scholarly journals ETHNOBOTANICAL, PHYTOCHEMICAL, AND PHARMACOLOGICAL PROPERTIES OF NEPENTHES SPECIES: A REVIEW

2017 ◽  
Vol 10 (11) ◽  
pp. 16 ◽  
Author(s):  
Shuaibu Babaji Sanusi ◽  
Mohd Fadzelly Abu Bakar ◽  
Maryati Mohamed ◽  
Siti Fatimah Sabran ◽  
Muhammad Murtala Mainasara
Keyword(s):  
Folk Medicine ◽  
Therapeutic Agents ◽  
Bioactive Components ◽  
Pharmacological Activities ◽  
Crude Extracts ◽  
Gastrointestinal Discomfort ◽  
Wide Range ◽  
Long Time ◽  
Phytochemical Compounds ◽  
Ethnobotanical Uses

The genus Nepenthes (Nepenthaceae) has been utilized in folk medicine for a long time in India and Southeast Asia countries. They are used in the treatment of leprosy, cholera, night blindness, gastrointestinal discomfort, dysentery, stomachache, and bed-wetting among others. This review highlights the ethnobotanical uses, phytochemicals, and pharmacological activities of both crude extracts and pure bioactive compounds of Nepenthes spp. The phytochemical compounds isolated from Nepenthes species include flavonoids, terpenoids, tannins, alkaloids, and steroids among other phytochemicals. A wide range of pharmacological activities was exhibited by the crude extracts and pure bioactive components such as antibacterial, antifungal, antimalarial antioxidant, antidiabetic, antiosteoporotic, anti-inflammatory, cytotoxicity, and hypolipidemic activities. This review revealed that many active compounds are present in Nepenthes spp. However, many pharmacological screenings such as anticancer, antiviral, wound healing, antihelminthic, antidiarrheal properties, among others have not been carried out yet. Therefore, more biological investigations and phytochemical screenings are required to fully explore the genus Nepenthes which may lead to development of new therapeutic agents.  

scholarly journals A review of the phytochemical compounds and pharmacological activities from selected Ficus plants

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 921-928
Author(s):  
Insanu M ◽  
Santoso F R C ◽  
Fidrianny I
Keyword(s):  
Scientific Work ◽  
Review Of The Literature ◽  
Steroid Saponin ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Ficus Virens ◽  
Pure Compounds ◽  
Phytochemical Compounds ◽  
Ficus Hirta ◽  
Ficus Lyrata

The Ficus genus belongs to the Moraceae family were used for medicinal purposes. Distributed in America, Asia, Africa, and Australia, there were sixteen species accepted in Indonesia. They were Ficus callosa, Ficus melinocarpa, Ficus elastica, Ficus drupaceae, Ficus geocarpa, Ficus Superba, Ficus heteropoda, Ficus fistulosa, Ficus hirta, Ficus ampelas, Ficus adenosperma, Ficus ardisioides, Ficus consociate, Ficus ribes, Ficus lyrata, Ficus virens Aiton. This article reviewed the scientific work of the Ficus genus. Their traditional usage, phytochemical compounds, and pharmacological activity were summarized. This study aims at providing a collection of publications on selected species of Ficus genus. A critical review of the literature data revealed secondary metabolite like triterpenoid, steroid, saponin, flavonoid, phenolic compound and alkaloid were found in some species of Ficus. Some pure compounds such as quercetin,  quercetin 3-O-α-L-arabinopyranoside, epilupeol acetate, oleanolic acid, friedelin, elastiquinone,  pinocembrin-7-O-β-D-glucoside, and ficusoside B were isolated. A wide range of pharmacological activities was observed. Antimicrobial, antioxidant, antiviral, antiparasitic, cytotoxic, and antimalarial were found in previous researches. Ficus genus was potential to be developed as a medicinal plant.

Vitex Diterpenoids: Structural Diversity and Pharmacological Activity

2020 ◽  
Vol 26 (1) ◽  
pp. 138-159 ◽  
Author(s):  
Yanfei Ban ◽  
Tianshuang Xia ◽  
Rui Jing ◽  
Yaoli Guo ◽  
Yiya Geng ◽  
...  
Keyword(s):  
Pharmacological Activity ◽  
Hormone Level ◽  
Biological Activities ◽  
Folk Medicine ◽  
Structural Diversity ◽  
Pharmacological Activities ◽  
Structure Activity ◽  
Wide Range ◽  
Potential Applications

