Effect of Propolis in Oral Health

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Romola Yumnam ◽  
Nandan N. ◽  
Kumar N.C. ◽  
Sunil Raj ◽  
Aneesha Mannepalli
Keyword(s):  
Honey Bees ◽  
Folk Medicine ◽  
General Purpose ◽  
Control Treatment ◽  
Oral Lesions ◽  
Storage Media ◽  
Dental Application ◽  
Plaque Control ◽  
Anti Inflammatory ◽  
Dental Applications

Propolis is a natural product derived from plant resins collected by honey bees. It is used by bees as glue, a general-purpose sealer and as draught-extruder for bee hives. Propolis has been used in folk medicine for centuries. The main chemical classes present in propolis are flavonoids, phenolics and other various aromatic compounds. Flavonoids are well known plant compounds that have antibacterial, antifungal, antiviral, antioxidant and anti-inflammatory proprieties. Propolis has been used in dentistry for various purposes and has a promising role in future medicine as well as in dentistry. Its natural resinous substance shows dental application based on its antimicrobial, anti-inflammatory and immunomodulating effects. Propolis is used in dentistry as active ingredient as mouth rinse for plaque control, treatment of various oral lesions, intracanal medicaments, storage media for avulsed teeth, wound healing. This paper gives an overview of propolis, its ingredients, properties and various therapeutic and dental applications.

Punica Granatum L - A nutraceutical functional food

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Priyadharshini K ◽  
Nandan N. ◽  
Sunil Raj ◽  
Kumar NC ◽  
Pooja BL ◽  
...  
Keyword(s):  
Punica Granatum ◽  
Control Treatment ◽  
Oral Lesions ◽  
Viral Pathogens ◽  
Storage Media ◽  
Wide Range ◽  
Plaque Control ◽  
Medicinal Properties ◽  
Dental Applications ◽  
Punica Granatum L

Pomegranate is a widely used plant having medicinal properties. Pomegranates and their extracts may serve as natural alternatives due to their potency against a wide range of bacterial and viral pathogens. The synergistic action of the pomegranate constituents appears to be superior to that of single constituents.Pomegranate provides health benefits, that is, a nutraceutical food. It is used in dentistry as an active ingredient such as mouth rinse for plaque control, treatment of various oral lesions, storage media for avulsed teeth, wound healing. This paper describes the uses of pomegranate, its mechanism and various therapeutic and dental applications.

Aloe Vera – Nature’s Power

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Dr. Jyothsna Chowdary Kantam ◽  
Kavita Rai ◽  
Nandan N.
Keyword(s):  
Wound Healing ◽  
Dental Implants ◽  
Active Ingredient ◽  
Aloe Vera ◽  
Control Treatment ◽  
Oral Lesions ◽  
Mouth Rinse ◽  
Anti Oxidant ◽  
Plaque Control ◽  
Dental Applications

Aloe vera is a plant used in various fields like Homeopathy, Ayurveda, Allopathy, Siddha, Unani, cosmetology, dermatology and surprisingly even in dentistry. Aloe vera is richest source of health for humans with various benefits and properties like wound healing, anti-microbial, anti-inflammatory, immunomodulatory, anti-septic, anti-helmenthic and anti-oxidant. Aloe vera is used in dentistry as active ingredient in tooth pastes, tooth gels and mouth rinse for plaque control, treatment of various oral lesions, halitosis and gingivitis, as decontaminant in endodontics, in extraction sockets, dental implants and in denture care. This paper gives an overview of aloe vera plant, its ingredients, properties and various therapeutic and dental applications.

scholarly journals Efficacy of an Eco-Friendly Bloom Thinning Formulation on Mango Trees and Its Olfactory Effect on an Insect Pollinator, Apis mellifera

Horticulturae ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 62
Author(s):  
Tae-Kwon Son ◽  
Md Munir Mostafiz ◽  
Hwal-Su Hwang ◽  
Nguyen Truong Thạnh ◽  
Kyeong-Yeoll Lee
Keyword(s):  
Apis Mellifera ◽  
Honey Bees ◽  
Fruit Size ◽  
Fruit Trees ◽  
Fruit Weight ◽  
Behavioral Changes ◽  
Control Treatment ◽  
Environmental Concerns ◽  
Olfactory Behavior ◽  
Insect Pollinator

