scholarly journals Characterization and Screening of Phytochemical Secondary Metabolite of Seri (Muntingia calabura, L) Leaves which is Potential as an Anti-Diabetic based on Indonesian Herbal Medicine Standard

2020 ◽  
Vol 10 (6-s) ◽  
pp. 92-94
Author(s):  
Kasta Gurning ◽  
Dan Hilda Sinaga

Indonesia has abundant natural resources, especially plants that can be used as raw material for herbal medicine. One of the plants is seri plant (Muntingia calabura, L.). The potential plant part in this study is the leaf part. The leaves of M. calabura were taken from plants that have produced fruit in fresh conditions, cleaned and dried in an open space protected from direct sunlight. The simplicia was powdered and then quartered, then extracted with ethanol as a solvent. The simplicia powder and extract obtained were screened for phytochemicals using the standard method. The characterization results showed that the simplicia powder and extract met the national standard of quality for Indonesian herbal medicines, both the simplicia powder and the extract contained secondary metabolites, including alkaloids, flavonoids, triterpenoids and steroids, saponins and tannins. The process of preparing and organizing samples from the leaves of this plant met the quality standards of Indonesian national herbal medicine and has the potential to be tested as an anti-diabetic. Keywords: Seri Leaves, characterization, phytochemical screening, quality standards, and anti-diabetic

2021 ◽  
Vol 914 (1) ◽  
pp. 012074
Author(s):  
Asmaliyah ◽  
E E W Hadi ◽  
E Novriyanti

Abstract Diabetics is known as a dangerous comorbid disease in covid 19 patience. Many herbal medicines are used to prevent diabetes. Recently, the use of herbal medicine increased rapidly. In Indonesia, many indigenous plants have been used as source of raw material of herbal medicine including Cinnamomum parthenoxylon. Previous study reported that in vitro administration of C. parthenoxylon extract could reduce the sugar level and increased the plasma insulin level. Data on phytochemistry and bio-activity of this species are unavailable yet. Therefore, this study examined the phytochemical constituents and antidiabetic activity of their leaves. The leaves of C. pathenoxylon were collected from Bangka Belitung and South Sumatra for phytochemical screening and in vitro study. The phytochemical screening showed that constituents of flavonoids, steroids, tannins, alkaloids, and saponins were contained in the water extract of C. pathenoxylon leaves. The study indicated that extract leaves of C. pathenoxylon contains antidiabetic activity. In conclusion, C. pathenoxylon has the potential to be utilized as a source of raw material for diabetes medication. However, further in vivo and human administration studies are essentially required.


2021 ◽  
Vol 6 (1) ◽  
pp. 1-6
Author(s):  
Fahrauk Faramayuda ◽  
Faizal Hermanto ◽  
Ari Sri Windyaswari ◽  
Soraya Riyanti ◽  
Viola Aditya Nurhayati

