scholarly journals Histopathological Profile of Therapeutic Doses of Mango Mistletoe Methanolic Extract (MMME) in Cardiac of Hypertensive Rats (DOCA-Salt)

JSMARTech ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 048-054
Author(s):  
Annisatul Hakimah ◽  
◽  
Nour Sjakoer ◽  
Nurul Mubarakati ◽  
◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Muscle Cells ◽  
Positive Control ◽  
Negative Control ◽  
P Value ◽  
Hypertensive Rats ◽  
Control Groups ◽  
Significant Difference ◽  
Heart Muscle Cells ◽  
And Control

This study determined the effect of Mango mistletoe Methanolic Extract (MMME) on the cardiac's histopathological profile of hypertensive rats (DOCA-Salt) treated. The MMME was treated on fifty rats for 14 days, divided into five treatments: negative control, positive control, doses 50, 100, and 200 mg/kg BW with five replications. One-way ANOVA analysis was used, namely JAMOVI with version 1.1.9.0, and for cell calculation, diameter using the IMAGE J application. Results showed that there were no significant differences in the histopathological profile of the cardiac in hypertensive rats (DOCA-Salt) treated with MMME for 14 days on the diameter of the heart muscle cells between the control (+) and control groups (-), treatments 1, 2, and 3. This is evidenced by the analysis of p-value> 0.05, namely 0.187 millimeters. Therefore, we concluded that MMME does not affect the diameter of heart/cardiac organ muscle cells. However, there was a significant difference in the amount of necrosis in the cardiac of hypertensive rats between control (+) and control (-) groups, treatments 1, 2, and 3. Based on the results, MMME reduces the number of necrosis in the heart/cardiac organ.

The possible regulatory mechanisms of aqueous, ethyl acetate and nhexane fractions of the Ribes khorassanicum extract on acute hypertension in rats

2020 ◽  
Vol 20 ◽  
Author(s):  
Reza Mohebbati ◽  
Yasamin Kamkar-De ◽  
Mohammad Naser Shafei
Keyword(s):  
Ethyl Acetate ◽  
Antihypertensive Effect ◽  
Cardiovascular Responses ◽  
Regulatory Mechanisms ◽  
Hypertensive Rats ◽  
Control Groups ◽  
Acute Hypertension ◽  
The North ◽  
Significant Difference ◽  
And Control

Objective: Our previous studies showed the antihypertensive effect of Ribes khorassanicum (R. khorassanicum), a medicinal herb growing in the North Khorasan Province of Iran. For further evaluation, the present study investigated the effect of n-hexane (HX), ethyl acetate (EA), and aqueous (AQ) fractions of hydroalcoholic R. khorassanicum extract on cardiovascular responses in angiotensin II (AngII) and NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats. Methods: Wistar rats were randomly divided into 11 groups (n=5): 1) control, 2) AngII (50 ng/kg, i.v), 3) AngII + losartan (10 mg/kg, i.p), 4) L-NAME (10 mg/kg, i.v), 5) L-NAME+ sodium nitroprusside (SNP) (50 mg/kg, i.p), 6,7,8) one dose of each fraction of R. khorassanicum (AQ/EA/HX (50 mg/kg, i.p)) +AngII, and 9,10,11) one dose of each fraction of R. khorassanicum (AQ/EA/HX (50 mg/kg, i.p)) + L-NAME. Treated rats received three fractions 30 min before the injection of L-NAME and AngII in separate groups. The cardiovascular parameters were recorded by the Power Lab instrument via an angiocath inserted into the femoral artery. The peak changes (∆) of mean arterial pressure (MAP), systolic blood pressure (SBP), and heart rate (HR) in treated groups were compared with those of the hypertensive and control groups. Result: AngII and L-NAME significantly increased ∆MAP and ∆SBP and attenuated by pretreatment of LOS and SNP, respectively. Pretreatment with polar (AQ) and semipolar (EA) fractions of R. khorassanicum reduced the peak changes of MAP and SBP in both AngII and L-NAME-treated groups. Only the fraction of the herb attenuated the HR increased in the L-NAME group. The HR in other groups did not demonstrate any significant difference. Conclusion: All fractions of R. khorassanicum have an antihypertensive effect. However, the effect of polar fractions is more salient. It is also conceivable that the antihypertensive effect of fractions is mostly mediated by the inhibition of AngII.

