Impact of European pet antibiotic use on enterococci and staphylococci antimicrobial resistance and human health

2021 ◽  
Vol 16 (3) ◽  
pp. 185-201
Author(s):  
Carla Miranda ◽  
Vanessa Silva ◽  
Gilberto Igrejas ◽  
Patrícia Poeta
Keyword(s):  
Public Health ◽  
Veterinary Medicine ◽  
Antimicrobial Resistance ◽  
Family Member ◽  
Close Contact ◽  
Antibiotic Use ◽  
Current Data ◽  
Urban Households ◽  
Inappropriate Use ◽  
European Distribution

Due to the inappropriate use of antibiotics described in both human and veterinary medicine, there is emerging evidence of antimicrobial-resistant organisms isolated from humans and pets, forming a multifaceted problem. Although the true magnitude of antimicrobial resistance in pets and other animals, as well as humans, are not fully known; pets, in particular dogs and cats, can contribute to the spread of antimicrobial resistance due to close contact with humans and their status as a family member in urban households. This review summarizes and highlights the current data concerning the antibiotic use on pets, and the European distribution of the increasing prevalence of multiresistant bacterial pathogens, such as enterococci and methicillin-resistant staphylococci on pets, as well as its implications for public health.

Production of polyclonal antibody for ciprofloxacin detection in Brazilian livestock

2003 ◽  
Vol 2003 ◽  
pp. 84-84
Author(s):  
S.P. Gobbo ◽  
C. Longo ◽  
I.C.S. Bueno ◽  
K.M.R. Duarte ◽  
C.F. Meirelles
Keyword(s):  
Public Health ◽  
Veterinary Medicine ◽  
Antimicrobial Resistance ◽  
Polyclonal Antibody ◽  
Polyclonal Antibodies ◽  
Antibiotic Use ◽  
Feed Additive ◽  
Human Consumption ◽  
The Public ◽  
Significant Question

The antibiotic use to increase the animal production can result in residual concentrations in products as meat, eggs and milk, exceeding the acceptable doses for human consumption. In Brazil nowadays, 14 antibiotics are employed as feed additive, however there are about 121 drugs used in Veterinary Medicine that contain antibiotics in their formulation. Due to amplitude and frequency of the antimicrobial resistance, it can be considered an emergent and significant question for the public health and an alert for the necessity of a global control about the use of those antibiotics. The immunoassays allow the diagnosis of these antibiotics with accessible costs and presenting good results. The aim of this work was to produce polyclonal antibodies for ciprofloxacin detection using ELISA.

scholarly journals Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Sirijan Santajit ◽  
Nitaya Indrawattana
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Antimicrobial Agents ◽  
Multidrug Resistant ◽  
Resistance Mechanisms ◽  
Global Public Health ◽  
Drug Usage ◽  
Inappropriate Use ◽  
Public Health Challenges ◽  
Eskape Pathogens

The ESKAPE pathogens (Enterococcus faecium,Staphylococcus aureus,Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa, andEnterobacterspecies) are the leading cause of nosocomial infections throughout the world. Most of them are multidrug resistant isolates, which is one of the greatest challenges in clinical practice. Multidrug resistance is amongst the top three threats to global public health and is usually caused by excessive drug usage or prescription, inappropriate use of antimicrobials, and substandard pharmaceuticals. Understanding the resistance mechanisms of these bacteria is crucial for the development of novel antimicrobial agents or other alternative tools to combat these public health challenges. Greater mechanistic understanding would also aid in the prediction of underlying or even unknown mechanisms of resistance, which could be applied to other emerging multidrug resistant pathogens. In this review, we summarize the known antimicrobial resistance mechanisms of ESKAPE pathogens.

scholarly journals PROBLEM OF ANTIBIOTIC USE AND ANTIMICROBIAL RESISTANCE IN INDONESIA: ARE WE REALLY MAKING PROGRESS?

2013 ◽  
Vol 4 (4) ◽  
pp. 5 ◽  
Author(s):  
Usman Hadi ◽  
Kuntaman Kuntaman ◽  
Mariyatul Qiptiyah ◽  
Hari Paraton
Keyword(s):  
Antimicrobial Resistance ◽  
Antibiotic Use ◽  
Teaching Hospitals ◽  
Resistant Bacteria ◽  
Prevention Study ◽  
Antibiotic Resistant ◽  
Inappropriate Use ◽  
Government Hospitals ◽  
Inappropriate Antibiotics ◽  
Very High

