208-OR: Fat Mass and Insulin Resistance Are Independent Risk Factors for Polyneuropathy in Non-DM Subjects Who Underwent Bariatric/Metabolic Surgery

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 208-OR
Author(s):  
KYUHO KIM ◽  
TAE JUNG OH ◽  
SUNGHEE CHOI ◽  
HAK CHUL JANG
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Fat Mass ◽  
Metabolic Surgery ◽  
Bariatric Metabolic Surgery ◽  
Independent Risk Factors

scholarly journals Influence of methyltestosterone postmenopausal therapy on plasma lipids, inflammatory factors, glucose metabolism and visceral fat: a randomized study

2006 ◽  
Vol 154 (1) ◽  
pp. 131-139 ◽  
Author(s):  
Lenora M Camarate S M Leão ◽  
Mônica Peres C Duarte ◽  
Dalva Margareth B Silva ◽  
Paulo Roberto V Bahia ◽  
Cláudia Medina Coeli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Postmenopausal Women ◽  
Fat Mass ◽  
Visceral Fat ◽  
Increased Risk

Background: There has been a growing interest in treating postmenopausal women with androgens. However, hyperandrogenemia in females has been associated with increased risk of cardiovascular disease. Objective: We aimed to assess the effects of androgen replacement on cardiovascular risk factors. Design: Thirty-seven postmenopausal women aged 42–62 years that had undergone hysterectomy were prospectively enrolled in a double-blind protocol to receive, for 12 months, percutaneous estradiol (E2) (1 mg/day) combined with either methyltestosterone (MT) (1.25 mg/day) or placebo. Methods: Along with treatment, we evaluated serum E2, testosterone, sex hormone-binding globulin (SHBG), free androgen index, lipids, fibrinogen, and C-reactive protein; glucose tolerance; insulin resistance; blood pressure; body-mass index; and visceral and subcutaneous abdominal fat mass as assessed by computed tomography. Results: A significant reduction in SHBG (P < 0.001) and increase in free testosterone index (P < 0.05; Repeated measures analysis of variance) were seen in the MT group. Total cholesterol, triglycerides, fibrinogen, and systolic and diastolic blood pressure were significantly lowered to a similar extent by both regimens, but high-density lipoprotein cholesterol decreased only in the androgen group. MT-treated women showed a modest rise in body weight and gained visceral fat mass relative to the other group (P < 0.05), but there were no significant detrimental effects on fasting insulin levels and insulin resistance. Conclusion: This study suggests that the combination of low-dose oral MT and percutaneous E2, for 1 year, does not result in expressive increase of cardiovascular risk factors. This regimen can be recommended for symptomatic postmenopausal women, although it seems prudent to perform baseline and follow-up lipid profile and assessment of body composition, especially in those at high risk of cardiovascular disease.

scholarly journals Weight Loss Efficacy of 4-Hour Versus 6-Hour Time Restricted Feeding in Adults with Obesity

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 584-584
Author(s):  
Sofia Cienfuegos ◽  
Kelsey Gabel ◽  
Faiza Kalam ◽  
Mark Ezpeleta ◽  
Vasiliki Pavlou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Disease ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Weight Loss ◽  
Body Weight ◽  
Fat Mass ◽  
Disease Risk ◽  
Metabolic Disease Risk ◽  
Ad Libitum

Abstract Objectives This study was undertaken to compare the effects of 4-h TRF to that of 6-h TRF on body weight, body composition, and metabolic disease risk factors in adults with obesity. We hypothesized that 4-h TRF would produce the greatest decreases in body weight, fat mass, blood pressure, and insulin resistance, compared to 6-h TRF. Methods Adults with obesity (n = 49) were randomized to 1 of 3 interventions for 8 weeks: 4-h TRF (ad libitum eating between 3:00 to 7:00 pm, water fasting between 7:00 to 3:00 pm); 6-h TRF (ad libitum eating between 1:00 to 7:00 pm, water fasting between 7:00 to 1:00 pm); or control (ad libitum food intake with no timing restrictions). Results Body weight decreased similarly in the 4-h TRF group (–3.3 ± 0.5%) and 6-h TRF group (–2.6 ± 0.5%) relative to controls over 8 weeks (P &lt; 0.001). Fat mass, blood pressure and insulin sensitivity also decreased in the 4-h TRF and 6-h TRF groups versus controls. LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, and HbA1c were not significantly different from controls after 8 weeks. Conclusions This is the first trial to examine the effects of 4-h vs. 6-h TRF on body weight and metabolic disease risk factors. We show here that 8 weeks of 4-h and 6-h TRF decreases body weight by ∼3–4% relative to controls. We also demonstrate that this fasting regimen produces significant reductions in blood pressure, fat mass, insulin and insulin resistance. These preliminary data offer promise for the use of 4-h and 6-h TRF as a weight loss techniques in adults with obesity, but larger, longer-term trials are needed to confirm these findings. Funding Sources Department of Kinesiology and Nutrition, University of Illinois Chicago

