scholarly journals Analytical Methods in Standardization of Bhasmas: A Review

2021 ◽  
Vol 11 (5) ◽  
pp. 183-192
Author(s):  
Dileep Kumar P G ◽  
Nataraja Yadav P. ◽  
Gananadhamu S. ◽  
Nataraj K.S.
Keyword(s):  
Chronic Diseases ◽  
Analytical Methods ◽  
Analytical Techniques ◽  
Short Review ◽  
Therapeutic Effects ◽  
Metallic Base ◽  
Ancient Science ◽  
Pharmaceutical Processes

Ayurveda the ancient science well known for its potential therapeutic effects with unique metallic, herbal juices/fruits in the treatment of chronic ailments. A well- known ayurvedic potent preparation, Bhasma is also known as ash which is a metallic base prepared by sophisticated pharmaceutical processes also plays a major role in acute, sub-acute, and chronic diseases. In order to determine its quality and purity to make sure the acceptability, the safety of the formulation standardization is very necessary. In this short review, an attempt has been made to present ancient methods to standardize  physical characterstics like Verna, Nisvadutam, Nishchandratvam, Varitara, Unama, Rekhapurmatvam, Slakshmatvam..etc.,and chemical characterstics of bhasmas like Apurnabhavta, Niruttha, Amla Pariksha with advanced methods like SEM, TEM, and NPST, along with other natural and ancient analytical techniques. Keywords: Bhasmas, Standardization, Analytical methods, SEM, TEM.

Synthesis, Analytical Characterization and Spectroscopic Investigation of Chloramphenicol Impurity A for the Quality Control of Chloramphenicol and its Formulation as Per International Compendium

2020 ◽  
Vol 17 (5) ◽  
pp. 382-388
Author(s):  
Aparna Wadhwa ◽  
Faraat Ali ◽  
Sana Parveen ◽  
Robin Kumar ◽  
Gyanendra N. Singh
Keyword(s):  
Quality Control ◽  
Synthesis Method ◽  
Analytical Techniques ◽  
International Markets ◽  
Therapeutic Effects ◽  
Reference Standard ◽  
Working Standard ◽  
Prior Art ◽  
New Synthesis ◽  
Synthetic Procedure

Objective: The main aim of the present work is to synthesize chloramphenicol impurity A (CLRMIMP- A) in the purest form and its subsequent characterization by using a panel of sophisticated analytical techniques (LC-MS, DSC, TGA, NMR, FTIR, HPLC, and CHNS) to provide as a reference standard mentioned in most of the international compendiums, including IP, BP, USP, and EP. The present synthetic procedure has not been disclosed anywhere in the prior art. Methods: A simple, cheaper, and new synthesis method was described for the preparation of CLRM-IMP-A. It was synthesized and characterized by FTIR, DSC, TGA, NMR (1H and 13C), LC-MS, CHNS, and HPLC. Results: CLRM-IMP-A present in drugs and dosage form can alter the therapeutic effects and adverse reaction of a drug considerably, it is mandatory to have a precise method for the estimation of impurities to safeguard the public health. Under these circumstances, the presence of CLRM-IMP-A in chloramphenicol (CLRM) requires strict quality control to satisfy the specified regulatory limit. The synthetic impurity obtained was in the pure form to provide a certified reference standard or working standard to stakeholders with defined potency. Conclusion: The present research describes a novel technique for the synthesis of pharmacopoeial impurity, which can help in checking/controlling the quality of the CLRM in the international markets.

Phytoceuticals in aniseeds: a practical approach for isolation and identification

2016 ◽  
Vol 5 (01) ◽  
pp. 4701
Author(s):  
Shobha R. I. ◽  
Andallu B.
Keyword(s):  
Chronic Diseases ◽  
Column Chromatography ◽  
High Performance ◽  
Methanolic Extract ◽  
Analytical Techniques ◽  
Therapeutic Agents ◽  
Systematic Research ◽  
Isolation And Identification ◽  
Traditional System ◽  
Pharmacologically Active

