BIOPHARMACEUTICAL ASPECTS OF CHOOSING THE BASIS OF PENCILS OF MEDICINAL WOUND-HEALING ACTION

2021 ◽  
pp. 25-30
Author(s):  
Nikiforova E.B. ◽  
Davitavyan N.A. ◽  
Gordienko M.V.
Keyword(s):  
Wound Healing ◽  
Polyethylene Oxide ◽  
Dosage Form ◽  
Component Composition ◽  
Regenerative Process ◽  
Biologically Active ◽  
Solid Paraffin ◽  
Accelerate Wound Healing ◽  
Liquid Extract ◽  
Active Substances

Damage to the skin is quite common in everyday life of a person and represents a loss of the integrity of the protective barrier of the skin, which can create conditions for the development of a local inflammatory process, as well as for the penetration of pathogens of various diseases into the human body. In order to more quickly restore the damaged area of the skin, it is important to accelerate wound healing through the use of combined drugs, including antiseptics and biologically active substances of natural origin, stimulating the natural local regenerative process. One of such rational combinations is the combination of chlorhexidine bigluconate and Japanese Sophora fruit liquid extract in the composition of the wound-healing preparation. Medicinal sticks are presented as the most rational dosage form for a wound-healing drug of the specified composition. The application of this dosage form to the treated surface leads to the formation of a thin, firmly adhering film, which evenly releases the active substances and protects the wound from external influences. The indicated positive properties of medicinal pencils are achieved due to the selection of a rational component composition of excipients with a set of necessary characteristics, among which the most significant is the ability to provide optimal release of active substances. In this regard, the purpose of this study was to conduct comparative biopharmaceutical studies to optimize the component composition of medicinal pencils with wound healing action containing chlorhexidine bigluconate and liquid extract of sophora fruit. The objects of research were Japanese Sophora fruits harvested in 2020 in the Krasnodar Territory that meet the requirements of regulatory documents; substance-solution of chlorhexidine bigluconate 20%; auxiliary substances of lipophilic and hydrophilic nature: solid paraffin, beeswax, cocoa butter, anhydrous lanolin, polyethylene oxide-400, polyethylene oxide-1500. To assess the degree of release of active substances from experimental compositions, the method of diffusion into agar was used, based on the diffusion of active substances from the dosage form into an agar gel containing a solution of ferric chloride as an indicator. It was found that the most suitable combination of auxiliary components of the dosage form, providing the best release of active substances, is a combination including solid paraffin (20 parts), beeswax (20 parts), anhydrous lanolin (20 parts), polyethylene oxide-1500 (10 parts), polyethylene oxide-400 (20 parts).

scholarly journals Senna leaves: component composition, pharmacological properties, standardization

2021 ◽  
Vol 24 (2) ◽  
pp. 53-65
Author(s):  
Anna A. Romanyuk ◽  
Dmitry V. Moiseev
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Component Composition ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Anthracene Derivatives ◽  
The Russian Federation ◽  
The Republic ◽  
Active Substances

Objective: generalization and analysis of scientific data on the component composition, pharmacological properties and standardization of senna leaves. Materials and methods. The article provides an overview of scientific publications in the journals of the search platforms Scopus and PubMed, as well as the databases of the Russian Science Citation Index. The analysis of the range of herbal medicinal products was carried out according to the data of the State Registers of Medicines of the Republic of Belarus, the Russian Federation and the Republic of Kazakhstan using content analysis, comparison and generalization of data. Results. In addition to the laxative effect, determined by the presence of anthracene derivatives in senna leaves, the complex of their biologically active substances has antimicrobial, hypoglycemic, antioxidant, antifungal and antitumor effects. Also, the chemical composition of the plant is represented by fatty acids, triglycerides, flavonoids, macro- and microelements. The analysis of medicinal herbal preparations based on senna leaves registered in the Russian Federation, the Republic of Belarus and the Republic of Kazakhstan has been carried out. The differences in the methods of their standardization, given in the normative documentation on quality, have been revealed. The scientific experience of using the method of high performance liquid chromatography for the determination of anthracene derivatives in senna leaves is generalized. Conclusion. The complex of biologically active substances of senna leaves exhibits various pharmacological effects, which, possibly, will expand the range of combined preparations based on them. The use of a modern and selective method of high-performance liquid chromatography in the analysis of senna leaves is a very promising direction in the field of standardization of this type of medicinal plant material.

scholarly journals Assessment of Monoterpene Components in Wild Rose Petals Extract

2020 ◽  
Vol 21 (2) ◽  
pp. 254-262
Author(s):  
Koval Inna
Keyword(s):  
Gas Chromatography ◽  
Steam Distillation ◽  
Botanical Garden ◽  
Component Composition ◽  
Biologically Active ◽  
National Academy Of Sciences ◽  
Volatile Organic ◽  
Rose Petals ◽  
Academy Of Sciences ◽  
Active Substances

