scholarly journals Nutrient Composition, Antioxidant Activities and Anti-Inflammatory Effect of Jujube Fruit

2021 ◽  
Vol 11 ◽  
pp. 164-174
Author(s):  
Suha M. Sabri ◽  
Hamed R. Takruri ◽  
Khalid M. Al Ismail
Keyword(s):  
Antioxidant Activities ◽  
Biologically Active ◽  
Promoting Effect ◽  
Biological Studies ◽  
Jujube Fruit ◽  
Mediterranean Regions ◽  
Health Promoting ◽  
Health And Disease ◽  
Ziziphus Jujuba ◽  
Anti Inflammatory

Jujube (Ziziphus jujuba) fruit belongs to the Rhamnaceous family and is widely located in the tropical and subtropical regions of Asia as well as in the Mediterranean regions including Jordan. Therefore, the aim of this review was to illustrate the nutritional value of jujube fruit and its importance in human health protection as antioxidant and anti-inflammatory agent. Recently, several scientific reports have been carried out about the presence of many biologically active compounds from Z. jujuba, which may have high potential benefit in human nutrition, health, and disease. Based on previous studies, jujube fruit can possess good antioxidant and anti-inflammatory activity rendering it a functional food. Since jujube fruit has diverse biological activity, further biological studies including clinical-based studies are recommended to explore the health promoting effect of jujube.

scholarly journals Melatonin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice

2021 ◽  
Vol 14 (8) ◽  
pp. 822
Author(s):  
Shijia Pan ◽  
Fan Hong ◽  
Letong Li ◽  
Yuan Guo ◽  
Xiaoxiao Qiao ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Antioxidant Activities ◽  
Intestinal Barrier ◽  
Inflammatory Cells ◽  
Inhibitory Effect ◽  
Immune Defense ◽  
Dextran Sodium Sulfate ◽  
Obese Mice ◽  
Promoting Effect ◽  
Anti Inflammatory

Epidemiological studies have indicated that obesity is an independent risk factor for colitis and that a high-fat diet (HFD) increases the deterioration of colitis-related indicators in mice. Melatonin has multiple anti-inflammatory effects, including inhibiting tumor growth and regulating immune defense. However, the mechanism of its activity in ameliorating obesity-promoted colitis is still unclear. This study explored the possibility that melatonin has beneficial functions in HFD-induced dextran sodium sulfate (DSS)-induced colitis in mice. Here, we revealed that HFD-promoted obesity accelerated DSS-induced colitis, while melatonin intervention improved colitis. Melatonin significantly alleviated inflammation by increasing anti-inflammatory cytokine release and reducing the levels of proinflammatory cytokines in HFD- and DSS-treated mice. Furthermore, melatonin expressed antioxidant activities and reversed intestinal barrier integrity, resulting in improved colitis in DSS-treated obese mice. We also found that melatonin could reduce the ability of inflammatory cells to utilize fatty acids and decrease the growth-promoting effect of lipids by inhibiting autophagy. Taken together, our study indicates that the inhibitory effect of melatonin on autophagy weakens the lipid-mediated prosurvival advantage, which suggests that melatonin-targeted autophagy may provide an opportunity to prevent colitis in obese individuals.

scholarly journals Synthesis and biological evaluation of coumarin derived chalcones as potent antimicrobial and antioxidant agents

2019 ◽  
Vol 10 (SPL1) ◽  
Author(s):  
Vijay Kotra ◽  
Lean Yen Long ◽  
Praveena Devi CHB ◽  
Long Chiau Ming
Keyword(s):  
Antioxidant Activities ◽  
Aromatic Aldehydes ◽  
Biological Evaluation ◽  
Biologically Active ◽  
Ortho Position ◽  
Antioxidant Agents ◽  
Anti Cancer ◽  
Simple Class ◽  
Anti Inflammatory ◽  
Anti Hiv

