scholarly journals Faktor Risiko Kepatuhan Kemoterapi pada Pasien Kanker Payudara

2017 ◽  
Vol 8 (3) ◽  
pp. 415
Author(s):  
Halimatussakdiah Halimatussakdiah ◽  
Junardi Junardi
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Standard Procedure ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cancer Data ◽  
Chi Square Test ◽  
Prevalence Of Cancer ◽  
Banda Aceh

The prevalence of cancer in Indonesia is significantly high. Based on data (Rikesdas) in 2013, it showed that the prevalence of cancer is 1,4 per 1000 people or approximately 330.000 people. The most popular cases faced by women is chest and cervix cancer. Data has shown that 75% of breast cancer had chemotherapy. The result of studies shows that more than 60% of chemotherapy patient caused hair fall, darken-nail, queasy, and loss appetite. The aim of this study was to find out factors related to the obedience to chemotherapy on breast cancer patients in wardThursina II BLUD Zainal Abidin Hospital Banda Aceh in 2017. This research was conducted from 1 April to 30 May 2017. This type of research was the correlation with crossectional study design approach. The population of the study included all of the breast cancer patients who were having chemotherapy. The technique of sampling used was accidental sampling that involved 65 participants. Data were analyzed using Chi-Square Test. The result of the study showed that there was a relationship self-concept and chemotherapy obedience (p-value=0,013); expense and chemotherapy obedience (p-value=0,036); family support and chemotherapy obedience (p-value=0,002); side-effects and chemotherapy obedient (p-value=0,007). It is hoped that all the employee in BLUD dr.Zainal Abidin Hospital Banda Aceh can improve nursing management and enhance operational standard procedure on chemotherapy for patients, especially for breast cancer patients.

COVID-related anxiety is prevalent and accurately reflects serious COVID risks in breast cancer patients.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 12053-12053
Author(s):  
Marisa C. Weiss ◽  
Stephanie Kjelstrom ◽  
Meghan Buckley ◽  
Adam Leitenberger ◽  
Melissa Jenkins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cancer Diagnosis ◽  
Breast Cancer Diagnosis ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Liver And Kidney ◽  
Chi Square Test ◽  
A Current

12053 Background: A current cancer diagnosis is a risk factor for serious COVID-19 complications (CDC). In addition, the pandemic has caused major disruptions in medical care and support networks, resulting in treatment delays, limited access to doctors, worsening health disparities, social isolation; and driving higher utilization of telemedicine and online resources. Breastcancer.org has experienced a sustained surge of new and repeat users seeking urgent information and support. To better understand these unmet needs, we conducted a survey of the Breastcancer.org Community. Methods: Members of the Breastcancer.org Community were invited to complete a survey on the effects of the COVID-19 pandemic on their breast cancer care, including questions on demographics, comorbidities (including lung, heart, liver and kidney disease, asthma, diabetes, obesity, and other chronic health conditions); care delays, anxiety due to COVID-related care delays, use of telemedicine, and satisfaction with care during COVID. The survey was conducted between 4/27/2020-6/1/2020 using Survey Monkey. Results were tabulated and compared by chi square test. A p-value of 0.05 is considered significant. Data were analyzed using Stata 16.0 (Stata Corp., Inc, College Station, TX). Results: Our analysis included 568 breast cancer patients of whom 44% had ≥1 other comorbidities associated with serious COVID-19 complications (per CDC) and 37% had moderate to extreme anxiety about contracting COVID. This anxiety increased with the number of comorbidities (p=0.021), age (p=0.040), and with a current breast cancer diagnosis (p=0.011) (see table). Anxiety was significantly higher in those currently diagnosed, ≥65, or with ≥3 other comorbidities, compared to those diagnosed in the past, age <44, or without other comorbidities. Conclusions: Our survey reveals that COVID-related anxiety is prevalent at any age regardless of overall health status, but it increased with the number of other comorbidities, older age, and a current breast cancer diagnosis. Thus, reported anxiety is proportional to the risk of developing serious complications from COVID. Current breast cancer patients of all ages—especially with other comorbidities—require emotional support, safe access to their providers, and prioritization for vaccination.[Table: see text]