Background: Based on the results Antimicrobial Resistance in Indonesia: prevalence and prevention-study (AMRIN-study), the Ministry of Health of Indonesia in 2005 began a program antibiotic resistance control (PPRA) in some government hospitals, and is currently developing to all government teaching hospitals in Indonesia. Aim: The core activities of the PPRA are to implement standardized surveillance emergence of antibiotic resistant bacteria, and the surveillance of antibiotic use in terms of quantity and quality. Method: Our research in the years 2003 showed the proportion of antibiotic use 84% of patients in a hospital. The use of inappropriate antibiotics was very high, 42% no indication. Result: In 2012 the results of surveillance showed decline of inappropriate use of antibiotic, but prevalence extended-spectrum b-lactamase (ESBL)-producing K.pneumoniae (58%), and E.coli (52%) andmethicillin-resistant S.aures (MRSA) (24%) were increasing. Conclusion: It was needed to implement the most appropriate programs to prevent the growth and development of bacteria resistant to antibiotics.

scholarly journals Exploring gender differences in knowledge and practices related to antibiotic use in Southeast Asia: A scoping review

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259069
Author(s):  
Phuc Pham-Duc ◽  
Kavitha Sriparamananthan
Keyword(s):  
Gender Differences ◽  
Antimicrobial Resistance ◽  
Southeast Asia ◽  
Scoping Review ◽  
Antibiotic Use ◽  
Educational Interventions ◽  
Sociodemographic Factors ◽  
Targeted Interventions ◽  
Inappropriate Use ◽  
Males And Females

Inappropriate use of antibiotics has been one of the main contributors to antimicrobial resistance, particularly in Southeast Asia. Different genders are prone to different antibiotic use practices. The objective of this scoping review is to understand the extent and type of evidence available on gender differences in antibiotic use across Southeast Asia. The search strategy for this scoping review involved PubMed, Semantic Scholar, BioMed Central and ProQuest. Two-level screening was applied to identify the final sample of relevant sources. Thematic content analysis was then conducted on the selected final sources to identify recurring themes related to gender differences in antibiotic use and a narrative account was developed based on the themes. Recommendations for next steps regarding reducing inappropriate antibiotic use and gender considerations that need to be made when developing future interventions were also identified. Research on gender and antibiotic use remains scarce. Studies that discuss gender within the context of antibiotic use often mention differences between males and females in knowledge, attitudes and/or behaviour, however, do not explore reasons for these differences. Gender differences in antibiotic use were generally examined in terms of: (i) knowledge of antibiotic use and antimicrobial resistance and (ii) practices related to antibiotic use. Evidence indicated that differences between males and females in knowledge and practices of antibiotic use varied greatly based on setting. This indicates that gender differences in antibiotic use are greatly contextual and intersect with other sociodemographic factors, particularly education and socioeconomic status. Educational interventions that are targeted to meet the specific needs of males and females and delivered through pharmacists and healthcare professionals were the most common recommendations for reducing inappropriate use of antibiotics in the community. Such targeted interventions require further qualitative research on factors influencing differences in knowledge and practices related to antibiotic use among males and females. In addition, there is also a need to strengthen monitoring and regulation practices to ensure accessibility to affordable, quality antibiotics through trusted sources.

scholarly journals Overuse of antibiotics in maternity and neonatal wards, a descriptive report from public hospitals in Dar es Salaam, Tanzania

2021 ◽  
Author(s):  
Mwaka Athuman Kakolwa ◽  
Susannah L. Woodd ◽  
Alexander M. Aiken ◽  
Fatuma Manzi ◽  
Giorgia Gon ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antimicrobial Resistance ◽  
Antibiotic Use ◽  
Dar Es Salaam ◽  
Prophylactic Antibiotics ◽  
Public Hospitals ◽  
Descriptive Data ◽  
Inappropriate Use ◽  
Control Drug ◽  
Postnatal Women

Abstract Background: Overuse of antibiotics is a major challenge and undermines measures to control drug resistance worldwide. Postnatal women and newborns are at risk of infections and are often prescribed prophylactic antibiotics, although there is no evidence to support their universal use in either group. Methods: We performed point prevalence surveys in three hospitals in Dar es Salaam, Tanzania, in 2018 to collect descriptive data on antibiotic use and infections in maternity and neonatal wards. Results: Prescribing of antibiotics was high in all three hospitals ranging from 90% (43/48) to 100% (34/34) in women after cesarean section, from 1.4% (1/73) to 63%(30/48) in women after vaginal delivery, and from 89%(76/85) to 100%(77/77) in neonates. The most common reason for prescribing antibiotics was medical prophylaxis in both maternity and neonatal wards.Conclusion: We observed substantial overuse of antibiotics in postnatal women and newborns.This calls for urgent antibiotic stewardship programs in Tanzanian hospitals to curb the inappropriate use and limit the spread of antimicrobial resistance.