Effect of Different Intermediary Bases on Microleakage of a Restorative Material in Class II Box Cavities of Primary Teeth

2017 ◽  
Vol 40 (2) ◽  
pp. 82-87 ◽  
Author(s):  
Faika Y. Abdelmegid ◽  
Fouad S. Salama ◽  
Waleed M. Al-Mutairi ◽  
Saud K. Al-Mutairi ◽  
Sultan O. Baghazal
Keyword(s):  
Primary Teeth ◽  
In Vitro Study ◽  
Class Ii ◽  
Positive Control ◽  
Negative Control ◽  
The Other ◽  
Control Groups ◽  
Significant Difference ◽  
The Mean

Introduction The aim of this in vitro study was to assess and compare the effect of different intermediary bases on microleakage between tooth and a nanocomposite interface in Class II box cavities in primary teeth. Methods Standard Class II box cavities were prepared in 52 primary molars and randomly divided into 9 groups according to the intermediary base used (Multicore Flow, Fuji II LC, SDR, Smart Dentin Replacement, and Biodentine). All specimens were subjected to thermocycling and prepared for microleakage testing and evaluation. Results There was significant difference in the mean ranks of microleakage between the 9 groups, which was observed in the gingival side (p<0.0001) and the occlusal side (p<0.0001). The mean ranks microleakage was significantly higher with experimental SDR, experimental Multicore Flow, and positive control materials when compared with the other 6 groups. The microleakage mean ranks were statistically significantly lower in experimental Fuji II LC, experimental Biodentine, and all negative control groups when compared with the other 3 groups. Conclusions Microleakage is affected by the application of intermediate material. Experimental Biodentine and Fuji II LC showed the lowest microleakage while experimental SDR and experimental Multicore Flow showed the highest microleakage.

scholarly journals Efficacy of a herbal toothpaste on patients with established gingivitis: a randomized controlled trial

2006 ◽  
Vol 20 (2) ◽  
pp. 172-177 ◽  
Author(s):  
Fabiana Ozaki ◽  
Claudio Mendes Pannuti ◽  
Ana Vitória Imbronito ◽  
Wellington Pessotti ◽  
Luciana Saraiva ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Controlled Trial ◽  
Test Group ◽  
Experimental Period ◽  
Positive Control ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Significant Difference ◽  
And Control

The aim of this randomised, double blind controlled trial was to verify the efficacy of a herbal dentifrice on the reduction of plaque and gingivitis. Forty eight volunteers with established gingivitis were randomly assigned to either a test group (herbal dentifrice) or positive control group (dentifrice with triclosan and fluoride). The dentifrices were distributed in plain white tubes by an independent pharmacy, which revealed the contents of each tube only after the experimental period. Plaque and gingivitis assessments were carried out on baseline and after 28 days of product use. All examinations were conducted by the same calibrated investigator. Subjects were instructed to brush their teeth three times daily using their assigned dentifrice for 28 days. There was a significant reduction in plaque levels in both the test and control groups. However, there was no significant difference between the groups. A significant reduction in gingivitis was observed in both groups, although there was no significant difference between them. No adverse reactions were reported. The authors concluded that both dentifrices were effective in reducing plaque and gingivitis in subjects with established gingivitis.

scholarly journals Prophylactic Effect of Memantine in Docetaxel Induced Neuropathy in Patients With Breast Cancer

2021 ◽  
Author(s):  
Pegah Mohammadzadeh ◽  
Elnaz Shaseb ◽  
Zohreh Sanaat ◽  
Parvin Sarbakhsh ◽  
Nasrin Gholami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Peripheral Neuropathy ◽  
Intervention Group ◽  
Metastatic Breast ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Abstract Purpose Peripheral neuropathy is a complication of taxane that in severe cases can limit the optimal treatment. The aim of this study was to evaluate the efficacy of memantine in prevention of docetaxel induced peripheral neuropathy in patients with breast cancer. Methods In this randomized clinical trial, 40 women between the ages of 18 and 64 years with non-metastatic breast cancer (stages I to III) were included (registry number: IRCT20160310026998N9 and registry date: 26 March 2019). All patients were treated with the AC-T regimen (with docetaxel). Patients in intervention group received memantine at a dose of 20 mg for 8 weeks at the beginning of the first cycle of docetaxel. Patients in control group did not take any medication for neuropathy prevention. To assess the neuropathy, DN4 and CTCAE questionnaires were used at baseline, one months, three months and six months after the intervention. Results The DN4 questionnaire score was remarkably less in memantine group in follow up one (p-value: 0.033) and three (p < 00.1). The CTCAE follow up score did not change during study. The Neuropathy duration and Neuropathy onset, were shown significant difference between the intervention and control groups, p = 0.050 and p = 0.001, respectively. From 40 patients, 8 (40%) in memantine group and 2 (10%) in control group, did not experience any kind of neuropathy. Conclusion Data showed that prophylactic administration of memantine 20 mg/day has been effective in prevention of severity and incidence of docetaxel induced neuropathy in patients with breast cancer.

