scholarly journals IMUNOKIMIAWI PGE2 USUS ILEUM YANG KEKURANGAN ENERGI PROTEIN

Author(s):  
R. Heru Prasetyo

Diarrhoeal disease mortality which suffered by children less than five years due to protein energy deficiency is increased significantly.The pathological mechanisms are not known in detail yet. The objective of this research was able to explain the intestine motility inprotein energy deficiency of mice Balb/c. Hormonal mechanism that regulates the intestine motility is roled by prostaglandine E2 hormone(PGE2). The observed variable was the immunity component of PGE2. The measurement was performed using immunohistochemistrymethod with monoclonal antibody against PGE2 to the ileum mice tissue. The result of this study showed that protein energy deficiencymice had much reduced PGE2 (reduction from 1492 to 145, p = 0.000 ). In conclusion, the marked decrease of ileum PGE2 will decreaseintestine motility and it may be one cause of the high diarrhoeal mortality due to protein energy deficiency.

1973 ◽  
Vol 26 (12) ◽  
pp. 1287-1302 ◽  
Author(s):  
Cyril O. Enwonwu ◽  
Roger V. Stambaugh ◽  
Kerry L. Jacobson

Author(s):  
R. F. Rakhmaeva ◽  
A. A. Kamalova ◽  
V. A. Ayupova

Children with cerebral palsy (CP) often develop nutritional disorders, their incidence reaches 80% (according to the literature data).Purpose. To analyze the frequency of nutritional disorders and features of nutritional status in children with CP.Characteristics of children and research methods. We studied the anthropometric indicators (weight, height, body mass index, triceps and subscapular skin fold thickness), physical development characteristics depending on the motor abilities of the child according to the Gross Motor Function Classification System scale and body composition by bioelectrical impedance.Results. Nutritional status disorders were detected in 88.8% of patients, while the diagnostic was based on a reduced physical development in 55.5% of patients. 22.2% of patients had protein-energy deficiency of the first degree, 15.5% of patients had protein-energy deficiency of the second degree, 6.7% of patients had protein-energy deficiency of the third degree, 11.1% of patients suffered from overweight. Besides, nutritional disorders were diagnosed in 33.3% of patients with normal physical development, but with altered body composition, namely, with the imbalance of fat and lean body weight, the isolated increase of the percentage of fat mass, the decrease of active cellular and musculoskeletal weight. These patients also require nutritional correction.Conclusion. These data confirm the dependence of physical development and body composition on the patient’s motor activity and demonstrate the need for complex comprehensive study of nutritional status in children with CP.


2020 ◽  
Vol 99 (8) ◽  
pp. 829-833
Author(s):  
Anastasiya O. Barg ◽  
Olga A. Kobjakova ◽  
Natalya A. Lebedeva-Nesevrja

Introduction. International research works have revealed that Russian children and teenagers tend to have one of the highest anxiety levels in the world. Anxiety at school can be a risk factor causing certain diseases.Purpose. To assess the relation between anxiety at school and morbidity among boys attending 5-11 grades at secondary schools in the Perm region.Material and methods. We conducted our research in spring 2019 in two secondary schools in the Perm region (in Perm and Kungur). Anxiety at school was estimated with F. Taylor questionnaire modified by N.M. Peisakhov (there were 30 statements in it that characterized various anxiety parameters; children filled it themselves). Morbidity was assessed by analyzing children’s medical profiles kept at schools (0.26/u-2000 form) and clinical examinations performed by medical experts. To establish a relation between certain anxiety parameters and morbidity, we applied non-parametric Spearman’s correlation test. To assess the risks of diseases for children with different anxiety levels, we applied the odds ratio (OR).Results and discussion. We revealed the greatest number of relations between anxiety and endocrine diseases, nutritional disorders, and metabolic disorders. Children who were anxious about controlling their knowledge were nervous, stress-filled, and had no self-confidence, authentically more frequently suffered from overweight, obesity, and protein-energy deficiency as well. This relation can be mediated with emotion-induced nutrition behavior which is especially typical for teenagers. Children who were anxious about controlling their knowledge and had no self-confidence (assessed as per three parameters) ran higher risks of functional dyspepsia than those who didn’t have anxiety. The same relations were detected regarding disorders in the immune mechanism and nervous system diseases. These relations can be explained by looking into psychosomatic mechanisms of disease occurrence. Established relations between anxiety and diseases of the eyes, respiratory organs, and musculoskeletal system more likely indicate that children and teenagers with somatic pathologies run higher risks of anxiety at school.Conclusion. It is necessary to perform complex activities aimed at reducing anxiety at school among schoolchildren attending secondary schools; their activities should involve the participation of medical experts with a wide range of specialties as well as parents.


