Different Cabergoline Effect on Metabolic and Anthropometric Parameters in Female Prolactinoma Patients Versus Idiopathic Hyperprolactinemia Patients

2019 ◽  
Vol 19 (4) ◽  
pp. 511-518
Author(s):  
Mohamed M. Aboelnaga ◽  
Eman H. Eladawy ◽  
Maha M. Elshafei ◽  
Nahed Abdullah ◽  
Moustafa El. Shaer
Keyword(s):  
Adipose Tissue ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Newly Diagnosed ◽  
Anthropometric Parameters ◽  
Adiposity Index ◽  
Female Patients ◽  
Adipose Tissue Dysfunction ◽  
One Year ◽  
Anthropometric Profile

Background: Hyperprolactinemia can lead to weight gain, insulin resistance, abnormal glucose homeostasis and dyslipidemia. Reversibility of these changes after normalization of prolactin with dopamine agonists is still controversial and needs more clarification. Objective: We aimed to: 1) evaluate and compare metabolic and anthropometric profile in female with newly diagnosed prolactin-secreting adenoma versus female idiopathic hyperprolactinemic patients; 2) compare the effects of one year cabergoline therapy on the metabolic profile and anthropometric parameters (by using visceral adiposity index as index for evaluation of adipose tissue dysfunction) in females with prolactinoma to female idiopathic hyperprolactinemic patients. Patients and Methods: We enrolled 40 female patients with newly diagnosed prolactinoma and 40 female patients with idiopathic hyperprolactinemia, who were matched according to: age; weight; BMI; waist; and prolactin levels. We enrolled the participants in this study at the time of diagnosis before therapy and they were followed up for 12 months. Results: Cabergoline therapy had significant favorable effects on metabolic and anthropometric parameters, visceral adiposity index and in all patients (apart from HDLc in prolactinoma patients). : Cabergoline therapy was significantly more effective in patient with idiopathic hyperprolactinemia than prolactinoma patients with regard to BMI, waist circumference, HDLc and visceral adiposity index despite normalization of prolactin levels in both groups. Conclusion: 12 months of Cabergoline treatment improved most of the anthropometric and metabolic parameters, and visceral adiposity index as a marker for adipose tissue dysfunction in both idiopathic hyperprolactinemia and prolactinoma patients. However, Cabergoline treatment was more effective in idiopathic hyperprolactinemic than prolactinoma patients.

scholarly journals Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Marco Calogero Amato ◽  
Carla Giordano
Keyword(s):  
Adipose Tissue ◽  
Cardiometabolic Risk ◽  
Polycystic Ovary ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Adiposity Index ◽  
Adipose Tissue Dysfunction ◽  
Conflicting Evidence ◽  
And Function

The Visceral Adiposity Index (VAI) has recently proven to be an indicator of adipose distribution and function that indirectly expresses cardiometabolic risk. In addition, VAI has been proposed as a useful tool for early detection of a condition of cardiometabolic risk before it develops into an overt metabolic syndrome. The application of the VAI in particular populations of patients (women with polycystic ovary syndrome, patients with acromegaly, patients with NAFLD/NASH, patients with HCV hepatitis, patients with type 2 diabetes, and general population) has produced interesting results, which have led to the hypothesis that the VAI could be considered a marker of adipose tissue dysfunction. Unfortunately, in some cases, on the same patient population, there is conflicting evidence. We think that this could be mainly due to a lack of knowledge of the application limits of the index, on the part of various authors, and to having applied the VAI in non-Caucasian populations. Future prospective studies could certainly better define the possible usefulness of the VAI as a predictor of cardiometabolic risk.

scholarly journals Changes in the Visceral Adiposity Index (VAI) Among Obese Older Adults After a 12-Month Exercise and Diet Intervention

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1247-1247
Author(s):  
Katelyn Senkus ◽  
Kristi Crowe-White ◽  
Julie Locher ◽  
Jamy Ard
Keyword(s):  
Older Adults ◽  
Adipose Tissue ◽  
Linear Models ◽  
Density Lipoprotein ◽  
Energy Restriction ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Necrosis Factor Alpha ◽  
Adiposity Index ◽  
Adipose Tissue Dysfunction