The content, component composition, and main directions of the use of monoterpenes of wild rose petals compounds are considered in the research. The study on six wild rose species was carried out in the collection of M.M. Gryshko National Botanical Garden of the National Academy of Sciences of Ukraine. Volatile organic compounds were isolated by steam distillation, and their determination was performed by means of gas chromatography. R. rugosa petals contained the highest number of monoterpenoids, while R. canina petals – the lowest. In our research twentyone different (acyclic, monocyclic, bicyclic) monoterpenoids were identified, including alcohols, aldehydes, ethers, and ketones. All groups of monoterpenoids are biologically active substances and have a significant effect on the aroma of the studied plants.

scholarly journals Biologically active substances from Achillea nobilis L.

2020 ◽  
Vol 100 (4) ◽  
pp. 52-59
Author(s):  
А.S. Kishkentayeva ◽  
◽  
S.N. Mantler ◽  
М.М. Zhakanov ◽  
S.М. Adekenov ◽  
...  
Keyword(s):  
Climatic Factors ◽  
Raw Materials ◽  
Sesquiterpene Lactones ◽  
Component Composition ◽  
Hot Water ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Phytochemical Study ◽  
Plant Raw Materials ◽  
Active Substances

The review summarizes data on biologically active compounds of Achillea nobilis L. and methods of their isolation. From Achillea nobilis L., collected in different places of growth, the following have been isolated: essential oil, the main components of which are monoterpene compounds; sesquiterpene lactones estafiatin, hanphyllin, anobin, chrysartemine A, canin, anolide and tanapartin-β-peroxide; the steroid acetyleucanbin; flavonoids: 3,5-dihydroxy-6,7,8-trimethoxyflavone, 5-hydroxy-3,6,7,4’-tetramethoxyflavone and 5,3’-di-hydroxy-3,6,7,4’-tetramethoxyflavone. It has been determined that the component composition of the essen-tial oil of Achillea nobilis L. largely depends on the soil and climatic factors in the places of its growth, the phase of the growing season and the method of its extraction from plant raw materials, and the extractant used (chloroform, ethanol, hot water, diethyl ether). Antibacterial, antimicrobial, antioxidant, antiparasitic activi-ties are characteristic both for the sums of extractive substances from Achillea nobilis L. and for individual compounds isolated from them. Methods for the isolation of biologically active substances from Achillea nobilis L. for the development of new drug substances are described. The main aim of this work was a com-parative analysis of the available research results on the phytochemical study of Achillea nobilis L.

scholarly journals Microalgae: A Promising Source of Valuable Bioproducts

Biomolecules ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1153 ◽  
Author(s):  
Vyacheslav Dolganyuk ◽  
Daria Belova ◽  
Olga Babich ◽  
Alexander Prosekov ◽  
Svetlana Ivanova ◽  
...  
Keyword(s):  
New Technologies ◽  
Value Added ◽  
Component Composition ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
High Productivity ◽  
Advantages And Disadvantages ◽  
Valuable Compounds ◽  
Promising Source ◽  
Active Substances

Microalgae are a group of autotrophic microorganisms that live in marine, freshwater and soil ecosystems and produce organic substances in the process of photosynthesis. Due to their high metabolic flexibility, adaptation to various cultivation conditions as well as the possibility of rapid growth, the number of studies on their use as a source of biologically valuable products is growing rapidly. Currently, integrated technologies for the cultivation of microalgae aiming to isolate various biologically active substances from biomass to increase the profitability of algae production are being sought. To implement this kind of development, the high productivity of industrial cultivation systems must be accompanied by the ability to control the biosynthesis of biologically valuable compounds in conditions of intensive culture growth. The review considers the main factors (temperature, pH, component composition, etc.) that affect the biomass growth process and the biologically active substance synthesis in microalgae. The advantages and disadvantages of existing cultivation methods are outlined. An analysis of various methods for the isolation and overproduction of the main biologically active substances of microalgae (proteins, lipids, polysaccharides, pigments and vitamins) is presented and new technologies and approaches aimed at using microalgae as promising ingredients in value-added products are considered.

scholarly journals The pharmaco-technological studies of the tablet solid dosage form for the treatment of otolarynological diseases

2020 ◽  
pp. 51-60
Author(s):  
М. К. Гулзода ◽  
A. У. Рахмонов ◽  
К. С. Махсудов ◽  
Р. С. Мусоєв ◽  
С. M. Мусозода ◽  
...  
Keyword(s):  
Dosage Form ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Technological Properties ◽  
Medicinal Products ◽  
Solid Dosage Form ◽  
Plant Raw Materials ◽  
Solid Dosage ◽  
Active Substances