Renal insufficiency in bone metastasis cancer patients: Prevalence and implications on anticancer drugs management, subgroup analysis of the IRMA study

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 9121-9121 ◽  
Author(s):  
N. Janus ◽  
C. Le Tourneau ◽  
V. Launay-Vacher ◽  
J. Gligorov ◽  
O. Rixe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Renal Insufficiency ◽  
Cancer Patients ◽  
Anticancer Drugs ◽  
Subgroup Analysis ◽  
Dosage Adjustment ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Chi Square Test

9121 Background: The IRMA study reported the high prevalence of renal insufficiency (RI) in 4684 solid tumour patients, with a glomerular filtration rate (GFR) <90 ml/min for 50–60%. Furthermore, 80.1% were receiving nephrotoxic anticancer drugs and 79.9% drugs necessitating dosage adjustment. We present the results for IRMA patients with bone metastasis (BM). Methods: Subgroup analysis of IRMA patients with BM. Data collected: sex, age, weight, serum creatinine (SCR), bone metastasis (BM) and anticancer drugs. The prevalence of SCR>110 μmol/L was assessed. GFR was estimated with Cockcroft-Gault (CG) and abbreviated MDRD (aMDRD) formulae. Drugs necessitating dosage adjustment and those potentially nephrotoxic were identified. Chi-square test was used to compare the prevalence of RI between patients with BM and patients without, for all patients and for breast cancer (BC) ones. Results: 1,000 patients (BC 577) with BM were included: median age 60, mean 59.8, weight 66 kg, 659 women. The prevalence of SCR>110 μmol/L was 8.3%. That of GFR<90 ml/min was 57.9% with CG and 54.7% with aMDRD. 83.4% of treated patients received at least one drug needing dosage adjustment (or no data) and 69% received at least one nephrotoxic drug. The prevalence of RI was not statistically different between patients with or without BM. However, the prevalence of RI was significantly higher in BC patients with BM as compared to BC patients without BM (62.1 versus 56.7 %, p=0.04). Conclusions: RI is highly frequent in cancer patients with BM. Appropriate evaluation of renal function necessitates CG or aMDRD calculation. In those patients, and especially in breast cancer patients with BM, anticancer drugs should be cautiously selected regarding their potential renal toxicity and need for dosage adjustment. [Table: see text] No significant financial relationships to disclose.

Cardiotoxicity risks of adjuvant trastuzumab in Asian breast cancer patients

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 561-561
Author(s):  
V. Shih ◽  
A. Chan ◽  
J. Chiang ◽  
C. Teo ◽  
J. Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Adjuvant Trastuzumab ◽  
Ventricular Ejection Fraction ◽  
Chi Square Test

561 Background: Adjuvant trastuzumab (T)-based chemotherapy has been shown to reduce relapse and improve survival in breast cancer patients but has been associated with increased risks of cardiotoxicity. Our study aims to define the incidence and severity of cardiotoxicity amongst Asian breast cancer patients. Methods: This is a retrospective review of patients who have received adjuvant T from June 2005 to 2007. Cardiotoxicity was defined as a drop in left ventricular ejection fraction (LVEF) to less than 50% and/or reduction of > 10% of baseline. Cardiovascular (CVS) risk factors were defined as having a family history or presence of CAD, hypertension, diabetes mellitus, hyperlipidemia and smoking. We used pair sampled t-test to evaluate the mean LVEF change and Chi-square test to evaluate the association of cardiotoxicity and demographics. Results: There were 179 female patients. Cardiotoxicity was reported in 70 (39.1%), of whom 59 had asymptomatic decline in LVEF and 11 experienced CHF. Mean LVEF, comparing various time points (3, 6, 9 and 12 months) against baseline showed statistically significant decline (p<0.05). T was withheld (n=33) due to asymptomatic decline in LVEF (n=24), symptomatic heart failure (n=4) and both (n=5). Twenty-one with resolution of CHF (n=7) or LVEF recovery (n=14) were rechallenged. Cardiotoxicity recurred in 9 - asymptomatic decline in LVEF (n=8) and recurrent CHF (n=1). There were no cardiac-related deaths. Neither patient demographics nor CVS risk factors predicted for cardiotoxicity. Conclusions: This is one of the largest series reported in Asians receiving T. As previously reported, T-induced cardiotoxicity resulted in mostly asymptomatic reversible decline in LVEF. Our incidence of cardiotoxicity appeared higher (39.1%) in Asians and more importantly, almost half of the patients experienced cardiotoxicity upon rechallenge. It would be prudent to explore whether there is any difference in susceptibility to T-induced cardiotoxicity between the different races. [Table: see text] No significant financial relationships to disclose.

