scholarly journals STUDI KOMPARASI PEMODELAN 1-D (SATU DIMENSI) DAN 2-D (DUA DIMENSI) DALAM MEMODELKAN BANJIR DAS CITARUM HULU

2017 ◽  
Vol 3 (2) ◽  
Author(s):  
Riza Inanda Siregar ◽  
Ivan Indrawan
Keyword(s):  
River Water ◽  
Rainfall Intensity ◽  
Hydraulic Modeling ◽  
Flood Modelling ◽  
Modeling Methods ◽  
River Flood ◽  
Calibration And Verification ◽  
The Difference ◽  
Hydrology Modeling ◽  
Selection Of

Pengelolaan Daerah Aliran Sungai (DAS) yang tidak baik akan menimbulkan kerusakan. Salah satu indikasi bahwa suatu DAS mengalami kerusakan adalah terjadinya banjir. Pada saat kondisi jumlah air sungai melebihi kapasitasnya atau menjadi terlalu banyak maka terjadi banjir yang diakibatkan oleh luapan sungai. Faktor dari peristiwa alami seperti intensitas curah hujan yang tinggi merupakan penyebab terjadinya banjir, ditambah lagi dengan faktor aktifitas manusia. Salah satu cara untuk mengantisipasi bencana banjir adalah dengan memprediksi terjadinya banjir tersebut. Studi ini bertujuan untuk menganalisis perbedaan hasil yang diperoleh pada pemodelan 1-D dan 2-D terkait akurasi hasil untuk analisis lanjutnya. Keterbatasan data yang diperoleh dan ketepatan pemilihan metode pemodelan banjir akan mengurangi keakuratan hasil pemodelan dalam memprediksi banjir. Secara garis besar metode pemodelan banjir terdiri dari dua bagian yaitu pemodelan hidrologi (hydrology modeling) dan pemodelan hidrolika (hydraulic modeling). Pemodelan hidrologi pada daerah studi yaitu DAS Citarum Hulu, Jawa Barat menggunakan hidrograf metode SCS dan Snyder dengan bantuan software HEC-HMS, sedangkan pemodelan hidrolika menggunakan bantuan software HEC-RAS. Hasil yang diperoleh akan dilakukan kalibrasi dan verifikasi. Pemodelan dengan HEC-RAS 5.03 dianalisis untuk model 1-D dan 2-D, kemudian kedua data komparasikan untuk menganalisis perbedaan atau rentang hasil yang diperoleh terkait pemilihan metode pada DAS yang lain. Kata Kunci : Banjir, Citarum, Flood Modeller, Pemodelan, Sungai Deli  ABSTRACT Management of Watersheds (DAS) will cause damage if one indication that a watershed is damaged is the occurrence of floods. When the condition of the river water exceeds its capacity or becomes too much, there will be flood caused by the river flood. Factors of natural events such as high rainfall intensity is the cause of flooding, coupled with the factor of human activity. One way to anticipate flood disaster is to predict the occurrence of the flood. This study aims to analyze the differences in results obtained in 1-D and 2-D modeling on yield accuracy for further analysis. Limitations of the data obtained and the accuracy of selection of flood modeling methods will reduce the accuracy of the modeling results in predicting flooding. The method consists of two parts, hydrology modeling and hydraulic modeling. Hydrology modeling in the study area is upper Citarum Watershed, West Java using hydrograph of SCS and Snyder method with HEC-HMS software, while hydraulic modeling using HEC-RAS software. The results obtained will be calibration and verification. Modeling with HEC-RAS 5.03 was analyzed for 1-D and 2-D models, then the two comparative data to analyze the difference or range of results obtained related to the selection of methods in other watersheds Keywords: Citarum, Deli River, Flood, Modelling

COMBINATORIAL POLYNOMIALLY COMPUTABLE CHARACTERISTICS OF SUBSTITUTIONS AND THEIR PROPERTIES

2020 ◽  
Vol 7 (2) ◽  
pp. 34-41
Author(s):  
VLADIMIR NIKONOV ◽  
◽  
ANTON ZOBOV ◽  
Keyword(s):  
Mathematical Expectation ◽  
Point Of View ◽  
Small Range ◽  
Computational Point ◽  
Wide Range ◽  
Bijective Function ◽  
The Difference ◽  
Element Base ◽  
Selection Of