Plants of the genus Vitex (Verbenaceae) are mainly distributed throughout tropical and temperate regions, and many Vitex plants have been traditionally used in folk medicine. Plants of this genus are a rich source of diterpenoids, which not only displayed versatile structural diversity with potential chemotaxonomical significance but also exhibited a wide range of biological activities, mainly including in vitro cytotoxic, antiinflammatory, antimicrobial, hormone level-regulating and antiangiogenic activities. Recently, a series of bioactive diterpenoids, with interesting carbon skeletons, have been reported and gathered considerable interest. This article systematically reviewed diterpenoids isolated from the genus Vitex that appeared in the literature up to December 2018, critically highlighting their structural diversity and pharmacological activities. Up to now, a total of 154 diterpenoids with diverse structures have been isolated and identified from Vitex plants. The authors also summarized the reported structure-activity relationships of those well explored Vitex diterpenoids. Finally, the authors discussed the challenges and potential applications of these diterpenoids in the future.

scholarly journals Advances in the Global Distribution, Chemical Constituents, and Pharmacology of Hippocampus, a Traditional Marine Chinese Medicine

2021 ◽  
Vol 8 ◽  
Author(s):  
Xinhai Cui ◽  
Xiangfeng Zhao ◽  
Jintong Li ◽  
Ziwei Li ◽  
Xia Ren ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Extraction Methods ◽  
Research Progress ◽  
Active Ingredients ◽  
Pharmacological Activities ◽  
Neuroprotective Effects ◽  
Worldwide Distribution ◽  
Wide Range ◽  
Long Time ◽  
Tonify Kidney

Hippocampus is an important traditional marine Chinese medicinal resource that has been used to warm and tonify kidney yang in the clinic for a long time in China. Modern pharmacological studies show that its active ingredients display a wide range of pharmacological activities associated with the kidney, such as anti-inflammation, antioxidation, antitumor, and neuroprotective effects. Herein, we systematically summarize and analyze the research progress on the resource distribution, active ingredients, pharmacological activities, and clinical application of Hippocampus. First, the species and worldwide distribution of Hippocampus were assessed to clarify the existing resources, and the results showed that 44 species of Hippocampus have been found in 159 countries and regions worldwide. Then, based on the analysis of 16 kinds of active ingredients and extraction methods, the relationship between the ingredient extraction and pharmacological activities of Hippocampus was revealed. This review may provide a foundation for further research on the potential active ingredients and mechanisms of Hippocampus. In addition, the research status of traditional prescriptions containing Hippocampus was evaluated. The results implied that research on Hippocampus is still in its infancy, and the mechanism and material basis of its efficacy have not been clarified. This paper should provide directions for further studies on Hippocampus.

scholarly journals A Comprehensive review on Dichrostachys cinerea

2021 ◽  
Vol 23 (09) ◽  
pp. 1298-1312
Author(s):  
Swadhini Subramaniam ◽  
◽  
Dhanalakshmi Jaganathan ◽  
Keyword(s):  
Indian Subcontinent ◽  
Biologically Active ◽  
Native Plant ◽  
Pharmacological Activities ◽  
Dichrostachys Cinerea ◽  
Clinical Investigations ◽  
Wide Range ◽  
Biological Compounds ◽  
Long Time ◽  
Medical Plants

For a very long time, the medical plants have been used worldwide to treat human diseases and it serves as a safe source of drugs to cure several diseases and conditions through complementary medicine system. It is a native plant of Indian subcontinent, Africa and North Australia and is known to have significant pharmacological activities. The wide range of pharmacological activities of D.cinerea are due to the presence of different groups of active biological compounds present in it. Traditionally, D.cinerea has been used for the treatment the treatment of many diseases such as headache, toothache, dysentery, leprosy, coughs, syphilis and also as diuretic, anthelmintic, purgative and laxative. Research on the pharmacological, biological isolation of metabolites and biologically active compounds of this plant have already been done worldwide. However, the study to evaluate the complete therapeutic values of this plant still needed to conduct. This paper briefly reviews the various pharmacological properties of D.cinerea that could be useful for further experimental and clinical investigations.

scholarly journals Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action

2021 ◽  
Vol 22 (9) ◽  
pp. 4294
Author(s):  
Marcin Ożarowski ◽  
Tomasz M. Karpiński ◽  
Aleksandra Zielińska ◽  
Eliana B. Souto ◽  
Karolina Wielgus
Keyword(s):  
Cannabis Sativa ◽  
Neural System ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Pharmacological Treatments ◽  
Pharmacological Activities ◽  
Beneficial Effects ◽  
Wide Range ◽  
Cancer Types ◽  
Molecular Mechanism Of Action

As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer’s disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach.