Bungur  (Lagerstroemia loudonii T. B) is a type of plant widely grown in Indonesia and can be found in teak forests, mixed forests, and is found as ornamental plants or protective trees on the roadside. In the fruit section, Lagerstroemia loudonii is used as antituberculous and antimalarial. On the bark, the part is used as antidiarrheal. Based on some parts of the Lagerstroemia loudonii  plants' activity data, this plant has the potential to be developed into traditional medicine. Standardized traditional medicine material is necessary to identify efficacious compounds and characterization in some parts of Lagerstroemia loudonii. The purpose of this research is to develop Lagerstroemia loudonii into traditional herbal medicine or standardized herbal medicine. Identification of efficacious compounds and characterization of crude leaf drugs, bark, stems, and fruit of Lagerstroemia loudonii. The phytochemical screening phase of the crude drugs of leaves, bark, stems, and fruit ofLagerstroemia loudonii against includes examining alkaloids, flavonoids,  quinones, tannins, polyphenols, saponins, steroids and triterpenes, monoterpenoids and sesquiterpenoids. The determination of the characteristics of raw material carried out includes nonspecific parameters. Nonspecific parameters are the determination of total ash content, water-soluble ash content, acid insoluble ash content. each experiment was carried out three times and calculated the average yield and deviation.  Identification results of the class of efficacious compounds in some parts of the Lagerstroemia loudonii  plant are on the leaves and fruits containing alkaloids, flavonoids, saponins, quinones, tannins, polyphenols, monoterpenoids, and sesquiterpenoids as well as steroids and triterpenoids. At the bark and stem, the bark contains alkaloids, flavonoids, saponins, quinones, tannins, polyphenols, monoterpenoids, and sesquiterpenoids. Characterization results of Lagerstroemia loudonii  leaf extract total ash content 4.45 ± 0.30% w/w, water-soluble ash content 4.08 ± 0.27% w/w, acid insoluble ash content 0.59 ± 0.06% w/w, the extract specific gravity was 0.59 ± 0.063. Lagerstroemia loudonii  stem bark extract, total ash content 1.94 ± 0.12% w/w, water-soluble ash content 1.47 ± 0.03% w/w, acid insoluble ash content 0.24 ± 0.02% w/w, the extract specific gravity is 0.82 ± 0.01. Lagerstroemia loudonii  stem extract, total ash content3.18 ± 0.16% w/w, water-soluble ash content 2.36 ± 0.38% w/w, acid insoluble ash content 0.43 ± 0.07% w/w, extract specific grafity 0.81 ± 0.01. Lagerstroemia loudonii  fruit extract, total ash content 11.45 ± 1.16%w/w, water-soluble ash content 10.1 ± 1.49% w/w, acid insoluble ash content 1.46 ± 0.88% w/w,extract specific grafity 0.81 ± 0.01. Based on phytochemical screening data and the characterization of bungur plants potential to be developed into raw materials for traditional medicineKeywords: Lagerstroemia loudonii, secondary metabolite, raw material characterization


Author(s):  
Harinarayanan M K ◽  
Jayanthy A. ◽  
Lubna S ◽  
Deepak M.

Some of the plant species of the genus Salacia are considered as an important anti-diabetic drug in ayurveda. Among them S. chinensis, S. fruticosa and S. oblonga possess great medicinal importance, mostly because of its promising anti-diabetic activity. The increasing demand of this drug, resulted in a huge decline in its availability and it is replaced by spurious ones mainly because of lack of adequate quality standards. There is now a felt need to develop a systematic approach for the authentication of these plants and to develop well-designed methodologies for its standardization. The present study focused on the Pharmacopoeial parameters like pharmacognostical characterization and preliminary phytochemical screening of these three species. which were found to be sufficient to evaluate the raw material and can also be used as reference standards for the quality control/quality assurance purposes. The pharmacognostic study revealed that there are specific diagnostic features for distinguishing these three species among themselves and also from other related species. The external morphology of these three species are also shows variation in their colour, odour and taste. Both the species of Salacia ie, S. chinensis is having bitter taste and S. fruticose is with astringent taste whereas S. oblonga has no characteristic taste of its own. The TLC profile showed similar pattern in S. chinensis and S. fruiticosa where as S. oblonga showed more band in the profile than that of the other two. This reveals that the S. chinensis and S. fruiticosa having similar compounds responsible for therapeutic efficacy, whereas S. oblonga has more chemical constituents.


Author(s):  
Dr Rahul Kumar Gupta ◽  
◽  
Dr Renu Bharat Rathi ◽  

Background : for acceptance of Ayurveda at global level there is needed to standardize herbal drugs according to modern techniques. For the standardization of herbal medicines it is essential to establish its identify, purity, quality, safety, and efficacy. This study reports on standardization of Martina annua linn root. In tribal pockets of satpura plateau in Madhya Pradesh. Root paste of Martina annua is used in folk medicine to treat cancer and rheumatism. Objective: This study aimed to indentify anthers herb and establishing pharmacognostical, Physiochemical and phytochemical standard for the Martina annua linn. Root. Material and Methods: Plant roots was collected from Govt. Ayurved college campus, Gwalior, Madhya Pradesh and evaluated for pharmacognostical, Physiochemical and phytochemical parameter using guidelines of the world health organization and pharmacopoeial laboratory for Indian medicine for quality control of herbal drugs. Results: Chemical evaluation shown presence of alkaloids, glycosides, flavonoids, steroids and tannins. The microscopic characters have shown presence of Epiblema, Periderm, Cortex, Phloem and Madullary Rays, and Xylem vessels. Microscopy analysis of the powder included the parenchyma cells, fibers and vessel. In results, it was found that the root containing various phytochemicals were present in its Aqueous extract, Hydroalcoholic extract and Alcoholic extract. Hydroalcoholic extract of Martynia annua root had the highest of total phenolic content (364.15 mg GAE /100gm) and highest total flavonoid content (139.84 mg QE /100gm). Conclusions: Pharmacognostical and preliminary phytochemical screening of Martynia annua roots will be useful in order to authenticate, standardize and avoid any adulteration in the raw material and will be helpful in the development of a monograph.