scholarly journals LDL-c as a predictor of hormonal status and determining factor for therapy of breast cancer patients

2021 ◽  
Vol 2 (2) ◽  
pp. 023-031
Author(s):  
Reynard Budy Setiawan ◽  
Desak Gede Agung Suprabawati ◽  
Jusak Nugraha
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Density Lipoprotein ◽  
P Value ◽  
Hormonal Status ◽  
Breast Cancer Patients ◽  
Characteristic Analysis ◽  
Chi Square ◽  
Cross Sectional

Background: Immunohistochemical testing is important in determining clinical diagnosis and therapy, and is useful as a prognostic and predictive factor, but it is not easy to do and is not always available. Breast cancer patient with higher low-density-lipoprotein cholesterol [LDL-c]. level tends to have larger tumor size, higher grade, higher proliferation rate, positive Human Epidermal growth factor Receptor-2 (HER2-neu) and occasionally come at late stage. High LDL-c receptors are found on the surface of breast cancer cells, where cancer cells will take up cholesterol in serum, and a metabolite of 27-hydroxycholesterol cholesterol will affect Estrogen Receptor-α. Methods: Analytical observational study by cross sectional method, during July 2020 – November 2020, at Oncology Clinic Dr. Soetomo Hospital Surabaya with a total sample size of 42. The data obtained were analyzed using the SPSS version 23.0 program, regression test and Chi-Square were performed for characteristic analysis and Chi-Square Fischer’s Exact Test were performed for correlation test between lipid profiles with hormonal status. Results: The mean value of LDL-c was 117.88 ± 33.89 mg/dL. In the analysis of the correlation between LDL-c and hormonal status, it was found that the majority of patients who had positive hormonal status had LDL-c levels of ≤160 mg/dL with p value = 0.049. ROC analysis shown LDL-c cut-off point of 132 mg/dL, p value = 0.034 (OR 5.031, 95% CI 1.159-21.848), sensitivity 46.7% and specificity 83.35%. Conclusion: There is a statistically significant relationship between LDL-c levels and hormonal status with the cut-off point of 132 mg/dL. The increase in LDL-c in serum increases the tendency of negative hormonal status, therefore LDL-c levels can be considerate in determining the therapy for breast cancer patients.

Disparities in breast cancer among 236,101 patients in Florida

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10790-10790
Author(s):  
C. P. Bowen-Wells ◽  
W. E. Sumner ◽  
F. Moffat ◽  
E. Avisar ◽  
D. Fraceschi
Keyword(s):  
Breast Cancer ◽  
New England ◽  
Racial Differences ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Pattern Of Care ◽  
Prevention Education ◽  
Cancer Data ◽  
Chi Square Test ◽  
Regional Disease