1991 ◽  
Vol 13 (4) ◽  
pp. 1-8 ◽  
Author(s):  
Manuel Amador ◽  
Manuel Peña

Positive changes in the nutrition and health of the Cuban population have taken place in the last three decades. The strategies developed for their attainment have been mainly in the public health sector. Changes in health indicators closely linked to the nutrition status of the community in the last 20 years indicate that the population's standard of living has risen. However, there has been a tendency to both an absolute and a relative increase in the prevalence of and mortality from chronic non-communicable diseases and in their associated risk factors. On the other hand, moderate or severe protein-energy deficiency is not common, but iron deficiency is still a problem, especially in small children and pregnant women. Several strategies and actions currently are in progress for promoting a positive change in food habits and lifestyle.


2018 ◽  
Vol 22 (4) ◽  
pp. 102-107 ◽  
Author(s):  
K. A. Vishnevsky ◽  
A. Sh. Rumyantsev ◽  
N. Yu. Korosteleva

The article reflects modern ideas about the causes and mechanisms of the physical functioning disorders in patients with chronic kidney  disease receiving program hemodialysis. Various types of physical  activity are considered and the rationale for their use in dialysis  patients is justified. The diagnostics possibilities of the protein- energy deficiency main variants are presented. Possible directions  for their correction are outlined. The possibilities and methods of  regular physical training in such a complex cohort of patients with  changes in almost all the basic systems of the body are described in  detail. For patients who cannot perform physical exercises in a  training mode, a new rehabilitation technique was developed and  tested on a representative sample, and a new rehabilitation  technique that was not previously used in nephrology – a cutaneous  bilateral electrostimulation of the muscles of the lower extremities –  was justified and considered in detail. The authors give their own data on long-term follow-up of patients, which confirm the  possibilities of the presented methods not only in terms of improving physical performance, but also in improving the adequacy  of dialysis and the quality of life.


2020 ◽  
Vol 18 (5) ◽  
pp. 31-35
Author(s):  
A. S. SAMOYLOV ◽  
◽  
A. V. ZHOLINSKIY ◽  
A. E. SHESTOPALOV ◽  
N. V. RYLOVA ◽  
...  

Recently, in high-performance sports, there has been a significant increase in the volume and intensity of training loads, an increase in the duration of the competition period and its intensity, significant psychoemotional loads that affect the health status and quality of life of professional athletes, determine the incidence rate and a higher risk of injury in highly qualified athletes. Trauma and disease are considered as a polyetiological variant of the systemic inflammatory response syndrome, associated with the formation of «pathological» systems and their further dynamic change. One of the most striking manifestations of the systemic inflammatory reaction syndrome is pronounced metabolic disorders with a shift in metabolic processes towards hypermetabolism-hypercatabolism. The catabolic type of metabolic processes is characterized by the development of a pronounced protein-energy deficiency, a violation of nutrition and the inability to provide the body with the necessary nutrients in a natural way.


2015 ◽  
Vol 9 (2) ◽  
pp. 0-0 ◽  
Author(s):  
Макишева ◽  
R. Makisheva

In the review of their own work and the literature it discussed accumulated contradictions of the effect of diabetes mellitus on cell death. The author proposes the concept of the damaging effects of excess insulin on cells with different degrees of sensitivity. The basis for reasoning adopted the following axioms. Insulin is needed by all cells of all living organisms. Insulin is the main regulator of pinocytosis into the cells. Energy and plastic tissue needs increase the number and sensitivity of insulin receptors. Excess insulin occurs when taking stimulants, secretion, degradation of β-cells, insulin overdose. Excess insulin promotes the rapid flow of sub-stances into the cell, then swelling and necrosis. Protection mechanisms against excess hormone are increased binding of insulin, fat cells, insulin resistance and increased growth factors. This leads to reduced apoptosis, ac-celerated angiogenesis, and reduction of the barrier functions of tissues. In diabetes, all the cells are exposed to elevated concentrations of insulin, but most of the cells are damaged endothelium in connection with their regu-lar division. Apoptosis of tissue cells in diabetes mellitus is caused by protein-energy deficiency. Apoptosis of β-cells is necessary to reduce excess insulin.