2020 ◽  
Vol 1 (1) ◽  
pp. 47-58
Author(s):  
Khodijatul Qodriyah

The lack of students’ knowledge of their teachers’ works and the less of their consciousness to the environment are crucial problems in some islamic boardingschool, especially in Nurul Jadid. These issues will be settled by implementation of religious preaching (dakwah) with poem (syi’ir) in Syu’abul Iman of Kiai Zaini Mun’im and prefentive action to the illness through herbal medicines of family crops medicine (tanaman obat keluarga). The program is undertaken with some phases, including planting family crops medicine, making herbal medicines, musicalisation of poem in book of Syu’abul Iman, socialization of the herbal medicine and musical poem of Syu’abul Iman. These phases have been structured with long-term, middle-term, and short-term programs which were finished during approximately 4 months (Augustus – November 2019). The involvement of many parties, such as activists of environment in Nurul Jadid, has strongly influenced on the successful implementation of these programs.Keywords: Family Crops Medicine, Nurul Jadid Islamic Boardingschool, Book of Syu’abul Iman


2020 ◽  
Vol 21 (9) ◽  
pp. 661-673 ◽  
Author(s):  
Mohammed Asadullah Jahangir ◽  
Chettupalli Anand ◽  
Abdul Muheem ◽  
Sadaf Jamal Gilani ◽  
Mohamad Taleuzzaman ◽  
...  

Herbal medicines are being used since ancient times and are an important part of the alternative and traditional medicinal system. In recent decades, scientists are embracing herbal medicines based on the fact that a number of drugs that are currently in use are derived directly or indirectly from plant sources. Moreover, herbal drugs have lesser side effects, albeit are potentially strong therapeutic agents. The herbal medicine market is estimated to be around US $62 billion globally. Herbal medicine has gained widespread acceptance due to its low toxicity, low cost, ease of accessibility and efficacy in treating difficult diseases. Safety and efficacy are another important factors in the commercialization process of herbal medicines. Nanotechnology has been shown to be potentially effective in improving the bioactivity and bioavailability of herbal medicines. Development of nano-phytomedicines (or by reducing the size of phytomedicine), attaching polymers with phytomedicines and modifying the surface properties of herbal drugs, have increased the solubility, permeability and eventually the bioavailability of herbal formulations. Novel formulations such as niosomes, liposomes, nanospheres, phytosomes etc., can be exploited in this area. This article reviews herbal medicines, which have prominent activity in the Central Nervous System (CNS) disorders and reported nano-phytomedicines based delivery systems.


Author(s):  
Md Abul Barkat ◽  
Anjali Goyal ◽  
Harshita Abul Barkat ◽  
Mohammad Salauddin ◽  
Faheem Hyder Pottoo ◽  
...  

Abstract:: Herbal medicines pays an important in treating the vaious diseases mainly due to the their potentially high therapeutic values and also due to the better acceptance of vaioruspatient under different health complications. The herbal medicine practice involves use of part of plant, entire plant or the selectctive isolated phytomedicineand the use and practices based on these has its pros and cons and has been greatly affected during the dawn. The search of new drugs during scientific era revives the interest in discovery of herbal drugs from different natural resources during 20th century. The present modern healthcare system invovlves utilization drugs and 50% of them are of ofnaural origin. Herbal drug disocovery found to be highly costly affair with low success rate and it hinders the further progress in utilizting the phytomedicine in treating the various deseases. But in recent years there is an increase in the search interest of herbal drugs mainly by the pharmaceutical industry and those invoves in the search of novel drugs from the herbs. Discovery of such new novel phytomedicines has to overcomes various challenges in indentification of active extracts and their toxicity, advereffects, herb drug interaction and importantly their regulatory requirments. The present review mainly focused on the history of herbal medicine, current clinical perspective, pharmaceutical, and regulatory challenges as well as its clinical presentation. Moreover, problems encountered in drug discovery from herbal resources and its possible solutions are delineated.


