Blood cells relationships in ischemic heart disease.

2021 ◽  
Author(s):  
В.Г. Шамратова ◽  
А.Р. Шамратова ◽  
А.З. Даутова ◽  
Е.А. Хажиева
Keyword(s):  
Factor Analysis ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Blood Cells ◽  
Blood Parameters ◽  
Ischemic Heart ◽  
Dominant Factor ◽  
Control Group ◽  
Platelet Volume ◽  
Coronary Syndrome

Введение. Современные гематологические анализаторы позволяют получить достаточный статистический материал для оценки количественных, корпускулярных и качественных характеристик клеток крови. Эти параметры эритроцитов, лейкоцитов и тромбоцитов крови человека при различных заболеваниях варьируют не в случайном порядке, а согласованно, при этом характер и выраженность взаимовлияний отличаются от имеющихся в здоровом организме связей. Цель исследования: изучить с помощью факторного анализа модификации корреляционных связей, возникающих при ишемической болезни сердца (ИБС), между количественными и корпускулярными характеристиками клеток крови. Материалы и методы. Основную группу составили 24 женщины в возрасте 60,0 ± 3,2 лет с острым коронарным синдромом; практически здоровые по результатам диспансеризации 27 женщин в возрасте 60,0 ± 2,5 лет вошли в контрольную группу. Изучены следующие показатели крови: количество эритроцитов, содержание гемоглобина, значение гематокрита, средний объем эритроцита, среднее содержание и концентрация гемоглобина в эритроците, ширина распределения эритроцитов по объему, количество лейкоцитов, нейтрофилов, незрелых гранулоцитов, лимфоцитов, моноцитов, эозинофилов, базофилов, тромбоцитов, ширина распределения тромбоцитов по объему, средний объем тромбоцитов, отношение объема крупных тромбоцитов (более 12 фл) к общему объему тромбоцитов, тромбокрит. Для выявления взаимоотношений клеток крови при ИБС был проведен факторный анализ. Результаты. Установлено, что факторные структуры, описывающие функциональный статус крови в контроле и при патологии, существенно различаются. У здоровых людей доминирующий фактор характеризует отрицательные реципрокные отношения количественных и корпускулярных параметров эритроцитов и тромбоцитов, способствующие оптимизации реологического состояния крови. При инфаркте миокарда (ИМ) корреляционными связями объединены уже все форменные элементы крови, и они имеют положительные знаки. Заключение. Однонаправленные изменения числа и объемов клеток разных пулов можно рассматривать отягощающей причиной ИМ, усиливающей нарушение проходимости крови в микроциркуляторном русле миокарда. Background. Modern hematological analyzers make it possible to obtain sufficient statistical material for assessing the quantitative, corpuscular and qualitative characteristics of blood cells. These parameters in erythrocytes, leukocytes, and platelets in human blood in various diseases do not vary randomly, but in concert, while the nature and severity of interactions differ from those in a healthy body. Objectives: to study, using factor analysis, the modification of correlations between the quantitative and corpuscular characteristics of blood cells arising in ischemic heart disease (IHD). Patients/Methods. The main group included 24 women aged 60.0 ± 3.2 years with acute coronary syndrome. Practically healthy 27 women aged 60.0 ± 2.5 years according to the results of clinical examination were included in the control group. The following blood parameters were studied: the number of erythrocytes, the hemoglobin content, the hematocrit value, the average erythrocyte volume, the average content and concentration of hemoglobin in the erythrocyte, the width of the distribution of erythrocytes by volume, the number of leukocytes, neutrophils, immature granulocytes, lymphocytes, monocytes, eosinophils, basophils, platelets, the width of platelet distribution by volume, the average platelet volume, the ratio of large platelet volume (more than 12 fl) to the total platelet volume, thrombocrit. To identify the relationship of blood cells in IHD, the factor analysis was performed. Results. It was found that the factor structures describing the functional status of blood in control and in pathology are signifi cantly different. In healthy people, the dominant factor characterizes the negative reciprocal ratios of the quantitative and corpuscular parameters of erythrocytes and platelets, which contribute to the optimization of blood rheological state. In myocardial infarction (MI) correlations have already united all blood formed elements, and they have positive signs. Conclusions. Unidirectional changes in the number and volume of cells in different pools can be considered an aggravating cause of MI, which increases the impairment of blood permeability in the myocardium microvasculature.

