scholarly journals Features of designing IoT systems

2019 ◽  
Vol 29 (2) ◽  
pp. 28-34
Author(s):  
A. Yu. Anufrienko
Keyword(s):  
Data Transfer ◽  
Early Stage ◽  
Technical Problem ◽  
Work Intensity ◽  
Fundamental Parameters ◽  
Radiated Power ◽  
Number Of Factors ◽  
Industrial Internet ◽  
Basic Characteristics ◽  
Proprietary Protocol

The development of IoT systems, especially in the field of Industrial Internet of things with a large number of end devices is a complex scientific and technical problem. Inability to take into account the number of factors at the early stage leads to a negative result. This document demonstrates the scientific approach to the creation of the above systems. The IoT protocols, the IoT system architecture and its components are described in this article. The problems arising in the design of IoT systems are described. The basic characteristics of the most common protocols are systematized. The method for solution of the actual scientific and applied problem, allowing to design the IoT system, taking into account various fundamental parameters including the frequency range, bandwidth, data transfer rate, radiated power, range, work intensity, as well as the fundamental constraints, is proposed. As a result of the application of the described method, the optimal IoT protocol can be chosen to build a system, or to determine and optimize the parameters of the proprietary protocol. That makes it possible to build a reliable and scalable IoT system for the solution of the relevant experimental problems.

Hikaru genki protein is secreted into synaptic clefts from an early stage of synapse formation in Drosophila

Development ◽  
1996 ◽  
Vol 122 (2) ◽  
pp. 589-597 ◽  
Author(s):  
M. Hoshino ◽  
E. Suzuki ◽  
Y. Nabeshima ◽  
C. Hama
Keyword(s):  
Critical Period ◽  
Synapse Formation ◽  
Neural Circuits ◽  
Motor Behavior ◽  
Early Stage ◽  
Axon Growth ◽  
Number Of Factors ◽  
Protein Functions ◽  
Abnormal Motor ◽  
Immunohistochemical Analyses

The development of neural circuits is regulated by a large number of factors that are localized at distinct neural sites. We report here the localization of one of these factors, hikaru genki (hig) protein, at synaptic clefts in the pupal and adult nervous systems of Drosophila. In hig mutants, unusually frequent bursting activity of the muscles and abnormal motor behavior during the adult stage suggest the misfunction of neuromuscular circuitry. Our immunohistochemical analyses revealed that hig protein, produced by neurons, is secreted from the presynaptic terminals into the spaces between the presynaptic and postsynaptic terminals. In addition, we have found that the localization of this protein in the synaptic spaces temporally correlates with its functional requirement during a critical period that occurs in the middle stage of pupal formation, a period when a number of dendrite and axon growth cones meet to form synapses. These findings indicate that hig protein functions in the formation of functional neural circuits from the early stages of synapse formation.

Perturbation of mammalian cell division: human mini segregants derived from mitotic cells

1975 ◽  
Vol 189 (1097) ◽  
pp. 591-602 ◽  
Keyword(s):  
Early Stage ◽  
Parental Cell ◽  
Optimal Conditions ◽  
Thiol Compounds ◽  
Number Of Factors ◽  
Wide Range ◽  
And Storage ◽  
Dense Chromatin ◽  
Size And Structure ◽  
Mitotic Cells

Mitotic HeLa cells can be induced to undergo abnormal cleavage and to give rise thereby to clusters of buds and/or to free mini segregants. A wide range of morphologies can be produced and the mini segregants vary considerably in size and structure. Some contain DNA which may or may not be enclosed in a nuclear membrane. This DNA in some of the mini segregants originates from dense ‘chromatin bodies’ which migrate to the periphery of the parental cell at an early stage of mitotic perturbation. The percentage of mitotic cells which undergo abnormal cleavage is affected by a number of factors including the pH of the medium, the presence of dithiothreitol or certain other thiol compounds, the absence of serum and storage of the mitotic cells at 4 °C before treatment. To date, the optimal conditions are: incubation at 37 °C in Hanks solution buffered at pH 8.0–8.4, after storage of the mitotic cells for about 3 h at 4 °C. Under these conditions about 70 % of the total mitotic population undergoes abnormal cleavage to produce clusters of mini segregants in the course of an incubation period of 3½ h. Possible mechanisms underlying the phenomenon are discussed.