scholarly journals Pengaruh pemberian klorofilin berbagai dosis terhadap indeks fagositosis makrofag dan kadar nitric oxide mencit BALB/c yang diinfeksi dengan Salmonella typhimurium

2014 ◽  
Vol 2 (2) ◽  
pp. 77-81
Author(s):  
Puspito Arum ◽  
Lisyani B Suromo ◽  
Niken Puruhita
Keyword(s):  
Immune Responses ◽  
Positive Control ◽  
Negative Control ◽  
Group Design ◽  
Macrophage Phagocytosis ◽  
Significant Difference ◽  
Post Test ◽  
Phagocytosis Index ◽  
And Control ◽  
One Way Anova

Background: Immune responses to eliminate Salmonella infection are by activating macrophage and by producing NO. Chlorophyllin is a chlorophyll derivate that has immunomodulator properties. Objective: The aim of this study was to prove effect of chlorophyllin in macrophage phagocytosis index and NO level. Methods: A post test only controlled group design was conducted in 5 groups Balb/c mice (negative control, positive control, dosage 100 µg/200 g BW, dosage 200 µg/200 g BW and dosage 380 µg/200 g BW). Macrophage phagocytosis index was measured by counting cells that phagocyte latexs particles. NO level was measured by Griess method. Macrophage phagocytosis index difference was analyzed by one way anova and NO level deference was analyzed by Kruskall-Wallis test (α 0,05).Results: Means of macrophage phagocytosis index were 0,7(±0,80), 1,8(±0,80), 2(±0,22), 2,5(±0,43) and 3,2(±0,68) respectively in negative control, positive control, chlorophyllin dosage 100 µg/g BW/day, 200 µg/g BW/day and 380 µg/g BW/day. There was a significant difference of macrophage phagocytosis index between group (p 0,000). Mean of NO level were 0,4 µM(±0,10), 0,6 µM(±0,60), 0,8 µM(±0,64), 0,6 µM(±0,67) and 0,4 µM(±0,26) respectively in negative control, positive control, chlorophyllin dosage 100 µg/g BW/day, 200 µg/g BW/day and 380 µg/g BW/day. There was no difference of  NO level between group (p 0,813).Conclusion: There was a significant difference of macrophage phagocytosis index between chlorophyllin administered group and control. The higher chlorophyllin dosage, the higher macrophage phagocytosis index. Therewas no difference of  NO level between chlorophyllin administered group and control.

scholarly journals Evaluation of in vivo anti-malarial potential of omidun obtained from fermented maize in Ibadan, Nigeria

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Favour O. Omeiza ◽  
George O. Ademowo ◽  
Funmilola A. Ayeni
Keyword(s):  
Scientific Evidence ◽  
Positive Control ◽  
Negative Control ◽  
Control Treatment ◽  
Malaria Therapy ◽  
Significant Difference ◽  
And Control ◽  
Final Group ◽  
Ibadan Nigeria