IMPACT OF RISK FACTORS OF ISCHEMIC HEART DISEASE ON THE DEVELOPMENT OF ACUTE CORONARY SYNDROME, PLATELET ULTRASTRUCTURE, AND ASPIRIN RESISTANCE

2019 ◽  
Vol 72 (11) ◽  
Author(s):  
Yulian H. Kyyak ◽  
Olga Yu. Barnett ◽  
Marta P. Halkevych ◽  
Olha Ye. Labinska ◽  
Hryhoriy Yu. Kyyak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Aspirin Resistance ◽  
Ischemic Heart ◽  
Coronary Syndrome

IMPACT OF RISK FACTORS OF ISCHEMIC HEART DISEASE ON THE DEVELOPMENT OF ACUTE CORONARY SYNDROME, PLATELET ULTRASTRUCTURE, AND ASPIRIN RESISTANCE

2019 ◽  
Vol 72 (11) ◽  
Author(s):  
Yulian H. Kyyak ◽  
Olga Yu. Barnett ◽  
Marta P. Halkevych ◽  
Olha Ye. Labinska ◽  
Hryhoriy Yu. Kyyak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Aspirin Resistance ◽  
Ischemic Heart ◽  
Coronary Syndrome

scholarly journals EVALUATION OF THE INTERNAL PICTURE OF HEALTH IN PATIENTS WITH ACUTE CORONARY SYNDROME IN PRESENTING WITHOUT ST-SEGMENT AFTER PERCUTANEOUS CORONARY INTERVENTIONS AND IN THE PROCESS OF REHABILITATION

2019 ◽  
Vol 3 ◽  
pp. 9-17
Author(s):  
Roksolana Nesterak
Keyword(s):  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Conservative Treatment ◽  
Ischemic Heart Disease ◽  
Coronary Intervention ◽  
Ischemic Heart ◽  
Life Questionnaire ◽  
Actual Problem ◽  
Coronary Syndrome ◽  
St Segment

Ischemic heart disease remains an actual problem of modern clinical and rehabilitation medicine. One of the forms of ischemic heart disease (IHD) is an acute coronary syndrome (ACS) in patients presenting without persistent ST-segment, the treatment of which involves the use of conservative treatment and reperfusion techniques. An integral part of the management of patients after acute coronary syndrome is rehabilitation and restoration with the search for methods of changing the attitude of the patient to his health. To improve the rehabilitation of patients it is important to assess the internal picture of health with the formation of the correct attitude of the patient to his health. Aim. To study the peculiarities of the components of the internal picture of health in patients with acute coronary syndrome in patients presenting without persistent ST-segment in the process of treatment and rehabilitation. Materials and methods. There were examined 135 patients with ACS presenting without persistent ST-segment, who were divided into the groups depending on the treatment performed; 60 patients with conservative treatment tactics and 75 patients with the performed PCI. The analysis of the internal picture of health was carried out with the help of methods: hospital scale for the detection of anxiety and depression (HADS); patient health questionnaire (PHQ-9); scale for measuring the level of reactive (situational) and personality anxiety of Spielberg-Hanin; SF-36; indicators of the Seattle Quality of Life Questionnaire for Patients with Angine Pectoris (Seattle Angina Questionnaire - SAQ). Results. The study of the internal picture of health in patients with ACS presenting without persistent ST-segment showed low levels of emotional, sensory, cognitive, value-motivational, behavioral components on the appropriate scales, which also depend on the method of treatment used. The revealed peculiarities of patients with ACS presenting without persistent ST-segment need to increase the knowledge of the patient about the disease and the importance of rehabilitation measures. Conclusions. In assessment of the internal picture of health in patients with ACS presenting without persistent ST-segment after transcutaneous coronary intervention and in the process of rehabilitation, it has been determined that the course of ischemic heart disease in patients with ACS presenting without persistent ST-segment, both during conservative treatment and in the course of PCI at the stages of rehabilitation, is accompanied by significant changes of the internal picture of health (IPH); the most significant changes in patients with ACS presenting without persistent ST-segment is the value-motivational and behavioral components of the internal picture of health. In order to increase the effectiveness of rehabilitation after ACS, it is advisable to apply programs that will significantly affect the positive changes in the rehabilitation of patients with ACS.