In various orchard fruit trees, thinning of blossoms and fruits is important to increase fruit size and quality and to promote a new bloom in the following season. Several chemical thinning agents are currently commercially available, but they are inconsistent and produce side effects in crop plants and insect pollinators. Because of environmental concerns, developing alternative eco-friendly bloom thinning agents is necessary. We developed an eco-friendly bloom thinning formulation (BTF) using minerals and extracts of various medicinal plants. Our BTF spray (0.1%, <i>w/v</i>) decreased the number of fruits per tree (46.5%) and fruit yield per tree (81.5%) but increased the fruit weight (196.8%) compared with the control treatment; the spray induced a small number of larger mango fruits in the treated trees. We also investigated the effect of BTF on the olfactory behavior of <i>Apis mellifera</i> L. (Hymenoptera, Apidae), a major insect pollinator. We analyzed the behavioral changes of adult workers at two different concentrations (0.1% and 1%) of nine different BTF spray components using a Y-tube olfactometer. The behavioral responses of honey bees to nine BTF components showed significant differences. However, honey bees showed no clear attraction or repellent behavior towards the tested BTF components. Our results suggest that the newly developed eco-friendly BTF is practically applicable in mango orchards without interrupting honey bee behavior.

Diterpenes from Euphorbia myrsinites and Their Anti-inflammatory Property

Planta Medica ◽  
2021 ◽  
Author(s):  
Laura Grauso ◽  
Bruna de Falco ◽  
Giuseppe Lucariello ◽  
Raffaele Capasso ◽  
Virginia Lanzotti
Keyword(s):  
Folk Medicine ◽  
Phytochemical Analysis ◽  
Spectroscopic Techniques ◽  
Significant Activity ◽  
Relative Configuration ◽  
Drug Candidates ◽  
The Usa ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Diterpene Alcohol

Abstract Euphorbia myrsinites is one of the oldest spurges described and used in folk medicine. It is characterized by blue-grey stems similar to myrtle, and it is spread in the Mediterranean region, Asia, and the USA. Chemical analysis of E. myrsinites collected in Turkey afforded the isolation of 4 diterpenes based on the so-called myrsinane skeleton being tetraesters of the tetracyclic diterpene alcohol myrsinol. In this study, the phytochemical analysis of this species collected in Italy has been undertaken to afford the isolation of a new atisane diterpene, named myrsatisane, 3 ingenol derivatives, along with the 4 tetraester derivatives previously found. A triterpene compound based on the euphane skeleton has also been isolated. Structural elucidation of the new myrsatisane was based on spectroscopic techniques, including HR-MS and 1- and 2-dimensional NMR experiments. Its relative configuration was determined by NOE correlations, while absolute stereochemistry was obtained by quantum-mechanical DFT studies. While diterpenes with the atisane skeleton are relatively common in Euphorbia species, this is the first report of an atisane diterpene from E. myrsinites. All the isolated terpenes were tested for anti-inflammatory activity on J774A.1 macrophages stimulated with lipopolysaccharide by evaluation of nitrite and pro-inflammatory cytokine Il-1β levels. Among tested compounds, the 3 ingenol diterpenes exhibited a dose-dependent (0.001 – 3 µM) significant activity, thus showing their potential as anti-inflammatory drug candidates.

scholarly journals Identification of the Active Principle Conferring Anti-Inflammatory and Antinociceptive Properties in Bamboo Plant

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3054
Author(s):  
Bruna Araujo Sousa ◽  
Osmar Nascimento Silva ◽  
William Farias Porto ◽  
Thales Lima Rocha ◽  
Luciano Paulino Silva ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Folk Medicine ◽  
Active Principle ◽  
Therapeutic Effects ◽  
Protein Biochemistry ◽  
Antinociceptive Effects ◽  
Cellular Pathways ◽  
Anti Inflammatory ◽  
Bamboo Plant

Early plants began colonizing earth about 450 million years ago. During the process of coevolution, their metabolic cellular pathways produced a myriad of natural chemicals, many of which remain uncharacterized biologically. Popular preparations containing some of these molecules have been used medicinally for thousands of years. In Brazilian folk medicine, plant extracts from the bamboo plant Guadua paniculata Munro have been used for the treatment of infections and pain. However, the chemical basis of these therapeutic effects has not yet been identified. Here, we performed protein biochemistry and downstream pharmacological assays to determine the mechanisms underlying the anti-inflammatory and antinociceptive effects of an aqueous extract of the G. paniculata rhizome, which we termed AqGP. The anti-inflammatory and antinociceptive effects of AqGP were assessed in mice. We identified and purified a protein (AgGP), with an amino acid sequence similar to that of thaumatins (~20 kDa), capable of repressing inflammation through downregulation of neutrophil recruitment and of decreasing hyperalgesia in mice. In conclusion, we have identified the molecule and the molecular mechanism responsible for the anti-inflammatory and antinociceptive properties of a plant commonly used in Brazilian folk medicine.