scholarly journals The Socio-cultural Dynamics of Antibiotic Misuse in Hyderabad City, India: a Qualitative Study of Dentist and Pharmacist

2019 ◽  
Vol 2 (3) ◽  
pp. 197-202
Author(s):  
Shoeb Ahmed
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Cultural Practices ◽  
Pharmacy Practice ◽  
Public Health Problem ◽  
Antibiotic Use ◽  
Cultural Dynamics ◽  
Dental Infection ◽  
Structured Interviews ◽  
Self Medication

 Background: Antibiotic resistance and antibiotic-associated adverse events are rapidly escalating and considered as a global health threat and public health problem. There is poor evidence base on the contextual specificities and everyday use of antibiotic in public health dentistry and pharmacy dispensing practices. The study explores the socio-cultural dynamics emergent around antimicrobials in the Indian Public dentistry and pharmacy practice in India. Methods: Using purposive sampling, dentists and pharmacists were recruited for the study in Hyderabad City, Telangana State, India. Using semi-structured interviews, dentists and pharmacists were asked about how antibiotics were prescribed and dispensed, perceptions of antibiotic use in community and socio-cultural norms prevailing in the use of the antimicrobial practice. Results: The dominant themes, emerged by both dentists and pharmacists, was the avoidance of dentist visit on encountering dental infection, reliance on self-medication, use of over-the-counter antibiotics and easy accessibility of antibiotics without prescription as a primary driver of antibiotic misuse and development of antimicrobial resistance, which is associated with socio-cultural practices and economic problems.  Conclusions: The speculations of qualitative responses to antimicrobial resistance are profoundly entangled in the specificities of dental infection management across cultures and locales in daily life. This study emphasizes the need for enforcement of regulatory mechanism on antibiotic dispensing over the counters, educating dental patients in avoiding self medications, educational and training initiatives are necessary to sensitize and rationalize dentist and pharmacist in the use of antibiotics. 

UK initiatives to reduce antimicrobial resistant infections, 2013-2018

2016 ◽  
Vol 21 (3) ◽  
pp. 131-138 ◽  
Author(s):  
Susan Hopkins
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Government Policy ◽  
Design Methodology ◽  
Antibiotic Use ◽  
Content Type ◽  
Uk Government ◽  
The Many ◽  
The Uk ◽  
The Impact

Purpose – The purpose of this paper is to highlight the local, national and global actions from the UK to reduce the impact of antimicrobial resistance (AMR) on human health. Design/methodology/approach – Synthesis of UK government policy, surveillance and research on AMR. Findings – Activities that are taking place by the UK government, public health and professional organisations are highlighted. Originality/value – This paper describes the development and areas for action of the UK AMR strategy. It highlights the many interventions that are being delivered to reduce antibiotic use and antimicrobial resistant infections.

Antimicrobial Resistance is a Global Problem

2018 ◽  
Vol 2 (4) ◽  
pp. 6-19
Author(s):  
A.G. Salmanov ◽  
V.V. Trokhymchuk ◽  
O.M. Verner ◽  
O.O. Lugach
Keyword(s):  
Public Health ◽  
Health Care ◽  
Antibiotic Resistance ◽  
Antimicrobial Resistance ◽  
Animal Health ◽  
Antibiotic Use ◽  
Modern Medicine ◽  
Full Spectrum ◽  
The Public ◽  
Treatment Action

Infectious agents resistance to antimicrobials remains a challenging open problem of health care around the world. As a result, treatment-induced infections pose a serious threat to public health in general. This problem has become so important that the overwhelming majority of countries consider it a threat to the national security. Resistance to antimicrobials threatens to offset the very fundamentals of modern medicine and the sustainability of the public health system effective global response to a permanent infectious diseases threat. Today, antimicrobial resistance issues can be tackled provided that one implements an effective One Health approach (the principle of human and animal health interrelation), assuming that there is a coordination between different sectors and subjects, including experts in medicine, veterinary medicine, agriculture, ecology, and well-informed consumers. To ensure effectiveness of treatment, action is urgently needed to counteract the further development and spread of antibiotic resistance, which is driven by antibiotic use in all sectors. Since this resistance has no ecological, sectoral or geographical borders, its appearance in one sector affects resistance in other sectors. National authorities, veterinarians, physicians, patients and farmers all have key roles in preserving the power of antibiotics. The prevention and containment of antibiotic resistance therefore requires addressing all risk factors for the development and spread of antibiotic resistance across the full spectrum of conditions, sectors, settings (from health care to use in food-animal production) and countries. This article explores the options for prevention and containment of antibiotic resistance in the food-chain through national coordination, including the regulation and reduction of antibiotic use in food animals, training and capacity building, surveillance of resistance trends and antibiotic usage, promotion of knowledge and research, and advocacy and communication to raise awareness of the issues. The article suggests possible ways for adopting a holistic, intersectoral, multifaceted approach to this growing problem.

