scholarly journals Influence of Hysteroscopic Metroplasty on Reproductive Outcome in Patients with Infertility and Recurrent Pregnancy Loss

PRILOZI ◽  
2014 ◽  
Vol 35 (2) ◽  
pp. 95-103
Author(s):  
Gligor Tofoski ◽  
Vesna Antovska

Abstract Introduction: Patients with congenital uterine anomalies (CUA) have decreased reproductive potential and an unfavourable reproductive outcome compared to the population with normal uterine cavity. Patients with untreated CUA have a higher abortion rate, higher foetal loss rate and decreased live birth rate. Hysteroscopic metroplasty is a standard, safe and minimally invasive method for the treatment of correctible types of congenital uterine anomalies. The aim of the study was to analyse the reproductive outcome in certain groups of patients with CUA and infertility, before and after hysteroscopic metroplasty. Material and methods: We analyzed 115 patients on whom 129 hysteroscopic metroplasty interventions were performed at the University Clinic of Obstetrics and Gynaecology in Skopje over a one-year period, between 01.01.2011 and 31.12.2011. Patients and their reproductive outcome were monitored over a two-year period and the same group served as a control group, taking into account their previous reproductive history before and after metroplasty. Statistical analysis was performed using the Chi-square test and p < 0.05 was considered to be statistically significant. Results: The most common CUA were types 5b and 6, represented by 83.3%. In a follow-up period of two years, there were 55 patients with previous foetal loss treated by hysteroscopic metroplasty, and 31 of them had pregnancies. There was a statistically significant decrease of abortion rate from 88.5% to 19.3%, and a significant increase in term delivery rate from 2.3% to 71%. Conclusion: Hysteroscopic metroplasty significantly improves the reproductive outcome in patients with previous foetal loss.

2014 ◽  
Vol 2 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Gligor Tofoski ◽  
Jadranka Georgievska

Introduction: Reproductive outcome can be negatively affected in patients with congenital uterine anomalies (CUA), increasing the number of unsuccessful pregnancies and obstetric complications. Compared with the population with normally formed uterus, patients with CUA have higher abortion rate, higher fetal loss rate and decreased live birth rate. Hysteroscopic metroplasty (HM) is a standard, safe and minimally invasive method for the treatment of correctible types of congenital uterine anomalies.Aim: The aim of the study was to analyze the reproductive outcome in group of patients with infertility and recurrent pregnancy loss and present CUA, before and after hysteroscopic metroplasty.Material and Methods: We analyzed 67 patients to whom 78 interventions hysteroscopic metroplasty were performed at the University Clinic of Obstetrics and Gynecology in Skopje during a two year period, between 01.01.2010 and 31.12.2011. Their reproductive outcome was monitored during a two-year period and the same group served as a control group, taking into account their previous reproductive history. Statistical analysis was performed using Chi-square test and p < 0.05 was considered to be statistically significant.Results: Most common CUA were types 5b and 6 represented by 88 %. In a follow up period of two years, 33 of the patients become pregnant. There was a statistically significant decrease of abortion rate from 92% to 21.2%, as well as an increase in the term delivery rate from 0% to 69.7%.Conclusion: Treatment with hysteroscopic metroplasty is significantly improving the reproductive outcome in patients with CUA and previous fetal loss.


2021 ◽  
Vol 15 (4) ◽  
pp. 183
Author(s):  
Hidayatul Hasni ◽  
Mayetti Mayetti ◽  
Dwi Novrianda

Background: Mucositis is one of the side effects of chemotherapy, which can be a severe problem for children with cancer. Cryotherapy can cause vasoconstriction and decrease blood flow to the oral mucosa, resulting in lower concentrations of chemotherapy agents to prevent mucositis. This study aims at determining the effectiveness of oral cryotherapy as prophylaxis mucositis in children with cancer undergoing chemotherapy.Methods: This quasi-experiment study with a pretest-posttest control-group design involved 45 respondents (22 in the intervention group and 23 in the control group) selected using consecutive sampling. The data collection instrument was the WHO mucositis scale. Results: Of the 45 children undergoing chemotherapy, 24 (53.3%) were of school age, 25 (55.6%) were male, 33 (73.3%) had good nutritional status, and 17 (37.8%) had mild neutropenia before undergoing chemotherapy. All respondents (100%) did not experience mucositis, but after chemotherapy, 9 children (40.9%) in the intervention group had mucositis, and 19 children (82.6%) experienced mucositis in the control group. The data were analyzed using the Wilcoxon test to see the difference between the intervention group and the control group and the Chi-Square test with Yates’s correction to see the effect of cryotherapy on the prevention of mucositis. The results showed that there was a difference in the incidence of mucositis between before and after intervention in the intervention group (p = 0.003) and the control group (p = 0.000), and cryotherapy was effective in preventing mucositis (p = 0.01).Conclusions: Cryotherapy is effective against the prevention of mucositis. Nurses and families need to be able to apply oral cryotherapy and other evidence-based treatment as a method to prevent mucositis 