Abstract Background The menace of resistance to anti-malarial drugs is a great challenge to malaria control, necessitating the search for new anti-malarial agents. This search has led to the exploration of natural products for efficacy in malaria therapy. Omidun is the supernatant of fermenting maize (ogi) slurry that has been widely investigated and reported to possess several health benefits and it is used traditionally as solvent for preparing anti-malarial herbs. However, there is no information on the anti-malarial activity of omidun itself. This study was conducted to investigate the prophylactic, curative and suppressive anti-malarial potential of omidun. Methods Experimental mice in the curative group were infected with 1 × 106 cells of Plasmodium berghei strain ANKA and treated with either 0.2 ml of omidun containing 3 × 109 cfu/ml of viable lactic acid bacteria or 0.2 ml of 5 mg/kg of chloroquine (positive control) or 0.2 ml of saline (negative control) for 4 days from day 3 post infection. The prophylactic group of mice were pre-treated with either omidun, chloroquine or saline for 4 days before infection with P. berghei, while the suppressive group was treated with omidun or chloroquine or saline and infected with P. berghei simultaneously. A group of mice were uninfected but treated (with omidun and control samples), while a final group was uninfected and untreated (controls). Parasitaemia and histopathology analysis were done in all groups. Results The curative and suppressive groups showed a significant difference between the omidun-treated mice (100% parasitaemia reduction) and the untreated mice (54.5% parasitaemia increase). There was no significance difference between the omidun treatment and chloroquine (positive control) treatment in suppressive group as both treatment had 100% parasitaemia reduction. The omidun prophylactic treatment however did not show any parasitaemia suppression, but a significant difference was observed between the omidun treatment (85% increase) and the chloroquine (positive control) treatment (100% reduction) in the group. Omidun treatment is non-toxic to the kidney. Conclusion This study provides scientific evidence supporting omidun usage in the treatment of malaria. Consequently, further work may yield the specific component of omidun responsible for the anti-malarial activity.

scholarly journals Comparative Study on Iris Manifestations between COVID-19 Severe Cases and Non-COVID Individuals

2021 ◽  
pp. 53-60
Author(s):  
Y. Rosy Ayda ◽  
A. Mooventhan ◽  
M. H. Vinothkumar ◽  
C. A. Kayelarasi ◽  
S. Vijaykanth ◽  
...  
Keyword(s):  
Group Analysis ◽  
Autonomic Nerve ◽  
P Value ◽  
Diagnostic Purpose ◽  
Control Analysis ◽  
Control Groups ◽  
Age And Gender ◽  
Significant Difference ◽  
And Gender ◽  
And Control

Aims: To compare the iris manifestations between COVID-19 positive (severe) cases and their age and gender matched non-COVID-19 individuals. Study Design and Setting: A comparative cross sectional survey performed in Government Omandurar Medical College, Chennai Methodology: This study was performed to compare the iris manifestations between COVID-19 positive (severe) cases (n = 119) and their age and gender matched non-COVID-19 individuals (n = 119). Iris manifestations (both right and left eyes) of all the subjects (both study and control groups) were observed at only one point in time, and was compared between the groups. Statistical Analysis: Descriptive statistics (Frequency distribution and percentage) were performed using Microsoft excel 2010. Within-group analysis was performed using Wilcoxon Signed Ranks Test, while the between-groups (study and control) analysis was performed using Chi-square test with the use of statistical package for the social sciences, version 16. P value < 0.05 was considered as significant. Results: The research findings in right iris showed a significant difference at p<0.05 in Inner Pupillary Border (IPB), Autonomic Nerve Wreath (ANW), Scurf Rim (SCR), Inflammatory Sign (IS) and Lung Lesion (LL), while no significant difference at p<0.05 in Pupil Size (PS), Absorption Ring (AR), Iris Constitution (IC) and Stress Ring (STR) between the study and control groups. Likewise, the results of the left iris showed a significant difference at p<0.05 in IPB, ANW, SCR, LL and STR, while no significant change at p<0.05 in PS, IC, AR and IS between the study and control groups. Conclusion: The paper aid comparison of the iris manifestations between COVID-19 positive and their age and gender matched non-COVID-19 individuals. The findings are of broad use to the scientific and medical communities searching for safe, cost-effective diagnostic approach. The present study is important in furthering our understanding of the importance of looking into the iris for diagnostic purpose.

scholarly journals Uji Efektivitas Bioinsektisida Berbahan Aktif Beauveria bassiana (Balsamo) Vuillemin terhadap Kutudaun Macrosiphoniela sanborni pada Krisan

2016 ◽  
Vol 21 (3) ◽  
pp. 265
Author(s):  
Evi Silfia Yusuf ◽  
Donald Sihombing ◽  
Wahyu Handayati ◽  
Waqiah Nuryani ◽  
Saepuloh
Keyword(s):  
Biological Control ◽  
Beauveria Bassiana ◽  
Active Ingredient ◽  
Block Design ◽  
Ornamental Plants ◽  
Positive Control ◽  
Negative Control ◽  
Dendranthema Grandiflora ◽  
Significant Difference ◽  
And Control

