scholarly journals Plant low-K responses are partly due to Ca and the low-K biomarker putrescine does not protect from Ca side effects but acts as a metabolic regulator

2020 ◽  
Author(s):  
Jing Cui ◽  
Marlene Davanture ◽  
Emmanuelle Lamade ◽  
Michel Zivy ◽  
Guillaume Tcherkez
Keyword(s):  
Primary Metabolism ◽  
Proteomics Analysis ◽  
High K ◽  
N Assimilation ◽  
K Deficiency ◽  
The Impact ◽  
Low K ◽  
K Response ◽  
K Fertilization ◽  
Made In

Effects of K deficiency have been investigated for several decades and recently, progress has been made in identifying metabolomics signatures thereby offering potential to monitor the K status of crops in the field. However, effects of low K conditions could also be due to the antagonism with other nutrients like calcium (Ca) and the well-known biomarker of K deficiency, putrescine, could be a response to Ca/K imbalance rather than K deficiency. We carried out experiments in sunflower grown at either low or high K, at high or low Ca, with or without putrescine added to the nutrient solution. Using metabolomics and proteomics analysis, we show that a significant part of the low-K response such as lower photosynthesis and N assimilation, is due to calcium and can be suppressed by low Ca conditions. Putrescine addition tends to restore photosynthesis and N assimilation but but aggravates the impact of low-K conditions on catabolism. We conclude that (i) effects of K deficiency can be partly alleviated by the use of low Ca and not only by K fertilization, and (ii) in addition to its role as a metabolite, putrescine participates in the regulation of the content in enzymes involved in carbon primary metabolism.

Enhancement and Modeling of Drain Current in Negative Capacitance Double Gate TFET

2021 ◽  
Author(s):  
SHIKHA U S ◽  
Rekha K James ◽  
Jobymol Jacob ◽  
Anju Pradeep
Keyword(s):  
Drain Current ◽  
Gate Oxide ◽  
Negative Capacitance ◽  
Double Gate ◽  
High K ◽  
Gate Control ◽  
Effect Transistor ◽  
Dimensional Simulation ◽  
The Impact ◽  
Low K

Abstract The drain current improvement in a Negative Capacitance Double Gate Tunnel Field Effect Transistor (NC-DG TFET) with the help of Heterojunction (HJ) at the source-channel region is proposed and modeled in this paper. The gate oxide of the proposed TFET is a stacked configuration of high-k over low-k to improve the gate control without any lattice mismatches. Tangent Line Approximation (TLA) method is used here to model the drain current accurately. The model is validated by incorporating two dimensional simulation of DG-HJ TFET with one dimensional Landau-Khalatnikov (LK) equation. The model matches excellently with the device simulation results. The impact of stacked gate oxide topology is also studied in this paper by comparing the characteristics with unstacked gate oxide. Voltage amplification factor (Av), which is an important parameter in NC devices is also analyzed.

Differential regulation of CHIF mRNA by potassium intake and aldosterone

1997 ◽  
Vol 272 (5) ◽  
pp. F617-F623 ◽  
Author(s):  
H. Wald ◽  
M. M. Popovtzer ◽  
H. Garty
Keyword(s):  
Xenopus Oocytes ◽  
Transmembrane Protein ◽  
Distal Colon ◽  
Differential Regulation ◽  
Aldosterone Level ◽  
Potassium Intake ◽  
High K ◽  
K Deficiency ◽  
Low K ◽  
Intact Rats

The channel-inducing factor (CHIF) is an epithelial-specific transmembrane protein, which is induced by aldosterone in distal colon (but not in kidney) and can evoke K+ conductance in Xenopus oocytes. The current study examined the possibility that CHIF participates in maintaining K+ balance by assessing its regulation during variations in K+ intake. In adrenal-intact rats, high-K+ diet stimulated, whereas K+ deficiency downregulated, CHIF mRNA both in kidney and colon. The downregulation of CHIF observed in rats fed a low-K+ diet for different periods of time closely correlated with a decrease in plasma K+ but also with changes in aldosterone levels. To differentiate between the two, modulation of CHIF has been studied in adrenalectomized rats with and without corticosteroid supplementation. These experiments have demonstrated that a low-K+ intake suppresses CHIF mRNA, irrespective of aldosterone level. On the other hand, the upregulation evoked by a high-K+ load is apparent only in adrenal-intact rats. This is despite the fact that infusing rats with aldosterone and corticosterone does not increase the expression of this mRNA in kidney. These findings may suggest a role for CHIF in preserving K+ balance.

