SEWAGE WATER AS INDICATOR FOR TRANSMISSION OF SARS-COV-2

2020 ◽  
Vol 7 (2) ◽  
pp. 212-216
Author(s):  
Shivbrat Upadhyay ◽  
Sahabjada Siddiqui ◽  
Rumana Ahmad ◽  
Anamika Gupta ◽  
Ishrat Husain
Keyword(s):  
Sewage Water ◽  
Large Percentage ◽  
Microbial Pathogens ◽  
Future Research ◽  
Human Being ◽  
Medical Surveillance ◽  
Current Review ◽  
Filtration System ◽  
Entire World ◽  
Continuous Field

Covid-19 disease, a pandemic condition, is extremely challenging for entire world and human being. The virus, officially called coronavirus 2 (SARS-CoV-2) severe acute respiratory syndromes, is widely recognized as the COVID-19 virus is recently discovered virus and the subsequent disease known as the COVID-19. In a large percentage of cases, SARS-CoV-2 was released due to faecal matter during in the currently underway outbreak of COVID-19. This eventually proves that human wastewater could be the cause of SARS-CoV-2. Through its function, the sewage filtration system is a manifestation of microbial pathogens with the potential to support transmissible of viruses such as SARS-CoV-2 in certain conditions. The involvement with sewage surveillance through monitoring the spread of SARS-CoV-2 among our populations has been underlined in the current review, which may integrate existing medical surveillance restricted to the most severe COVID-19 patients. Although there is little success here, sewage surveillance is nevertheless a continuous field of vigorous research and could be promising in future research.

scholarly journals Efficacy of Phytocannabinoids in Epilepsy Treatment: Novel Approaches and Recent Advances

2021 ◽  
Vol 18 (8) ◽  
pp. 3993
Author(s):  
Aaron M. Farrelly ◽  
Styliani Vlachou ◽  
Konstantinos Grintzalis
Keyword(s):  
Therapeutic Potential ◽  
Significant Proportion ◽  
Future Research ◽  
Specific Reference ◽  
Undesirable Side Effect ◽  
Treatment Resistant ◽  
Current Review ◽  
Epilepsy Treatment ◽  
Clinical Environments

Epilepsy is a neurological disorder mainly characterised by recurrent seizures that affect the entire population diagnosed with the condition. Currently, there is no cure for the disease and a significant proportion of patients have been deemed to have treatment-resistant epilepsy (TRE). A patient is deemed to have TRE if two or more antiepileptic drugs (AEDs) fail to bring about seizure remission. This inefficacy of traditional AEDs, coupled with their undesirable side effect profile, has led to researchers considering alternative forms of treatment. Phytocannabinoids have long served as therapeutics with delta-9-THC (Δ9-THC) receiving extensive focus to determine its therapeutic potential. This focus on Δ9-THC has been to the detriment of analysing the plethora of other phytocannabinoids found in the cannabis plant. The overall aim of this review is to explore other novel phytocannabinoids and their place in epilepsy treatment. The current review intends to achieve this aim via an exploration of the molecular targets underlying the anticonvulsant capabilities of cannabidiol (CBD), cannabidavarin (CBDV), delta-9-tetrahydrocannabivarin (Δ9-THCV) and cannabigerol (CBG). Further, this review will provide an exploration of current pre-clinical and clinical data as it relates to the aforementioned phytocannabinoids and the treatment of epilepsy symptoms. With specific reference to epilepsy in young adult and adolescent populations, the exploration of CBD, CBDV, Δ9-THCV and CBG in both preclinical and clinical environments can guide future research and aid in the further understanding of the role of phytocannabinoids in epilepsy treatment. Currently, much more research is warranted in this area to be conclusive.

scholarly journals Recent Advances in Nanotechnology with Nano-Phytochemicals: Molecular Mechanisms and Clinical Implications in Cancer Progression

2021 ◽  
Vol 22 (7) ◽  
pp. 3571
Author(s):  
Bonglee Kim ◽  
Ji-Eon Park ◽  
Eunji Im ◽  
Yongmin Cho ◽  
Jinjoo Lee ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Future Research ◽  
Clinical Implications ◽  
Research Perspectives ◽  
Current Review ◽  
Gold Silver ◽  
Significant Efficacy ◽  
Rapid Clearance