Abstract Objectives The Visceral Adiposity Index (VAI) was developed to estimate adipose tissue dysfunction as well as visceral fat distribution. In an ancillary analysis of the CROSSROADS Study (clinicaltrials.gov #NCT00955903), this study investigated the effects of exercise with and without intentional energy restriction on VAI changes among older adults with obesity. Methods Participants (n = 163, 37.4% male, 70.3 ± 4.7 years) were randomized to the following groups: exercise only, exercise + nutrient-dense weight maintenance diet, and exercise + nutrient-dense energy restriction of 500 kcal/d. Visceral adiposity determined by magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA), anthropometrics, and cardiometabolic biomarkers were assessed at baseline and 12 months. Waist circumference, body mass index, triglycerides, and high-density lipoprotein (HDL) cholesterol were used to compute VAI at both time points. Data were analyzed utilizing Spearman's correlations and general linear models to determine differences among groups following adjustment for covariates. Results Among all participants, significant correlations were observed between VAI and glucose, insulin, tumor necrosis factor-alpha (TNF-α), and the adiponectin: leptin ratio at baseline (r = 0.343, P < 0.001; r = 0.363, P < 0.001; r = 0.200, P = 0.011; r = −0.246, P = 0.002, respectively). DXA and MRI measures of visceral adiposity were not significantly correlated with VAI. Upon completion of the 12-month study period, there were significant differences in VAI among groups [F (2,137) = 5.957, P = 0.003)]. Post hoc analysis revealed that VAI was significantly lower in the exercise + nutrient-dense energy restriction group compared to the exercise only group (P = 0.002). Conclusions Results suggest that VAI may be an adequate measure of adipose tissue dysfunction, yet its ability to estimate levels of visceral adiposity warrants further investigation to determine clinical utility. Nonetheless, results suggest that an exercise + nutrient-dense energy restriction intervention may reduce VAI among older adults with obesity. Funding Sources NIH.

scholarly journals Comparative study of visceral adiposity index and lipid profile with Body Mass Index in adolescent and young adults

2019 ◽  
Vol 6 (6) ◽  
pp. 1722
Author(s):  
T. Anusha ◽  
Y. Sree Harsha ◽  
D. S. S. K. Raju
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Age Group ◽  
Adult Age ◽  
Adiposity Index ◽  
Waist Hip Ratio ◽  
Subcutaneous Adipose

Background: Obesity is associated with increased rate of mortality and morbidity if untreated. Obesity is a health hazard it required attention towards adolescent and adult age group. Generally, body fat is distributed into two main compartments that are subcutaneous adipose tissue and visceral adipose tissue. Waist Hip Ratio measures the subcutaneous adipose tissue, determination of visceral adiposity will further helpful for determination of cardiovascular disease.Methods: The study comprised of 120 subjects, of these adolescents comprised of 60 healthy adolescent childrens. The adults comprised of 60 healthy individuals. In all the subjects, Height was estimated in centimetres and Weight was measured in kilogram measured and BMI was calculated. The waist hip ratio and visceral adiposity index was calculated. In all the subjects, venous blood was collected from all the subjects for lipid profile estimation.Results: In present study BMI more than 25 have soon increased waist hip ratio and visceral adiposity index value than BMI less than 25 and it’s statically significant in both adolescent and adult group. It is also reported that BMI more than 25 have increased level of mean serum triglycerides, serum total cholesterol, LDL cholesterol and VLDL the increase was statistically significant. The mean serum HDL cholesterol was significantly decreased in BMI>25 group when compared with BMI<25.Conclusions: It was concluded that different age groups of adolescent and adult, appropriate methods should be planned specifically for adolescent and adult age group. Regular educational sessions are needed to make changes adolescent and adults toward obesity.

Association of visceral adiposity index with insulin resistance in adults with diabetes mellitus

2020 ◽  
Vol 14 (1) ◽  
pp. 5-12
Author(s):  
Sultana Parveen ◽  
Tohfa E Ayub ◽  
Tahniyah Haq ◽  
Nazmun Nahar ◽  
Naureen Manbub ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Adult Population ◽  
Fasting Blood Glucose ◽  
Visceral Adiposity ◽  
High Rate ◽  
Visceral Adiposity Index ◽  
Model Assessment ◽  
Anthropometric Parameters ◽  
Adiposity Index