2022 ◽  
pp. 65-69
Author(s):  
D. A. Yakhieva-Onikhimovskaia ◽  
S. M. Kolesnikova ◽  
E. N. Suprun ◽  
V. V. Filippova

Objective: Identification of perinatal risk factors as differential predictors of violent and non-violent crimes among children and adolescents who come under the attention of juvenile departments of the internal affairs bodies of the Russian Federation.Methods: Study of the perinatal history data of 148 juvenile offenders of comparable age (13-16 years old), selected using continuous sampling method in the course of a clinical observational cohort retrospective study.Results: Children from the control group in half of the cases were “late premature” (48%), with protein-energy malnutrition (frequency of occurrence of FGRP 56.8% BMI 56.1 ± 13.65). The beginning of their life was accompanied by a low score according to Apgar scale (6.9 ± 1.81). From the first minutes of life, they required urgent therapy in the delivery room (35.9%) and subsequent treatment at the ICU (25.7%) due to the damage of the respiratory system (asphyxia 11.5%, RDS 19.6%, episodes of apnea 16.2 %) and increasing dysfunction of the central nervous system (IVH II-IV grade 24.3%). Subsequently, they demonstrated a disruption of early neonatal adaptation and a clinical picture of the realization of intrauterine fetal developmental disorders, which arose both as a result of improper metabolism and of a prolonged oxygen starvation (adrenal hypoplasia 27.7%, cardiomyopathy 29.7%, hypoxia 48.6%).Conclusions: The initial protein-energy deficiency revealed in the course of the study if accompanied by the course of both acute and chronic oxygen starvation could influence the formation of destructive behavior in the group of juvenile offenders.


2012 ◽  
Vol 9 (1) ◽  
pp. 25 ◽  
Author(s):  
Tsalissavrina Iva ◽  
Endy Paryanto Prawirohartono ◽  
Lily Arsanti Lestari

Background: Protein energy deficiency is a major public health problem in Indonesia. WHO has recommended F100 made from skim milk for undernourished patient. Alternative formulas have been developed using other nutritious foods that are cheaper, easily accessible and can be used for children with lactose intolerance such as tempe flour.Objective: To investigate the effect of F100 and tempe flour formula supplementation on serum Fe and hemoglobin (Hb) levels of undernourished child.Method: This was an experimental study with randomized controlled clinical trial design and purposive sampling method. Subjects of the study were undernourished patients aged 1-10 years hospitalized at Dr. Saiful Anwar Hospital Malang. Sample consisted of 30 patients divided into 2 groups; group 1 supplemented with F100 and group 2 with tempe flour formula. Hb level was assessed by cyanmethemoglobin and serum Fe level by colorimetric method. Dietary intake data was collected by visual comstock and food recall. Data were analyzed by chi square, unpaired t-test and double linear regression.Results: Statistical analysis showed that there were no significant differences in Hb (p=0.139) and serum Fe levels (p=0.313) between both groups after treatment. Intake data indicated that there was a significant disparity in protein (p=0.019) and Fe intake (p=0.006) between the two groups, whereas energy, fat and carbohydrate intake showed no significant differences. Lastly, the association between energy and nutrient intake with serum Fe and Hb levels was not significant and the correlation was weak (r<1).Conclusion: There were no significant differences in hemoglobin and serum Fe levels between F100 group and tempe flour formula group, but there was a significant difference in protein and Fe intake.


