scholarly journals Effectiveness of Ficus Elastica Roxb. Ex Hornem Leaf Extract in Reducing Total Cholesterol Level in High Fat Induced Diet Wistar Male Rats

2020 ◽  
Author(s):  
Muhamad Seto Sudirman ◽  
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Ethanol Extract ◽  
Study Groups ◽  
Male Rats ◽  
Plant Metabolites ◽  
Quasi Experimental ◽  
Mean Differences ◽  
Biology Laboratory

ABSTRACT Background: Kebo rubber leaves (ficus elastica roxb) contain flavonoids, polyphenols, and tannins. Flavonoids in the leaves of ficus elastica roxb such as catechins, isoflavones are polyphenolic antioxidants from plant metabolites. The leaves of ficus elastica roxb are trusted and proven empirically in the community to reduce cholesterol levels in the blood. Mice choose animals because they are considered to have physiological similarities with humans. This study aimed to determine the effect of ethanol extract of ficus elastica roxb leaves on reducing total cholesterol level in male Swiss Webster mice. Subjects and Method: This was a quasi-experimental study conducted at Biology Laboratory of the Faculty of Agriculture, Fisheries and Biology, University of Bangka Belitung from April to June, 2017. A sample of 25 male Swiss Webster mice was selected at random and allocated into groups. The dependent variable was total cholesterol. The independent variable was the extract of ficus elastica rox. The data were tested by One-Way ANOVA. Result: There were statistically significant mean differences among the study groups (p= 0.002), indicating the effect of ethanol extract of Ficus Elastica Roxb leaves on reducing total cholesterol level in male Swiss Webster mice at various doses. Conclusion: There are statistically significant mean differences among the study groups, indicating the effect of ethanol extract of Ficus Elastica Roxb leaves on reducing total cholesterol level in male Swiss Webster mice at various doses. Keyword: Ethanol extract of Ficus Elastica Roxb leaves, total cholesterol, mice Correspondence: Muhamad Seto Sudirman. School of Health Polytechnic, Pangkalpinang. Email: [email protected] DOI: https://doi.org/10.26911/the7thicph.05.10

scholarly journals ANALISIS POTENSI ANTIHIPERKOLESTEROLEMIA EKSTRAK ETANOL BUAH ASAM JAWA (Tamarindus indica L) TERHADAP STRUKTUR MIKROSKOPIS HATI MENCIT (Mus musculus)

2018 ◽  
Vol 18 (2) ◽  
pp. 86-92
Author(s):  
Ervina Dewi ◽  
Fadliyani Fadliyani ◽  
Ismiranda Ismiranda
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Block Design ◽  
Ethanol Extract ◽  
Normal Diet ◽  
High Cholesterol Diet ◽  
Microscopic Structure ◽  
Randomized Block Design ◽  
Structure Observation

