Antiproteinuric and nephroprotective activity of some peptide drugs in experimental nephropathy

2017 ◽  
pp. 45-51
Author(s):  
К.В. Сивак ◽  
К.И. Стосман ◽  
Т.Н. Саватеева-Любимова ◽  
С.В. Петленко
Keyword(s):  
Immune System ◽  
Cd8 T Cells ◽  
The Other ◽  
Peptide Drugs ◽  
Positive Effects ◽  
Peptide Bioregulators ◽  
Experimental Nephropathy ◽  
Functional Immunity ◽  
Nephroprotective Activity ◽  
Positive Effect

Цель исследования - изучение антипротеинурической и нефропротекторной активности пептидных препаратов при нефропатии на модели экспериментального аутоиммунного нефрита Хейманна. Методы. Данную патологию моделировали на крысах путем введения антигенной суспензии почки материнской особи в полном адъюванте Фрейнда (в/бр). Для оценки эффективности препаратов использовали показатели функции почек и системы иммунитета. Результаты. Препарат эпиталамин обладал наибольшим влиянием на скорость клубочковой фильтрации и величину гематурии, кортексин наиболее эффективно уменьшал протеинурию. Тимодепрессин оказывал наиболее выраженное позитивное влияние на уровень общего белка в крови. Эпиталамин и кортексин в наибольшей степени уменьшали уровень общего холестерина. Эпиталамин и тимодепрессин максимально снижали уровень мочевины. Все исследованные препараты в равной мере приводили к нормализации уровня креатинина, функционального состояния иммунитета, сопоставимо повышали уровень кортизола, сниженный при патологии. Препарат эпиталамин, в отличие от тимодепрессина и кортексина, вызывал частичную нормализацию уровня CD8+ Т-клеток и подавлял продукцию криоглобулинов. Эпиталамин обладал максимальной суммарной эффективностью в отношении показателей эндотоксикоза. Выводы. Полученные данные свидетельствуют о значительной клинической эффективности пептидных биорегуляторов в отношении большинства нарушенных показателей функциональной активности почек и иммунной системы, а также эндотоксикоза. The aim of the study was to study the antiproteinuric and nephroprotective activity of some peptide drugs using the model of experimental Heymann active nephritis. Methods. Heymann’s active nephritis was modeled on rats by injecting an intraperitoneal antigenic suspension of the mother’s kidney in Freund’s complete adjuvant. To assess the effectiveness of the drugs, indicators of kidney function and immunity system wereused. Results.The epithalamine was shown to bethe most effective drugthat increasedthe glomerular filtrationrate and decreasedthe level of hematuria.Cortexin reduced proteinuria more than the other peptides. The most pronounced positive effect on the level of total protein in the blood was seen withthymodepressin. Epithalamin and cortexin reduced the level of total cholesterol. Epithalamin and timodepressinmaximally decreased the level of urea. All the studied drugs equally led to the normalization of creatinine level and functional immunity, as well as increased the level of cortisol reduced as the result of pathology. Epithalamin normalized the level of CD8+ T-cells and suppressed the production of cryoglobulins. Epithalamin was the most effective drug reducingendotoxicosis. Conclusion. The obtained results demonstrated that the use of peptide bioregulators in the treatment had positive effects on the functional activity of kidneys, the immune system and markers of endotoxicosis.

scholarly journals Weaning Holstein Calves at 17 Weeks of Age Enables Smooth Transition from Liquid to Solid Feed

Animals ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1132
Author(s):  
Sarah Schwarzkopf ◽  
Asako Kinoshita ◽  
Jeannette Kluess ◽  
Susanne Kersten ◽  
Ulrich Meyer ◽  
...  
Keyword(s):  
Metabolic Stress ◽  
Live Weight ◽  
The Other ◽  
Smooth Transition ◽  
Blood Metabolites ◽  
Positive Effects ◽  
Weaning Age ◽  
Holstein Calves ◽  
Positive Effect ◽  
Over Time

Development of calves depends on prenatal and postnatal conditions. Primiparous cows were still maturing during pregnancy, which can lead to negative intrauterine conditions and affect the calf’s metabolism. It is hypothesized that weaning calves at higher maturity has positive effects due to reduced metabolic stress. We aimed to evaluate effects of mothers’ parity and calves’ weaning age on growth performance and blood metabolites. Fifty-nine female Holstein calves (38.8 ± 5.3 kg birth weight, about 8 days old) were used in a 2 × 2 factorial experiment with factors weaning age (7 vs. 17 weeks) and parity of mother (primiparous vs. multiparous cows). Calves were randomly assigned one of these four groups. Live weight, live weight gain and morphometry increased over time and were greater in calves weaned later. Metabolic indicators except total protein were interactively affected by time and weaning age. Leptin remained low in early-weaned calves born to primiparous cows, while it increased in the other groups. The results suggest that weaning more mature calves has a positive effect on body growth, and calves born to primiparous cows particularly benefit from this weaning regimen. It also enables a smooth transition from liquid to solid feed, which might reduce the associated stress of weaning.