scholarly journals Circulating Cell-Free Tumour DNA for Early Detection of Pancreatic Cancer

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3704
Author(s):  
Jedrzej J. Jaworski ◽  
Robert D. Morgan ◽  
Shivan Sivakumar
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Early Stage ◽  
Lower Sensitivity ◽  
Detection Rates ◽  
Early Stage Disease ◽  
Genetic Sequencing ◽  
Number Of Factors ◽  
Stage Disease ◽  
Invasive Method

Pancreatic cancer is a lethal disease, with mortality rates negatively associated with the stage at which the disease is detected. Early detection is therefore critical to improving survival outcomes. A recent focus of research for early detection is the use of circulating cell-free tumour DNA (ctDNA). The detection of ctDNA offers potential as a relatively non-invasive method of diagnosing pancreatic cancer by using genetic sequencing technology to detect tumour-specific mutational signatures in blood samples before symptoms manifest. These technologies are limited by a number of factors that lower sensitivity and specificity, including low levels of detectable ctDNA in early stage disease and contamination with non-cancer circulating cell-free DNA. However, genetic and epigenetic analysis of ctDNA in combination with other standard diagnostic tests may improve early detection rates. In this review, we evaluate the genetic and epigenetic methods under investigation in diagnosing pancreatic cancer and provide a perspective for future developments.

scholarly journals Funkcionalni rezultati lecenja pocetnih karcinoma glotisne regije larinksa

2009 ◽  
Vol 56 (3) ◽  
pp. 95-100 ◽  
Author(s):  
J.P. Milovanovic ◽  
V.B. Djukic ◽  
A.P. Milovanovic ◽  
A.S. Trivic ◽  
I.S. Baljosevic ◽  
...  
Keyword(s):  
Open Surgery ◽  
Early Stage ◽  
Voice Quality ◽  
Functional Results ◽  
Point Of View ◽  
Glottic Cancer ◽  
Study Group ◽  
Crucial Difference ◽  
Basic Characteristics ◽  
The Voice

Early stage glottic cancer can be successfully treated with open surgery, LASER surgery or radiotherapy. During this treatment the physician obviously has to bear in mind principles of oncological radicality, but also, none the less, the preservation of all the functions of the larynx, and especially the preservation of voice quality. The aim of the study is to compare, in a specifically designed prospective study, the method of treatment with the functional results of basic characteristics of spoken voice of patients with early stage cancer of the glottis region. Then, based on the analysis of the results, to try and determine the most successful method of treatment. The first study group consisted of 72 patients operated using transoral laser microsurgery; the second study group consisted of 75 patients operated using open surgery; and the third study group consisted of 74 patients treated with radiotherapy. The voice quality is much better after laser chordectomy compared to open surgery chordectomy with reconstruction. Furthermore, the functional results of voice quality, after a laser chordectomy, are worse when compared to the group of patients treated with radiotherapy. Taking into account all objective and subjective phoniatric parameters, we determined that there is no crucial difference in the voice quality of patients operated using laser chordectomy and patients primarily treated with radiotherapy. From a functional point of view these two methods are superior to open surgery chordectomy.

scholarly journals Factors that Influence the Adoption of Contact Tracing Applications: A Protocol for a Systematic Review (Preprint)

2021 ◽  
Author(s):  
Kiemute Oyibo ◽  
Kirti Sundar Sahu ◽  
Arlene Oetomo ◽  
Plinio Pelegrini Morita
Keyword(s):  
Systematic Review ◽  
Technology Acceptance ◽  
Systematic Reviews ◽  
Early Stage ◽  
Close Contact ◽  
Empirical Studies ◽  
Contact Tracing ◽  
Privacy Concerns ◽  
Number Of Factors ◽  
Barriers And Challenges