Abstrak. Penelitian ini bertujuan untuk mengetahui potensi antihiperkolesterolemia ekstrak etanol buah asam jawa terhadap struktur mikroskopis hati mencit. Rancangan yang digunakan adalah Rancangan Acak Lengkap, terdiri atas 6 perlakuan dan 4 ulangan. Perlakuan terdiri atas Pemberian pakan standard dan akuades (P0), pakan aterogenik dan Aquades (P1), pakan aterogenik dan simvastatin 10 mg (P2), pakan aterogenik dan ekstrak asam jawa 5, 25 dan 50 mg/kg bb (P3, P4, P5). Volume simvastatin dan ekstrak etanol buah asam jawa adalah 0,5mL. Pembuatan sediaan histologis menggunakan metode parafin. Parameter yang diamati adalah kadar kolesterol total, infiltrasi lemak, degenerasi lemak dan nekrosa hepatosit. Data hasil penelitian dianalisis dengan analisis varian dan dilanjutkan dengan Uji Berjarak ganda Duncan. Hasil penelitian menunjukkan ekstrak etanol buah asam jawa berpengaruh nyata dalam menurunkan rerata infiltrasi lemak, degenerasi lemak dan nekrosa sel hati yan diindikasikan dengan penurunan kadar kolesterol secara bermakna. Kesimpulannya,  ekstrak etanol buah asam jawa mampu menurunkan rerata infiltrasi lemak, degenerasi lemak dan nekrosa sel hati mencit akibat pakan aterogenikKata Kunci : Pakan Aterogenik, Hiperkolesterolemia, Hati, Ekstrak Etanol Buah Asam Jawa, SimvastatinAbstract. This research aimed to determine  the potential  antihypercholesterolemic of ethanol extract of tamarind  at heart microscopic structure of mice induced with high cholesterol diet. A completely randomized-block design was used with 6 treatments and 4 repetitions of eachtreatment. The treatments were normal diet and aquadest (P0), hight-fat diet and aquadest (P1), hight-fat diet and Simvastatin 10 mg/Kg (P2), hight-fat diet and tamarind extract 5, 25 and 50 mg/Kg (P3, P4, P5). The volume of Simvastatin and tamarind extract given to each mice is 0,5 mL. Paraffin method was apllied of microscopic structure observation. The parameters observed were  total cholesterol level, lipid infiltration, lipid degeneration and necrosis of hepatocyte of hepatocyte. A variance analysis followed by Duncan Multiple Range Test was tested to the data mice microscopic structure. The result showed that etnanol extract of tamarind could significant to decrease of lipid infiltration, lipid degeneration and necrosis of hepatocyte showed decrease total cholesterol level. Inconlusion, the that etnanol extract of tamarind  could significant to  decrease of lipid infiltration, lipid degeneration and necrosis of hepatocyte due to hight-fat diet.Key Word : Atherogenic Feed, Hypercholesterolemia, Liver, Ethanol Extract of Tamarind, Simvastatin

scholarly journals Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar

2019 ◽  
Vol 2 (1) ◽  
pp. 1-10
Author(s):  
Nuralifah Nuralifah ◽  
Wahyuni Wahyuni ◽  
Parawansah Parawansah ◽  
Ulan Dwi Shintia
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Blood Lipids ◽  
Total Cholesterol Level ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Antioxidant Compounds ◽  
Cholesterol Levels ◽  
Fat Consumption

Hyperlipidemia is an increase of lipid due to excessive fat consumption, that the intake and alteration of lipid is not balanced. Notika are plants that contain secondary metabolites in the form of flavonoids, tannins, saponins and triterpenoids which are antioxidant compounds that are thought to have the effect of reducing blood lipids. This study aims to determine the effect of ethanol extract of leaves of Notika on decreasing total cholesterol levels in rats induced by egg and propylthiouracil (PTU). This research was experimental in 6 groups, namely 4 groups given ethanol extract of leaves of Notika at a dose of 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB, one group was given Na CMC 0.5% as a negative control, and one group was given simvastatin 10 mg as a positive control. The results showed that the ethanol extract of the leaves of Notika significantly reduced the total cholesterol level of rats with a significant value 0.05 and 300 mg/kgBB is an effective dose to reduce total cholesterol level.

scholarly journals Prevention of Increasing Total Cholesterol Level Using Cowpea Yoghurt

2020 ◽  
Vol 3 (1) ◽  
pp. 38
Author(s):  
Maulana Rahmat Hidayatullah
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Lipoprotein Metabolism ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
Metabolism Disorder ◽  
Significant Difference ◽  
Coa Reductase

Atherosclerosis is lipoprotein metabolism disorder which is marked by an increase of total cholesterol level in blood serum. Cowpea contains a lot of isoflavones that can inhibit the activity of the enzyme HMG-CoA reductase in the cholesterologenesis process. The aim of this study is to find out cowpea yogurt which can prevent the increasing total cholesterol level. This study used an experimental study with a post-test only control group design in 30 male rats. It was divided into 5 groups: Results showed that the total cholesterol level among the fifth group was a significant difference (Kruskal-Wallis, p = 0,000). The conclusion of this study is cowpea yogurt can prevent the increasing total cholesterol levels of Wistar rats induced by a high-fat diet.

scholarly journals Mean Differences of Total Cholesterol Levels among Vegetarians and Non-Vegetarians at Maha Vihara Maitreya Duta Palembang, Indonesia

