Wybrane problemy dermatologiczno-ginekologiczne z uwzględnieniem niektórych aspektów dietetycznych u dziewcząt

2018 ◽  
Vol 21 (4) ◽  
Author(s):  
Jacek Boroch ◽  
Grażyna Jarząbek-Bielecka ◽  
Małgorzata Mizgier ◽  
Mariola Pawlaczyk ◽  
Magdalena Pisarska-Krawczyk ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Family Doctor ◽  
Disease Process ◽  
Allergic Diseases ◽  
Old Patients ◽  
Balanced Diet ◽  
Developmental Age ◽  
Infection And Inflammation ◽  
Congenital Immunodeficiency ◽  
Protection Against Infection

Dermatological-gynaecological problems in girls are an important issue also in the practice of a family doctor. In the case of girls before menarche, vulvovaginal inflammation accounts for 75% of all gynaecology reports. However, there is a need to differentiate inflammatory diseases of the vulva from dermatoses. Symptoms of vulval diseases, which are reported by patients, often require consultation and dermatological treatment. Since dermatoses are not limited to genitals, the vulva is only one of possible locations of the disease process; therefore, the whole skin of the patient should be inspected. Vaginal and vaginal inflammation is a gynaecological problem in patients of all ages ? from neonatal period to old age. In developmental age gynaecology, it is often found in 3-10-year-old patients. The etiopathogenesis of vulvovaginitis in girls depends on child's age, systemic diseases, and often dermatological problems. For example, such factors as diabetes, long-term antibiotic therapy, immunosuppression, congenital immunodeficiency, allergic diseases and allergic rhinitis predispose to infections in girls. Lactobacillus plays an important role in bacterial protection against infection and inflammation. A balanced diet is also important.

Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives

2020 ◽  
Vol 15 ◽  
Author(s):  
Wang Gong ◽  
Fei Wang ◽  
Yuqing He ◽  
Blake Heath ◽  
Xin Zeng ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Immune Regulation ◽  
Tissue Damage ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Research Progress ◽  
Epithelial Tissue ◽  
Oral Diseases ◽  
Mesenchymal Stem Cell Therapy

: Mesenchymal stem cell (MSC) therapy for clinical diseases associated with inflammation and tissue damage has become a progressive treatment strategy. MSCs have unique biological functions, such as homing, immune regulation, and differentiation capabilities, which provide the prerequisites for treatment of clinical diseases. Oral diseases are often associated with abnormal immune regulation and epithelial tissue damage. In this review, we summarize previous studies that use MSC therapy to treat various oral inflammatory diseases, including oral ulceration, allergic diseases, chemo/radiotherapy-induced oral mucositis, periodontitis, osteonecrosis of the jaw, Sjögren's syndrome (SS), among other similar diseases. We highlight MSC treatment as a promising approach in the management of oral inflammatory diseases, and discuss the obstacles that remain and must be overcome for MSC treatment to thrive in the future.

Medyczne i humanistyczne zagadnienia związane z psychodermatologią w praktyce lekarza rodzinnego, ginekologa i seksuologa

2020 ◽  
Vol 23 (3) ◽  
Author(s):  
Grażyna Jarząbek-Bielecka ◽  
Katarzyna Plagens-Rotman ◽  
Małgorzata Mizgier ◽  
Piotr Merks ◽  
Magdalena Czarnecka-Operacz ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Family Doctor ◽  
Holistic Approach ◽  
Self Esteem ◽  
Skin Lesions ◽  
The Body ◽  
Skin Changes ◽  
Developmental Age ◽  
Pain And Suffering ◽  
Similar Search

A family doctor, as well as a sexologist, gynecologist, in his medical practice encounters problems related to skin diseases significantly affecting the sense of femininity or masculinity. An example of such an issue, especially in gynecology of developmental age, is the problem of skin changes associated with androgenization syndromes. Typical dermatological diseases are sometimes associated with enormous pain, not only physical, but also mental, resulting from the fact that skin disease processes significantly disfigure the body, lower self-esteem and significantly affect the sexual sphere. Selected aspects related to the holistic approach to the issue of pain and suffering, also related to skin lesions, are presented. This issue, like all medical fields, is a source of philosophical reflection. It is inseparable from psychodermatology. The experience of the SARS-CoV-2 coronavirus pandemic, taking into account skin lesions, also prompts a similar search.