Coumarin derivatives are important biologically active compounds with anti-cancer, antimicrobial, anti-inflammatory, anti-HIV, anti-oxidant, anti-coagulant, anti-tubercular, anti-psychotic, and anti-malarial activities. Chalcones are the most common and simple class of aromatic five-membered heterocycles with anti-cancer, anti-oxidative, antibiotic, anthelmintic, anti-inflammatory, anti-hypertensive, and anti-HIV activities. Based on the above literature, an attempt was made to synthesize some new styryl coumarin derived chalcones and evaluated for antimicrobial and antioxidant activities. Acetyl 7-methyl coumarins were synthesized from 4-methyl salicylaldehyde, which on treating with various aromatic aldehydes in the presence of alkalinemethanol yielded various coumarin chalcone derivatives. These molecules on treating with various aromatic aldehydes yielded the title compounds (SCC 1-10). The synthesized title compounds were evaluated for antimicrobial and antioxidant activities. All the synthesized compounds were characterized by IR, NMR, and mass spectroscopy and screened for antimicrobial and antioxidant activities. Among the compounds SCC 1-10, compound SCC 7, 9, and 10 showed potent activity, and compounds 3, 4 and 8, showed moderately potent antibacterial activity.  Compounds SCC 3, 7, 9 showed potent and compounds 5, 6, and 8 showed moderately potent antifungal activity. Compounds SCC 3, 4, 7, and 9 showed potent antioxidant activity. From the results, it was concluded that the compounds bearing nitro and chloro group have shown prominent activity when compared to compounds without these groups. It was also confirmed that the groups in para position showed better activity when compared to the groups in ortho position. The above results establish the fact that styrylcoumarin fused with chalcone can be a rich source for exploitation.

scholarly journals An Integrated Characterization of Jujube (Ziziphus jujuba Mill.) Grown in the North Adriatic Region

2019 ◽  
Vol 57 (1) ◽  
pp. 17-28
Author(s):  
Ana Miklavčič Višnjevec ◽  
Ajda Ota ◽  
Dunja Bandelj ◽  
Nataša Poklar Ulrih ◽  
Milena Bučar-Miklavčič ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Positive Impact ◽  
Dry Mass ◽  
Biologically Active ◽  
Aqueous Extracts ◽  
Local Variety ◽  
Jujube Fruit ◽  
Ziziphus Jujuba

Jujube (Ziziphus jujuba Mill.) has favourable horticultural properties including adaptation to arid conditions, abiotic and biotic stresses, as well as positive impact on human health. The present study describes the characterization of genetic diversity of the germ­plasm of jujube from the Istrian peninsula, the determination of important chemical compounds, antioxidative properties in relation to antibacterial and antifungal activities of jujube fruit extracts, and the determination of nutritional properties of jujube fruit. The results of the genetic analysis showed that most of the samples from the Istrian peninsula belong to two recently introduced varieties, 'Li' and 'Lang', and the most widespread local variety 'Navadna žižola'. The local variety has smaller fruit than the ‘Li’ and ‘Lang’ varieties, with thick and fleshy mesocarp. Chemical analysis indicated that fruits of the local variety contained a valuable source of dietary fibre ((9.7±0.6) g/100 g) and were rich in minerals such as (in g/100 g dry mass): potassium (829±51), calcium (177±11) and phosphorus (129±19). Aqueous extracts showed slight antibacterial activity, while ethanol extracts had higher mass fractions of phenolic compounds (expressed as gallic acid equivalents (GAE), 5.8-8.7 mg/g) than the aqueous extracts, but did not show antimicrobial activity. Compounds other than phenolic compounds in jujube fruit may be more biologically active. Based on the results of these analyses, the local Istrian jujube variety is a promising candidate for cultivation potential.

scholarly journals Lactobacillus Bacteria in Breast Milk

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3783
Author(s):  
Katarzyna Łubiech ◽  
Magdalena Twarużek
Keyword(s):  
Breast Milk ◽  
Growth And Development ◽  
Early Stage ◽  
The Body ◽  
Biologically Active ◽  
Promoting Effect ◽  
Genus Lactobacillus ◽  
Health Promoting ◽  
Nutritional Needs ◽  
The Many