2021 ◽  
Vol 56 (3) ◽  
pp. 197
Author(s):  
Lathifah Nudhar ◽  
Subandrate Subandrate ◽  
Susilawati Susilawati ◽  
Liniyanti Oswari
Keyword(s):  
Risk Factor ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Nutritional Intervention ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Fat Consumption ◽  
Cross Sectional Design ◽  
Mean Differences

Total cholesterol level is one of the risk factor of cardiovascular disease. The proportion rate of hypercholesterolemia in Indonesia remains high, numbering around one third of (35,9%) Indonesians. Hypercholesterolemia is a modifiable risk factor, one of early measures that can be taken to prevent hypercholesterolemia is nutritional intervention. A dietary pattern high in plant sources and lower fat consumption has been recommended by several health organisation for prevention of hypercholesterolemia. This study was intended to determine mean difference of cholesterol level between vegetarian and nonvegetarian in Maha Vihara Maitreya Duta Palembang. This was an observational analytical study with cross-sectional design. A total of 173 subjects at Maha Vihara Maitreya Duta Palembang was included which consist of 80 Vegetarian and 93 Nonvegetarian. Measurement of total cholesterol level was done using rapid diagnostic test (RDT) Autocheck® Multi Monitoring System and parametric Independent T Test was chosen as method of statistical analysis. p <0.001 indicates significant differences of total cholesterol level between vegetarian (172,51± 39,05 mg/dL ) and nonvegetarian (228,67±68,07 mg/dL) groups. The mean differences of total cholesterol of vegetarian group is 56,16 mg/dl lower than non vegetarian groups. A significant differences exist in total cholesterol level between vegetarian and non vegetarian group at Maha Vihara Maitreya Duta Palembang. Vegetarian groups has lower total cholesterol level compared to nonvegetarian.

scholarly journals THE EFFECT OF MELON SEEDS FLOUR (Cucumis Melo L.) TOWARD TOTAL CHOLESTEROL LEVEL IN WHITE MALE WISTAR STRAIN RATS (Rattus Norvegicus)

2018 ◽  
Vol 12 (2) ◽  
pp. 151
Author(s):  
Maruni Wiwin Diarti ◽  
Erlin Yustin Tatontos ◽  
Yunan Jiwintarum ◽  
Anggun Sari Mianti
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Cucumis Melo ◽  
Total Cholesterol Level ◽  
White Male ◽  
The Body ◽  
Male Rats ◽  
Wistar Strain ◽  
Melon Seeds ◽  
Cucumis Melo L

Abstract: Cholesterol is an important element in the body, but in high quantities, it can cause atherosclerosis that will eventually possess an impact on coronary heart disease. One of the foods that can reduce cholesterol is a food contains flavonoids which is found in melon seeds (Cucumis melo l.). It contains high fiber that can reduce either of excessive insulin or blood fat levels. The objective study was to determine the effect of Melon seeds flour Toward Total Cholesterol Level in White Male Wistar Strain Rats. This research was carried out with pre-expriment research design, used One group pretest-postest with 5 male wistar strain rats. Data collected in the form of data examination results of total cholesterol level before and after introducing Melon seeds flour. The mean result of total cholesterol test in white male rats before giving Melon seeds flour was 261 mg / dL, whereas the result of total cholesterol test after giving Melon seeds flour was 190.2 mg/dL. Cholesterol levels decreased by 70.8 mg/dl. In short, presenting Melon seeds flour (Cucumis melo l.) for 14 days can decrease total cholesterol level in white male wistar rats. Keywords: Melon Seeds, wistar strain, total cholesterol.