Kutudaun Macrosiphoniela sanborni merupakan salah satu hama penting yang menimbulkan kerugian yang cukup serius pada budidaya krisan. Untuk mengendalikannya petani biasa menggunakan pestisida kimia sintetis. Selain itu pengendalian hayati berpotensi dapat menekan hama. Beauveria bassiana merupakan agens pengendali hayati  yang memiliki potensi besar untuk mengendalikan beberapa hama penting tanaman hias. Biorama 1, 2, dan 3 merupakan bioinsektisida berbahan aktif  B. bassiana dengan kepadatan1010 konidia per g bahan pembawa dengan bahan pembawa yang berbeda (tepung jagung, sekam, dan talk) yang dibuat di Laboratorium Biokontrol, Balai Penelitian Tanaman Hias (Balithi). Bioinsektisida tersebut terbukti efektif mengendalikan trips pada tanaman krisan. Penelitian bertujuan mengetahui efektivitas bioinsektisida Biorama 1, 2, dan 3 dalam mengendalikan kutudaun krisan. Penelitian dilaksanakan di Rumah Plastik Balithi Segunung sejak bulan Juli hingga November 2008. Bahan yang digunakan dalam penelitian ini ialah Dendranthema grandiflora kultivar Sakuntala. Perlakuan yang diuji yaitu Biorama 1 (1010 konidia/g tepung jagung), Biorama 2 (1010 konidia/g arang sekam), dan  Biorama 3 (1010 konidia/g talk) masing-masing dengan konsentrasi aplikasi 5 g/l, suspensi B. bassiana dengan kepadatan 1010 konidia/ml, Natural BVR adalah bioinsektisida komersial berbahan aktif B. bassiana (1010 konidia/g bahan pembawa) dengan konsentrasi aplikasi 5 g/l sebagai kontrol positif dan air sebagai kontrol negatif. Penelitian disusun menggunakan rancangan acak kelompok terdiri atas enam perlakuan dan lima ulangan. Hasil penelitian menunjukkan bahwa bioinsektisida Biorama 1, 2, dan 3  efektif mengendalikan kutudaun M. sanborni dan efektivitasnya tidak berbeda nyata dibandingkan dengan Natural BVR dan suspensi  Beauveria. Perlakuan tersebut mampu menekan serangan M. sanborni, masing-masing dengan 68,58,  60,59, dan  54,37 % secara berurutan. Bioinsektisida memberikan pengaruh nyata terhadap mortalitas kutudaun. Biorama 1 dan 2 menunjukkan keefektifan yang paling tinggi  (22,30 dan 24,20%) dalam menekan kerusakan bunga  dibandingkan dengan perlakuan lain dan kontrol. Implikasi dari penelitian ini ialah Biorama memiliki potensi yang besar diaplikasikan sebagai pestisida hayati ramah lingkungan pada budidaya krisan.<br /><br /><br /><br />Macrosiphoniela sanborni is one of the important pests causing serious losses on Chrysanthemum. Beauveria bassiana is a biological control agents, which has great potential to control several important pests on ornamental plants. Biorama 1, 2, and 3 are bioinsecticides containing B. bassiana as an active ingredient and made in Biological Control Laboratory of Indonesian Ornamental Crops Research Institute (IOCRI). The bioinsecticides were successfully tested and gave significant effect on controlling Chrysanthemum thrips. The study was aimed to determine the effectiveness of Biorama 1, 2, and 3 on controlling Chrysanthemum aphids. The experiment was conducted at the Plastichouse of  IOCRI from July to November 2008. Plant material used in this study was Dendranthema grandiflora cv. Sakuntala. The treatments tested were Biorama 1 (1010 conidia/g corn powder), Biorama 2 (1010 conidia/g activated-carchoal), and  Biorama 3 (1010 conidia/g talk) respectively with a concentration of 5 g/l, B. bassiana suspension with a density of 1010 conidia/ml, Natural BVR is a bioinsecticide with active ingredient B. bassiana, which has been commercialized as positive control in concentration 5 g/l and water as negative control. The experiment was arranged by a randomized complete block design consisted of  six treatments and five replications. The results showed that Biorama 1, 2, and 3 were effective to control  M. sanborni and the results did not give significant difference compared to  Natural BVR and Beauveria suspension. They reduced Chrysanthemum aphids up to 68.58, 60.59, and 54,37% respectively. Bioinsecticide provide real impact on the mortality of aphids. The Biorama 1 and 2 indicated the highest effectiveness (22.3 and 24.2% respectively) on lowering to flower damage compared to other treatments and control. This results indicated that Biorama have high potential applied as an environmental friendly biopesticide on Chrysanthemum cultivation.