2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Ari Damayanti Wahyuningrum ◽  
Misbahul Subhi

Scabies is a skin infestation by Sarcoptes scabiei. Several risk factors for scabies infestation is individual personal hygiene and environmental sanitation is not maintained, density, crowding, poverty, lack of knowledge, direct contact with the infested person and use of contaminated equipment. According to Orem theory of self care every individual has the ability to care for themselves so that they can maintain the health and welfare of yourself. The purpose of the study was to investigate knowledge and attitude of adolescent in Nurul Abyadh Orphanage Malang in healthy behavior and on handling scabies. Desain use pre test post test non equivalent control group. The population adolescent Orphanage Nurul Abyadh as the treatment group was 38 respondents and adolescent Orphanage Sunan Ampel as the control group was 29 respondents, taken according to inclusion criteria. Research variables include of knowledge variable and attitude variable. Data were collected using structure questionnaire. Data were then analyzed using level of significance ≤ 0,05. Before and after treatment using analysis of the Wilcoxon and Mc Nemar, treatment and control groups using Mann Whitney and Chi Square.


2020 ◽  
Vol 7 (2) ◽  
pp. 140
Author(s):  
Dinda Puspita ◽  
Dwi Yati

Nyeri yang disebabkan oleh sectio caesarea pada umumnya akan terasa hingga beberapa hari. Rasa nyeri tersebut biasanya dirasakan meningkat pada hari pertama post operasi sectio caesarea dan akan semakin terasa apabila pengaruh dari analgesik hilang. Manajemen untuk mengatasi nyeri dapat dilakukan dengan cara non-farmakologi menggunakan aromaterapi. Tujuan Penelitian  mengetahui pengaruh aromaterapi lavender terhadap nyeri post partum sectio caesarea. Metode penelitian merupakan kuantitatif menggunakan desain quasi experiment dengan pendekatan pre test and post test non equivalent control group design yang dilakukan dari bulan Agustus–September 2020. Teknik pengambilan sampel secara consecutive sampling dengan jumlah 22 ibu postpartum sectio caesarea di Ruang Alamanda 3 RSUD Panembahan Senopati Bantul. Uji statistik menggunakan Chi-Square. Hasil: Sebagian besar ibu postpartum sectio caesarea memiliki tingkat nyeri sebelum diberikan aromaterapi lavender pada kategori sedang (4-6) sebanyak 12 orang (54.5%). Setelah dilakukan pemberian aromaterapi lavender memiliki tingkat nyeri ringan (1-3) sebanyak 16 orang (72.7%). Terdapat perbedaan rerata tingkat nyeri ibu postpartum sectio caesarea sebelum dan setelah pemberian aromaterapi lavender dengan nilai mean 0.121, standar deviasi 0.568 dan nilai p-value sebesar 0,000 (p value<0,05).Kesimpulan: Ada pengaruh sebelum dan setelah pemberian aromaterapi lavender terhadap nyeri postpartum sectio caesareadi Ruang Alamanda 3 RSUD Panembahan Senopati Bantul. Kata Kunci: nyeri  postpartum; sectio caesarea; aromaterapi lavender.LAVENDER AROMATERAPY EFFECT ON POSTPARTUM SECTIO CAESAREA PAIN AT PANEMBAHAN SENOPATI HOSPITAL OF BANTUL   ABSTRACT Pain caused by section caesarea are generally felt for several days. The pain is usually felt on the first day of post caesarean section surgery and will be more painful when the effect of analgesic has gone. One of the ways in pain management is non-pharmacological therapy using lavender aromatherapy. This study aim was to determine the effectiveness of lavender aromatherapy on postpartum sectio caesarea mother at  Panembahan Senopati General Hospital of  Bantul. The study used a quasi experimental design with pre test and post test approach non equivalent control group design. This research was conducted from August until September 2020. The research sampling methods used consecutive sampling with a total of 22 postpartum sectio caesarea mothers in the Alamanda 3 room of Panembahan Senopati General Hospital of Bantul. Data analysis used chi square test. Most of the postpartum sectio Caesarea mothers had a level of pain before being given aromatherapy (pre test) in a moderate category (4-6) as much as 12 people (54.5%). After being given lavender aromatherapy had a mild category (1-3) as much as 16 people (72.7%). There is an influence between the level of pain in postpartum mother with section caesarea before and after giving lavender aromatherapy with a mean value of 0.121, standard deviation of 0.568 and a p-value of 0.000 (p value< 0,05). There is an effetiveness before and after being given lavender aromatherapy on postpartum sectio caesarea pain in the Alamanda 3 room at Panembahan Senopati General Hospital of Bantul. Keyword : Postpartum pain; sectio caesarea; lavender aromatherapy