Canola, narrow-leafed lupin and wheat differ in growth response to low–moderate sodium on a potassium-deficient sandy soil

2016 ◽  
Vol 67 (11) ◽  
pp. 1168 ◽  
Author(s):  
Qifu Ma ◽  
Richard Bell
Keyword(s):  
Seed Yield ◽  
Triticum Aestivum L ◽  
Interactive Effects ◽  
Growth And Yield ◽  
Brassica Napus L ◽  
High K ◽  
K Deficiency ◽  
Salt Affected Soils ◽  
K Concentration ◽  
Low K

Although soil salinity and potassium (K) deficiency are widespread in agricultural lands, there is a paucity of knowledge about the interactive effects of sodium (Na) and K on the growth and yield of major grain crops. In pot experiments, we examined salt tolerance of canola (Brassica napus L.), narrow-leafed lupin (Lupinus angustifolius L.) and wheat (Triticum aestivum L.), and crop K requirement under Na supply ranging from low to high. Plant growth and seed yield of all three crops were lower at 40 mg K/kg than at 100 mg K/kg soil. Although 100 mg Na/kg (4 dS/m in soil solution) had little effect on canola cv. Boomer and wheat cv. Wyalkatchem, the salt-treated narrow-leafed lupin cv. Mandelup died at 47 days after sowing, regardless of amount of soil K. In low-K soils, canola with 100 mg Na/kg and wheat with 50 mg Na/kg did not show K-deficiency symptoms and produced greater seed yield than plants with nil Na addition. At 100 mg K/kg, Na-induced reduction in growth and yield occurred only to plants with 200 mg Na/kg. However, at 160 mg K/kg, 200 mg Na/kg did not have an adverse effect. In canola and wheat, shoot K concentration increased and shoot Na concentration decreased with increasing amount of soil K; however, high soil K did not reduce shoot Na concentration in narrow-leafed lupin. The study showed that narrow-leafed lupin was very susceptible to salinity, whereas canola and wheat plants were relatively salt-tolerant. The stimulation of growth and yield in canola and wheat by low–moderate Na in low-K soils suggests partial K substitution by Na, and that adaptation of canola and wheat to salt-affected soils can be enhanced by high K supply.

scholarly journals Ambipolar Current Suppression, Analog/RF and Linearity Performance Improvement of Dual Material Stacked Gate Oxide TFET with Dielectric Pocket

2021 ◽  
Author(s):  
dharmender nishad ◽  
kaushal Nigam
Keyword(s):  
Gate Dielectric ◽  
Rf Circuits ◽  
Gate Oxide ◽  
High K ◽  
Ambipolar Current ◽  
High K Dielectric ◽  
Rf Performance ◽  
The Impact ◽  
Dual Material ◽  
Low K

Abstract In this article, the impact of high-K and low-K dielectric pockets on DC, analog/RF, and linearity performance parameters of dual material stacked gate oxide-dielectric pocket-tunnel field-effect transistor (DMSGO-DP-TFET) is investigated. In this regard, a stacked gate oxide (SiO2 + HfO2) with workfunction engineering is taken into consideration to improve the ON-state current (ION ), and suppress the ambipolar current (Iamb). To further improve the performance of the device, a high-K dielectric pocket (HfO2) is used at the drain-channel interface to suppress the Iamb, and at the source-channel interface a low-K dielectric pocket is used to improve the ION and analog/RF performance. Moreover, length of stacked gate segments (L1, L2, L3), pocket height, and thickness are optimized to attain better ION /IOFF ratio, and suppress the Iamb which helps to achieve higher gain and design of analog/RF circuits. The DMSGO-DP-TFET outperforms the dual material control gate-dielectric pocket-TFET (DMCG-DP-TFET) with SiO2 gate oxide and shows increment in ION /IOFF (∼ 4.23 times), 84 % increment in transconductance (gm), 136 % increment in cut-off frequency (fT ), 126 % increment in gain-bandwidth-product (GBP), and better linearity performance parametrs such as gm2 ,gm3, VIP2, VIP3 and IIP3 making the proposed device useful for low power and radio frequency applications.

Electron Probe Analysis of Vertebrate Smooth Muscle: Distribution of Ca and Ci

1976 ◽  
Vol 34 ◽  
pp. 334-335 ◽  
Author(s):  
Avril V. Somlyo ◽  
H. Shuman ◽  
A.P. Somlyo
Keyword(s):  
Smooth Muscle ◽  
Electron Probe ◽  
Preliminary Report ◽  
Cell Damage ◽  
Electron Probe Analysis ◽  
Perinuclear Space ◽  
Probe Analysis ◽  
High K ◽  
Low K ◽  
Initial Results

This is a preliminary report of electron probe analysis of rabbit portal-anterior mesenteric vein (PAMV) smooth muscle cryosectioned without fixation or cryoprotection. The instrumentation and method of electron probe quantitation used (1) and our initial results with cardiac (2) and skeletal (3) muscle have been presented elsewhere.In preparations depolarized with high K (K2SO4) solution, significant calcium peaks were detected over the sarcoplasmic reticulum (Fig 1 and 2) and the continuous perinuclear space. In some of the fibers there were also significant (up to 200 mM/kg dry wt) calcium peaks over the mitochondria. However, in smooth muscle that was not depolarized, high mitochondrial Ca was found in fibers that also contained elevated Na and low K (Fig 3). Therefore, the possibility that these Ca-loaded mitochondria are indicative of cell damage remains to be ruled out.