The prevalence of acute respiratory diseases, the particular severity of their course, as well as the frequent relapses and complications require constant search for new, more effective and safe medicines for their prevention and treatment and introduction of these drugs into clinical practice. Generally, most of the medications used in the treatment of acute respiratory viral infections have a number of side effects. Currently, one of the promising areas of pharmacy is the study of biologically active substances, the medicinal plant raw material, and production of extracts and herbal medicines based on them. Objective – pharmaceutical development of a scientifically based composition, technology for obtaining anti-inflammatory and antimicrobial tablets developed on the basis of a selected and standardized plant substance-a thick extract of the leaves of sage nutmeg, which grows in Tajikistan.  When solving the task used the methods of evaluating the technological properties of LRS, physico-chemical properties of plant extracts, physical and technological properties of the mass for tabletting, pharmaco-technological tests of the developed tabletsa study of quantitative content of biologically active substances was determined by Pharmacopoeia methods. The developed solid dosage form with thick extract of sage leaves can be registered as a medicinal product, and the developed technology of tablets with thick extract of sage leaves can be of interest to manufacturers of medicinal products from plant raw materials. The developed methods can be used in laboratories for the detection and quantitative determination of BAS in plant raw materials of Clary sage leaves and medicinal products from this LRS. Thus, based on the results of pharmacological and technological research, we have developed a technology for obtaining a thick extract of sage nutmeg and tablets based on it for the treatment of otolaryngological diseases, which in turn is of interest for further research of the developed drug and its introduction into production.

STUDY OF WOUND-HEALING EFFECTS OF EXTRACTS OF CERTAIN PLANTS OF THE ARID ZONE

2021 ◽  
Vol 1 (3) ◽  
pp. 335-342
Author(s):  
A.S. Baimukhambetova ◽  
◽  
M.A. Egorov ◽  
A.K. Azhikova ◽  
D.K. Magzanova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Plant Species ◽  
Tissue Repair ◽  
Arid Zone ◽  
Glycyrrhiza Glabra ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
White Rats ◽  
Glycyrrhiza Glabra L ◽  
Active Substances

In an experiment on white rats, the regenerating effect of biologically active substances of plant species growing in the Astrakhan region was shown: Achillea micrantha Willd., Helichrysum arenarium, Glycyrrhiza glabra L., Helichrysum nogaicum Tzvel. The article presents data from planimetric studies of damaged skin. The results obtained make it possible to consider extracts as the basis of tissue repair stimulants, as well as to recommend them as anti-inflammatory and wound healing agents.

scholarly journals An Overview of Cutaneous Wounds and the Beneficial Roles of Medicinal Plants in Promoting Wound Healing

2021 ◽  
Author(s):  
Nura Muhammad Umar ◽  
Thaigarajan Parumasivam ◽  
Seok-Ming Toh
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Molecular Mechanisms ◽  
Chronic Wounds ◽  
Therapeutic Agents ◽  
Biologically Active ◽  
Cutaneous Wounds ◽  
Active Substances ◽  
Significant Attention

It is undeniable that many patients worldwide suffer from various types of wounds, especially from chronic wounds. The complex and intricate process of wound healing has a severe impact on the patient's quality of life as well as causing an economic burden on healthcare institutions. Although various new therapies have become available for treating patients with acute and chronic wounds for the past decade, the available therapies are often expensive or accompanied by undesirable side effects. Hence, the discovery of a new arsenal for wound healing remains a hot topic of research. Recently, plants or herbs and their derivatives have garnered significant attention as a source of therapeutic agents to treat wounds. This is because plants provide a rich reservoir of phytochemicals that could potentially become effective and affordable therapeutic agents. Thus, the present review attempted to outline wound healing mechanisms and analysed some renowned medicinal plants with potential wound healing properties from the existing literature from various electronic databases. This review also sheds light on the plant's underlying molecular mechanisms and, wherever available, acknowledges the biologically active substances found in these plants.

scholarly journals Accumulation of biologically active substances in plants of Elsholtzia stauntonii Benth. grown in the foothill zone of the Crimea

2020 ◽  
Vol 202 (11) ◽  
pp. 76-84
Author(s):  
Ol'ga Pehova ◽  
Lidiya Timasheva ◽  
Irina Danilova ◽  
Irina Belova
Keyword(s):  
Essential Oil ◽  
Raw Materials ◽  
Dry Weight ◽  
Component Composition ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Active Growth ◽  
The Crimea ◽  
Active Substances