2020 ◽  
Vol 8 (3) ◽  
pp. 396
Author(s):  
Nurasih Nurasih ◽  
Endang Nurrochmi

In Indonesia, Yoga is currently one of the most popular sports, not only for the general public but also for pregnant women. Many benefits can be obtained from prenatal yoga including the mother feeling comfortable and relaxed throughout pregnancy and during childbirth, training the pelvic floor muscles and perineum, keeping the body's muscles relaxed, balanced during childbirth, reducing stress, increasing and improving oxygen circulation to the body and fetus. . This study aims to determine the effect of prenatal yoga on optimizing fetal position on third trimester Primigravida maternal delivery output at Puskesmas Cirebon City. This research is a quasi-experimental research pre post control group design and only post control group design with T test and Chi Square test. Paired T Test results of the intervention group (mean difference = 3.111, P value = 0.000, control group (mean difference = 0.833, P value = 0.318). Independent T Test results obtained (average difference = -1.944, P value = 0.024), Chi Square test obtained a value of P = 0.73. There is a difference in the average anxiety before and after the intervention in the intervention group, there is no difference in average anxiety before and after the intervention in the control group. There is a difference in the average anxiety between the intervention and control groups. There is a difference in mean Long I stage between the intervention and control groups There was no effect of prenatal yoga on the type of labor.


2017 ◽  
Author(s):  
◽  
Ansuya Naidoo

Background Shade matching is a challenging aspect of aesthetic dentistry (Vichi et al., 2011). For a long time, aesthetically pleasing prostheses have been achieved using the porcelain-fused-to-metal crown whereby the metal is masked with an opaque layer and then consecutive layers of veneering ceramic are built up (McLean, 1979). The growing popularity of all-ceramic restorations has created a need for an understanding of its colour characteristics in preference to porcelain fused to metal restorations. The study aims to assist dental technicians in making a more informed decision when choosing an all-ceramic system in terms of colour stability. Objectives The objectives were to identify colour changes of the zirconia after each firing cycle and defining if there are any microstructural changes in the zirconia cores after subsequent firing. Methods This is a quantitative study with a sample size of eighteen which was used for each experimental group. Green state zirconia blocks from Cercon (Dentsply DeguDent, USA), Lava (3M ESPE,USA), and Zirkon Zahn (Zirkonzahn Gmbh, Bruneck, Italy) were trimmed, finished and sintered to a final thickness of 0.5mm according to the manufacturers’ instructions. Each sample group was obtained directly from the manufacturer. In each group, nine specimens were shaded and nine were unshaded. The colour of each specimen was recorded before being exposed to firing cycles. This data formed the control group. All specimens were subjected to three firings and spectrophotometer reading. After each firing, SEM analysis was done after one and three firings. There was a total of thirty six specimens x three firings; n = 108. The raw data for the statistical analysis was obtained from the spectrophotometer readings recorded after the firings (n=108). The data of the study was analyzed using the SPSS version 22.0. The data were compared among the three groups using Pearsons chi square tests, where the data of the firings were measured as a binary or nominal variable, and using t-tests where a measured normally distributed variable was compared. The general linear model (GLM) looked at combinations of the variables and their effects on the dependant variable. The Multivariate tests table indicates the actual result of the one-way MANOVA. Results The Cercon results for both the control and experimental groups reveal the same result patterns and was maintained before and after firing. Lava also revealed the same results before and after firing, however, the cores in the control group differed in colour. The Zirkon Zahn system proved to be the least stable in colour. Conclusion This study supports the hypothesis that colour differences would occur relative to the number of firings for shaded zirconia. It can be concluded that Cercon displayed the most stable results in terms of colour. The acumen gained in this study may better assist dental technicians in their selection of an all-ceramic zirconia system.