MANFAAT JERUK NIPIS (CITRUS AURANTIFOLIA) DAN OLAHRAGA UNTUK MENURUNKAN KOLESTEROL TOTAL KLIEN DEWASA

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Yunus Elon ◽  
Jacqueline Polancos
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Sampling Technique ◽  
Blood Cholesterol ◽  
Lime Juice ◽  
Citrus Aurantifolia ◽  
Significant Difference ◽  
Blood Total Cholesterol ◽  
Quasi Experimental

ABSTRAK Pendahuluan: Tanpa penanganan kesehatan,klien hiperkolesterolemia akan mengalami komplikasi penyakit kardiovaskular dan bahkan kematian. Berolahraga dan pengobatan antihiperlipidemia dapat menurunkan resiko tersebut. Jeruk nipis (Citrus Aurantifolia) mengandung fitokimia yang memiliki efek menurunkan kolesterol darah. Tujuan: Untukmengetahui efek dari terapi jeruk nipis dan terapi jeruk nipis dibarengi olaraga terhadap penurunan kadar kolesterol total darah. Metode: Penelitian ini menggunakan quasi-experimental research design dengan membandingkan dua kelompok intervensi. Teknik sampling purposive digunakan untuk memilih 20 orang partisipan yang secara acak dibagi dalam 2 kelompok intervensi. Partisipan di kelompok pertama meminum jus jeruk nipis 1,5 cc/kgbb setiap pagi selama 7 hari. Sedangkan partisipan di kelompok kedua meminum jus jeruk nipis dengan dosis yang sama ditambah dengan olahraga 30 menit perhari selama 6 hari. Hasil: Rata-rata kadar kolesterol total responden pada kedua kelompok sebelum dan sesudah intervensi menunjukkan perubahan yang signifikan (p=<.05). Sedangkan skor pencapaian oleh kedua kelompok menunjukkan perbedaan yang tidak signifikan. Diskusi: Terapi jus jeruk nipis efektif  menurunkan kadar kolesterol darah karena kandungan fitokimianya yang aktif sebagai agen hipolipidemik.   Kata Kunci: Jeruk nipis, Kadar kolesterol darah ABSTRACT Introduction: Without health management, hypercholesterolemic clients would have cardiovascular diseases as complication, and even death. Exercise and anti-hyperlipidemic medication can decreased these health risks Lime (Citrus aurantifolia) possess phytochemicals that have reducing effects on blood cholesterol. Aim: To determine the effects of lime (Citrus aurantifolia) therapy and lime therapy with exercise on reducing blood total cholesterol level. Method: This study utilized a quasi-experimental design which compared two groups intervention. A purposive sampling technique was used to select 20 participants that randomly divided into 2 intervention groups.  Participants in the first group drinks 1,5 cc/kgbw  of lime juice every morning for 7 days. While participants in the second group drinks the same dosage of lime juice with 30 minutes exercise every day for 6 days. Results: The mean of total cholesterol level of participants in both groups before and after intervention reveal a significant changes (p=<.05). While the gain score of the two groups reveals no significant difference. Discussion: Lime juice therapy effective in reducing blood total cholesterol level for its active phytochemicals that acts as hypolipidemic agent. Key words: Cholesterol level, Lime Full printable version: PDF

scholarly journals Mean Differences of Total Cholesterol Levels among Vegetarians and Non-Vegetarians at Maha Vihara Maitreya Duta Palembang, Indonesia

2020 ◽  
Vol 56 (3) ◽  
pp. 197
Author(s):  
Lathifah Nudhar ◽  
Subandrate Subandrate ◽  
Susilawati Susilawati ◽  
Liniyanti Oswari
Keyword(s):  
Risk Factor ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Nutritional Intervention ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Fat Consumption ◽  
Cross Sectional Design ◽  
Mean Differences

Total cholesterol level is one of the risk factor of cardiovascular disease. The proportion rate of hypercholesterolemia in Indonesia remains high, numbering around one third of (35.9%) Indonesians. Hypercholesterolemia is a modifiable risk factor, one of early measures that can be taken to prevent hypercholesterolemia is nutritional intervention. A dietary pattern high in plant sources and lower fat consumption has been recommended by several health organisation for prevention of hypercholesterolemia. This study was intended to determine mean difference of cholesterol level between vegetarian and nonvegetarian in Maha Vihara Maitreya Duta Palembang. This was an observational analytical study with cross-sectional design. A total of 173 subjects at Maha Vihara Maitreya Duta Palembang was included which consist of 80 Vegetarian and 93 Nonvegetarian. Measurement of total cholesterol level was done using rapid diagnostic test (RDT) Autocheck® Multi Monitoring System and parametric Independent T Test was chosen as method of statistical analysis. p<0.001 indicates significant differences of total cholesterol level between vegetarian (172.51± 39.05 mg/dL) and nonvegetarian (228.67±68.07 mg/dL) groups. The mean differences of total cholesterol of vegetarian group is 56,16 mg/dl lower than non vegetarian groups. A significant differences exist in total cholesterol level between vegetarian and non vegetarian group at Maha Vihara Maitreya Duta Palembang. Vegetarian groups has lower total cholesterol level compared to nonvegetarian.