The construction and selection of a suitable bijective function, that is, substitution, is now becoming an important applied task, particularly for building block encryption systems. Many articles have suggested using different approaches to determining the quality of substitution, but most of them are highly computationally complex. The solution of this problem will significantly expand the range of methods for constructing and analyzing scheme in information protection systems. The purpose of research is to find easily measurable characteristics of substitutions, allowing to evaluate their quality, and also measures of the proximity of a particular substitutions to a random one, or its distance from it. For this purpose, several characteristics were proposed in this work: difference and polynomial, and their mathematical expectation was found, as well as variance for the difference characteristic. This allows us to make a conclusion about its quality by comparing the result of calculating the characteristic for a particular substitution with the calculated mathematical expectation. From a computational point of view, the thesises of the article are of exceptional interest due to the simplicity of the algorithm for quantifying the quality of bijective function substitutions. By its nature, the operation of calculating the difference characteristic carries out a simple summation of integer terms in a fixed and small range. Such an operation, both in the modern and in the prospective element base, is embedded in the logic of a wide range of functional elements, especially when implementing computational actions in the optical range, or on other carriers related to the field of nanotechnology.

FEATURES OF ORGANOPHOSPHATES IMMOBILIZATION VIA STREPTAVIDIN-BIOTIN SYSTEM FOR EXPERIMENTS ON SELECTION OF APTAMERS

2020 ◽  
pp. 12-20
Author(s):  
D. A. Belinskaya ◽  
Yu. V. Chelusnova ◽  
V. V. Abzianidze ◽  
N. V. Goncharov
Keyword(s):  
Polyethylene Glycol ◽  
Organophosphorus Compounds ◽  
Binding Energies ◽  
Rna Aptamers ◽  
Main Method ◽  
Modeling Methods ◽  
Molecular Dynamics Methods ◽  
Systematic Evolution ◽  
Exponential Enrichment ◽  
Selection Of

Poisoning with organophosphorus compounds occupy one of the leading places in exotoxicosis. At the first stage, the detoxification of organophosphates can be provided with the help of DNA or RNA aptamers that bind the poison in the bloodstream. Currently, the main method of searching for aptamers is the experimental method of systematic evolution of ligands by exponential enrichment (SELEX). In the process of aptamer selection, the target molecule must be immobilized via the streptavidin-biotin complex. Since the poison molecule is small in size, to increase its availability for binding to aptamer, it is necessary to use a spacer between organophosphorus compounds and biotin. The aim of this work was to optimize the selection of aptamers for organophosphorus compounds by increasing the availability of a poison molecule immobilized via the streptavidin-biotin complex on the example of paraoxon. For this purpose, three spacers between organophosphorus compounds and biotin were tested using molecular modeling methods: three links of polyethylene glycol (3-PEG), four links of polyethylene glycol (4-PEG) and aminohexyl. The conformation of the biotinylated paraoxon complex with streptavidin and the interaction of paraoxon with the binding fragment of the aptamer were modeled using molecular docking and molecular dynamics methods. The ability of biotinylated paraoxon to bind to the aptamer has been evaluated by analyzing the surface area of the paraoxon available to the solvent, as well as by calculating the free binding energies. It has been shown that only in the case of aminohexyl immobilized paraoxon can contact the aptamer. At the final stage, the synthesis of paraoxon bound to biotin via aminohexyl was carried out.

scholarly journals Age-dependency in mortality of Finnish family caregivers: a nationwide register-based study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
T M Mikkola ◽  
H Kautiainen ◽  
M Mänty ◽  
M B von Bonsdorff ◽  
T Kröger ◽  
...  
Keyword(s):  
General Population ◽  
Family Caregivers ◽  
Family Caregiver ◽  
Causes Of Death ◽  
Lower Mortality ◽  
All Cause Mortality ◽  
The Difference ◽  
Caregiver Role ◽  
Selection Of

Abstract Purpose Mortality appears to be lower in family caregivers than in the general population. However, there is lack of knowledge whether the difference in mortality between family caregivers and the general population is dependent on age. The purpose of this study was to analyze all-cause mortality in relation to age in family caregivers and to study their cause-specific mortality using data from multiple Finnish national registers. Methods The data included all individuals, who received family caregiver's allowance in Finland in 2012 (n = 42 256, mean age 67 years, 71% women) and a control population matched for age, sex, and municipality of residence (n = 83 618). Information on dates and causes of death between 2012 and 2017 were obtained from the Finnish Causes of Death Register. Flexible parametric survival modeling and competing risk regression adjusted for socioeconomic status were used. Results The total follow-up time was 717 877 person-years. Family caregivers had lower all-cause mortality than the controls over the follow-up (8.1% vs. 11.6%) both among women (hazard ratio [HR]: 0.64, 95% CI: 0.61-0.68) and men (HR: 0.73, 95% CI: 0.70-0.77). Younger adult caregivers had equal or only slightly lower mortality than their controls, but after age 60, the difference increased markedly resulting in over 10% lower mortality in favor of the caregivers in the oldest age groups. Caregivers had lower mortality for all the causes of death studied, namely cardiovascular, cancer, neurological, external, respiratory, gastrointestinal and dementia than the controls. Of these, the lowest was the risk for dementia (subhazard ratio=0.29, 95%CI: 0.25-0.34). Conclusions Older family caregivers have lower mortality than the age-matched controls from the general population while younger caregivers have similar mortality to their peers. This age-dependent advantage in mortality is likely to reflect selection of healthier individuals into the family caregiver role. Key messages The difference in mortality between family caregivers and the age-matched general population varies considerably with age. Advantage in mortality observed in family caregiver studies is likely to reflect the selection of healthier individuals into the caregiver role, which underestimates the adverse effects of caregiving.