Biocompatible nanoparticles (NPs) containing polymers, lipids (liposomes and micelles), dendrimers, ferritin, carbon nanotubes, quantum dots, ceramic, magnetic materials, and gold/silver have contributed to imaging diagnosis and targeted cancer therapy. However, only some NP drugs, including Doxil® (liposome-encapsulated doxorubicin), Abraxane® (albumin-bound paclitaxel), and Oncaspar® (PEG-Asparaginase), have emerged on the pharmaceutical market to date. By contrast, several phytochemicals that were found to be effective in cultured cancer cells and animal studies have not shown significant efficacy in humans due to poor bioavailability and absorption, rapid clearance, resistance, and toxicity. Research to overcome these drawbacks by using phytochemical NPs remains in the early stages of clinical translation. Thus, in the current review, we discuss the progress in nanotechnology, research milestones, the molecular mechanisms of phytochemicals encapsulated in NPs, and clinical implications. Several challenges that must be overcome and future research perspectives are also described.

Second language structural priming: A critical review and directions for future research

2017 ◽  
Vol 34 (4) ◽  
pp. 539-552 ◽  
Author(s):  
Carrie N. Jackson
Keyword(s):  
Second Language ◽  
Future Research ◽  
Structural Priming ◽  
Cognitive Mechanisms ◽  
L2 Acquisition ◽  
Current State ◽  
Current Review ◽  
Open Questions ◽  
Key Issues ◽  
State Of Research

The last 15 years has seen a tremendous growth in research on structural priming among second language (L2) speakers. Structural priming is the phenomenon whereby speakers are more likely to repeat a structure they have recently heard or produced. Research on L2 structural priming speaks to key issues regarding the underlying linguistic and cognitive mechanisms that support L2 acquisition and use, and the extent to which lexical and grammatical information are shared across an L2 speaker’s languages. As the number of researchers investigating L2 priming and its implications for L2 learning continues to grow, it is important to assess the current state of research in this area and establish directions for continued inquiry. The goal of the current review is to provide an overview of recent research on within-language L2 structural priming, with an eye towards the open questions that remain.

Misperceptions of Friendly Behavior as Sexual Interest: A Survey of Naturally Occurring Incidents

1987 ◽  
Vol 11 (2) ◽  
pp. 173-194 ◽  
Author(s):  
Antonia Abbey
Keyword(s):  
Gender Differences ◽  
Gender Difference ◽  
Sexual Activity ◽  
Sexual Interest ◽  
Large Percentage ◽  
Future Research ◽  
Naturally Occurring ◽  
Retrospective Reports ◽  
Sexual Intent ◽  
The Individual

The studies described in this article examine retrospective reports of naturally occurring misperceptions of friendliness as sexual interest. Previous research has demonstrated that men perceive other people and situations more sexually than women do. The purpose of this research was to examine how this gender difference in perceptions of sexuality is exhibited in actual interactions between women and men. Two surveys of undergraduates were conducted. The results indicated that a large percentage of both women and men had experienced such misperceptions, although more women had than men. Most of these incidents were quickly resolved without problems; however, others involved some degree of forced sexual activity and left the individual feeling angry, humiliated, and depressed. Gender differences in the characteristics of these incidents and reactions to them are described. The implications of these findings for future research on gender differences in perceptions of sexual intent are discussed.

scholarly journals An integrative systematic review of creative arts interventions for older informal caregivers of people with neurological conditions

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243461
Author(s):  
J. Yoon Irons ◽  
Gulcan Garip ◽  
Ainslea J. Cross ◽  
David Sheffield ◽  
Jamie Bird
Keyword(s):  
Meta Analysis ◽  
Informal Caregivers ◽  
Small Sample ◽  
Cochrane Library ◽  
Future Research ◽  
Creative Arts ◽  
Qualitative Synthesis ◽  
Current Review ◽  
Neurological Conditions ◽  
Creative Interventions