2021 ◽  
Vol 1 (3) ◽  
pp. 189-197
Author(s):  
Nining Fitrianingsih ◽  
Tisna Yanti ◽  
Ludfi Putra Madienda

ABSTRACT: CORRELATION BETWEEN BETWEEN MATERNAL KNOWLEDGE ABOUT NUTRITION WITH PROTEIN-ENERGY LACK IN CHILDREN AGED 2-5 YEARS IN SITUDAUN VILLAGE, BOGOR REGENCY Background of the study: PEM (Less Protein Energy) is one of the most important nutritional disorders in Indonesia and other developing countries. PE patients have various pathological conditions caused by a lack of energy and protein in varying proportions. PEM disease was given an international name, namely Calory Protein Malnutrition (CPM), then converted into Protein Energy Malnutrition (PEM). This disease began to be widely investigated in Africa, and in that continent, PEM is known by the local name kwashiorkor which means red hair disease.Objective: To be able to know the description of mother's knowledge about nutrition for toddlers on things that support nutrition improvement and its relationship with the state of Protein Energy Deficiency in children 24 - 60 months at Posyandu Melati II Kp. Pasir Ipis Situdaun Village, Tenjolaya District, Bogor Regency and the factors that influence it.Research Methods: This research is primary data using an observational approach with a cross-sectional study design (cross-sectional). This analysis is used to determine whether or not there is a relationship between the two variables using the Chi-Square (X2) test because the dependent and independent variables are categories with a 95% confidence level.Research Results: It can be seen from 79 respondents that the mother's level of knowledge is mostly 40 people (50.6%), and a small portion as many as 39 people (49.4%) in Posyandu Melati II, Situdaun Tenjolaya Village, Bogor Regency. And p-value 0.00 (<0.05). This indicates that there is a significant relationship between the mother's level of knowledge about nutrition and the incidence of protein-energy deficiency in children aged 2-5 years.Conclusion: There is a significant correlation between the level of knowledge of mothers about nutrition with the incidence of protein-energy deficiency in children aged 2-5 years in the village of situdaun, Bogor district, with a p-value = 0.000. Keywords: Mother's knowledge about nutrition, Protein Energy Lack, Children    INTISARI: HUBUNGAN TINGKAT PENGETAHUAN IBU TENTANG GIZI DENGAN KEJADIAN KURANG ENERGI PROTEIN PADA ANAK USIA 2-5 TAHUN DI DESA SITUDAUN KABUPATEN BOGOR Latar Belakang: KEP (Kurang Energi Protein) merupakan salah satu penyakit gangguan gizi yang penting di Indonesia maupun di negara yang sedang berkembang lainnya. Penderita KEP memiliki berbagai  macam keadaan patologis yang disebabkan oleh kekurangan energi maupun protein dalam proporsi yang bermacam-macam. Penyakit KEP diberi nama secara internasional yaitu Calory Protein Malnutrition (CPM), kemudian diubah menjadi Protein Energy Malnutrition (PEM). Penyakit ini mulai banyak diselidiki di Afrika, dan di benua tersebut KEP dikenal dengan nama lokal kwashiorkhor yang berarti penyakit rambut merah.Tujuan: Untuk dapat Mengetahui gambaran pengetahuan ibu tentang gizi balita terhadap hal hal yang mendukung perbaikan gizi dan hubungannya dengan keadaan Kurang Energi Protein pada anak 24 - 60 bulan di Posyandu Melati II Kp. Pasir Ipis Desa   Situdaun  Kecamatan Tenjolaya, Kabupaten Bogor serta faktor yang mempengaruhinya.Metode Penelitian: Penelitian ini merupakan data primer dengan menggunakan pendekatan observasional dengan desain studi cross sectional (potong lintang). analisis ini digunakan untuk mengetahui ada atau tidaknya hubungan antara dua variebel tersebut dengan menggunakan uji Chi-Square (X2) karena variabel dependen dan independennya adalah kategori dengan tingkat kepercayaan 95%.Hasil Penelitian: Didapatkan dapat diketahui dari 79 responden bahwa tingkat penegtahuan ibu sebagian besar 40 orang (50.6%), dan sebagian kecil sebanyak 39 orang (49.4%)  di Posyandu Melati II Desa Situdaun Tenjolaya Kabupaten Bogor. Dan p value 0.00 (<0.05). Menandakan adanya hubungan yang significant antara hubungan tingkat pengetahuan ibu tentang gizi dengan kejadian kurang energi protein pada anak usia 2-5 tahun.Kesimpulan: Terdapat  korelasi yang bermakna antara hubungan tingkat pengetahuan ibu tentang gizi dengan kejadian kurang energi protein pada anak usia 2-5 tahun di desa situdaun kabupaten bogor, dengan p-value= 0.000. Kata Kunci: Pengetahuan Ibu tentang gizi, Kurang Energi Protein , Anak


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