UNSTRUCTURED Digital contact tracing apps (CTAs) have become prevalent worldwide due to the COVID-19 pandemic, which began in the first quarter of 2020. Specifically, they have been developed to fast-track the identification and self-isolation of individuals who must have been exposed to the COVID-19 coronavirus by being in close contact with infected persons. However, their uptake has been low and slow due to a number of factors, which have been speculated in the gray and academic literature, for example, privacy concerns, lack of trust, poor persuasive design, etc. However, there is little understanding of the overall factors that hinder or facilitate the acceptance and adoption of CTAs from the viewpoint of the users. According to Zhang et al., “There is a dearth of evidence [especially based on systematic reviews] regarding the barriers and facilitators to uptake and engagement with COVID-19 digital contact tracing applications.” Although a handful of systematic reviews have been carried out, the majority of them were not related to technology acceptance. Moreover, they were conducted at the early stage of the pandemic in 2020 when only few peer-reviewed empirical studies had been conducted and published. Specifically, systematic reviews such as Braithwaite et al., Davalbhakta et al. and Juneau et al. were not particularly focused on technology acceptance aimed to uncover the facilitators and barriers militating against CTA adoption. Hence, a systematic review of the existing literature is necessary to understand users’ perceptions, including the factors that facilitate the adoption of CTAs, the barriers and challenges militating against their adoption, the measures being taken to tackle the challenges, and the moderating effect of demographic/human factors. The findings will uncover available opportunities to increase the design, adoption and effectiveness of CTAs in future iterations.

scholarly journals Basic characteristics of tontine insurance

2021 ◽  
Vol 59 (3) ◽  
pp. 268-284
Author(s):  
Vladimir Čolović
Keyword(s):  
United States ◽  
Life Insurance ◽  
Early Stage ◽  
The United States ◽  
Eu Law ◽  
Group Life ◽  
Insurance Group ◽  
Mutual Insurance ◽  
The Republic ◽  
Basic Characteristics

Tontine insurance is tied to life insurance. This type of insurance is also a type of mutual insurance. However, we must look at tontines separately, having in mind its origin and goal. Tontine insurance originated in the 17th century and was developed in England and the United States, until the beginning of the 20th century, when it became banned. Tontine insurance at an early stage contained elements of group annuity insurance, group life insurance and lottery. Today, tontine insurance is a type of fund within which policyholders, i.e., members, agree to jointly capitalize, i.e., finance their contributions to the fund and to divide the capitalized assets between those policyholders who reach a certain age and the heirs of the deceased insured. The Act on Insurance of the Republic of Serbia also regulates tontine insurance. The author pays attention to the provisions of EU law in this area.

Error-free, automated data integration of exosome cargo protein data with extensive clinical data in an ongoing, multi-omic translational research study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16743-e16743
Author(s):  
Ana Oromendia ◽  
Dorina Ismailgeci ◽  
Michele Ciofii ◽  
Taylor Donnelly ◽  
Linda Bojmar ◽  
...  
Keyword(s):  
Clinical Data ◽  
Biomarker Discovery ◽  
Mean Squared Error ◽  
Data Transfer ◽  
Early Stage ◽  
Genomic Analysis ◽  
Data Interpretation ◽  
Related Data ◽  
Data Object ◽  
Omic Data

e16743 Background: Major advances in understanding the biology of cancer have come from genomic analysis of tumor and normal tissue. Integrating extensive patient-related data with deep analysis of omic data is crucial to informing omic data interpretation. Currently, such integrations are a highly manual, asynchronous, and costly process as well as error-prone and time-consuming. To develop new blood assays that may detect very early stage PDAC, a multi-omic investigation with deep clinical annotation is needed. Using pilot data from an on-going study, we test a new platform allowing automated error-free integration of an extensive clinical database with extensive omic data. Methods: Demographic, clinical, family pedigree and pathology data were collected on the Rave EDC platform. Exosomes were purified from 46 plasma samples from 14 controls and 24 PDAC patients and cargo proteins were quantified via SILAC. The Rave Omics platform was used to ingest and integrate clinical and omic data, run quality checks and generate integrated clinical-omic datasets. Data fidelity was validated by systematically computing differences between corresponding values in the source flies with those present in the extracted data object (integrated data). The root mean squared error (RMSE) was calculated for numeric values in each sample. Additional validation was conducted by manual inspection to ascertain data integrity. Results: We demonstrated automatic integration, without human intervention, of a subset of the clinical data and all available SILAC data into an analysis-ready data object. Data transfer was completely faithful, with 100% concordance between the source and the integrated data without loss of features. All proteins (n = 1515) and clinical variables (n = 64) were imported. Their nomenclature and corresponding sample values (n = 69690) and clinical values (n = 2432) matched exactly between datasets. In all samples, the RMSE was exactly zero, indicating no deviation between data sources. Conclusions: We demonstrated that automatic, efficient, and reliable integration of clinical-omic data is achievable during an in-flight PDAC trial. Automatic exploratory analytics supporting biomarker discovery are currently being used to uncover associations between omic and clinical features. The Rave Omics platform is disease-agnostic and we plan to expand to trials of varying size, indication, and completion status where systematic, automated integration of clinical and (multi)omic data is needed.