scholarly journals Estimated Lean Mass and Fat Mass Differentially Affect Femoral Bone Density and Strength Index but Are Not FRAX Independent Risk Factors for Fracture

2014 ◽  
Vol 29 (11) ◽  
pp. 2511-2519 ◽  
Author(s):  
William D Leslie ◽  
Eric S Orwoll ◽  
Carrie M Nielson ◽  
Suzanne N Morin ◽  
Sumit R Majumdar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Density ◽  
Fat Mass ◽  
Lean Mass ◽  
Femoral Bone ◽  
Strength Index ◽  
Femoral Bone Density ◽  
Independent Risk Factors

scholarly journals Effect of Insulin Resistance on Recurrence After Radiofrequency Catheter Ablation in Patients with Atrial Fibrillation

2021 ◽  
Author(s):  
Zhe Wang ◽  
Yi-Jia Wang ◽  
Zhi-Yu Liu ◽  
Qing Li ◽  
Ya-wei Kong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Insulin Resistance ◽  
Fasting Blood Glucose ◽  
Multivariable Analysis ◽  
Diabetic Patients ◽  
Model Assessment ◽  
Af Ablation ◽  
Independent Risk Factors ◽  
Af Recurrence

Abstract Background Recurrence after atrial fibrillation(AF) ablation has many risk factors. the relationship between the recurrence rate after ablation and IR in the non-diabetic patients with AF is not clear.MethodsRetrospective cohort study enrolled AF patients without diabetes who underwent ablation between 2018~2019 in the first affiliated hospital of zhengzhou university. Homeostasis model assessment of insulin resistance (HOMA‐IR) was calculated and a value of ≥2.69 was defined as insulin resistant(IR). The patients were categaried into two groups: those with HOMA‐IR<2.69 in group 1(n=163); HOMA‐IR≥2.69 in group 2 (n=69). Multivariable adjusted Cox proportional hazard models were performed to compare the risk of AF recurrence after ablation. The definition of AF recurrence was documented AF, atrial flutter, or atrial tachycardia lasting >30 seconds recorded in ECG or 24‐hour Holter monitoring after 3 months blanking period.Results232 AF patients receiving ablation were enrolled and the median age was 59.5±11.3 years . There were 166 cases of paroxysmal AF and 66 cases of persistent AF. Patients with IR (n=69)were more likely to have Dyslipidemia, higher fasting blood glucose and fasting insulin than those in non-IR group. Patients with IR also were more likely to recieve antiarrhythmic drugs before ablation. After a mean follow‐up of 322±85 days, 62(26.7%) patients had documented recurrence of AF. Multivariable analysis showed that HOMA-IR value and left atrial diameter（LAD）were independent risk factors for recurrence after AF ablation (HR: 1.259, 95% CI:1.086~1.460, P=0.002; HR: 1.043, 95% CI:1.005~1.083, P=0.025; respectively).ConclusionsHOMA-IR and LAD are independent risk factors for AF recurrence after ablation in patients without diabetes.

scholarly journals Early Arteriosclerosis and Its Risk Factors in Prediabetes and New-Onset Diabetes Subjects

2020 ◽  
Author(s):  
Xiaoli Liu ◽  
Lanxiang Liu ◽  
Rui Wang ◽  
Xiaojiao Jia ◽  
Binbin Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Glucose Tolerance ◽  
Resistance Index ◽  
Insulin Resistance Index ◽  
Onset Diabetes ◽  
Independent Risk Factors ◽  
New Onset