scholarly journals TAK1/AP-1-Targeted Anti-Inflammatory Effects of Barringtonia augusta Methanol Extract

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3053
Author(s):  
Anh Thu Ha ◽  
Mi-Yeon Kim ◽  
Jae Youl Cho
Keyword(s):  
Mouse Model ◽  
Methanol Extract ◽  
Folk Medicine ◽  
Activator Protein 1 ◽  
Western Blot Assay ◽  
In Vivo Experiments ◽  
Chemokine Ligand ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Barringtonia augusta methanol extract (Ba-ME) is a folk medicine found in the wetlands of Thailand that acts through an anti-inflammatory mechanism that is not understood fully. Here, we examine how the methanol extract of Barringtonia augusta (B. augusta) can suppress the activator protein 1 (AP-1) signaling pathway and study the activities of Ba-ME in the lipopolysaccharide (LPS)-treated RAW264.7 macrophage cell line and an LPS-induced peritonitis mouse model. Non-toxic concentrations of Ba-ME downregulated the mRNA expression of cytokines, such as cyclooxygenase and chemokine ligand 12, in LPS-stimulated RAW264.7 cells. Transfection experiments with the AP-1-Luc construct, HEK293T cells, and luciferase assays were used to assess whether Ba-ME suppressed the AP-1 functional activation. A Western blot assay confirmed that C-Jun N-terminal kinase is a direct pharmacological target of Ba-ME action. The anti-inflammatory effect of Ba-ME, which functions by β-activated kinase 1 (TAK1) inhibition, was confirmed by using an overexpression strategy and a cellular thermal shift assay. In vivo experiments in a mouse model of LPS-induced peritonitis showed the anti-inflammatory effect of Ba-ME on LPS-stimulated macrophages and acute inflammatory mouse models. We conclude that Ba-ME is a promising anti-inflammatory drug targeting TAK1 in the AP-1 pathway.

scholarly journals Phytochemical Analysis, Antioxidant and Anti-Inflammatory Activity of Calyces from Physalis peruviana

2014 ◽  
Vol 9 (11) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Reina M. Toro ◽  
Diana M. Aragón ◽  
Luis F. Ospina ◽  
Freddy A. Ramos ◽  
Leonardo Castellanos
Keyword(s):  
Antioxidant Activities ◽  
Folk Medicine ◽  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Phytochemical Analysis ◽  
Physalis Peruviana ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Bio Assay

Physalis peruviana calyces are used extensively in folk medicine. The crude ethanolic extract and some fractions of calyces were evaluated in order to explore antioxidant and anti-inflammatory activities. The anti-inflammatory activity was evaluated by the TPA-induced ear edema model. The antioxidant in vitro activity was measured by means of the superoxide and nitric oxide scavenging activity of the extracts and fractions. The butanolic fraction was found to be promising due to its anti-inflammatory and antioxidant activities. Therefore, a bio-assay guided approach was employed to isolate and identify rutin (1) and nicotoflorin (2) from their NMR spectroscopic and MS data. The identification of rutin in calyces of P. peruviana supports the possible use of this waste material for phytotherapeutic, nutraceutical and cosmetic preparations.

scholarly journals Bioactivities of the ethanol extract from Ageratum fastigiatum branches: antioxidant, antinociceptive and anti-inflammatory

2016 ◽  
Vol 88 (3) ◽  
pp. 1471-1484
Author(s):  
GLAUCIEMAR DEL-VECHIO-VIEIRA ◽  
BRUNA C.S. SANTOS ◽  
MARIA SILVANA ALVES ◽  
AÍLSON L.A. ARAÚJO ◽  
CÉLIA H. YAMAMOTO ◽  
...  
Keyword(s):  
Antinociceptive Effect ◽  
Folk Medicine ◽  
Reducing Power ◽  
Ethanol Extract ◽  
Immersion Test ◽  
Significant Inhibition ◽  
Paw Edema ◽  
Hot Plate ◽  
Tail Immersion ◽  
Anti Inflammatory