scholarly journals Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiang-Gen Kong ◽  
Jin Geng ◽  
Tao Zhang ◽  
Bin Wang ◽  
An-Zhao Wu ◽  
...  
Keyword(s):  
Early Stage ◽  
Laboratory Data ◽  
Clinical Findings ◽  
Chinese Family ◽  
Limited Data ◽  
Immune Markers ◽  
Laboratory Findings ◽  
Family Cluster ◽  
The Family ◽  
Basic Characteristics

AbstractAlthough several cases of family clusters with SARS-Cov-2 infection have been reported, there are still limited data preventing conclusions from being drawn regarding the characteristics and laboratory findings in the COVID-19 population within family clusters. In the present study, we retrospectively collected five family clusters with COVID-19 and summarized the dynamic profiles of the clinical characteristics, laboratory findings, immune markers, treatment and prognosis of this population. Furthermore, we also compared clinical and laboratory data between the SARS-Cov-2 infection with family cluster (n = 21) and those without family cluster (n = 16). We demonstrated that the duration of SARS-Cov-2 replication might be varied based on the different family clusters due to their different genetic backgrounds. The onset improved lung radiology might start at the end of the SARS-Cov-2 positive period. Furthermore, the obtained results demonstrated that similar basic characteristics and clinical findings seem to exist between the cases with SARS-Cov-2 and without family clusters. The serum level of ferritin might have a different biological function and be a new biomarker for the family cluster. Further studies with larger numbers of patients are required.

Blockchain-Enabled Decentralized Reliable Smart Industrial Internet of Things (BCIIoT)

2021 ◽  
pp. 192-204
Author(s):  
Chandramohan Dhasarathan ◽  
Shanmugam M. ◽  
Shailesh Pancham Khapre ◽  
Alok Kumar Shukla ◽  
Achyut Shankar
Keyword(s):  
Machine Learning ◽  
Internet Of Things ◽  
Wireless Communication ◽  
Information Flow ◽  
Data Transfer ◽  
Base Station ◽  
Transmission Power ◽  
Wireless Devices ◽  
Industrial Internet ◽  
Iot Devices

The development of wireless communication in the information technological era, collecting data, and transfering it from unmanned systems or devices could be monitored by any application while it is online. Direct and aliveness of countless wireless devices in a cluster of the medium could legitimate unwanted users to interrupt easily in an information flow. It would lead to data loss and security breach. Many traditional algorithms are effectively contributed to the support of cryptography-based encryption to ensure the user's data security. IoT devices with limited transmission power constraints have to communicate with the base station, and the data collected from the zones would need optimal transmission power. There is a need for a machine learning-based algorithm or optimization algorithm to maximize data transfer in a secure and safe transmission.

Data Transmission Optimization Based on Memobus RTU Communication Protocol

2013 ◽  
Vol 443 ◽  
pp. 374-379
Author(s):  
Bing Dong
Keyword(s):  
Data Transmission ◽  
Functional Data ◽  
Data Transfer ◽  
Communication Protocol ◽  
Technical Problem ◽  
Response Speed ◽  
Data Block ◽  
System Response ◽  
Data Transfer Optimization ◽  
Message Format

The article introduces the constitution and message format of Memo bus RTU Communication Protocol, and provides a method for data transfer optimization through by the analysis of the communication protocol format. This method is fit on the inverter and controller which is based on the Memo bus RTU communication protocol and utilized theRS-485 port while the data being transported. By Considering this kind of inverter's distribution, this paper puts forward a method which is based on dividing by functional data block, able to sequence rankly criterion of the function data block, and able to transport date block divided by the function, thereby, this method decreases the redundancy enormously, elevates the system response speed, and solves the technical problem of controller PID output port's real time remote control to multiple inverters.

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