Nature has provided mankind with a broad and structurally diverse array of pharmacologically active chemical compounds, phytoceuticals, which have proved to be indispensable for the cure of chronic diseases or as lead structures for novel therapeutic agents. Almost, 70% of modern medicines in India have been developed from plants used in the traditional system of medicine. With the technological advances and the development of more sophisticated isolation and analytical techniques, there is great scope for further systematic research to screen and isolate many more phytoceuticals which might be more effective/as effective as synthetic drugs and thereby assess their potential in protecting against chronic diseases. The present investigation is aimed at isolation and identification of phytoceuticals in a spice, aniseed (Pimpinella anisum L), therapeutically less-exploited and widely used only for culinary purpose, using analytical techniques viz. column chromatography, high performance thin layer chromatography (HPTLC.) and nuclear magnetic resonance spectrometry. Among all the solvent fractions of methanolic extract tested, methanolic extract and ethyl acetate fraction possessed highest amounts of bioactive compounds viz. phenolics, flavonoids, flavonols which was confirmed by qualitative, quantitative and HPTLC. analyses. Spectral analysis using NMR. of one of the sub-fractions of aniseeds obtained by column chromatography, revealed the presence of a glycosylated flavone, luteolin-6C-glucoside in aniseeds.  The present study revealed aniseeds to be a great source of bioactive phytoceuticals which can be novel candidates for development of new therapeutic agents.

A Short Review on Structural Equation Modeling: Applications and Future Research Directions

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Surajit Bag
Keyword(s):  
Structural Equation Modeling ◽  
Structural Equation ◽  
First Generation ◽  
Analytical Techniques ◽  
Short Review ◽  
Equation Modeling ◽  
Future Research ◽  
Multivariate Techniques ◽  
Statistical Efficiency ◽  
Future Research Directions

The application of multivariate techniques is mainly to expand the researchers explanatory ability and statistical efficiency. The first generation analytical techniques share a common limitation i.e. each technique can examine only a single relationship at a time. Structural Equation Modeling, an extension of several multivariate techniques is the technique popularly used today can examine a series of dependence relationships simultaneously. The purpose of this study is to provide a short review on Structural Equation Modeling (SEM) being used in social sciences research. A comprehensive literature review of article appearing in top journals is conducted in order to identify how often SEM theory is used. Also the key SEM steps have been provided offering potential researchers with a theoretical supported systematic approach that simplify the multiple options with performing SEM.

scholarly journals Electroanalytical Techniques for the Detection of Selenium as a Biologically and Environmentally Significant Analyte—A Short Review

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1768
Author(s):  
Miroslav Rievaj ◽  
Eva Culková ◽  
Damiána Šandorová ◽  
Zuzana Lukáčová-Chomisteková ◽  
Renata Bellová ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Essential Element ◽  
Analytical Techniques ◽  
High Sensitivity ◽  
Stripping Voltammetry ◽  
Short Review ◽  
Electroanalytical Methods ◽  
High Concentrations ◽  
Speed Of Analysis

This short review deals with the properties and significance of the determination of selenium, which is in trace amounts an essential element for animals and humans, but toxic at high concentrations. It may cause oxidative stress in cells, which leads to the chronic disease called selenosis. Several analytical techniques have been developed for its detection, but electroanalytical methods are advantageous due to simple sample preparation, speed of analysis and high sensitivity of measurements, especially in the case of stripping voltammetry very low detection limits even in picomoles per liter can be reached. A variety of working electrodes based on mercury, carbon, silver, platinum and gold materials were applied to the analysis of selenium in various samples. Only selenium in oxidation state + IV is electroactive therefore the most of voltammetric determinations are devoted to it. However, it is possible to detect also other forms of selenium by indirect electrochemistry approach.

scholarly journals Medical Applications of Diode Lasers: Pulsed versus Continuous Wave (cw) Regime

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 710
Author(s):  
Michał Michalik ◽  
Jacek Szymańczyk ◽  
Michał Stajnke ◽  
Tomasz Ochrymiuk ◽  
Adam Cenian
Keyword(s):  
Diode Laser ◽  
Continuous Wave ◽  
Diode Lasers ◽  
Short Review ◽  
Medical Application ◽  
Medical Applications ◽  
Therapeutic Effects ◽  
Pulsed Mode ◽  
Medical Therapies

The paper deals with the medical application of diode-lasers. A short review of medical therapies is presented, taking into account the wavelength applied, continuous wave (cw) or pulsed regimes, and their therapeutic effects. Special attention was paid to the laryngological application of a pulsed diode laser with wavelength 810 nm, and dermatologic applications of a 975 nm laser working at cw and pulsed mode. The efficacy of the laser procedures and a comparison of the pulsed and cw regimes is presented and discussed.

scholarly journals Examination of Thick-Films Using Modern Surface Analytical Techniques

1984 ◽  
Vol 11 (3) ◽  
pp. 219-223 ◽  
Author(s):  
G. Harsányi ◽  
G. Ripka
Keyword(s):  
Integrated Circuits ◽  
Thick Film ◽  
Analytical Methods ◽  
Thick Films ◽  
Analytical Techniques ◽  
Electrical Measurements ◽  
Surface Impurity ◽  
And Migration

Modern surface analytical methods/EMPA, AES, SIMS etc. were used for studying the different layers in thick-film integrated circuits. Diffusion and migration effects, surface impurity distributions and surface compositions were examined. Some of the results are presented in this paper. Electrical measurements are not discussed here; only examples of the practical use of the methods are demonstrated.