THE INFLUENCE OF THIOURACIL ON THE RESPONSES OF THE IMMATURE PULLET TO ESTROGEN, WITH REFERENCE TO OVIDUCT HYPERTROPHY, SERUM CALCIUM, AND LIVER COMPOSITION

1958 ◽  
Vol 36 (1) ◽  
pp. 1023-1035
Author(s):  
R. H. Common ◽  
W. A. Maw ◽  
D. S. Layne ◽  
K. A. McCully
Keyword(s):  
Deoxyribonucleic Acid ◽  
Live Weight ◽  
Liver Weight ◽  
Estradiol Benzoate ◽  
The Other ◽  
Liver Fat ◽  
Calcium Response ◽  
Blood Calcium ◽  
Positive Effects ◽  
Positive Effect

Thiouracil was given to sexually immature pullets at a level of 0.05% of the diet for 14 days before and also during treatment with 0.5 mg estradiol benzoate (ODB) or 1.0 mg ODB daily for 14 days. The thiouracil treatment did not modify the estrogen-induced hypercalcemia after 7 days, but after 14 days it enhanced significantly the blood calcium response to 1.0 mg ODB per day. The positive effects of thiouracil and of estrogen on liver weight per kg live weight were significant and additive. The comparatively low level of thiouracil used did not increase liver fat per kg live weight significantly, but it increased significantly the positive effect of estrogen on liver fat. The thiouracil treatment had no significant effect on liver deoxyribonucleic acid phosphorus (DNAP) but it increased liver pentose nucleic acid phosphorus (RNAP) per kg live weight significantly both in absence and presence of estrogen. The thiouracil treatment had no effect on the responses of the oviduct to estrogen.In a second experiment the effects of (a) 1.0% thiouracil for 10 days before and also during a 14-day estrogen treatment of 1.0 mg ODB per day and of (b) 1.0% thiouracil given concurrently with 1.0 mg ODB per day were studied. Neither thiouracil treatment affected the response of the oviduct to estrogen. The other results confirmed previous observations.In a third experiment, 1.5 mg ODB was given every other day for 14 days. When thiouracil at a level of 1% was given concurrently with the estrogen, it enhanced significantly the response of the oviduct. When 1% thiouracil was given also for 10 days before the estrogen, then it did not enhance the response of the oviduct. This experiment suggests that the conditions under which thiouracil will enhance estrogen-induced hypertrophy of the oviduct are narrowly defined. Other results were in general agreement with previous observations.

On Your Mark, Get Set, Develop!

2015 ◽  
pp. 712-726 ◽  
Author(s):  
Scott A. Beaulier ◽  
Daniel J. Smith
Keyword(s):  
Economic Growth ◽  
Economic Reform ◽  
Economic Transition ◽  
The Other ◽  
Initial Moment ◽  
Political Leader ◽  
Middle Ground ◽  
Positive Effects ◽  
Positive Effect ◽  
The Ideal

One of the lingering questions for development economists is that of economic transition and whether development can be promoted by a strong political leader. Earlier writings on leadership and economic development tend to fall into one of two camps: (1) leaders matter and can contribute positively to economic growth, or (2) leaders seldom have positive effects and, at best, can avoid doing a great deal of harm. This article establishes a third option—a middle-ground position—between these two views. Good leadership can, indeed, have a positive effect on economic growth but only during the initial moment when economic reform is up for grabs. Once the opportunity to implement sweeping reform has passed, interests become entrenched, and the opportunity for growth-enhancing reform passes. Bad leaders, on the other hand, can hamper economic growth in periods well beyond the ideal reform moment.

scholarly journals The Effect of Sea Lettuce (Ulva lactuca) Liquid Fertilizer and Zeolite Combinations on the Development of Cucumber (Cucumis sativus)

2019 ◽  
Vol 7 (7) ◽  
pp. 1021
Author(s):  
Mustafa Türkmen ◽  
Ayşe Su
Keyword(s):  
Cucumis Sativus ◽  
Organic Liquid ◽  
Germination Rate ◽  
Ulva Lactuca ◽  
The Other ◽  
Control Group ◽  
Liquid Fertilizer ◽  
Positive Effects ◽  
Fertilizer Material ◽  
Positive Effect