Author(s):  
Tahereh Molkara ◽  
Maliheh Motavasselian ◽  
Farideh Akhlaghi ◽  
Mohammad Arash Ramezani ◽  
Hamideh Naghedi Baghdar ◽  
...  

: Sexual health plays an important role in the women’s health and quality of life. Sexual health management is a prerequisite for physical and psychological health of women. Sexual desire, arousal, and orgasm are three factors of female sexual response. So far many different methods has been known for the treatment of female sexual dysfunction, however none of them are not an efficacious therapy. Generally, use of herbal medicine is a safe and effective therapeutic method in the treatment of women with sexual dysfunction. The role of herbal and nutritional supplementation in female sexual function has attracted researchers’ interest in recent years. This study aimed to the evaluation of the studies focusing on the herbal medicine on women sexual function and the assessment of its effectiveness.


2018 ◽  
Vol 30 (4) ◽  
pp. 371-377
Author(s):  
J Gini ◽  
A Amara ◽  
Sujan D Penchala ◽  
David J Back ◽  
L Else ◽  
...  

Herbal medication use amongst people living with human immunodeficiency virus (PLWH) is widespread and understudied. This study aimed to evaluate the prevalence of herbal medicine use amongst PLWH and possible contamination with antiretrovirals (ARVs). Countrywide collection of herbal samples sold by street vendors in Nigeria for the following indications: human immunodeficiency virus (HIV), acquired immune deficiency syndrome, fever and general weakness. Samples were screened using a validated liquid chromatography-mass spectrometry/mass spectrometry method for the presence of the following ARVs: efavirenz, nevirapine, lopinavir, darunavir, ritonavir, atazanavir, emtricitabine, tenofovir and lamivudine. A survey was conducted among 742 PLWH attending four HIV clinics in Nigeria. Data were collected using a structured questionnaire and analysed using IBM SPSS statistics version 22.0 (IBM Corp., 2013, Armond, NY). Of the 138 herbal medicines sampled, three (2%) contained detectable levels of tenofovir, emtricitabine and/or lamivudine. Additionally, of the 742 PLWH surveyed, 310 (41.8%) reported herbal medicine use. Among the users, 191 (61.6%) started taking herbals after commencing HIV therapy while herbal medicine use preceded ARVs treatment in 119 (38.4%) PLWH. We found herbal use to be widespread among PLWH in Nigeria, with increasing use after commencing ARV. Three herbal preparations were also found to contain detectable levels of ARVs. This is a concern and should be studied widely across the region and countries where herbal medicine use is prevalent and poorly regulated.


Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 251
Author(s):  
Behdad Jahromi ◽  
Iulia Pirvulescu ◽  
Kenneth D. Candido ◽  
Nebojsa Nick Knezevic

Complementary and alternative medicines such as herbal medicines are not currently part of the conventional medical system. As the popularity of and global market for herbal medicine grows among all age groups, with supporting scientific data and clinical trials, specific alternative treatments such as herbal medicine can be reclassified as a practice of conventional medicine. One of the most common conditions for which adults use herbal medicine is pain. However, herbal medicines carry safety concerns and may impact the efficacy of conventional therapies. Unfortunately, mechanisms of action are poorly understood, and their use is unregulated and often underreported to medical professionals. This review aims to compile common and available herbal medicines which can be used as an alternative to or in combination with conventional pain management approaches. Efficacy and safety are assessed through clinical studies on pain relief. Ensuing herb–drug interactions such as cytochrome modulation, additive and synergistic effects, and contraindications are discussed. While self-management has been recognized as part of the overall treatment strategy for patients suffering from chronic pain, it is important for practitioners to be able to also optimize and integrate herbal medicine and, if warranted, other complementary and alternative medicines into their care.


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