Handshake antimicrobial stewardship as a model to recognize and prevent diagnostic errors

Diagnosis ◽  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Justin B. Searns ◽  
Manon C. Williams ◽  
Christine E. MacBrayne ◽  
Ann L. Wirtz ◽  
Jan E. Leonard ◽  
...  
Keyword(s):  
Antimicrobial Stewardship ◽  
Interrater Reliability ◽  
Diagnostic Errors ◽  
Diagnostic Error ◽  
Primary Treatment ◽  
Treatment Team ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
The Impact ◽  
Made In

AbstractObjectivesFew studies describe the impact of antimicrobial stewardship programs (ASPs) on recognizing and preventing diagnostic errors. Handshake stewardship (HS-ASP) is a novel ASP model that prospectively reviews hospital-wide antimicrobial usage with recommendations made in person to treatment teams. The purpose of this study was to determine if HS-ASP could identify and intervene on potential diagnostic errors for children hospitalized at a quaternary care children’s hospital.MethodsPreviously self-identified “Great Catch” (GC) interventions by the Children’s Hospital Colorado HS-ASP team from 10/2014 through 5/2018 were retrospectively reviewed. Each GC was categorized based on the types of recommendations from HS-ASP, including if any diagnostic recommendations were made to the treatment team. Each GC was independently scored using the “Safer Dx Instrument” to determine presence of diagnostic error based on a previously determined cut-off score of ≤1.50. Interrater reliability for the instrument was measured using a randomized subset of one third of GCs.ResultsDuring the study period, there were 162 GC interventions. Of these, 65 (40%) included diagnostic recommendations by HS-ASP and 19 (12%) had a Safer Dx Score of ≤1.50, (Κ=0.44; moderate agreement). Of those GCs associated with diagnostic errors, the HS-ASP team made a diagnostic recommendation to the primary treatment team 95% of the time.ConclusionsHandshake stewardship has the potential to identify and intervene on diagnostic errors for hospitalized children.

scholarly journals Optimal Solutions for the Use of Sewage Sludge on Agricultural Lands

Water ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 585
Author(s):  
Catalina Iticescu ◽  
Puiu-Lucian Georgescu ◽  
Maxim Arseni ◽  
Adrian Rosu ◽  
Mihaela Timofti ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Sewage Sludge ◽  
Agricultural Production ◽  
Agricultural Land ◽  
Chemical Characteristics ◽  
Optimal Solutions ◽  
Physico Chemical ◽  
Agricultural Areas ◽  
The Impact ◽  
Made In

The use of sewage sludge in agriculture decreases the pressure on landfills. In Romania, massive investments have been made in wastewater treatment stations, which have resulted in the accumulation of important quantities of sewage sludge. The presence of these sewage sludges coincides with large areas of degraded agricultural land. The aim of the present article is to identify the best technological combinations meant to solve these problems simultaneously. Adapting the quality and parameters of the sludge to the specificity of the land solves the possible compatibility problems, thus reducing the impact on the environment. The physico-chemical characteristics of the fermented sludge were monitored and optimal solutions for their treatment were suggested so as to allow that the sludge could be used in agriculture according to the characteristics of the soils. The content of heavy metals in the sewage sludge was closely monitored because the use of sewage sludge as a fertilizer does not allow for any increases in the concentrations of these in soils. The article identifies those agricultural areas which are suitable for the use of sludge, as well as ways of correcting some parameters (e.g., pH), which allow the improvement of soil quality and obtained higher agricultural production.

scholarly journals Monitoring the Impact of the Large Building Investments on the Neighborhood

2021 ◽  
Vol 11 (14) ◽  
pp. 6537
Author(s):  
Marian Łupieżowiec
Keyword(s):  
Groundwater Level ◽  
Soil Improvement ◽  
Deep Excavation ◽  
Large Area ◽  
Safety Measures ◽  
High Rise ◽  
The Impact ◽  
Large Building ◽  
Additional Safety ◽  
Made In

The article presents the concept of monitoring buildings and infrastructure elements located near large construction investments (the construction of high-rise buildings of the Oak Terraces housing estate in Katowice and the construction of a tunnel under the roundabout in Katowice along the intercity express road DTŚ). The impacts include deep excavation, lowering of the groundwater level over a large area, and dynamic influences related to the use of impact methods of soil improvement. The presented monitoring includes observation of the groundwater level with the use of piezometers, geodetic measurements of settlement and inclinations, as well as the measurement of vibration amplitudes generated during the works involving shocks and vibrations. It was also important to observe the development of cracks on the basis of a previously made inventory of damage. The results of the monitoring allow corrections to be made in the technology of works (e.g., reduction of vibration amplitudes, application of additional protections at excavations, etc.) or the use additional safety measures. Currently, there are also monitoring systems used during the operation of completed facilities.

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