2019 ◽  
Vol 8 (2) ◽  
pp. 95-100
Author(s):  
Mehry Bozorgnejad ◽  
Mohammad Reza Zarei ◽  
Leila Mamashli ◽  
Fatemeh Mohaddes Ardebili

Background: Burning is one of the worst accidents that people may now experience in modern society. One of the most critical problems of burn patients is the anxiety caused by medical treatments such as burn dressing. The present study aimed to determine the effect of rhythmic breathing on the anxiety of dressing change in burn patients. Materials and Methods: This experimental clinical trial was done on 60 burn hospitalized patients in Ayatollah Mousavi educational-therapeutic hospital of Zanjan province in 2017. The sampling was performed continuously and the samples were randomly assigned to control and experimental groups (30 subjects in each group). The data collection tool included a demographic questionnaire and numerical anxiety scale. First, the demographic characteristics questionnaire was completed by the samples. Then, the rhythmic breathing was taught to the experimental group for 20 minutes until complete learning, and they were asked to perform the rhythmic breathing during dressing. Before and after dressing, anxiety was evaluated in the experimental and control groups for 3 consecutive days. After collecting data and entering them into SPSS 20, data were analyzed using descriptive statistics, chi-square test, independent and dependent t test, and Friedman test. Results: Based on the findings of the study, both groups were homogeneous in terms of age, gender, education, percentage and the degree of burn, and there was no statistically significant difference. The results of the Friedman test showed that the anxiety severity had a statistically significant difference in both control and experimental groups before and after the intervention (P<0.001). However, the severity of anxiety after the intervention further reduced in the experimental group compared to the control group, and this reduction was statistically significant in the experimental group (P<0.001). Conclusion: In general, rhythmic breathing is effective in reducing anxiety caused by a dressing change in burn patients. Thus, this method can be used to decrease the anxiety of dressing.


Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 3424-3424
Author(s):  
Maite Antonio ◽  
Montserrat Arnan Sangerman ◽  
Eva Domingo-Domenech ◽  
Eva González-Barca ◽  
Casimiro Javierre ◽  
...  

BACKGROUND As the result of population aging, hematologists increasingly face the challenge of effectively managing older adults with oncological diseases. The heterogeneity of the aging process means that chronological age does not serve as a pivotal variable on which the clinical or treatment decisions are based. To improve outcomes in older population it is critical to select treatment considering patients' frailty profile and patients' needs to ensure they complete the treatment proposedComprehensive geriatric assessment (CGA) is a gold-standard multidimensional tool to characterize older patients according to their biological frailty profile. CGA identifies patient- and condition-related factors that might be potentially reversible through subsequent clinical interventions Older patient may present some degree of physical decline during the treatment due to variables related to the disease itself and/or to the treatment. This can lead to an accelerated decline from aging, affect their functional independence, their quality of life, and their ability to complete the treatment There is evidence that nutritional support and physical exercise during and after oncological treatments provides benefits in muscular and aerobic condition, quality of life, fatigue and adherence to treatment. But data on hematological patient, usually treated with more intensive schemes associated with a higher incidence of cytopenia and fatigue is scarce ENDPOINT - PRIMARY To determine the impact of an individualized geriatric intervention program of physical exercise and nutritional support on adherence to planned oncological treatment in patients ≥ 70 years with hematological malignancies - SECONDARY Analyze the relation between CGA and aging biomarkersEvaluate adherence to the intervention programDetermine the rate of completion and causes for non-completion of treatmentMeasure at the beginning and end of intervention, and 6 months after treatment completion: The program's effect on physical condition parametersChanges in functional capacity: basic and instrumental activities of daily lifeLevels of fatigueQuality of lifeDetermine the incidence and degree of severity of toxicityDetermine treatment response parameters: time to treatment failure and to progression, disease-free, overall and cancer-specific survival METHODS DESIGN Prospective clinical trial, randomized, parallel and open groupsSETTING Comprehensive cancer centerINCLUSION CRITERIA Histopathological diagnosis of hematological malignancies: multiple myeloma, lymphoproliferative syndromes and myelodisplastic syndromesPatients who meet criteria for medical treatment: chemotherapy, radiotherapy, immunotherapy or targeted therapiesPatients in optimal conditions to perform moderate intensity physical exercise (responsible doctor's judgement)Signature of informed consentEXCLUSION CRITERIA Failure to meet any of the inclusion criteria.INTERVENTION All patients will be assessed through a CGA. The intervention group will received the standard treatment according to the clinical protocol of the institution and will participate in a program of personalized physical exercise and nutritional support. The control group will be treated in a standard manner according to the institution's clinical protocolRANDOMIZATION Subjects will be assigned a 1.1 ratio to one of the groups using a simple randomisation methodMAIN VARIABLE: rate of treatment compliance (relationship between the prescribed dose and the dose administered)SECONDARY VARIABLES: CGA scales, aging biomarkers, nutritional parameters and basal body composition before and after the intervention, quality of life before and after the intervention, toxicity and complications during treatment and response to treatment.STATISTICAL ANALYSIS The comparability of the components of the intervention and control group will be analyzed by Chi square test (qualitative variables) and Student's t test and Wilcoxson test (quantitative variables). The analysis of the intervention will be carried out according to the intention of treatment. The main variable will be analyzed by comparison test of chi-square proportions and confidence intervals will be calculated. The variable will be measured at the end of the intervention, according to the degree of compliance with the nutritional and physical exercise program. Disclosures Domingo-Domenech: Takeda: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Travel expenses; Seattle Genetics: Research Funding; Bristol-Myers Squibb: Other: Travel expenses; Roche: Other: Travel expenses. González-Barca:Kiowa: Consultancy; Roche: Consultancy, Honoraria; Celgene: Consultancy; Celtrion: Consultancy; AbbVie: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Honoraria. Sureda:Roche: Honoraria; BMS: Consultancy, Honoraria; Novartis: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Gilead: Consultancy; Sanofi: Consultancy, Honoraria; Takeda: Consultancy, Honoraria, Speakers Bureau.