Abstract. The purpose of the research was to study the quality of Elsholtzia stauntonii Benth. raw materials grown in the foothill zone of the Crimea. In the course of the research, we studied such indicators as the content of essential oil and other types of biologically active substances (BAS), which allow using elsholtzia as an essential oil, food, or medicinal raw materials. Research methods. Determination of the quality of E. stauntonii raw materials was carried out according to generally accepted methods. Results. Peculiarities of the accumulation of essential oil in various organs of E. stauntonii were determined. The variability of the mass fraction of essential oil, its component composition and BAS depending on the plant’s growth stage is shown. We found that the main oil-synthesizing organs of E. stauntonii are leaves and inflorescences. The largest amount of essential oil (1.82 %) was obtained from inflorescences. In the fractional composition of raw materials, they amounted to 45.6 %. The maximum amount of essential oil with the dominant components (rosefuran and rosefuran epoxide) accumulated in plants during the phase of mass flowering (1.48 % in terms of absolutely dry weight). The highest content of BAS, namely phenolic compounds, accumulated in the stage of active growth of vegetative and the formation of generative organs of plants (regrowth and bud formation); extractives – in the stage of regrowth. During two years of storage of air-dry raw materials, there is a loss of essential oil as a result of its evaporation (54.0 %) and a change in its component composition (an increase in monoterpene derivatives of furan by 26.6 % and a decrease in sesquiterpene hydrocarbons by 23.5 %). To store air-dry raw materials of E. stauntonii for more than two years is not, however, reasonable because of significant losses of essential oil. Scientific novelty. The quality of raw materials of E. stauntonii variety Rozovoe oblako, which was grown in the foothill zone of the Crimea, was studied for the first time. Raw materials and essential oil of E. stauntonii have a broad spectrum of biological activity and can be used in medicine, as well as in essential oil and food industries.

scholarly journals Some biochemical characteristics of species of the genus Monarda

2021 ◽  
Vol 38 ◽  
pp. 00098
Author(s):  
Anastasia Petruk ◽  
Irina Lobanova ◽  
Elisaveta Bolotnik
Keyword(s):  
High Performance Liquid Chromatography ◽  
High Performance ◽  
Botanical Garden ◽  
Component Composition ◽  
Biologically Active ◽  
Biochemical Characteristics ◽  
Ethanol Extracts ◽  
Academy Of Sciences ◽  
Analytical Hplc ◽  
Active Substances

The paper presents a comparative study of the content and composition of biologically active substances of the aboveground parts of plants of some Monarda species cultivated in the Botanical Garden, Ural Branch of Russian Academy of Sciences, Ekaterinburg. The greatest quantity of flavones, tannins were found in M. citriodora Cerv. ex Lag., carotenoids, pectins, saponins in M. fistulosa L., pectins in M. didyma L., protopectins in M. media Will. The component composition of the phenolic complex of the samples was studied by high-performance liquid chromatography on an analytical HPLC-system Agilent 1200. 70% ethanol extracts of plants of Monarda species contained at least 35 compounds of phenolic nature, including flavones luteolin, luteolin 7-glucoside, chlorogenic acid.

scholarly journals Sulfated Polysaccharides From Sea Algae as the Basis of Modern Biotechnologies for Creating Wound Coverings: Current Achievements and Coming Prospects

2020 ◽  
Author(s):  
Boris Andryukov ◽  
Natalya Besednova ◽  
Tatyana Kuznetsova ◽  
Tatyana Zaporozhets ◽  
Svetlana Ermakova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Trial Data ◽  
Biological Properties ◽  
Biologically Active ◽  
Wound Dressings ◽  
Sulfated Polysaccharides ◽  
Accelerate Wound Healing ◽  
In Vivo Experiments

Wound healing involves a complex cascade of cellular, molecular, and biochemical responses and signaling processes. It consists of successive interrelated phases, the duration of which depends on multifactorial processes. Wound treatment is a major healthcare issue that can be resolved by development of effective and affordable wound dressings based on natural materials and biologically active substances. Proper use of modern wound dressings can significantly accelerate wound healing with minimal cosmetic defects. The innovative biotechnologies for creating modern natural interactive dressings are based on sulfated polysaccharides from seaweeds with their unique structures and biological properties, the availability of their sources in the form of wild bushes, and in the form of aquaculture, as well as with a high potential for participation in process control wound healing. These natural biopolymers are a novel and promising biologically active source for designing wound dressings based on alginates, fucoidans, carrageenans, and ulvans, which serve as active and effective therapeutic tools. The aim of this review is to summarize available information about the modern wound dressing’s technologies based on seaweed-derived polysaccharides, including those successfully implemented in commercial products, with the emphasis on promising and innovative designs. The further prospect of using marine biopolymers is related to the need to analyze the results of numerous in vitro and in vivo experiments, summarize clinical trial data, develop a scientifically based approach and relevant practical recommendations for the treatment of wounds.

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