10790 Background: For minorities with breast cancer, access to healthcare has been an issue. A number of studies have reported racial differences in the pattern of care for women with breast cancer. A recent publication in New England Journal of Medicine indicated that the trend has narrowed between whites and black. In our institution we have noted a persistent higher rate of advanced breast cancer in minority patients. Studies have also showed that minority patients present with more advance disease and are more likely to have receptor negative tumors. Minority patients have higher mortality than whites. Younger minorities appear to do worse than older minorities as a result of lack of insurance. Minorities are less likely to be part of clinical trials. Method: We reviewed the Florida Cancer Data System (FCDS), a large cancer registry. 236,101 cases of breast cancer patients were identified between 1981–1992. Comparisons were made by Chi Square test. Results: Ninety one percentages (91%) of the patients were Whites, 6.8% were Blacks and 2.2% represented all others. Most patients presented with localized disease: Whites had 49%; Blacks had 36% and the other minority 36.3%. Blacks had a significantly higher incidence of regional disease (see figure), and had the highest percentage of metastatic disease at presentation (p < 0.01). Conclusion: Disparities in breast cancer care still clearly exist amongst ethnic group in Florida. The disparities are resulting in higher mortality among non-whites as compared to whites. Better results could be achieved with sets at prevention, education about early detection, screening and access. No significant financial relationships to disclose.

Murine Double Minute Clone 2 309T/G and 285G/C Promoter Single Nucleotide Polymorphism as a Risk Factor for Breast Cancer: A Polish Experience

2012 ◽  
Vol 27 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Piotr Piotrowski ◽  
Margarita Lianeri ◽  
Blazej Rubis ◽  
Hanna Knula ◽  
Maria Rybczynska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Statistical Power ◽  
Protective Factor ◽  
P Value ◽  
Sequencing Analysis ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Polish Experience ◽  
Chi Square Test ◽  
Genetic And Environmental Factors

Background Breast cancer is a multifactorial disease caused by complex interactions between genetic and environmental factors. Recently, a functional polymorphism, MDM2 285G>C (rs117039649), has been discovered. This polymorphism antagonizes the effect of the 309T>G (rs2279744) polymorphism on the same gene, resulting in decreased MDM2 transcription. Methods The MDM2 285G>C and 309T>G polymorphisms were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis in women with breast cancer (n=468) and controls (n=550). Results The odds ratio (OR) for breast cancer patients with the MDM2 285C/C and 285G/C genotypes was 0.4768 (95% confidence interval [CI] 0.2906–0.7824; p=0.0033, pcorr=0.0066). We also found a significantly lower frequency of the MDM2 285C allele in patients with breast cancer than in controls: the OR for the C allele in patients with breast cancer was 0.4930 (95% CI=0.3059–0.7947, p=0.0031, pcorr=0.0062). The p value of the chi-square test for the trend observed for the MDM2 285G>C polymorphism was statistically significant (ptrend=0.0036). The statistical power of this study amounted to 85% for the G/C or C/C genotypes and 85% for the C allele. However, we did not observe significant differences between the distribution of MDM2 309T>G genotypes and alleles in patients with breast cancer and healthy controls. Conclusion In a sample of the Polish population, we observed that the MDM2 285C gene variant may be a significant protective factor against breast cancer.

scholarly journals HUBUNGAN MEKANISME KOPING DENGAN KUALITAS HIDUP PADA PASIEN KANKER PAYUDARA

2018 ◽  
Vol 1 (1) ◽  
pp. 38
Author(s):  
Abdul Wakhid ◽  
Wiwik Nurhikmah ◽  
Rosalina Rosalina
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Sampling Technique ◽  
P Value ◽  
Coping Mechanism ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional

THE ROLE OF MENTAL HEALTH CADRES IN THE HANDLING OF MENTAL PATIENTS ABSTRACTPatients with cancer have a very significant increase including breast cancer that causes death. Breast cancer affects the greatest impact on the sufferer, thus affecting the quality of life. Decreased quality of life that is not resolved will inhibit treatment that will cause death. The purpose of this study was to determine the relationship between coping mechanism with quality of life in breast cancer patients. This research design is descriptive correlational with cross sectional approach. The population of this study was breast cancer patients with a sample of 55 respondents using accidental sampling technique and data collection tool using Cancer Coping Questionnaire 21 and WHOQoL-BREF. Data analysis used chi square test. The results showed that the mechanism of coping cancer patients 65.5% adaptive category, quality of life of breast cancer patients bad category 52,7%. There is a relationship of coping mechanism with quality of life in breast cancer patients who underwent chemotherapy with p value 0,048 (α = 0,05). Should the hospital facilitate interaction activities with fellow breast cancer patients in order to share experiences about improving the quality of life. Keywords: Mechanism of Coping, Quality of Life, Breast Cancer Patients

scholarly journals Hubungan Kesejahteraan Spiritual dengan Kualitas Hidup pada Pasien Kanker Payudara di Poli Bedah RSUP Dr. M. Djamil Padang