Abstract Background: We aimed to investigate early arteriosclerosis and its risk factors in populations with prediabetes and new-onset diabetes. Materials and Methods: A total of 148 participants without known diabetes mellitus were assigned to three groups: normal glucose tolerance (NGT); impaired glucose regulation (IGR), also known as prediabetes; and new-onset type 2 diabetes mellitus (T2DM) through an oral glucose tolerance test (OGTT). The insulin resistance index was assessed using the homeostasis model (HOMA-IR). An enzyme-linked immunosorbent assay was used to determine the expression level of the fibroblast growth factor 21 (FGF21). An arteriosclerosis detector was used to measure the brachial-ankle pulse wave velocity (baPWV) and the ankle-brachial index (ABI). The baPWV, ABI and FGF21 were used to assess early arteriosclerosis. Results: Significant differences in age, systolic blood pressure (SBP), fasting plasma glucose (FPG), 2-hour plasma glucose (2hPG), 2-hour insulin (2hINS) and HOMA-IR were found between the NGT group and the prediabetic and new-onset diabetic groups. All except 2hINS showed an increasing trend. The FGF21 and the baPWV increased from the NGT group to prediabetic and the new-onset diabetic group, but no significant difference was noted in the ABI. The age, SBP, diastolic blood pressure (DBP), FPG, 2hPG and FGF21 positively correlated with the baPWV. The BMI, SBP, DBP, FPG, 2hPG and HOMA-IR positively correlated with the ABI. The age, BMI, FPG, FGF21 and HOMA-IR were independent risk factors for the baPWV, and the SBP and the HOMA-IR were independent risk factors for ABI. Conclusions: Patients with prediabetes and new-onset diabetes had more significant early arteriosclerosis. The blood glucose and insulin resistance index were independent risk factors for early arteriosclerosis.

Insulin Resistance and Cardiometabolic Risk Profile Among Non-Diabetic American Young Adults: Insights from NHANES

2021 ◽  
Author(s):  
Vibhu Parcha ◽  
Brittain Heindl ◽  
Rajat Kalra ◽  
Peng Li ◽  
Barbara Gower ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Young Adults ◽  
Fat Mass ◽  
Cardiometabolic Risk ◽  
Temporal Trends ◽  
Cardiometabolic Risk Factors ◽  
Model Assessment ◽  
Cross Sectional Survey ◽  
Cross Sectional

Abstract Background The burden of insulin resistance (IR) among young American adults has not been previously assessed. We evaluated the 1) prevalence and trends of IR and cardiometabolic risk factors and, 2) assessed the association between measures of adiposity and IR among adults aged 18-44 years without diabetes and preexisting cardiovascular disease. Methods Cross-sectional survey data from six consecutive National Health and Nutrition Examination Survey (2007-2008 to 2017-2018) cycles were analyzed. IR was defined by the homeostatic model assessment for IR (HOMA-IR) of ≥2.5. The temporal trends of IR, cardiometabolic risk factors, and the relationship between IR and measures of adiposity were assessed using multivariable-adjusted regression models. Results Among 6,247 young adults aged 18-44 years, the prevalence of IR was 44.8% (95% CI: 42.0-47.6%) in 2007-2010 and 40.3% (95% CI: 36.4-44.2%) in 2015-2018 (Ptrend=0.07). There was a modest association of HOMA-IR with higher body mass index (BMI), waist circumference, total lean fat mass, and total and localized fat mass (all p&lt;0.001). Participants with IR had a higher prevalence of hypertension (31.3% [95% CI: 29.2-33.5%] vs. 14.7% [95% CI: 13.2-16.2%]), hypercholesterolemia (16.0% [95% CI: 12.4-19.5%] vs. 7.0% [95% CI: 5.8-8.5%]), obesity (56.6% [95% CI: 53.9-59.3%] vs. 14.7% [95%CI: 13.0-16.5%]) and poor physical activity levels (18.3% [95% CI: 16.4-20.2%] vs. 11.7% [95%CI: 10.3-13.1%]) compared to participants without IR (all p&lt;0.05). Conclusions Four-in-ten young American adults have IR, which occurs in a cluster with cardiometabolic risk factors. Nearly half of young adults with IR are non-obese. Screening efforts for IR irrespective of BMI may be required.

scholarly journals Early arteriosclerosis and its risk factors in subjects with prediabetes and new-onset diabetes