scholarly journals Effects of Linalyl Acetate on Thymic Stromal Lymphopoietin Production in Mast Cells

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1711 ◽  
Author(s):  
Phil-Dong Moon ◽  
Na-Ra Han ◽  
Jin Lee ◽  
Hyung-Min Kim ◽  
Hyun-Ja Jeong
Keyword(s):  
Intracellular Calcium ◽  
Inflammatory Diseases ◽  
Quantitative Polymerase Chain Reaction ◽  
Allergic Diseases ◽  
Nuclear Factor Κb ◽  
Thymic Stromal Lymphopoietin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Linalyl Acetate ◽  
Caspase 1 ◽  
Wide Range

Thymic stromal lymphopoietin (TSLP) is an important factor responsible for the pathogenesis of allergic diseases, such as atopic dermatitis and asthma. Because linalyl acetate (LA) possesses a wide range of pharmacological properties, being antispasmodic, anti-inflammatory, and anti-hyperpigmentation, we hypothesized that LA could inhibit TSLP. Therefore, enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, caspase-1 assay, Western blot analysis, fluorescent analyses of the intracellular calcium levels, and the phorbol myristate acetate (PMA)-induced edema model were used to investigate how LA inhibits the production of TSLP in HMC-1 cells. LA reduced the production and mRNA expression of TSLP in HMC-1 cells. LA also inhibited the activation of nuclear factor-κB and degradation of IκBα. PMA plus A23187 stimulation up-regulated caspase-1 activity in HMC-1 cells; however, this up-regulated caspase-1 activity was down-regulated by LA. Finally, LA decreased intracellular calcium levels in HMC-1 cells as well as PMA-induced ear swelling responses in mice. Taken together, these results suggest that LA would be beneficial to treatment of atopic and inflammatory diseases by reducing TSLP.

scholarly journals Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin

2005 ◽  
Vol 202 (4) ◽  
pp. 541-549 ◽  
Author(s):  
Jane Yoo ◽  
Miyuki Omori ◽  
Dora Gyarmati ◽  
Baohua Zhou ◽  
Theingi Aye ◽  
...  
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Transgenic Mice ◽  
Elevated Serum ◽  
Allergic Inflammation ◽  
Disease Process ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Thymic Stromal Lymphopoietin ◽  
Common Disease

The cytokine thymic stromal lymphopoietin (TSLP) has recently been implicated in the pathogenesis of atopic dermatitis (AD) and other allergic diseases in humans. To further characterize its role in this disease process, transgenic mice were generated that express a keratinocyte-specific, tetracycline-inducible TSLP transgene. Skin-specific overexpression of TSLP resulted in an AD-like phenotype, with the development of eczematous lesions containing inflammatory dermal cellular infiltrates, a dramatic increase in Th2 CD4+ T cells expressing cutaneous homing receptors, and elevated serum levels of IgE. These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease.

scholarly journals Nutrients, Infectious and Inflammatory Diseases

Nutrients ◽  
2017 ◽  
Vol 9 (10) ◽  
pp. 1085 ◽  
Author(s):  
Helieh Oz
Keyword(s):  
Inflammatory Diseases ◽  
Nutritional Elements ◽  
Balanced Diet ◽  
Healthy Body

A balanced diet with sufficient essential nutritional elements is critical for maintaining a healthy body.[...]

scholarly journals Calprotectin in rheumatic diseases

2016 ◽  
Vol 242 (8) ◽  
pp. 859-873 ◽  
Author(s):  
Francesca Ometto ◽  
Lara Friso ◽  
Davide Astorri ◽  
Costantino Botsios ◽  
Bernd Raffeiner ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Potential Role ◽  
Inflammatory Diseases ◽  
Disease Process ◽  
Serum Levels ◽  
Autoimmune Disorders ◽  
High Serum ◽  
Response To Treatment ◽  
Tnf Α ◽  
Activated Monocytes