Immature Platelets and Risk of Cardiovascular Events among Patients with Ischemic Heart Disease: A Systematic Review

2020 ◽  
Author(s):  
Julie Faber ◽  
Anne-Mette Hvas ◽  
Steen Dalby Kristensen ◽  
Erik Lerkevang Grove ◽  
Kasper Adelborg
Keyword(s):  
Systematic Review ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Cardiovascular Events ◽  
Ischemic Heart ◽  
Cochrane Library ◽  
Coronary Syndrome ◽  
Immature Platelet Fraction ◽  
Immature Platelets ◽  
Stable Cad

Abstract Background Immature platelets are larger and may be more thrombogenic than mature platelets. This systematic review included studies on the association between mean platelet volume (MPV), immature platelet count (IPC), and immature platelet fraction (IPF) and the risk of major cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) or stable coronary artery disease (CAD). Methods The literature search included studies in PubMed, Embase, Web of Science, and Cochrane Library. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Effect estimates that included multivariate adjusted odds ratios, relative risks, or hazard ratios were extracted. Results Forty-two studies were identified. High MPV was positively associated with MACE in 20 of 26 studies of patients with ACS, four of five studies in patients with stable CAD, and in all six studies comprising a combined population with ACS and stable CAD. Using continuous models of MPV in patients with ACS, effect estimates varied from 0.90 (95% confidence interval [CI]: 0.95–1.03) to 1.66 (95% CI: 1.32–2.09). The strength of these associations was broadly similar among patients with stable CAD and in combined populations. Five studies investigated IPC or IPF as exposures and all reported positive associations with MACE among patients with ACS, stable CAD, or in combined populations. Conclusion This review demonstrated clear evidence for positive associations between measures of immature platelets and subsequent risk of MACE in acute and stable ischemic heart disease patients.

Nonthyroidal Illness Syndrome and Hypothyroidism in Ischemic Heart Disease Population: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 105 (8) ◽  
pp. 2830-2845
Author(s):  
Chun-Yu Chang ◽  
Yung-Jiun Chien ◽  
Po-Chen Lin ◽  
Chien-Sheng Chen ◽  
Meng-Yu Wu
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Meta Analysis ◽  
Ischemic Heart ◽  
Cochrane Library ◽  
Future Research ◽  
Sufficient Information ◽  
Cardiac Events ◽  
Coronary Syndrome ◽  
All Cause Mortality

Abstract Context The association of non-thyroidal illness syndrome (NTIS) and hypothyroidism with the prognosis in ischemic heart disease (IHD) population is inconclusive. Objective We aimed to evaluate the influence of NTIS and hypothyroidism on all-cause mortality and major adverse cardiac events (MACE) in IHD population. Data Sources We searched PubMed, EMBASE, Scopus, Web of Science, and Cochrane Library from inception through February 17, 2020. Study Selection Original articles enrolling IHD patients, comparing all-cause mortality and MACE of NTIS and hypothyroidism with those of euthyroidism, and providing sufficient information for meta-analysis were considered eligible. Data Extraction Relevant information and numerical data were extracted for methodological assessment and meta-analysis. Data Synthesis Twenty-three studies were included. The IHD population with NTIS was associated with higher risk of all-cause mortality (hazard ratio [HR] = 2.61; 95% confidence interval [CI] = 1.89-3.59) and MACE (HR = 2.22; 95% CI = 1.71-2.89) than that without. In addition, the IHD population with hypothyroidism was also associated with higher risk of all-cause mortality (HR = 1.47; 95% CI = 1.10-1.97) and MACE (HR = 1.53; 95% CI = 1.19-1.97) than that without. In the subgroup analysis, the acute coronary syndrome (ACS) subpopulation with NTIS was associated with higher risk of all-cause mortality (HR = 3.30; 95% CI = 2.43-4.48) and MACE (HR = 2.19; 95% CI = 1.45-3.30). The ACS subpopulation with hypothyroidism was also associated with higher risk of all-cause mortality (HR = 1.67; 95% CI = 1.17-2.39). Conclusions The IHD population with concomitant NTIS or hypothyroidism was associated with higher risk of all-cause mortality and MACE. Future research is required to provide evidence of the causal relationship and to elucidate whether normalizing thyroid function parameters can improve prognosis.