Objective We aimed to assess and synthesise the current state of quantitative and qualitative research concerning creative arts interventions for older informal caregivers of people with neurological conditions. Methods A systematic search was employed to identify studies that examined creative arts interventions for older informal caregivers, which were synthesised in this integrative review. We searched the following databases: MEDLINE, PubMed, EBSCO, CINAHL, EMBASE, PsycINFO, Cochrane Library, Scopus, Web of Science, and Google Scholar. We also backwards searched references of all relevant studies and inspected trials registers. Results Of the 516 studies identified, 17 were included: one was quantitative, nine were qualitative and seven used mixed methods. All included quantitative studies were pilot or feasibility studies employing pre- and post-test design with small sample sizes. Studies varied in relation to the type of creative intervention and evaluation methods, which precluded meta-analysis. Large effect sizes were detected in wellbeing measures following singing and art interventions. The qualitative synthesis highlighted that interventions created space for caregivers to make sense of, accept and adapt to their identity as a caregiver. Personal developments, such as learning new skills, were viewed positively by caregivers as well as welcoming the opportunity to gain cognitive and behavioural skills, and having opportunities to unload emotions in a safe space were important to caregivers. Group creative interventions were particularly helpful in creating social connections with their care-recipients and other caregivers. Conclusions The current review revealed all creative interventions focused on caregivers of people living with dementia; subsequently, this identified gaps in the evidence of creative interventions for informal caregivers of other neurological conditions. There are encouraging preliminary data on music and art interventions, however, little data exists on other art forms, e.g., drama, dance. Creative interventions may appeal to many caregivers, offering a range of psycho-social benefits. The findings of the current review open the way for future research to develop appropriate and creative arts programmes and to test their efficacy with robust tools.

scholarly journals Diagnosis and Management of Lymphatic Disorders in Congenital Heart Disease

2020 ◽  
Vol 22 (12) ◽  
Author(s):  
Benjamin Kelly ◽  
Sheyanth Mohanakumar ◽  
Vibeke Elisabeth Hjortdal
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Treatment Options ◽  
Future Research ◽  
Protein Losing Enteropathy ◽  
Current Review ◽  
Lymphatic Complications ◽  
And Function ◽  
Lymphatic Imaging

Abstract Purpose of Review Lymphatic disorders have received an increasing amount of attention over the last decade. Sparked primarily by improved imaging modalities and the dawn of lymphatic interventions, understanding, diagnostics, and treatment of lymphatic complications have undergone considerable improvements. Thus, the current review aims to summarize understanding, diagnostics, and treatment of lymphatic complications in individuals with congenital heart disease. Recent Findings The altered hemodynamics of individuals with congenital heart disease has been found to profoundly affect morphology and function of the lymphatic system, rendering this population especially prone to the development of lymphatic complications such as chylous and serous effusions, protein-losing enteropathy and plastic bronchitis. Summary Although improved, a full understanding of the pathophysiology and targeted treatment for lymphatic complications is still wanting. Future research into pharmacological improvement of lymphatic function and continued implementation of lymphatic imaging and interventions may improve knowledge, treatment options, and outcome for affected individuals.

scholarly journals Feasibility of the Bag-Mediated Filtration System for Environmental Surveillance of Poliovirus in Kenya

2019 ◽  
Vol 12 (1) ◽  
pp. 35-47 ◽  
Author(s):  
Nicolette A. Zhou ◽  
Christine S. Fagnant-Sperati ◽  
Evans Komen ◽  
Benlick Mwangi ◽  
Johnstone Mukubi ◽  
...  
Keyword(s):  
Cell Culture ◽  
Phase Separation ◽  
Culture Method ◽  
World Health ◽  
Future Research ◽  
Effective Volume ◽  
Environmental Surveillance ◽  
Two Phase ◽  
Filtration System ◽  
Acute Flaccid Paralysis Surveillance

