva and serum in patients  with thalassemia and iron deficiency anemia. For this purpose, 35 healthy children as control group and 71 thalassemia major, 10 thalassemia intermedia and 15 thalassemia trait patients were involved. Their saliva  and serum iron and ferritin levels were measured.  There was no statistically difference between age and gender in all groups and control group (p>0.05).  In all groups saliva iron levels are higher than serum iron levels(p<0.05). Furthermore there was a positive correlation betwen serum and saliva  iron levels in thalassemia major, intermedia and trait groups ( p=0.000, r=0.972, r=0.720, r=0.955) and also there was a positive correlation between serum and saliva iron levels in control and iron deficiency group (p= 0.000, r= 0.885, r= 0.368).  In conclusion,  Saliva iron and ferritin levels increase  as well as serum in patients with thalassemia and decrease in patients with iron deficiency anemia. Saliva can be used for diagnosis routinely  to shows the iron overload  and deficiency of the body and its easy applicability and also a non-invasive procedure is important advantage.

scholarly journals Changes of Serum Ferritin, Hemoglobin, and Serum Iron (SI) and Treatment Effect of Iron Proteinsuccinylate Oral Solution Combined with Vitamin A and D Drops on Children with Nutritional Iron Deficiency Anemia

2022 ◽  
Vol 2022 ◽  
pp. 1-6
Author(s):  
Yan Ma ◽  
Yanbo Ma ◽  
Xiuqing Zhang ◽  
Xuejing Wang ◽  
Zhigang Sun
Keyword(s):  
Iron Deficiency ◽  
Vitamin A ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Treatment Effect ◽  
Serum Iron ◽  
Oral Solution ◽  
Deficiency Anemia ◽  
Control Group ◽  
Observation Group

Objective. The purpose was to evaluate the treatment effect of iron proteinsuccinylate oral solution combined with vitamin A and D drops on children with nutritional iron deficiency anemia. Methods. 124 children treated in the outpatient department of our hospital from January 2017 to January 2020 were selected as the study subjects. They were randomly divided into control and observation two groups. The control group was treated with iron proteinsuccinylate oral solution (1.5 mL/kg) in the morning and evening, respectively. The observation group received adjuvant treatment with oral vitamin A and D drops based on the treatment of the control group. The treatment effect of proteinsuccinylate oral solution combined with vitamin A and D drops was evaluated by the serum iron (SI), serum ferritin (SF), and transferrin (TRF) levels, the values of CD3+, CD4+, and CD4+/CD8+, and other evaluation indicators. Results. After treatment, the SI and SF levels of children in both groups significantly increased ( P < 0.01 ) while the TRF level significantly decreased ( P < 0.01 ), and the SI and SF levels in the observation group increased more significantly, and the TRF level decreased more significantly compared with those in the control group ( P < 0.01 ). After treatment, the values of CD3+, CD4+, and CD4+/CD8+ of children in both groups significantly increased compared with those before treatment ( P < 0.01 ), and the values of CD3+, CD4+, and CD4+/CD8+ increased more significantly in the observation group compared with those in the control group ( P < 0.01 ). In addition, the evaluation results of treatment effect showed that the markedly effective rate in the observation group was significantly higher than that in the control group ( P < 0.01 ). Conclusion. Iron proteinsuccinylate oral solution combined with vitamin A and D drops can better improve the anemia symptoms in children, with high application value.

Serum Hepcidin: Its Correlation with Serum Ferritin, Serum Iron and Hemoglobin in Patients of Iron Deficiency Anemia

2015 ◽  
Vol 14 (2) ◽  
pp. 105-113
Author(s):  
Sajjad H. Naqvi ◽  
Syed Faizan-ul-Hassan Naqvi ◽  
Iftikhar H. Naqvi ◽  
Muhammad Farhan ◽  
Tanveer Abbas ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Serum Hepcidin

Study to Evaluate Efficacy of Vajravatakmaņdura in Iron Deficiency Anemia in Adolescent Girls: A Randomized Controlled Trial

2018 ◽  
Vol 3 (01) ◽  
Author(s):  
Rashmi Pareek Ayatullah Hosne Asif ◽  
Nisha Kumari Ojha
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Adolescent Girls ◽  
Controlled Trial ◽  
Control Programme ◽  
Deficiency Anemia ◽  
Group A ◽  
The Government ◽  
Trial Drug ◽  
And Control