2020 ◽  
Vol 7 (2) ◽  
pp. 118
Author(s):  
Lola Despitasari ◽  
Lenni Sastra ◽  
Fitria Alisa ◽  
Letivia Azro
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
General Hospital ◽  
Poor Quality ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional

Di Indonesia peningkatan jumlah kasus baru serta jumlah kematian akibat kanker payudara terus meningkat. Situasi yang dialami pasien kanker payudara menyebabkan permasalahan meliputi perubahan secara fisik, fungsi sosial, psikis maupun spiritual seseorang dan ini mempengaruhi kualitas hidup pasien kanker payudara. Salah satu faktor yang mempengaruhi kualitas hidup pasien kanker payudara adalah kesejahteraan spiritual. Tujuan penelitian untuk mengetahui hubungan kesejahteraan spiritual dengan kualitas hidup pada pasien kanker payudara di Poli Bedah RSUP Dr. M. Djamil Padang. Jenis penelitian analitik dengan desain cross sectional. Populasi pada semua wanita penderita kanker payudara yang datang ke poli bedah RSUP Dr.M.Djamil Padang sebanyak 509 orang dengan jumlah sampel sebanyak 83 orang.Teknik pengambilan sampel dengan accidental sampling. Data di analisa menggunakan uji Chi square. Hasil penelitian 44,6% pasien kanker payudara memiliki kualitas hidup buruk, 53% memiliki kesejahteraan spiritual yang buruk. Hasil uji statistik didapatkan p value 0,000(p ≤ 0,05), terdapat hubungan antara kesejahteraan spiritual dengan kualitas hidup pada pasien kanker payudara di Poli Bedah RSUP Dr.M.Djamil Padang. Disimpulkan bahwa pasien kanker payudara dengan kesejahteraan spiritual buruk cenderung memiliki kualitas hidup buruk. Diharapkan kepada tenaga kesehatan melakukan penyuluhan dan informasi yang edukatif tentang kualitas hidup kanker payudara sehingga meningkatkan kesejahteraan spiritual.Kata kunci : kanker payudara; kualitas hidup; kesejahteraan spiritual THE RELATIONSHIP OF SPIRITUAL WELFARE WITH QUALITY OF LIFE IN BREAST CANCER PATIENTS IN SURGERY POLYCLINIC AT Dr. M. DJAMIL PROVINCIAL GENERAL HOSPITAL OF PADANG ABSTRACTIn Indonesia the increase of new cases and the number of deaths from breast cancer continues to increase. The situation experienced by breast cancer patients cause problems include physical changes, social functions, psychic and spiritual of someone. The impact of these problems will affect the quality of life of breast cancer patients. One of the factors that affect the quality of life of breast cancer patients is spiritual welfare. The purpose of this study was to determine the relationship of spiritual welfare with quality of life in breast cancer patients in Surgery Policlinic at Dr. M. Djamil Provincial General Hospital of Padang. The type of research used was analytic survey, cross sectional study design. The population in this study were all women with breast cancer who came through surgery polyclinic at  Dr. M. Djamil Provincial General Hospital of Padang as many as 509 people with samples were 83 people taken by accidental sampling technique. Univaria data were analyzed using frequency table and bivariate used Chi square. The results showed almost half 44.6%, of breast cancer patients had poor quality of life, more than half 53%,  had poor spiritual welfare. Statistical test results obtained p value 0,000 (p ≤ 0.05) means there is a relationship between spiritual welfare with quality of life in breast cancer patients at surgery polyclinic at  Dr. M. Djamil Provincial General Hospital of Padang.The results of this study can be concluded that breast cancer patients with poor spiritual welfare have poor quality of life, while breast cancer patients with spiritual well-being have good quality of life. It is expected that health workers to educate and educational information about the quality of life of breast cancer.Keywords : breast cance; quality of life; spiritual welfare