The combinations of organic liquid fertilizer material obtained from sea lettuce (Ulva lactuca) and different concentrations of zeolite were applied to the cucumber (Cucumis sativus) plant in six treatments with three replicates each. The combinations of the experimental groups were as follows; control group, G1 group 180 g Z (Zeolite), G2 group 90 g Z + 1140 ml Liquid Fertilizer (LF), G3 group 180 g Z + 620 ml LF, G4 group 270 g Z + 310 ml LF, G5 group 620 ml LF. Except the control group, all zeolites were applied with the first dose of liquid fertilizer, and other liquid fertilizer doses were given in three periods, after germination, flowering and yield. While the lowest germination rate was in control group, the highest rate was in group with 60 g zeolite. While the lowest seedling weight was observed in group with 90 g zeolite + 1140 ml liquid fertilizer, the highest rate was in group with 180 g zeolite + 620 ml liquid fertilizer. While the highest cucumber weight was observed in group with 270 g zeolite + 310 ml liquid fertilizer, the lowest was in group with 620 ml liquid fertilizer. Therefore, it may be said that zeolite has positive effect on germination. On the other hand, liquid fertilizer and zeolite combinations may have positive effects on the weight of the cucumber seedling and yield.

THE INFLUENCE OF THIOURACIL ON THE RESPONSES OF THE IMMATURE PULLET TO ESTROGEN, WITH REFERENCE TO OVIDUCT HYPERTROPHY, SERUM CALCIUM, AND LIVER COMPOSITION

1958 ◽  
Vol 36 (10) ◽  
pp. 1023-1035
Author(s):  
R. H. Common ◽  
W. A. Maw ◽  
D. S. Layne ◽  
K. A. McCully
Keyword(s):  
Deoxyribonucleic Acid ◽  
Live Weight ◽  
Liver Weight ◽  
Estradiol Benzoate ◽  
The Other ◽  
Liver Fat ◽  
Calcium Response ◽  
Blood Calcium ◽  
Positive Effects ◽  
Positive Effect

Thiouracil was given to sexually immature pullets at a level of 0.05% of the diet for 14 days before and also during treatment with 0.5 mg estradiol benzoate (ODB) or 1.0 mg ODB daily for 14 days. The thiouracil treatment did not modify the estrogen-induced hypercalcemia after 7 days, but after 14 days it enhanced significantly the blood calcium response to 1.0 mg ODB per day. The positive effects of thiouracil and of estrogen on liver weight per kg live weight were significant and additive. The comparatively low level of thiouracil used did not increase liver fat per kg live weight significantly, but it increased significantly the positive effect of estrogen on liver fat. The thiouracil treatment had no significant effect on liver deoxyribonucleic acid phosphorus (DNAP) but it increased liver pentose nucleic acid phosphorus (RNAP) per kg live weight significantly both in absence and presence of estrogen. The thiouracil treatment had no effect on the responses of the oviduct to estrogen.In a second experiment the effects of (a) 1.0% thiouracil for 10 days before and also during a 14-day estrogen treatment of 1.0 mg ODB per day and of (b) 1.0% thiouracil given concurrently with 1.0 mg ODB per day were studied. Neither thiouracil treatment affected the response of the oviduct to estrogen. The other results confirmed previous observations.In a third experiment, 1.5 mg ODB was given every other day for 14 days. When thiouracil at a level of 1% was given concurrently with the estrogen, it enhanced significantly the response of the oviduct. When 1% thiouracil was given also for 10 days before the estrogen, then it did not enhance the response of the oviduct. This experiment suggests that the conditions under which thiouracil will enhance estrogen-induced hypertrophy of the oviduct are narrowly defined. Other results were in general agreement with previous observations.

scholarly journals Positive Effects of Different Drug Forms of Silybin in the Treatment of Metabolic Syndrome

2015 ◽  
pp. S507-S512 ◽  
Author(s):  
M. PORUBA ◽  
Z. MATUŠKOVÁ ◽  
L. KAZDOVÁ ◽  
O. OLIYARNYK ◽  
H. MALÍNSKÁ ◽  
...  
Keyword(s):  
Total Cholesterol Level ◽  
Hdl Cholesterol ◽  
The Other ◽  
Lipid Homeostasis ◽  
Control Group ◽  
Positive Effects ◽  
Hypotriglyceridemic Effect ◽  
Dose Dependent ◽  
Positive Properties ◽  
Positive Effect