Pengaruh Pemberian Terapi Oksigen Hiperbarik Terhadap Kadar Kolesterol Total Pada Tikus Putih (Rattus novergicus) Jantan Galur Wistar Yang Di Induksi Diet Tinggi Lemak

2018 ◽  
Vol 16 (1) ◽  
pp. 1 ◽  
Author(s):  
AZRUL HILDAN SAFRIZAL
Keyword(s):  
Cardiovascular Disease ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
High Fat Diet ◽  
Oxygen Therapy ◽  
Total Cholesterol Level ◽  
High Fat ◽  
Cholesterol Levels

<p>The pattern and lifestyle of today's society with the presence of an interner facility makes people spend more time sitting out than on exercise and increased consumption of high-fat foods may increase the risk of cardiovascular disease. An effective therapy is needed in preventing the occurrence of cardiovascular disease. Hyperbaric oxygen now starts to develop for the treatment of several diseases, which in turn can increase the gene forming antioxidant enzymes and ROS. To determine effect of hyperbaric oxygen therapy on total cholesterol levels of wistar white rats (Rattusnovergicus) induced bye high fat. The study was carried out in an expeative post test only group control of three groups. One group is given standard feed. All groups induced high-fat diet and standard feed. Of the two groups induced, one group was given hyperbaric oxygen therapy with a dose of 3 x 30 minutes for six days on day 7 at a blood test to determine total cholesterol levels<strong>. </strong>One way Anova parametric statistic test showed that p = 0.007 &lt; α proved hypothesis that hyperbaric oxygen therapy giving effect to total cholesterol level of white mice of jantangalurist rings induced by high fat diet. Total cholesterol was significantly different between K (-) and K (+) and between K (-) and P. It was found that hyperbaric oxygen therapy had an effect on total cholesterol level dose of 3x30 minutes for six days.</p>

Tracking of Serum Cholesterol Levels in a Multiracial Sample of Preschool Children

PEDIATRICS ◽  
1992 ◽  
Vol 90 (1) ◽  
pp. 80-86 ◽  
Author(s):  
David S. Freedman ◽  
Tim Byers ◽  
Karen Sell ◽  
Sarah Kuester ◽  
Eva Newe1l ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Initial Level ◽  
Total Cholesterol Level ◽  
Relative Weight ◽  
Cholesterol Levels ◽  
Final Measurement ◽  
Subsequent Measurement ◽  
Initial Measurement

The relation of an initial measurement of serum total cholesterol to subsequent levels over a (mean) 13-month interval was examined in a multiracial (white, Hispanic, American Indian, and black) sample of 1680 one- to four-year-olds. Although the relation of the initial level to the final measurement (r = .54) did not vary by race, sex, relative weight, or changes in relative weight, the association increased with age at the time of the initial measurement (eg, r .64 among 4-year-olds). Based on the initial and final total cholesterol determinations, the within-person standard deviation was 21 mg/dL and the coefficient of variation was 13%. Although the final total cholesterol level was within 5 mg/dL of the initial level for 18% of the children, the two determinations differed by ≥25 mg/dL for about 35% of the children and by ≥50 mg/dL for about 8%. Of the 149 children who had an initial cholesterol level ≥200 mg/dL, 34% (about five times the expected number) had a follow-up level that was similarly elevated whereas 25% had a subsequent measurement below 170 mg/dL. The results indicate that although an initial cholesterol level in early life is moderately predictive of subsequent levels, it may be difficult to interpret a single total cholesterol determination because of substantial within-person variability.

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