Calprotectin is a heterodimer formed by two proteins, S100A8 and S100A9, which are mainly produced by activated monocytes and neutrophils in the circulation and in inflamed tissues. The implication of calprotectin in the inflammatory process has already been demonstrated, but its role in the pathogenesis, diagnosis, and monitoring of rheumatic diseases has gained great attention in recent years. Calprotectin, being stable at room temperature, is a candidate biomarker for the follow-up of disease activity in many autoimmune disorders, where it can predict response to treatment or disease relapse. There is evidence that a number of immunomodulators, including TNF-α inhibitors, may reduce calprotectin expression. S100A8 and S100A9 have a potential role as a target of treatment in murine models of autoimmune disorders, since the direct or indirect blockade of these proteins results in amelioration of the disease process. In this review, we will go over the biologic functions of calprotectin which might be involved in the etiology of rheumatic disorders. We will also report evidence of its potential use as a disease biomarker. Impact statement Calprotectin is an acute-phase protein produced by monocytes and neutrophils in the circulation and inflamed tissues. Calprotectin seems to be more sensitive than CRP, being able to detect minimal residual inflammation and is a candidate biomarker in inflammatory diseases. High serum levels are associated with some severe manifestations of rheumatic diseases, such as glomerulonephritis and lung fibrosis. Calprotectin levels in other fluids, such as saliva and synovial fluid, might be helpful in the diagnosis of rheumatic diseases. Of interest is also the potential role of calprotectin as a target of treatment.

scholarly journals Increases of Cardiac Troponin in Conditions other than Acute Coronary Syndrome and Heart Failure

2009 ◽  
Vol 55 (12) ◽  
pp. 2098-2112 ◽  
Author(s):  
Walter E Kelley ◽  
James L Januzzi ◽  
Robert H Christenson
Keyword(s):  
Heart Failure ◽  
Acute Coronary Syndrome ◽  
Respiratory Disease ◽  
Cardiac Troponin ◽  
Inflammatory Diseases ◽  
Disease Process ◽  
Length Of Hospital Stay ◽  
Myocardial Damage ◽  
Coronary Syndrome ◽  
Upper Gastrointestinal

AbstractBackground: Although cardiac troponin (cTn) is a cornerstone marker in the assessment and management of patients with acute coronary syndrome (ACS) and heart failure (HF), cTn is not diagnostically specific for any single myocardial disease process. This narrative review discusses increases in cTn that result from acute and chronic diseases, iatrogenic causes, and myocardial injury other than ACS and HF.Content: Increased cTn concentrations have been reported in cardiac, vascular, and respiratory disease and in association with infectious processes. In cases involving acute aortic dissection, cerebrovascular accident, treatment in an intensive care unit, and upper gastrointestinal bleeding, increased cTn predicts a longer time to diagnosis and treatment, increased length of hospital stay, and increased mortality. cTn increases are diagnostically and prognostically useful in patients with cardiac inflammatory diseases and in patients with respiratory disease; in respiratory disease cTn can help identify patients who would benefit from aggressive management. In chronic renal failure patients the diagnostic sensitivity of cTn for ACS is decreased, but cTn is prognostic for the development of cardiovascular disease. cTn also provides useful information when increases are attributable to various iatrogenic causes and blunt chest trauma.Summary: Information on the diagnostic and prognostic uses of cTn in conditions other than ACS and heart failure is accumulating. Although increased cTn in settings other than ACS or heart failure is frequently considered a clinical confounder, the astute physician must be able to interpret cTn as a dynamic marker of myocardial damage, using clinical acumen to determine the source and significance of any reported cTn increase.

scholarly journals The Role of CD4+ Resident Memory T Cells in Local Immunity in the Mucosal Tissue – Protection Versus Pathology –

2021 ◽  
Vol 12 ◽  
Author(s):  
Kiyoshi Hirahara ◽  
Kota Kokubo ◽  
Ami Aoki ◽  
Masahiro Kiuchi ◽  
Toshinori Nakayama
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Effector Memory ◽  
Mucosal Tissue ◽  
Local Immunity ◽  
Protective Function ◽  
Bowel Diseases