scholarly journals Feeling the Force: Measurements of Platelet Contraction and Their Diagnostic Implications

2018 ◽  
Vol 45 (03) ◽  
pp. 285-296 ◽  
Author(s):  
Evelyn Williams ◽  
Oluwamayokun Oshinowo ◽  
Abhijit Ravindran ◽  
Wilbur Lam ◽  
David Myers
Keyword(s):  
Mechanical Properties ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Material Properties ◽  
Blood Cells ◽  
Ischemic Heart ◽  
Force Measurements ◽  
Blood Clots ◽  
Order Of Magnitude

AbstractIn addition to the classical biological and biochemical framework, blood clots can also be considered as active biomaterials composed of dynamically contracting platelets, nascent polymeric fibrin that functions as a matrix scaffold, and entrapped blood cells. As platelets sense, rearrange, and apply forces to the surrounding microenvironment, they dramatically change the material properties of the nascent clot, increasing its stiffness by an order of magnitude. Hence, the mechanical properties of blood clots are intricately tied to the forces applied by individual platelets. Research has also shown that the pathophysiological changes in clot mechanical properties are associated with bleeding and clotting disorders, cancer, stroke, ischemic heart disease, and more. By approaching the study of hemostasis and thrombosis from a biophysical and mechanical perspective, important insights have been made into how the mechanics of clotting and the forces applied by platelets are linked to various diseases. This review will familiarize the reader with a mechanics framework that is contextualized with relevant biology. The review also includes a discussion of relevant tools used to study platelet forces either directly or indirectly, and finally, concludes with a summary of potential links between clotting forces and disease.

Ischemic Heart Disease in Subjects of Young Age: Current State of the Problem. Features of Etiology, Clinical Manifestation and Prognosis

Kardiologiia ◽  
2018 ◽  
Vol 58 (11) ◽  
pp. 24-34 ◽  
Author(s):  
E. Yu. Andreenko ◽  
I. S. Yavelov ◽  
М. М. Loukianov ◽  
A. N. Vernohaeva ◽  
O. M. Drapkina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Molecular Genetic ◽  
Young Patients ◽  
Ischemic Heart ◽  
Coronary Syndrome ◽  
Current State ◽  
Monogenic Diseases ◽  
Conventional Risk Factors

In addition to conventional risk factors in young patients with ischemic heart disease (IHD) numerous other risk factors including genetics play an important role in its causation. Molecular genetic testing is recommended for the detection of monogenic diseases with a high risk of developing IHD, such as familial hypercholesterolemia. In majority ofyoung patients, the first manifestation of IHD is an acute coronary syndrome. Young patients with IHD more often have normal coronary arteries or single-vessel coronary disease, and in up to 20% of them cause of myocardial ischemia is not related to atherosclerosis. In general, young patients with IHD have better prognosis. However, there are sex differences in IHD outcomes the prognosis of patients with premature IHD and reason for this is still unclear.

scholarly journals Depression in Acute Coronary Syndrome Patients: A Cross-sectional Study in Malaysia