ABSTRACT The present study was designed to investigate the antioxidant, antinociceptive and anti-inflammatory activities of the ethanol extract from Ageratum fastigiatum branches. Phytochemical screening and total phenol and flavonoid contents were determined. The antioxidant activity was assessed by 2,2-diphenyl-1-pycrilhydrazin (DPPH) and iron reducing power methods. The antinociceptive effect was evaluated using the acetic acid-induced writhing, formalin, hot plate and tail immersion assays; while the carrageenan-induced paw edema and pleurisy tests were performed to examine the anti-inflammatory activity against acute inflammation. The extract revealed the presence of flavonoids, tannins, coumarins, terpenes, sterols and saponins. Expressive levels of total phenols and flavonoids and a promising antioxidant effect were quantified. At the doses of 50, 100 and 200 mg/kg, the extract inhibited the writhing, reduced both phases of paw licking time and increased the reaction time on the hot plate. In the tail immersion test, the extract (50, 100 and 200 mg/kg) caused a significant inhibition of pain. In these doses, the paw edema, exudate volume and leucocyte mobilization were significantly reduced. These results suggest that A. fastigiatum can be an active source of substances with antioxidant, antinociceptive and anti-inflammatory activities, adding scientific support to the appropriate use in the Brazilian folk medicine.

scholarly journals Investigation of Pharmacological Activity of Caralluma penicillata: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Nabil Albaser ◽  
Najeeb Ghanem ◽  
Mohanad Shehab ◽  
Adnan Al-Adhal ◽  
Mohammed Amood AL-Kamarany
Keyword(s):  
Chronic Inflammation ◽  
Guinea Pigs ◽  
Therapeutic Potential ◽  
Histological Study ◽  
Folk Medicine ◽  
Ethanol Extract ◽  
Optimum Dose ◽  
Repeated Doses ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Caralluma is a plant that possessing a great therapeutic potential in folk medicine in Yemen, namely, Caralluma penicillata (C. penicillata) as antiulcer. The study aims to evaluate the anti-inflammatory properties and gastritis protection activity of C. penicillata against indomethacin in adult guinea pigs. The study was divided into four parts: firstly, the optimum dose of extract as anti-inflammatory effect was determined. Secondly, the acute anti-inflammatory effect of extract were estimated. Thirdly, the repeated doses of extract against chronic inflammation was estimated. The anti-inflammatory activity of extract was compared with indomethacin as a prototype of drug against inflammation. Fourthly, the gastritis protection properties of extract with/without indomethacin were performed. The results showed that a 400 mg/kg of 10% ethanol extract produced the maximum of anti-inflammatory effect. Also, the single dose of extract was equipotent for indomethacin (10 mg/kg), but shorter in duration with regard to acute anti-inflammatory effect. In addition, the repeated doses of extract against chronic inflammation were less potent than indomethacin with regard to ulcerogenic effect. On the other hand, extract-indomethacin combination reduced the gastritis effect of indomethacin based on ulcer index and histological study.

scholarly journals The Anti-Rheumatoid Arthritis Property of the Folk Medicine Dianbaizhu (Gaultheria leucocarpa var. yunnanensis, Ericaceae)

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Meng Xie ◽  
Yi Lu ◽  
Cheng Yan ◽  
Rui Jiang ◽  
Weirui Liu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis ◽  
Folk Medicine ◽  
Plant Parts ◽  
Effective Components ◽  
Water Fractions ◽  
Anti Inflammatory ◽  
Preferred Species ◽  
Necrosis Factor ◽  
Inflammatory Effect

The Chinese folk medicine Dianbaizhu, consisting of Gaultheria species, is widely used for the treatment of rheumatoid arthritis by several minority nationalities. The species and plant parts of this genus used as Dianbaizhu in clinical application are confused. In order to elucidate the species and the medicinal parts, as well as to ascertain the effective components and the probable optimal source of Dianbaizhu, the different plant parts and polarity fractions of its mainstream species, G. leucocarpa var. yunnanensis were investigated. The inhibition of nitric oxide and tumor necrosis factor produced in macrophage J774 were used to assess the anti-inflammatory effect of those samples. G. leucocarpa var. yunnanensis may be the preferred species for anti-RA effect. The underground parts of this taxon showed the best anti-inflammatory and anti-RA activities; the n-butanol and water fractions of the underground parts may be the most anti-RA active.

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