Silymarin and silybin are widely used for their hepatoprotective properties. Our previous studies confirm positive effect of silymarin on lipoprotein profile and lipid homeostasis. Advanced drug forms may improve the bioavailability of these compounds. In this study, we investigate the effects of silybin in different drug forms (standardized silybin, micronized silybin, and silybin in form of phytosomes) on dyslipidemia and glucose metabolism in hereditary hypertriglyceridemic (HHTg) rats. Male HHTg rats were divided into four groups of seven animals and were fed by experimental diets. Silybin significantly decreased serum level of triglycerides in groups of rats fed by standardized silybin and silybin in form of phytosomes compared to control group. Results show that silybin did not affect the total cholesterol level, but significantly increased the levels of HDL cholesterol in all groups of animals. Silybin in a standardized form had the highest hypotriglyceridemic effect. On the other hand, the micronized form has caused the highest increase of protective HDL and most significantly decreased glucose and insulin levels. Our results suggest that silybin is probably responsible for some positive properties of silymarin. Subsequent dose-dependent studies of silybin action may reveal the intensity of its positive effects on lipid and glucose parameters.

Impact of Digitalization on Service Work in Knowledge-Intensive Business Services: An Empirical Study in Tax Consultancies

2019 ◽  
Vol 3 (4) ◽  
pp. 209-222
Author(s):  
Philipp K. Görs ◽  
Henning Hummert ◽  
Anne Traum ◽  
Friedemann W. Nerdinger
Keyword(s):  
Work Engagement ◽  
Service Work ◽  
Psychological Consequences ◽  
Business Services ◽  
Knowledge Intensive Business Services ◽  
Positive Effects ◽  
Knowledge Intensive ◽  
The Impact ◽  
Positive Effect ◽  
Special Case

Digitalization is a megatrend, but there is relatively little knowledge about its consequences for service work in general and specifically in knowledge-intensive business services (KIBS). We studied the impact of digitalization on psychological consequences for employees in tax consultancies as a special case of KIBS. We compare two tax consulting jobs with very different job demands, those of tax consultants (TCs) and assistant tax consultants (ATCs). The results show that the extent of digitalization at the workplace level for ATCs correlates significantly positively with their job satisfaction. For TCs, the same variable correlates positively with their work engagement. These positive effects of digitalization are mediated in the case of ATCs by the impact on important job characteristics. In the case of TCs, which already have very good working conditions, the impact is mediated by the positive effect on self-efficacy. Theoretical and practical consequences of these results are discussed.

The Determinants of Capital Adequacy Ratio: The Case of the Vietnamese Banking System in the Period 2011-2015

2017 ◽  
Vol 33 (2) ◽  
Author(s):  
Ngoc Anh Nguyen
Keyword(s):  
Banking System ◽  
Precious Metals ◽  
Capital Adequacy ◽  
The Other ◽  
Total Asset ◽  
Data Set ◽  
Hand Size ◽  
Net Interest Margin ◽  
Capital Adequacy Ratio ◽  
Positive Effect

The analysis of a data set of observation for Vietnamese banks in period from 2011 - 2015 shows how Capital Adequacy Ratio (CAR) is influenced by selected factors: asset of the bank SIZE, loans in total asset LOA, leverage LEV, net interest margin NIM, loans lost reserve LLR, Cash and Precious Metals in total asset LIQ. Results indicate based on data that NIM, LIQ have significant effect on CAR. On the other hand, SIZE and LEV do not appear to have significant effect on CAR. Variables NIM, LIQ have positive effect on CAR, while variables LLR and LOA are negatively related with CAR.

Astrobiology and its influence on the renewal of the way we see the world from the teloempathic, educational and astrotheological perspective

2020 ◽  
Vol 19 (4) ◽  
pp. 330-334
Author(s):  
Octavio A. Chon Torres
Keyword(s):  
Natural Sciences ◽  
The Other ◽  
Positive Effects ◽  
The World ◽  
The Way

AbstractThere is a record of the positive effects of astrobiological research for the natural sciences and eventually for their technological use on Earth. However, on the philosophical effects, this is not as visible as the other sciences, which is why it can be assumed that it is a waste of time speculating on astrobioethics or also on the philosophy of astrobiology. This is the reason why this work seeks to identify and sustain the philosophical utility of astrobioethics. To achieve this, this article focuses on three essential aspects: teloempathy, education and astrotheology. Russell's argument about the value of philosophy will be used as a fundamental basis for the usefulness of astrobioethics.

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