scholarly journals Kebar Grass Extract (Biophitum Petersianum) Increases Diameter Of The Seminiferous Tubules Of Diabetic Mice

2021 ◽  
Vol 17 (1) ◽  
pp. 41-48
Author(s):  
Faraida Arvilla
Keyword(s):  
Oxidative Stress ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Seminiferous Tubules ◽  
Control Group ◽  
P Value ◽  
Diabetic Mice ◽  
Significant Difference ◽  
Stress Oxidative

Diabetes is a metabolic disease that can affect the male reproductive system. The condition of hyperglycemia will increase the production of ROS, causing oxidative stress. Oxidative stress causes microangiopathy, triggers cell apoptosis, interferes with spermatogenesis, thereby affecting the diameter of the seminiferous tubules. Kebar grass contains of flavonoid and vitamin E which can be used to reduce ROS reactions and inhibit oxidative stress. This research was to prove that kebar grass extract can increase diameter of the seminiferous tubules of diabetic mice. Total of 30 samples were divided into 5 groups: negative control group (K-) was given CMC-Na, positive control group (K+) was given metformin 2mg/kg, groups P1, P2 and P3 received 2mg/kg metformin and kebar grass extract with different dosages (67.5mg/kg, 135mg/kg and 270mg/kg). The treatment lasted for 35 days. On the 36th day the mice were sacrificed and the testes were taken, then histological observations were made with HE staining to measure the diameter of tubules. The result showed that there was a significant difference in the diameter of seminiferous tubules with p value=0,000. Kebar grass extract can increase the diameter of seminiferous tubules of diabetic mice.

scholarly journals The Potential of Billygoat Weed Leaf Extract (Ageratum Conyzoides) in Increasing Platelet Counts of Male Mice (Mus Musculus)

2020 ◽  
Vol 11 (1) ◽  
pp. 51-57
Author(s):  
Yessy Velina ◽  
Nirva Diana ◽  
Aulia Annisa
Keyword(s):  
Platelet Count ◽  
Positive Control ◽  
Negative Control ◽  
Plain Water ◽  
P Value ◽  
Male Mice ◽  
Ageratum Conyzoides ◽  
Platelet Counts ◽  
Randomized Design ◽  
Significant Difference

Billygoat weed (Ageratum conyzoides) is mainly used to treat wounds and fever. People also do not understand the use of these leaves in the treatment to increase the platelet counts. The objectives of this research Objectives were to test whether the Billygoat Weed’s leaves can increase platelet count of male mice and to find out what is the most effective dose of the Billygoat Weed on the platelet count of male mice. This research was done by employing the true experimental approach with the completely randomized design which consisted of 5 treatments, namely the negative control (plain water), the positive control (acetylsalicylic acid), 1.68 mg/kgBW, 2.52 mg/kgBW, and 3.36 mg/kgBW on five mice in each treatment. The increase in the platelet counts, based on the results of One-Way ANOVA with a p-value of 0,0004, the Billygoat Weed extract was able to increase the platelet counts. Through further testing, the smallest significant difference showed that a dose of 3.36 mg/kgBW was effectively able to increase the platelet counts of male mice with an average of 11140.80/. Billygoat weed (Ageratum conyzoides) is mainly used to treat wounds and fever. People also do not understand the use of these leaves in the treatment to increase the platelet counts. The objectives of this research Objectives were to test whether the Billygoat Weed’s leaves can increase platelet count of male mice and to find out what is the most effective dose of the Billygoat Weed on the platelet count of male mice. This research was done by employing the true experimental approach with the completely randomized design which consisted of 5 treatments, namely the negative control (plain water), the positive control (acetylsalicylic acid), 1.68 mg/kgBW, 2.52 mg/kgBW, and 3.36 mg/kgBW on five mice in each treatment. The increase in the platelet counts, based on the results of One-Way ANOVA with a p-value of 0,0004, the Billygoat Weed extract was able to increase the platelet counts. Through further testing, the smallest significant difference showed that a dose of 3.36 mg/kgBW was effectively able to increase the platelet counts of male mice with an average of 11140.80/𝑚𝑚3.

Sign in / Sign up

Export Citation Format

Share Document