scholarly journals A microfluidic device enabling drug resistance analysis of leukemia cells via coupled dielectrophoretic detection and impedimetric counting

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yağmur Demircan Yalçın ◽  
Taylan Berkin Töral ◽  
Sertan Sukas ◽  
Ender Yıldırım ◽  
Özge Zorlu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
K562 Cells ◽  
Leukemia Cells ◽  
Drug Resistant ◽  
Wild Type ◽  
Gene Expressions ◽  
Before And After ◽  
The Difference ◽  
Selection Of ◽  
Resistant Cells

AbstractWe report the development of a lab-on-a-chip system, that facilitates coupled dielectrophoretic detection (DEP-D) and impedimetric counting (IM-C), for investigating drug resistance in K562 and CCRF-CEM leukemia cells without (immuno) labeling. Two IM-C units were placed upstream and downstream of the DEP-D unit for enumeration, respectively, before and after the cells were treated in DEP-D unit, where the difference in cell count gave the total number of trapped cells based on their DEP characteristics. Conductivity of the running buffer was matched the conductivity of cytoplasm of wild type K562 and CCRF-CEM cells. Results showed that DEP responses of drug resistant and wild type K562 cells were statistically discriminative (at p = 0.05 level) at 200 mS/m buffer conductivity and at 8.6 MHz working frequency of DEP-D unit. For CCRF-CEM cells, conductivity and frequency values were 160 mS/m and 6.2 MHz, respectively. Our approach enabled discrimination of resistant cells in a group by setting up a threshold provided by the conductivity of running buffer. Subsequent selection of drug resistant cells can be applied to investigate variations in gene expressions and occurrence of mutations related to drug resistance.

scholarly journals Weightage Effect during Back-Calculation of Rock-Mass Quality from the Installed Tunnel Support in Rock-Mass Rating and Tunneling Quality Index System

2019 ◽  
Vol 9 (10) ◽  
pp. 2065 ◽  
Author(s):  
Jonguk Kim ◽  
Hafeezur Rehman ◽  
Wahid Ali ◽  
Abdul Muntaqim Naji ◽  
Hankyu Yoo
Keyword(s):  
Rock Mass ◽  
Quality Index ◽  
Rock Bolt ◽  
Rock Mass Rating ◽  
Rock Mass Quality ◽  
Back Calculation ◽  
The Difference ◽  
Bolt Spacing ◽  
Q System ◽  
Selection Of

In extensively used empirical rock-mass classification systems, the rock-mass rating (RMR) and tunneling quality index (Q) system, rock-mass quality, and tunnel span are used for the selection of rock bolt length and spacing and shotcrete thickness. In both systems, the rock bolt spacing and shotcrete thickness selection are based on the same principle, which is used for the back-calculation of the rock-mass quality. For back-calculation, there is no criterion for the selection of rock-bolt-spacing-based rock-mass quality weightage and shotcrete thickness along with tunnel-span-based rock-mass quality weightage. To determine this weightage effect during the back-calculation, five weightage cases are selected, explained through example, and applied using published data. In the RMR system, the weightage effect is expressed in terms of the difference between the calculated and back-calculated rock-mass quality in the two versions of RMR. In the Q system, the weightage effect is presented in plots of stress reduction factor versus relative block size. The results show that the weightage effect during back-calculation not only depends on the difference in rock-bolt-spacing-based rock-mass quality and shotcrete along with tunnel-span-based rock-mass quality, but also on their corresponding values.

scholarly journals A Robust Rerank Approach for Feature Selection and Its Application to Pooling-Based GWA Studies