scholarly journals Drivers of antibiotic use in Vietnam: implications for designing community interventions

2021 ◽  
Vol 6 (7) ◽  
pp. e005875
Author(s):  
Shannon McKinn ◽  
Duy Hoang Trinh ◽  
Dorothy Drabarek ◽  
Thao Thu Trieu ◽  
Phuong Thi Lan Nguyen ◽  
...  
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Symptom Control ◽  
Antibiotic Use ◽  
Structural Factors ◽  
Community Members ◽  
Community Based Interventions ◽  
Community Based ◽  
Health Security ◽  
Global Challenge

IntroductionAntimicrobial resistance is a global challenge that threatens our ability to prevent and treat common infectious diseases. Vietnam is affected by high rates of antimicrobial resistant infections, driven by the overuse of antibiotics and the Vietnamese government has recognised antimicrobial resistance as a health security priority. This study aimed to understand how people in Vietnam use antibiotics in community settings, and the factors that impact their practices and decision-making regarding antibiotics.MethodsWe conducted 43 qualitative in-depth interviews with 50 community members in two urban and two rural sites in Vietnam. We conducted iterative, inductive thematic analysis alongside data collection through a process of systematic debriefings based on detailed interview summaries. Through this process, we developed a coding framework that was then applied to transcribed interview data.ResultsFrequent and indiscriminate use of antibiotics was driven by the powerful appeal that antibiotics held for many Vietnamese consumers. Consumers were discerning in making decisions in their purchase and use of antibiotics. Consumers’ decisions were affected by perceptions of what constitutes high-quality medicine (effective, strong, accessible and affordable); privileging symptom control over diagnosis; social constructions of antibiotics as a trusted remedy with embodied evidence of prior efficacy, which is reinforced by advice from trusted sources in their community; and varied, generally incomplete, understanding of the concept of antibiotic resistance and its implications for individuals and for public health.ConclusionAntibiotic use at the community and primary care level in Vietnam is driven by community members’ social and economic response to what constitutes effective healthcare, rather than biomedical logic. Community-based interventions to reduce unnecessary antibiotic use need to engage with the entangled socio-structural factors that ‘resist’ current public health efforts to ration antibiotic use, alongside biomedical drivers. This study has informed the design of a community-based trial to reduce unnecessary antibiotic use.

scholarly journals Antimicrobial stewardship: Assessment of knowledge, awareness of antimicrobial resistance and appropriate antibiotic use among healthcare students in a Nigerian University

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wuraola Akande-Sholabi ◽  
Amen T. Ajamu
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Stewardship ◽  
Healthcare Professionals ◽  
Antibiotic Use ◽  
The Body ◽  
Healthcare Students ◽  
Inappropriate Use ◽  
The Past ◽  
Inadequate Knowledge ◽  
Nigerian University

Abstract Background Inappropriate use of antibiotics is a major cause of antimicrobial resistance (AMR). Inadequate knowledge about AMR among healthcare students could affect their practice of antimicrobial stewardship as future healthcare professionals. This study aims to assess the use of antibiotics and knowledge of AMR among future healthcare professionals of a Nigerian University. Methods Respondents’ knowledge of antimicrobial resistance, use of antibiotics, and source of antibiotics in the past 12 months was explored using a self-administered questionnaire. Multivariate analyses were used to evaluate the relationship between specific variables and respondents’ knowledge. Results Of the 939 questionnaires administered to the students, 866 were filled given a response rate of 92.2 %. A total of (765; 88.3 %) of the respondents were aware that antimicrobial resistance makes it harder to eliminate the infection from the body as existing drugs become less effective. In all 824, (95.2 %) of the respondents had use antibiotics in the past 12 months. The use of antibiotics to treat malaria was self-reported by (175; 21.2 %). About half (432; 52.4 %) purchased the antibiotics from community pharmacies, while others obtained their antibiotics from the hospitals (192; 23.3 %), patent medicine stores (150; 18.2 %), and friends and family (50; 6.1 %) in the last 12 months. In all 506, (58.4 %) had good knowledge of antimicrobial resistance. Logistic regression shows that students in 3rd to 6th year 9.29 [AOR = 9.29, 95 % CI: (3.7–22.96)], had greater knowledge of antimicrobial resistance. Conclusions The healthcare students demonstrated a moderate knowledge of AMR. This underscores the need to adopt several educational tactics to introduce the concepts of AMR to the students and ensure there are strict policies to regulate the flow of antibiotics.

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