2020 ◽  
Author(s):  
Wan Nor Asyikeen Wan Adnan ◽  
Siti Azrin Ab Hamid ◽  
Zatul Rathiah Sulong ◽  
Mohd Hashairi Fauzi
Keyword(s):  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Female Gender ◽  
Cross Sectional Study ◽  
Ischemic Heart ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Coronary Syndrome

Background and purpose: Linked with high mortality rate, depression is common among acute coronary syndrome (ACS) patients. The current study sought to identify the factors associated with depression among ACS patients in Malaysia. Materials and Methods: A cross-sectional study was conducted on 400 ACS patients in two Malaysian hospitals: Hospital Universiti Sains Malaysia (USM), Kelantan and Hospital Sultanah Nur Zahirah (HSNZ), Terengganu. ACS patients were included if they were above 18 years of age, able to read and/or write in Bahasa Melayu language and had informed consent. Patients were excluded if they were intubated, had an altered mental status, mental retardation and had psychological problems prior to ACS. Depression in this study was defined as having dysphoria, hopelessness, devaluation of life, self-deprecation, lack of interest or involvement, anhedonia, and inertia among ACS patients. A questionnaire was distributed to all 400 ACS patients. Simple and multiple logistic regressions were used for data analysis. Results: The mean (standard deviation) age of ACS patients was 60.4 (11.3) years at Hospital USM and 61.2 (10.4) years at HSNZ. Nearly all of the depressive-ACS patients were Malay (79.4%), 85.9% were male, and 79.7% were married. Approximately 87.7% of depressive-ACS patients had ischemic heart disease, 87.1% had stroke, 83.4% had hyperlipidaemia, 81.8% had diabetes mellitus, and 80.7% had hypertension. The factors associated with depression were female gender (adjusted odd ratio (OR): 2.48, 95% confidence interval (CI): 1.50, 4.10, p<0.001) and ischemic heart disease (adjusted OR: 2.44, 95% CI: 1.41, 4.25, p=0.002). Conclusion: The results showed that female gender and ischemic heart disease were the most significant associated factors of depression among ACS patients.

scholarly journals Evaluation of Ischemic Heart Disease in the Young Population of Georgia

2021 ◽  
Vol 17 (18) ◽  
Author(s):  
Gogishvili Giorgi
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Young People ◽  
Ischemic Heart Disease ◽  
Night Shift ◽  
Young Patients ◽  
Female Gender ◽  
Ischemic Heart ◽  
Control Group ◽  
Ischemic Disease

Objective: Study of risk factors (RF) for ischemic heart disease (IHD) in young people is a significant problem in cardiology. Aims: Study and prognosis of ischemic heart disease in Georgian population under 45 years of age. Methods: The study included 107 young patients with coronary heart disease (from 18 to 44 years old), who were treated in the cardiology department of the St. John the Merciful Private Clinic. The average age was (34.68 ± 6.2) years. The control group consisted of 199 healthy volunteers without cardiovascular diseases at the age from 18 to 44 years, the average age was (35.9 ± 5.2) years. In all patients, traditional risk factors were assessed. Results: Regression analysis has shown that it increases the risk of ischemic heart disease: living in the city - OR=6.90(95%CI:1.28-37.18); sleep disturbance - OR=45.62(95%CI:3.52-590.64); obesity -OR=24.56(95%CI:4.14-145.66); hypertension - OR=40.76(95%CI:8.07-205.92); excess intake of saturated fats - OR=79.94(95%CI:10.93-584.43); night shift - OR=39.01(95%CI:3.75-405.75); early detection of ischemic disease in grade I-II relatives - OR=44.22(95%CI:8.07-242.17); decrease - female gender - OR=0.14 (95%CI:0.03-0.70) and married - OR=0.01(95%CI:0.00-0.08); Conclusion: The ability to predict the risk of developing IHD in young people on the basis of traditional RFs, most of which are modifiable, as well as the study of "new" RFs opens up new perspectives in the formation of a strategic approach to the management of young patients in the presence of high risk.

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