2021 ◽  
Author(s):  
Xiaoli Liu ◽  
Lanxiang Liu ◽  
Rui Wang ◽  
Jia Xiaojiao ◽  
Binbin Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Resistance Index ◽  
Diabetes Group ◽  
Insulin Resistance Index ◽  
Onset Diabetes ◽  
Independent Risk Factors ◽  
New Onset

Background: We aimed to investigate early arteriosclerosis and its risk factors in populations with prediabetes and new-onset diabetes. Materials and Methods: A total of 148 participants who did not have diabetes mellitus were assigned to three groups through an oral glucose tolerance test: the normal glucose tolerance group; the impaired glucose regulation, also known as prediabetes, group; and the new-onset type 2 diabetes mellitus group. The insulin resistance index was assessed using the Homeostatic Model Assessment of Insulin Resistance. An enzyme-linked immunosorbent assay was used to determine the level of fibroblast growth factor 21. An arteriosclerosis detector was used to measure the brachial-ankle pulse wave velocity and ankle-brachial index. baPWV, ABI, and FGF21 were used to assess early arteriosclerosis. Results: Significant differences in age, systolic blood pressure, fasting plasma glucose, 2-hour plasma glucose, 2-hour insulin, and HOMA-IR were found between the NGT group and the prediabetes and new-onset diabetes groups. All the above except 2hINS showed an increasing trend. FGF21 was higher in the new-onset diabetes group than in the NGT group, and baPWV was higher in the new-onset diabetes group than in the other two groups, but no significant difference was noted in ABI. Age, SBP, diastolic blood pressure, FPG, 2hPG, and FGF21 were positively correlated with baPWV. Moreover, BMI, SBP, DBP, FPG, 2hPG, and HOMA-IR were positively correlated with ABI. In addition, age, BMI, FPG, FGF21, and HOMA-IR were independent risk factors for baPWV, and SBP and HOMA-IR were independent risk factors for ABI. Conclusions: Patients with prediabetes and new-onset diabetes maybe have more significant early arteriosclerosis. The blood glucose level and insulin resistance index maybe the independent risk factors for early arteriosclerosis.

scholarly journals Androgens and Glucuronidated Androgen Metabolites Are Associated with Metabolic Risk Factors in Men

2007 ◽  
Vol 92 (11) ◽  
pp. 4130-4137 ◽  
Author(s):  
Liesbeth Vandenput ◽  
Dan Mellström ◽  
Mattias Lorentzon ◽  
Charlotte Swanson ◽  
Magnus K. Karlsson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Young Adult ◽  
Fat Mass ◽  
Fat Distribution ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Model Assessment ◽  
Elderly Men ◽  
Negatively Associated

Abstract Context: Androgens are associated with metabolic risk factors in men. However, the independent impact of androgens and androgen metabolites on metabolic risk factors in men is unclear. Objective: Our objective was to determine the predictive value of serum levels of androgens and glucuronidated androgen metabolites for metabolic risk factors. Design and Study Subjects: We conducted a population-based study of two Swedish cohorts (1068 young adult and 1001 elderly men). Main Outcome Measures: We measured correlation of serum dihydrotestosterone (DHT), testosterone (T), and glucuronidated androgen metabolites with fat mass, fat distribution, serum lipids, and insulin resistance. Results: Both DHT and T were negatively associated with different measures of fat mass in both cohorts (P &lt; 0.001). Further statistical analysis indicated that DHT, but not T, was independently negatively associated with different measures of fat mass and insulin resistance (P &lt; 0.001). The glucuronidated androgen metabolite androstane-3α,17β-diol-17glucuronide (17G) was independently positively associated with fat mass (P &lt; 0.001). Most importantly, the 17G to DHT ratio was strongly correlated, not only with fat mass but also with central fat distribution, intrahepatic fat, disturbed lipid profile, insulin resistance, and diabetes, explaining a substantial part of the total variance in total body fat (12% in young adult men, 15% in elderly men), the homeostasis model assessment index (10%), and high-density lipoprotein cholesterol (7%). Conclusion: Our findings demonstrate that 17-glucuronidation of the DHT metabolite androstane-3α,17β-diol is strongly associated with several metabolic risk factors in men. Future longitudinal studies are required to determine the possible impact of the 17G to DHT ratio as a metabolic risk factor in men.

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