Bioactive Compounds and Distinctive Pharmacological Activity Guided Review of Aegle marmelos: A Miraculous Plant of Indigenous Medicine System

2020 ◽  
Vol 16 (7) ◽  
pp. 965-977
Author(s):  
Sourav Ghosh ◽  
Arvind Kumar ◽  
Neetu Sachan ◽  
Phool Chandra
Keyword(s):  
Bioactive Compounds ◽  
New Drugs ◽  
Therapeutic Effects ◽  
Human Beings ◽  
Indigenous Medicine ◽  
Aegle Marmelos ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Ethnobotanical Uses ◽  
Different Parts

Background: It is always thought that traditional herbal drugs are safe, effective and economical and are used worldwide for healing purposes. Aegle marmelos, belonging to family Rutaceae, is an important medicinal plant of the indigenous medicine system in India. Despite the study on ethnobotanical uses and the presence of bioactive compounds, there was only a handful of research on A. marmelos. The therapeutic use of bioactive compounds is not explored properly. Objective: The objective of this study is to provide comprehensive data on the botanical description, ethnobotany, isolated bioactive compounds and their therapeutic effects according to the pharmacology of A. marmelos and its future prospects for further scientific investigation for the development of effective bioactive compounds. Methods: Literature searches were performed in various databases, such as PubMed, SciFinder and Google Scholar, for peer-reviewed research literature pertaining to the bioactive compounds present and distinctive pharmacological activities of A. marmelos. Results: The literature review indicates that different parts of A. marmelos possess various ethnobotanical uses. A large number of bioactive compounds isolated from different parts of the plant were reviewed which mainly belong to alkaloids, terpenoids, steroids, coumarins, flavonoids and carbohydrate in nature. The plant also possesses a wide range of pharmacological activities, such as antidiarrheal, antimicrobial, anticancer, hepatoprotective, antifertility, anti-inflammatory, wound healing, radioprotective, hypoglycemic and cardioprotective activity. Conclusion: It is clearly proven that different parts of A. marmelos possess numerous therapeutic effects for treating various ailments of human beings. As the scientists anticipated to develop new drugs from natural sources, investigation of modern drugs from A. marmelos should be emphasized. Still, extensive research studies are required on A. marmelos as it is the most important plant of the indigenous medicine system in India. Therefore, this review could be used as a good source of information for researchers who wish to proceed their exploration of A. marmelos.

Brassica oleracea var. capitata f. alba: a review on its botany, traditional uses, phytochemistry and pharmacological activities.

2021 ◽  
Vol 21 ◽  
Author(s):  
Lipi Rani Ray ◽  
Muhammad Shaiful Alam ◽  
Md. Junaid ◽  
Sakia Ferdousy ◽  
Rasheda Akter ◽  
...  
Keyword(s):  
Brassica Oleracea ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Cruciferous Vegetable ◽  
Traditional Uses ◽  
White Cabbage ◽  
Whole Plant ◽  
Wide Range ◽  
Phytochemical Compounds ◽  
Phytochemical Constituents

Background: Brassica oleracea var. Capitata F. Alba (white cabbage) is a cruciferous vegetable which used as a vegetable and traditional medicine all over the world. Different preparation from several parts of the plant - roots, shoots, leaves and the whole plant are used to treat a wide range of diseases including diabetes, cancer, gastric, inflammation, hypertension, hypercholesterolemia, bacterial, oxidation, and obesity. Objective: The aim of the current review is to evaluate the botany, distribution, traditional uses, phytochemistry and pharmacological activities of B. oleracea var. Capitata. Moreover, this review will guide to fill the existing gaps in information and highlight additional research prospects in the field of phytochemistry and pharmacology. Method: Various resources including research papers, review papers, books and reports were collected to obtain over all information of Brassica oleracea var. Capitata, which were obtained by an online search of worldwide-accepted scientific databases. Phytochemical constituents’ structures were drawn by ChemDraw software. Results: About 72 isolated phytochemical compounds of B. oleracea var. Capitata have been collected from different article, which included different type of compounds such as alkaloids, flavonoids, organic acids, glucosinolates, steroids, hydrocarbons etc. Crude extracts and phytoconstituents of B. oleracea var. Capitata have various pharmacological effects including antidiabetic, anticancer, antihypertensive, anticholesterolemic, antioxidant, anti-inflammatory, antibacterial, antiobesity, anticoagulant & hepatoprotective. We have enlisted all these pharmacological data along with all the phytochemical constituents of Brassica oleracea var. Capitata. Conclusion: The study was focused on the traditional uses, pharmacological activities and phytochemistry of Brassica oleracea var. Capitata and the findings indicating that B. oleracea var. Capitata is an important medicinal plant which shows several pharmacological effects. We hope our review on this plant will provide more basic and useful information and fill some research gap for further investigation and drug design. Despite we found some important traditional uses and pharmacological activities of Brassica oleracea var. Capitata there are insufficient work found in the field of phytochemical activities.