Background and objectives: Visceral adiposity is linked to excess morbidity and mortality and positively correlates with the risk of insulin resistance, type-2 diabetes mellitus, cardiovascular disease and premature death. The study was conducted to find out the relationship between visceral adiposity index (VAI) and homeostatic model assessment insulin resistance (HOMA-IR) in diabetes mellitus (DM). Materials and methods: This cross sectional study was carried out on adult population with and without DM. Waist circumference (WC) and body mass index (BMI) were measured. BMI of 25-29.9 kg/m2 and ≥30 kg/m2 was defined as overweight and obese respectively. HOMA-IR method was used to calculate insulin resistance (IR). Standard formula using BMI, WC, triglyceride (TG) and high density lipoprotein cholesterol (HDL-c) was used to calculate VAI. Blood was analyzed for fasting blood glucose (FBS), TG, HDL-c and insulin level. Results: A total of 439 individuals were included in the study of which 269 had DM and 170 were healthy volunteers and the mean age was 41.47±6.82 and 36.16±7.44 years respectively. Compared to healthy controls, a greater number of diabetics had high VAI (86.5% vs. 98.9%) and high IR (43.5% vs. 85.1%). We found the highest sensitivity and specificity at a cut-off of 2.23 of VAI while at 3.65 had the highest specificity. Insulin resistance was observed significantly higher in those with diabetes compared to control, both in case of normal and high VAI at all cut-offs of VAI. Among anthropometric parameters (WC, BMI and VAI), VAI had positive (r=0.21, p<0.001) correlation with HOMA-IR than WC (r=0.10, p=0.043). Visceral fat was linearly related with insulin resistance (ß=0.18, p<0.001). Area under the curve (AUC) (0.66) showed that VAI can discriminate HOMA-IR. Conclusion: There was a high rate of raised VAI in cases with DM. VAI had positive association with HOMA-IR in diabetes mellitus. Although weak, there was an acceptable discrimination between them. Ibrahim Med. Coll. J. 2020; 14(1): 5-12

scholarly journals Visceral Adiposity in Relation to Body Adiposity and Nutritional Status in Elderly Patients with Stable Coronary Artery Disease

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2351
Author(s):  
Bartosz Hudzik ◽  
Justyna Nowak ◽  
Janusz Szkodziński ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Adipose Tissue ◽  
Nutritional Status ◽  
Predictive Value ◽  
The Body ◽  
Visceral Adiposity ◽  
Severe Malnutrition ◽  
Adiposity Index ◽  
Body Adiposity ◽  
Adipose Tissue Dysfunction ◽  
Stable Cad

Introduction: The accumulation of visceral abdominal tissue (VAT) seems to be a hallmark feature of abdominal obesity and substantially contributes to metabolic abnormalities. There are numerous factors that make the body-mass index (BMI) a suboptimal measure of adiposity. The visceral adiposity index (VAI) may be considered a simple surrogate marker of visceral adipose tissue dysfunction. However, the evidence comparing general to visceral adiposity in CAD is scarce. Therefore, we have set out to investigate visceral adiposity in relation to general adiposity in patients with stable CAD. Material and methods: A total of 204 patients with stable CAD hospitalized in the Department of Medicine and the Department of Geriatrics entered the study. Based on the VAI-defined adipose tissue dysfunction (ATD) types, the study population (N = 204) was divided into four groups: (1) no ATD (N = 66), (2) mild ATD (N = 50), (3) moderate ATD (N = 48), and (4) severe ATD (N = 40). Nutritional status was assessed using the Controlling Nutritional Status (CONUT) score. Results: Patients with moderate and severe ATD were the youngest (median 67 years), yet their metabolic age was the oldest (median 80 and 84 years, respectively). CONUT scores were similar across all four study groups. The VAI had only a modest positive correlation with BMI (r = 0.59 p < 0.01) and body adiposity index (BAI) (r = 0.40 p < 0.01). There was no correlation between VAI and CONUT scores. There was high variability in the distribution of BMI-defined weight categories across all four types of ATD. A total of 75% of patients with normal nutritional status had some form of ATD, and one-third of patients with moderate or severe malnutrition did not have any ATD (p = 0.008). In contrast, 55–60% of patients with mild, moderate, or severe ATD had normal nutritional status (p = 0.008). ROC analysis demonstrated that BMI and BAI have poor predictive value in determining no ATD. Both BMI (AUC 0.78 p < 0.0001) and BAI (AUC 0.66 p = 0.003) had strong predictive value for determining severe ATD (the difference between AUC 0.12 being p = 0.0002). However, BMI predicted mild ATD and severe ATD better than BAI. Conclusions: ATD and malnutrition were common in patients with CAD. Notably, this study has shown a high rate of misclassification of visceral ATD via BMI and BAI. In addition, we demonstrated that the majority of patients with normal nutritional status had some form of ATD and as much as one-third of patients with moderate or severe malnutrition did not have any ATD. These findings have important clinical ramifications for everyday practice regarding the line between health and disease in the context of malnutrition in terms of body composition and visceral ATD, which are significant for developing an accurate definition of the standards for the intensity of clinical interventions.