Correlation of AGR2 expression with the incidence of metastasis in luminal breast cancer

2021 ◽  
pp. 1-5
Author(s):  
David Samuel Kereh ◽  
John Pieter ◽  
William Hamdani ◽  
Haryasena Haryasena ◽  
Daniel Sampepajung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Mean Value ◽  
Rank Test ◽  
Luminal Breast Cancer ◽  
P Value ◽  
Strong Positive Correlation ◽  
Breast Cancer Patients ◽  
The Mean ◽  
Spearman Test

BACKGROUND: AGR2 expression is associated with luminal breast cancer. Overexpression of AGR2 is a predictor of poor prognosis. Several studies have found correlations between AGR2 in disseminated tumor cells (DTCs) in breast cancer patients. OBJECTIVE: This study aims to determine the correlation between anterior Gradient2 (AGR2) expression with the incidence of distant metastases in luminal breast cancer. METHODS: This study was an observational study using a cross-sectional method and was conducted at Wahidin Sudirohusodo Hospital and the network. ELISA methods examine AGR2 expression from blood serum of breast cancer patients. To compare the AGR2 expression in metastatic patients and the non-metastatic patient was tested with Mann Whitney test. The correlation of AGR2 expression and metastasis was tested with the Rank Spearman test. RESULTS: The mean value of AGR2 antibody expression on ELISA in this study was 2.90 ± 1.82 ng/dl, and its cut-off point was 2.1 ng/dl. Based on this cut-off point value, 14 subjects (66.7%) had overexpression of AGR2 serum ELISA, and 7 subjects (33.3%) had not. The mean value AGR2 was significantly higher in metastatic than not metastatic, 3.77 versus 1.76 (p < 0.01). The Spearman rank test obtained a p-value for the 2 tail test of 0.003 (p < 0.05), which showed a significant correlation of both, while the correlation coefficient of 0.612 showed a strong positive correlation of AGR2 overexpression and metastasis. CONCLUSIONS: AGR2 expression is correlated with metastasis in Luminal breast cancer.

scholarly journals Human Plasma Metabolomics for Biomarker Discovery: Targeting the Molecular Subtypes in Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 147
Author(s):  
Leticia Díaz-Beltrán ◽  
Carmen González-Olmedo ◽  
Natalia Luque-Caro ◽  
Caridad Díaz ◽  
Ariadna Martín-Blázquez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Biomarker Discovery ◽  
Molecular Subtypes ◽  
Breast Cancer Subtype ◽  
P Value ◽  
Plasma Samples ◽  
Breast Cancer Patients ◽  
Clinical Value ◽  
Molecular Phenotypes

Purpose: The aim of this study is to identify differential metabolomic signatures in plasma samples of distinct subtypes of breast cancer patients that could be used in clinical practice as diagnostic biomarkers for these molecular phenotypes and to provide a more individualized and accurate therapeutic procedure. Methods: Untargeted LC-HRMS metabolomics approach in positive and negative electrospray ionization mode was used to analyze plasma samples from LA, LB, HER2+ and TN breast cancer patients and healthy controls in order to determine specific metabolomic profiles through univariate and multivariate statistical data analysis. Results: We tentatively identified altered metabolites displaying concentration variations among the four breast cancer molecular subtypes. We found a biomarker panel of 5 candidates in LA, 7 in LB, 5 in HER2 and 3 in TN that were able to discriminate each breast cancer subtype with a false discovery range corrected p-value < 0.05 and a fold-change cutoff value > 1.3. The model clinical value was evaluated with the AUROC, providing diagnostic capacities above 0.85. Conclusion: Our study identifies metabolic profiling differences in molecular phenotypes of breast cancer. This may represent a key step towards therapy improvement in personalized medicine and prioritization of tailored therapeutic intervention strategies.

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