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Jia-Rou Liu ◽  
Po-Hsiu Kuo ◽  
Hung Hung
Keyword(s):  
Characteristic Curve ◽  
Real Data ◽  
Tuning Parameter ◽  
Practical Implementation ◽  
Tuning Parameters ◽  
Genome Wide ◽  
Feature Based ◽  
The Difference ◽  
Gwa Studies ◽  
Selection Of

Large-p-small-ndatasets are commonly encountered in modern biomedical studies. To detect the difference between two groups, conventional methods would fail to apply due to the instability in estimating variances int-test and a high proportion of tied values in AUC (area under the receiver operating characteristic curve) estimates. The significance analysis of microarrays (SAM) may also not be satisfactory, since its performance is sensitive to the tuning parameter, and its selection is not straightforward. In this work, we propose a robust rerank approach to overcome the above-mentioned diffculties. In particular, we obtain a rank-based statistic for each feature based on the concept of “rank-over-variable.” Techniques of “random subset” and “rerank” are then iteratively applied to rank features, and the leading features will be selected for further studies. The proposed re-rank approach is especially applicable for large-p-small-ndatasets. Moreover, it is insensitive to the selection of tuning parameters, which is an appealing property for practical implementation. Simulation studies and real data analysis of pooling-based genome wide association (GWA) studies demonstrate the usefulness of our method.

scholarly journals Do experienced physiotherapists apply equal magnitude of force during a grade I central pa on the cervical spine?

2004 ◽  
Vol 60 (4) ◽  
Author(s):  
M. Conradie ◽  
E. Smit ◽  
M. Louw ◽  
M. Prinsloo ◽  
L. Loubser ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Spinal Disorders ◽  
Joint Mobilization ◽  
Treatment Techniques ◽  
Average Maximum ◽  
Manual Examination ◽  
The Mean ◽  
The Difference ◽  
Posterior Anterior ◽  
Selection Of

Background and purpose: Physiotherapists frequently use central posterior-anterior (PA) joint mobilization techniques for assessing and managing spinal disorders. Manual examination findings provide the basis for the selection of treatment techniques. From the literature it is evident that the level of reliability varies when physiotherapists perform different mobilization techniques. Repeatability of mobilization techniques is important for better physiotherapy management. The aim of the study was to determine whether experienced physiotherapists apply equal magnitude of force during a grade I central PA mobilisation technique on the cervical spine. Another aim was to determine the variation in the magnitude of forceapplied by each individual physiotherapist. Subjects: Sample of convenience, consisting of sixteen (n=16) selected qualified physiotherapists with experience inOrthopaedic Manual Therapy.Methods: A grade I central PA was performed on the Flexiforce TM sensors positioned on C6 of the same asymptomatic model to measure the applied magnitude of force. Two separate measurements, each lasting 30-seconds, were obtained.Results: The average maximum peak force applied by the majority of physiotherapists (87.5%) was between 10.95gand 72g. The difference in the forces applied for the two measurements ranged between 0.64g and 24.4g. The BlandAltman scatterplot determined the mean of the difference between measurement one and two, calculated for the group, was zero. When comparing the two measurements, little variation was noted in the forces applied, as well as the coefficient of variation for each physiotherapist.Conclusion and Discussion: Current results demonstrated good intra-therapist and moderate to good inter-therapist repeatability. Further research is required to generalize results.

scholarly journals Variabilitas Penggunaan Model Pembelajaran Pada Kegiatan Pembelajaran Sejarah Peminatan Kelas X IPS di Kota Depok

2020 ◽  
Vol 2 (2) ◽  
pp. 94-104
Author(s):  
Yusuf Budi Prasetya Santosa ◽  
Fahmi Hidayat
Keyword(s):  
Learning Strategies ◽  
Learning Process ◽  
Qualitative Methodology ◽  
Learning Models ◽  
History Teachers ◽  
Teachers And Students ◽  
History Teacher ◽  
The Difference ◽  
Teaching Learning ◽  
Selection Of

The use of varied learning models by history teachers will facilitate teachers and students in implementing and following the learning process. This study aims to determine the learning process and the use of learning models used by history teachers. This study uses a qualitative methodology with an observation and interview approach conducted at two high schools, Dian Didaktika High School and SMA Negeri 2 Depok. From the results of the study it can be seen, that the history teacher at the two schools has carried out the learning process using a scientific approach. There is no difference in the selection of learning strategies, both of them use the contextual teaching learning model. The difference between the two is in the selection of learning methods, where the history teacher Dian Didaktika uses the method of learning project base learning and the history teacher of SMA Negeri 2 Depok uses a method of learning outside the classroom by visiting museums.

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