2014 ◽  
Vol 83 (4) ◽  
pp. 299-305
Author(s):  
Przemysław Wirstlein ◽  
Mateusz Mikołajczyk ◽  
Jana Skrzypczak

Introduction. Numerous reports lead to conclusion that either the absence or insufficient amounts of heparanase and heparin binding growth factors on the luminal surface of the epithelium in the endometrium may be associated with impaired reproduction. The aim of this study was to assess the suitability of the fluid from the uterus to predict reproductive disorders. Material and methods. The group consisted of 32 women with 2 or more consecutive unexplained miscarriages, and 33 idiopathic infertility patients; the control group comprised 22 women with normal reproductive potential. Concentration of the studied factors was assayed by ELISA in uterine fluid.Results. The uterine flushings from women with two or more consecutive miscarriages showed significantly lower concentrations of HPA1 (p < 0.001) compared to the control group and infertile patients. In contrast, we didn't observe statistically significant differences of concentration of HB-EGF, VEGF, FGF2 in the studied groups. Statistically significant correlations were obtained between the levels of HPA1 and growth factors in all groups p < 0.05. The ROC curve was used to test the diagnostic value of HPA1. With a cut-off point of 8.56 U/L for HPA1 levels, we achieved 58.6% sensitivity and 84.6% specificity in the detection of women with recurrent miscarriage compared to fertile controls and infertile women combined. The area under curve (AUC) value was 0.751. Conclusions. The procedure for determining the concentrations of HPA1, HB-EGF, VEGF, FGF2 by ELISA in fluids derived from the uterine cavity is insufficient to predict either success of reproduction or reproductive disorders.


2021 ◽  
Vol 2 (4) ◽  
pp. 1340-1345
Author(s):  
Sitti Mukarramah ◽  
Indriani ◽  
Zulaeha A. Amdadi

Family planning is a strategy to reduce maternal mortality, especially mothers with 4T conditions. Counseling plays an important role in achieving quality family planning services. A balanced counseling strategy (SKB) began to be developed and adapted for use in 2016, to strengthen postpartum family planning counseling services (KBPP). The purpose of this study was to determine the effect of the Family Planning Balanced Counseling Strategy (SKB-KB) on the choice of contraceptives at Kassi-Kassi Community Health Center Makassar City. The type of research used is Quasi Experimental (quasi-experimental). This study conducted an intervention in both groups by assessing before and after treatment / counseling. One group intervened with the SKB-KB method, while the other group intervened with the ABPK method. Data were analyzed using the chi square test with a significance level of p <0.05. The results showed that the SKB-KB method had an influence on the choice of contraceptives between the intervention group and the control group (p: 0.0008; α 0.05).


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