Science of Art and Analysis: A Mixture for Undergraduate Non-Specialists

1992 ◽  
Vol 267 ◽  
Author(s):  
W. Stanley Taft ◽  
James W. Mayer
Keyword(s):  
Physical Properties ◽  
Computer Science ◽  
Undergraduate Students ◽  
Analytical Methods ◽  
Art History ◽  
Analytical Techniques ◽  
Cornell University ◽  
The Third ◽  
Works Of Art ◽  
Modern Analytical

ABSTRACTAt Cornell University we are in the third year of teaching an interdisciplinary, undergraduate course on the physical properties and structures of works of Art, and the modern analytical methods used to investigate them: Art, Isotopes, and Analysis. The challenge is to explain concepts familiar to museum scientists and conservators to a group of 150 undergraduate students with a background that ranges from Art History to Computer Science. Painting techniques (Fresco, Tempera, Oil, etc.) are demonstrated to the class. The analytical techniques involve the interactions of electrons, photons, ions and neutrons with pigments and other materials. This instructional approach serves as an introduction to published analyses of works of art.

scholarly journals Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4957
Author(s):  
Wanda Baer-Dubowska ◽  
Maria Narożna ◽  
Violetta Krajka-Kuźniak
Keyword(s):  
Signaling Pathways ◽  
Oleanolic Acid ◽  
Short Review ◽  
Therapeutic Effects ◽  
Pentacyclic Triterpenoid ◽  
Anti Cancer ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Derivatives ◽  
Cancer Activity

Naturally occurring pentacyclic triterpenoid oleanolic acid (OA) serves as a good scaffold for additional modifications to achieve synthetic derivatives. Therefore, a large number of triterpenoids have been synthetically modified in order to increase their bioactivity and their protective or therapeutic effects. Moreover, attempts were performed to conjugate synthetic triterpenoids with non-steroidal anti-inflammatory drugs (NSAIDs) or other functional groups. Among hundreds of synthesized triterpenoids, still the most promising is 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), which reached clinical trials level of investigations. The new group of synthetic triterpenoids are OA oximes. The most active among them is 3-hydroxyiminoolean-12-en-28-oic acid morpholide, which additionally improves the anti-cancer activity of standard NSAIDs. While targeting the Nrf2 and NF-κB signaling pathways is the main mechanism of synthetic OA derivatives′ anti-inflammatory and anti-cancer activity, most of these compounds exhibit multifunctional activity, and affect cross-talk within the cellular signaling network. This short review updates the earlier data and describes the new OA derivatives and their conjugates in the context of modification of signaling pathways involved in inflammation and cell survival and subsequently in cancer development.

scholarly journals Magnetically responsive materials for solid phase extraction

2019 ◽  
Vol 6 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Ivo Safarik ◽  
Jitka Prochazkova ◽  
Eva Baldikova ◽  
Kristyna Pospiskova
Keyword(s):  
Solid Phase Extraction ◽  
Limit Of Detection ◽  
Solid Phase ◽  
Analytical Techniques ◽  
Magnetic Solid Phase Extraction ◽  
Short Review ◽  
Biologically Active ◽  
Phase Extraction ◽  
Responsive Materials ◽  
Magnetic Solid

Magnetically responsive materials have found many important applications in analytical chemistry. In this short review the basic information about Magnetic solid phase extraction and Magnetic textile solid phase extraction is given. These analytical techniques enable to preconcentrate target biologically active compounds or pollutants from water samples. Both procedures enable to lower the limit of detection using conventional analytical procedures.

Analytical Techniques for Glass Contamination of Food: A Guide for Administrators and Analysts

1990 ◽  
Vol 53 (10) ◽  
pp. 895-899 ◽  
Author(s):  
JOHN S. GECAN ◽  
STANLEY M. CICHOWICZ ◽  
PARIS M. BRICKEY
Keyword(s):  
Quality Assurance ◽  
Analytical Methods ◽  
Analytical Techniques ◽  
Consumer Products ◽  
Analytical Scheme

An analytical scheme is presented to provide an overview of techniques applicable to glass contamination in a variety of consumer products. Procedures are referenced or presented in detail, with emphasis on quality assurance. References on forensic and analytical methods for the examination of glass are provided.

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