Breast milk is an optimal food for infants and toddlers. The composition of breast milk adapts to the needs of the developing organism, satisfying nutritional needs at an early stage of growth and development. The results of research to date have shown that breast milk is the best food for a child, containing not only nutrients but also biologically active substances that aid in the optimal, proper growth and development of infants. Among the many components of breast milk, an important element is the probiotic microflora, including bacteria of the genus Lactobacillus spp. These organisms exert a multidirectional, health-promoting effect on the body of children who consume breast milk. The number of lactic acid bacteria, including Lactobacillus, colonizing the breast milk environment and their species diversity varies and depends on many factors, both maternal and environmental. Breast milk, as a recommended food for infants, is an important source of probiotic microflora. The aim of this study was to present the current understanding of probiotic bacteria of the genus Lactobacillus present in breast milk.

scholarly journals Biochemical Composition of Cumin Seeds, and Biorefining Study

Biomolecules ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1054 ◽  
Author(s):  
Othmane Merah ◽  
Bouchra Sayed-Ahmad ◽  
Thierry Talou ◽  
Zeinab Saad ◽  
Muriel Cerny ◽  
...  
Keyword(s):  
Essential Oils ◽  
Antioxidant Activities ◽  
Industrial Process ◽  
Antibacterial Activities ◽  
Promoting Effect ◽  
Yield And Quality ◽  
Health Promoting ◽  
First Time ◽  
By Products ◽  
Potential Use

A new biorefinery approach has been developed in the present study, and applied on cumin (Cuminum cyminum) seeds as a potential source of phytochemicals of interest. Cumin is a popular spice used widely for its distinctive aroma. It is a rich reserve of both vegetable and essential oils. The biorefinery approach here focused on the evaluation of the influence of four different geographical origins (i.e., Lebanon, France, Algeria and Syria) on oil yield and quality in cumin seed, and on the valorization of remaining by-products by investigating their nutritional content and biological activity for the first time. Vegetable and essential oils were extracted, and their compositions were determined. Nutritional traits were also assessed. The delipidated and hydrodistillated cakes just as aromatic water were characterized for their fiber, sugar, protein, phenol and flavonoid contents. Antibacterial and antioxidant activities were also determined. Cumin seeds showed high contents in both vegetable and essential oils, proteins and sugars regardless their origin. Moreover, this Apiaceae species exhibited high levels of petroselinic fatty acid (an isomer of oleic acid) and sterols. Cakes and aromatic water also presented high levels of proteins, fibers, sugars and phenols. These residues revealed interesting antioxidant and antibacterial activities. These results emphasized the potential use of cumin in a biorefinery concept, with a multi-purpose industrial process. In addition, large differences were observed between the four geographical origins for phytochemical contents and compositions. These findings highlight the perspectives for developing selection programs for nutritional traits and industrial interests. All obtained results validate the health promoting effect of cumin composition as well as its industrial importance along with the residues.

An insight into the dermatological applications of neem: a review on traditional and modern aspect

2021 ◽  
Vol 16 ◽  
Author(s):  
Varinder Singh ◽  
Meghaditya Roy ◽  
Nidhi Garg ◽  
Amit Kumar ◽  
Sandeep Arora ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Antioxidant Activities ◽  
Complex Compounds ◽  
Health Concern ◽  
Skin Delivery ◽  
Skin Cancers ◽  
Health Promoting ◽  
Dermatological Disorders ◽  
Ancient Times ◽  
Anti Inflammatory

Background : Dermatological disorders are cutaneous infirmities that are frequently occurring and increasing at an alarming rate. These range from mild itching/redness (dermatitis) to fatal skin cancers and have posed a major health concern. Azadirachta indica A. Juss (commonly known as neem), a member of the Meliaceae family, is an Indian medicinal plant that has been known for its health-promoting effects since ancient times. Objective: The review highlights the traditional practices, pharmacological aspects, and formulation approach of neem for the treatment of dermatological disorders. Further, recent patents and novel delivery systems (developed and in the pipeline) improving skin delivery and the therapeutic profile of neem are discussed. Results : Neem is a traditional medicinal plant that has been employed for the prevention and treatment of numerous ailments covering systemic and topical disorders. Scientific studies have validated the traditional claims of neem and attributed these health benefits to the present more than 300 structurally diverse and complex compounds. It possesses anti-inflammatory, antibacterial, analgesic, antiviral, antifungal, immunomodulatory, and antioxidant activities which substantiate its use as skin therapy. Various novel formulations and associated patents that improved the permeability of neem-based products across skin could be found in the literature. Conclusion : Critical appraisal of available literature revealed that neem possesses anti-microbial, anti-inflammatory, antioxidant, and antiseptic properties. Thus it has the potential to be developed as a single effective therapy for the management of multimodal skin disorders. Further, pharmaceutical tailoring of neem by implication of novel carriers could enhance its penetrability across the skin.

Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder

2020 ◽  
Vol 28 (2) ◽  
pp. 360-376 ◽  
Author(s):  
Atefeh Amiri ◽  
Maryam Mahjoubin-Tehran ◽  
Zatollah Asemi ◽  
Alimohammad Shafiee ◽  
Sarah Hajighadimi ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Antioxidant Activities ◽  
Natural Compounds ◽  
Therapeutic Effects ◽  
Inflammatory Disorder ◽  
Inflammatory Disorders ◽  
Therapeutic Modalities ◽  
Anti Cancer ◽  
Current Therapies ◽  
Anti Inflammatory

: Cancer and inflammatory disorders are two important public health issues worldwide with significant socio.economic impacts. Despite several efforts, the current therapeutic platforms are associated with severe limitations. Therefore, developing new therapeutic strategies for the treatment of these diseases is a top priority. Besides current therapies, the utilization of natural compounds has emerged as a new horizon for the treatment of cancer and inflammatory disorders as well. Such natural compounds could be used either alone or in combination with the standard cancer therapeutic modalities such as chemotherapy, radiotherapy, and immunotherapy. Resveratrol is a polyphenolic compound that is found in grapes as well as other foods. It has been found that this medicinal agent displays a wide pharmacological spectrum, including anti-cancer, anti-inflammatory, anti-microbial, and antioxidant activities. Recently, clinical and pre-clinical studies have highlighted the anti-cancer and anti-inflammatory effects of resveratrol. Increasing evidence revealed that resveratrol exerts its therapeutic effects by targeting various cellular and molecular mechanisms. Among cellular and molecular targets that are modulated by resveratrol, microRNAs (miRNAs) have appeared as key targets. MiRNAs are short non-coding RNAs that act as epigenetic regulators. These molecules are involved in many processes that are involved in the initiation and progression of cancer and inflammatory disorders. Herein, we summarized various miRNAs that are directly/indirectly influenced by resveratrol in cancer and inflammatory disorders.

Redox-Active Selenium in Health and Disease: A Conceptual Review

2019 ◽  
Vol 19 (9) ◽  
pp. 720-726 ◽  
Author(s):  
Boguslaw Lipinski
Keyword(s):  
Food Supplement ◽  
Biologically Active ◽  
Immune Recognition ◽  
Potential Candidate ◽  
Irreversible Damage ◽  
Human Fibrinogen ◽  
Virus Attachment ◽  
Redox Active ◽  
Health And Disease ◽  
Highly Hydrophobic

Although it is generally accepted that selenium (Se) is important for life, it is not well known which forms of organic and/or inorganic Se compound are the most biologically active. In nature Se exists mostly in two forms, namely as selenite with fourvalent and selenate with sixvalent cations, from which all other inorganic and organic species are derived. Despite a small difference in their electronic structure, these two inorganic parent compounds differ significantly in their redox properties. Hence, only selenite can act as an oxidant, particularly in the reaction with free and/or protein- bound sulhydryl (SH) groups. For example, selenite was shown to inhibit the hydroxyl radicalinduced reduction and scrambled reoxidation of disulfides in human fibrinogen thus preventing the formation of highly hydrophobic polymer, termed parafibrin. Such a polymer, when deposited within peripheral and/or cerebral circulation, may cause irreversible damage resulting in the development of cardiovascular, neurological and other degenerative diseases. In addition, parafibrin deposited around tumor cells produces a protease-resistant coat protecting them against immune recognition and elimination. On the other hand, parafibrin generated by Ebola’s protein disulfide isomerase can form a hydrophobic ‘spike’ that facilitates virus attachment and entry to the host cell. In view of these specific properties of selenite this compound is a potential candidate as an inexpensive and readily available food supplement in the prevention and/or treatment of cardiovascular, neoplastic, neurological and infectious diseases.

Sign in / Sign up

Export Citation Format

Share Document