Background: Anemia in adolescent girls possess greatest burden on their health as it leads to poor cognitive development, poor reproductive health and if not treated may lead to intrauterine growth retardation in their developing fetus. The prevalence of anemia among adolescent is 27% in developing country and 6% in developed country. The Government of India has launched National Anemia Control Programme, to prevent and control anaemia in children and adolescents. But the problem is still persisting because of many issues like - poor palatability, intolerance to the drug used, poor absorption of the drugs used, constipation, discoloration of stool, unpleasant odor and taste etc. result in poor compliance and therefore non adherence to the therapy which finally results in poor improvement. By looking at the magnitude of the problem, an Ayurveda drug Vajravatakmandura has been selected for the study and the present study was undertaken to evaluate the efficacy of the trial drug in iron deficiency anemia in adolescent girls. Material and methods: 100 subjects satisfying inclusion and exclusion criteria were selected and were randomly divided in two groups. In group A, the trial drug Vajravatakmaņdura was administered and in group B, IFA tablets were given for two month of duration with follow up at every fortnight. Result: Both the trial and control groups showed extremely significant result over subjective parameters. Trial drug Vajravatakmaņdura in group A was found more effective over the subjective parameters - weakness, palpitation, pallor and loss of appetite with % gain of 39.77%, 39.39%, 39.17%, 38.09% respectively. Statistical analysis between before and after treatment findings of objective parameters, extremely significant (P less than 0.0001) improvement was found in both groups in all parameters, except for RBC count in group A, which was significant. No adverse effects were reported during entire period of study by any of the patients in trial group treated with trial drug. Conclusion: The trial drug “Vajravatakmandura” is effective, safe and palatable for the management of iron deficiency anemia in adolescent girls.

scholarly journals Lactoferrin Efficacy versus Ferrous Sulfate in Treatment of Children with Iron Deficiency Anemia

2021 ◽  
Vol 11 (01) ◽  
pp. e199-e204
Author(s):  
Osama Mahmoud El-Asheer ◽  
Ahmed Gaber Ahmed ◽  
Zainab AbdelAal Abdel Hafez ◽  
Marwa AbdelHafiz Dahpy ◽  
Amal AbdElSalam Soliman
Keyword(s):  
Side Effects ◽  
Iron Deficiency ◽  
Patient Compliance ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Serum Transferrin ◽  
Iron Binding ◽  
Clinical Benefits

AbstractLactoferrin (LF) is an iron-binding globular glycoprotein that is structurally and chemically similar to serum transferrin. Many studies have been done to evaluate the effect of oral LF administration on iron deficiency anemia (IDA) with controversial results. This study was designed to compare the efficacy of LF versus oral ferrous sulfate (OFS) therapy in the treatment of children with IDA. A significant increase in mean hemoglobin and serum iron concentrations was noted in the group that received oral bovine LF (11.06 ± 0.96 and 42.79 ± 6.14, respectively) versus the group that received OFS (10.24 ± 0.57 and 28.94 ± 5.05, respectively, with p < 0.001 for each) after 30 days of the treatment with fewer side effects (9.3 vs. 33.3% with p = 0.043). Oral bovine LF is a more effective and safer alternative in treating iron deficiency and IDA compared with OFS with clinical benefits of fewer side effects and better patient compliance.

scholarly journals Role of Serum Transferrin Receptor in Diagnosing and Differentiating Iron Deficiency Anemia from Anemia of Chronic Disease in Patients with Chronic Kidney Disease

2017 ◽  
Vol 7 (2) ◽  
pp. 132-137
Author(s):  
Abdul Latif ◽  
Muhammad Rafiqul Alam ◽  
Asia Khanam ◽  
Farhana Hoque ◽  
Muhammad Abdur Rahim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Chronic Disease ◽  
Kidney Disease ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Transferrin Receptor ◽  
Deficiency Anemia ◽  
Control Group ◽  
Anemia Of Chronic Disease ◽  
Female Ratio

Background: Anemia is common in patients with chronic kidney disease (CKD) and this is generally anemia of chronic disease, but iron deficiency anemia (IDA) is also common. Soluble transferrin receptor (sTfR) is a useful marker for IDA. Present study was undertaken to assess the utility of sTfR as a marker of IDA in selected group of Bangladeshi patients with CKD.Methods: This cross-sectional study was conducted in the Department of Nephrology, BSMMU, Dhaka, Bangladesh from January 2013 to December 2014. Patients with anemia admitted in nephrology department whether on hemodialysis or not and medicine department of BSMMU were taken for study. The study population was further divided into two groups; Group A, patients who are having IDA and Group B, patients with ACD and a control group was also selected. Data were collected by face to face interview and laboratory investigations with a self-administered questionnaire.Results: The mean age of the patients in two study groups were 38.40±13.23 and 34.85±10.52 years respectively and male-female ratio were 0.5:1 and 1:0.5. Mean sTfR level was higher (4.81± 1.64 ?g/ml) in patients with IDA than (2.89±1.40 ?g/ml) in patients with ACD (p <0.0001). In our study mean ferritin level was 599.59± 449.15?g/L in ACD patients whereas 101.23±119.42 in IDA patients (p<0.0001). Total iron binding capacity (TIBC) was more in ACD patients with sTfRe”3?g/ml as compared to ACD patients with sTfR<3?g/ml. Transferrin saturation (TSAT) level was significantly decreased in ACD patients with sTfR ?3?g/ml as compared to ACD patients with sTfR<3?g/ml.Conclusion: sTfR has a comparable ability to S. ferritin in diagnosing IDA and ACD. However, sTfR and serum ferritin alone cannot definitely exclude co-existing iron deficiency in ACD. As sTfR is not affected by infection and/or inflammation, thus providing a non-invasive alternative to bone marrow study.Birdem Med J 2017; 7(2): 132-137

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