scholarly journals Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population

Metabolites ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 604
Author(s):  
Berenice Palacios-González ◽  
Guadalupe León-Reyes ◽  
Berenice Rivera-Paredez ◽  
Isabel Ibarra-González ◽  
Marcela Vela-Amieva ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Adipose Tissue ◽  
Bone Mineral ◽  
Health Workers ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Mineral Density ◽  
Adiposity Index ◽  
Low Bone Mineral Density ◽  
Visceral Adipose

Recent evidence shows that obesity correlates negatively with bone mass. However, traditional anthropometric measures such as body mass index could not discriminate visceral adipose tissue from subcutaneous adipose tissue. The visceral adiposity index (VAI) is a reliable sex-specified indicator of visceral adipose distribution and function. Thus, we aimed to identify metabolomic profiles associated with VAI and low bone mineral density (BMD). A total of 602 individuals from the Health Workers Cohort Study were included. Forty serum metabolites were measured using the targeted metabolomics approach, and multivariate regression models were used to test associations of metabolomic profiles with anthropometric, clinical, and biochemical parameters. The analysis showed a serum amino acid signature composed of glycine, leucine, arginine, valine, and acylcarnitines associated with high VAI and low BMD. In addition, we found a sex-dependent VAI in pathways related to primary bile acid biosynthesis, branched-chain amino acids, and the biosynthesis of pantothenate and coenzyme A (CoA). In conclusion, a metabolic profile differs by VAI and BMD status, and these changes are gender-dependent.

scholarly journals Visceral Adiposity Index is Associated With Silent Brain Infarct in a Healthy Population

2020 ◽  
Author(s):  
Ki-Woong Nam ◽  
Hyung-Min Kwon ◽  
Han-Yeong Jeong ◽  
Jin-Ho Park ◽  
Hyuktae Kwon ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Healthy Population ◽  
Consecutive Series ◽  
Brain Infarct ◽  
Adiposity Index ◽  
Silent Brain Infarct ◽  
Visceral Adipose

Abstract Background Visceral adiposity index (VAI) is a novel indicator of the mass and function of visceral adipose tissue, and it has been associated with metabolic disease, cardiovascular disease, and subclinical atherosclerosis; however, there is limited information about its association with cerebrovascular diseases, especially in subclinical pathology. In this study, we evaluated the relationship between VAI and silent brain infarct (SBI) in a healthy population. Methods We evaluated a consecutive series of healthy volunteers over the age of 40 between January 2006 and December 2013. SBI was defined as an asymptomatic, well-defined lesion with a diameter ≥ 3 mm with the same signal characteristics as the cerebrospinal fluid on T1- or T2 weighted images. VAI was calculated using sex-specific equations as described in previous studies, and was based on a number of parameters including waist circumference, triglycerides, high-density lipoprotein cholesterol, and body mass index. Results A total of 2,596 subjects were evaluated (mean age 56y, male sex: 54%), and SBI was found in 218 (8%) participants. In multivariable analysis, VAI (adjusted odds ratio [aOR] = 1.30; 95% confidence interval [CI] = 1.03–1.66; P = 0.030) remained a significant predictor of SBI after adjustment for confounders. On the other hand, visceral adipose tissue area on computed tomography did not show any statistical significance with SBI. The close relationship between VAI and SBI was prominent only in females (aOR = 1.44; 95% CI = 1.00-2.07; P = 0.048). In the evaluation between VAI and the burden of SBI, VAI showed a positive dose-response relationship with the number of SBI lesions (P for trend = 0.037). Conclusions High VAI was associated with a higher prevalence and burden of SBI in a neurologically healthy population, especially in females. Our findings indicate that VAI could be used as a simple and convenient predictor for SBI.

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