Abstract The bag-mediated filtration system (BMFS) was developed to facilitate poliovirus (PV) environmental surveillance, a supplement to acute flaccid paralysis surveillance in PV eradication efforts. From April to September 2015, environmental samples were collected from four sites in Nairobi, Kenya, and processed using two collection/concentration methodologies: BMFS (> 3 L filtered) and grab sample (1 L collected; 0.5 L concentrated) with two-phase separation. BMFS and two-phase samples were analyzed for PV by the standard World Health Organization poliovirus isolation algorithm followed by intratypic differentiation. BMFS samples were also analyzed by a cell culture independent real-time reverse transcription polymerase chain reaction (rRT-PCR) and an alternative cell culture method (integrated cell culture-rRT-PCR with PLC/PRF/5, L20B, and BGM cell lines). Sabin polioviruses were detected in a majority of samples using BMFS (37/42) and two-phase separation (32/42). There was statistically more frequent detection of Sabin-like PV type 3 in samples concentrated with BMFS (22/42) than by two-phase separation (14/42, p = 0.035), possibly due to greater effective volume assayed (870 mL vs. 150 mL). Despite this effective volume assayed, there was no statistical difference in Sabin-like PV type 1 and Sabin-like PV type 2 detection between these methods (9/42 vs. 8/42, p = 0.80 and 27/42 vs. 32/42, p = 0.18, respectively). This study demonstrated that BMFS can be used for PV environmental surveillance and established a feasible study design for future research.

scholarly journals Correlation between Microstructural Alteration, Mechanical Properties and Manufacturability after Cryogenic Treatment: A Review

Materials ◽  
2019 ◽  
Vol 12 (20) ◽  
pp. 3302 ◽  
Author(s):  
Abbas Razavykia ◽  
Cristiana Delprete ◽  
Paolo Baldissera
Keyword(s):  
Mechanical Properties ◽  
Phase Transfer ◽  
Cryogenic Treatment ◽  
Future Research ◽  
Treatment Processes ◽  
Current Review ◽  
Conventional Heat Treatment ◽  
Refinement Process ◽  
Properties Of Materials ◽  
Quenching And Tempering

Cryogenic treatment is a supplemental structural and mechanical properties refinement process to conventional heat treatment processes, quenching, and tempering. Cryogenic treatment encourages the improvement of material properties and durability by means of microstructural alteration comprising phase transfer, particle size, and distribution. These effects are almost permanent and irreversible; furthermore, cryogenic treatment is recognized as an eco-friendly, nontoxic, and nonexplosive process. In addition, to encourage the application of sustainable techniques in mechanical and manufacturing engineering and to improve productivity in current competitive markets, cryo-treatment can be considered as a promising process. However, while improvements in the properties of materials after cryogenic treatment are discussed by the majority of reported studies, the correlation between microstructural alteration and mechanical properties are unclear, and sometimes the conducted investigations are contradictory with each other. These contradictions provide different approaches to perform and combine cryogenic treatment with pre-and post-processing. The present literature survey, mainly focused on the last decade, is aimed to address the effects of cryogenic treatment on microstructural alteration and to correlate these changes with mechanical property variations as a consequence of cryo-processing. The conclusion of the current review discusses the development and outlines the trends for the future research in this field.

Low-Frequency Neural Oscillations Support Dynamic Attending in Temporal Context

2014 ◽  
Vol 2 (1) ◽  
pp. 62-86 ◽  
Author(s):  
Molly J. Henry ◽  
Björn Herrmann
Keyword(s):  
Empirical Work ◽  
Low Frequency ◽  
Neural Oscillations ◽  
Future Research ◽  
Temporal Context ◽  
Stimulus Processing ◽  
Temporal Regularity ◽  
Environmental Stimuli ◽  
Current Review

Behaviorally relevant environmental stimuli are often characterized by some degree of temporal regularity. Dynamic attending theory provides a framework for explaining how perception of stimulus events is affected by the temporal context within which they occur. However, the precise neural implementation of dynamic attending remains unclear. Here, we provide a suggestion for a potential neural implementation of dynamic attending by appealing to low-frequency neural oscillations. The current review will familiarize the reader with the basic theoretical tenets of dynamic attending theory, and review empirical work supporting predictions derived from the theory. The potential neural implementation of dynamic attending theory with respect to low-frequency neural oscillations will be outlined, covering stimulus processing in regular and irregular contexts. Finally, we will provide some more speculative connections between dynamic attending and neural oscillations, and suggest further avenues for future research.

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