Memory T cells are crucial for both local and systemic protection against pathogens over a long period of time. Three major subsets of memory T cells; effector memory T (TEM) cells, central memory T (TCM) cells, and tissue-resident memory T (TRM) cells have been identified. The most recently identified subset, TRM cells, is characterized by the expression of the C-type lectin CD69 and/or the integrin CD103. TRM cells persist locally at sites of mucosal tissue, such as the lung, where they provide frontline defense against various pathogens. Importantly, however, TRM cells are also involved in shaping the pathology of inflammatory diseases. A number of pioneering studies revealed important roles of CD8+ TRM cells, particularly those in the local control of viral infection. However, the protective function and pathogenic role of CD4+ TRM cells that reside within the mucosal tissue remain largely unknown. In this review, we discuss the ambivalent feature of CD4+ TRM cells in the protective and pathological immune responses. We also review the transcriptional and epigenetic characteristics of CD4+ TRM cells in the lung that have been elucidated by recent technical approaches. A better understanding of the function of CD4+ TRM cells is crucial for the development of both effective vaccination against pathogens and new therapeutic strategies for intractable inflammatory diseases, such as inflammatory bowel diseases and chronic allergic diseases.

scholarly journals Role of Emollients in Prevention of the Comorbid Allergic Diseases Development in Children with Atopic Dermatitis

2020 ◽  
Vol 17 (4) ◽  
pp. 334-339
Author(s):  
Nikolay N. Murashkin ◽  
Roman A. Ivanov ◽  
Dmitri V. Fedorov ◽  
Eduard T. Ambarchyan ◽  
Roman V. Epishev ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Main Role ◽  
Social Maladjustment ◽  
Active Components ◽  
Epidermal Barrier ◽  
New Class

Atopic dermatitis (AD) is one of the common multifactorial inflammatory diseases manifesting predominantly in childhood. There is significant number of cases of self-regression of the disease with aging. On the other hand, there is also another scenario ending with AD persistent course and/or development of comorbid allergic pathologies that can significantly worsen patient’s quality of life and finally lead to social maladjustment. The pathogenesis of such way includes epidermal barrier disturbance, transcutaneous sensibilisation and aberrant allergic (Th2) immune systemic response development. Main role in preventing of this pathological pathway is lying on the new class of moisturizers containing active components "emollients plus". They are considered as foundation for the therapy and prevention of the development of AD and other allergic diseases. This literature review provides relevant data on AD pathogenesis and development of comorbid allergic pathologies. This paper also covers data on the effect of emollients in restoration of the epidermal barrier and their use as preventive measures.

scholarly journals Neutrophil Myeloperoxidase Derived Chlorolipid Production During Bacteria Exposure

2021 ◽  
Vol 12 ◽  
Author(s):  
Kaushalya Amunugama ◽  
Grant R. Kolar ◽  
David A. Ford
Keyword(s):  
Hypochlorous Acid ◽  
Inflammatory Diseases ◽  
White Blood Cells ◽  
Neutrophil Extracellular Trap ◽  
Neutrophil Chemotaxis ◽  
Bacterial Killing ◽  
E Coli ◽  
Infection And Inflammation ◽  
Strain Cft073 ◽  
Different Strains

Neutrophils are the most abundant white blood cells recruited to the sites of infection and inflammation. During neutrophil activation, myeloperoxidase (MPO) is released and converts hydrogen peroxide to hypochlorous acid (HOCl). HOCl reacts with plasmalogen phospholipids to liberate 2-chlorofatty aldehyde (2-ClFALD), which is metabolized to 2-chlorofatty acid (2-ClFA). 2-ClFA and 2-ClFALD are linked with inflammatory diseases and induce endothelial dysfunction, neutrophil extracellular trap formation (NETosis) and neutrophil chemotaxis. Here we examine the neutrophil-derived chlorolipid production in the presence of pathogenic E. coli strain CFT073 and non-pathogenic E. coli strain JM109. Neutrophils cocultured with CFT073 E. coli strain and JM109 E. coli strain resulted in 2-ClFALD production. 2-ClFA was elevated only in CFT073 coculture. NETosis is more prevalent in CFT073 cocultures with neutrophils compared to JM109 cocultures. 2-ClFA and 2-ClFALD were both shown to have significant bactericidal activity, which is more severe in JM109 E. coli. 2-ClFALD metabolic capacity was 1000-fold greater in neutrophils compared to either strain of E. coli. MPO inhibition reduced chlorolipid production as well as bacterial killing capacity. These findings indicate the chlorolipid profile is different in response to these two different strains of E. coli bacteria.

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