scholarly journals A comprehensive review on the pharmacological properties of Diplazium esculentum, an edible fern

2020 ◽  
Vol 3 (1) ◽  
pp. 01-09
Author(s):  
Tapas Chaudhuri
Keyword(s):  
Chemical Constituents ◽  
Folk Medicine ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Wide Range ◽  
Structural Formulas ◽  
The World ◽  
Ethnomedicinal Plant ◽  
Young Leaves ◽  
Ethnomedicinal Uses

Diplazium esculentum (Family: Athyriaceae), one of the most popular wild edible fern, is considered as a pharmacologically diverse ethnomedicinal plant. The coiled fronds and young leaves of this plant have a wide range ethnomedicinal uses in folk medicine around the world directed for a number of ailments. The present article is the first comprehensive review on the pharmacological activities of this particular edible fern. The structural formulas of all the chemical constituents identified and isolated so far from D. esculentum are also provided in the present review. The most thoroughly studied pharmacological activities viz., antioxidant, antimicrobial, immunomodulatory, neuromodulatory, anti-fertility, cytotoxic, etc.) of the D. esculentum extracts have been discussed. This comprehensive review will be of help for the future researchers investigating for more potent compounds and their pharmacological activities.

scholarly journals Screening of Ipomoea tuba Leaf Extract for Identification of Bioactive Constitutes and Evaluation of Its in vitro Anti-Proliferative Activity Against MCF-7 and HeLa Cells

2020 ◽  
Vol 58 (1) ◽  
pp. 71-85
Author(s):  
Thirupati Chinna Venkateswarulu ◽  
Gaddam Eswaraiah ◽  
Srirama Krupanidhi ◽  
Karlapudi Abraham Peele ◽  
Indira Mikkili ◽  
...  
Keyword(s):  
Hela Cells ◽  
Leaf Extract ◽  
Methanol Extract ◽  
In Vitro Cytotoxicity ◽  
Gas Chromatography Mass Spectrometry ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Phytochemical Compounds ◽  
Mcf 7

Mangroves contain a wide range of bioactive compounds with pharmacological activities. In the present study, we analysed the separation and detection of phytoconstituents with the methanol extract of Ipomoea tuba leaf using gas chromatography-mass spectrometry (GC-MS) and tested its in vitro cytotoxicity effect against MCF-7 and HeLa cells. Phytochemical compounds such as docosanoic, octadecatrienoic and cis-9-octadecanoic acids, triterpenoid γ-sitosterol, and terpene alcohol in methanol extract of I. tuba leaf were identified. Furthermore, in vitro antiproliferative activity of the extract of I. tuba leaf was evaluated using MCF-7 and HeLa cells. The results indicated a reduction of cell viability of 37.43 and 41.89 % of MCF-7 and HeLa cells respectively. The methanol extract of I. tuba leaf proved to be effective in protecting the cells against oxidative stress. This is the first report on the in vitro cytotoxicity effect of I. tuba leaf extract on MCF-7 and HeLa cells.

scholarly journals Macadamia Genus: An Updated Review of Phytochemical Compounds and Pharmacological Activities

2021 ◽  
Vol 11 (6) ◽  
pp. 14480-14489
Keyword(s):  
Southern Hemisphere ◽  
Chemical Compounds ◽  
The Other ◽  
Google Scholar ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Phytochemical Compounds ◽  
Anti Inflammatory

The Macadamia genus of the Proteaceae family, which can be found mainly in the southern hemisphere, has many benefits in some disease treatments. Phytochemical compounds and pharmacological activities of this genus were comprehensively reviewed in this article. This article was written by collecting and reviewing a minimum of 50 scientific articles in PubMed, Google Scholar, Science Direct, Elsevier, and PubChem that contain the phytochemical compounds and pharmacological activities of the Macadamia genus. The articles were published in the last 15 years, a minimum of 20 articles in the last 2 years, and they also must have a DOI. The phytochemical compounds that comprised of flavonoid, proanthocyanidin, and other polyphenols compounds. These phytochemical compounds can promote a wide range of pharmacological activities such as antioxidant, anti-inflammatory, anti-dyslipidemia, dietary controlled, antimicrobial, chemopreventive, and NAFLD prevention. Nevertheless, many investigations on phytochemical compounds and pharmacological activities only focussed on a few parts of a plant, especially nuts. Therefore, further research is needed to determine the other parts of Macadamia genus plants' potential chemical compounds and pharmacological activities.

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