Serum Vitamin D, Calcium and Phosphate among children with pneumonia

Background: Vitamin D is partly responsible for maintaining calcium and phosphate homeostasis but has been shown to have immune modulatory functions. Objective: To measure serum levels of vitamin D, and plasma levels of calcium and phosphate in children with pneumonia and compare with those of apparently healthy controls. Methods: A cross-sectional study involving seventy-six children with pneumonia, matched with 76 apparently healthy controls. Results: There was no statistically significant difference in the mean serum vitamin D levels between the cases and the controls (t = 1.190, p = 0.236). The mean serum vitamin D level was significantly higher in children with non-severe pneumonia than in those with severe pneumonia (t = 3.299, p = .002). The mean serum vitamin D level was higher among the controls than those with severe pneumonia (t = 2.674, p = 0.009). The mean plasma calcium and phosphate levels in the controls were significantly higher than in the cases (t = 2.528, p = .013 and t = 4.594, p < .001 respectively). Plasma calcium and phosphate levels did not vary with the severity of pneumonia. Pneumonia was independently associated with the occurrence of hypocalcaemia and hypophosphataemia (OR = 4.366, 95% CI = 1.851-10.295, p = 0.001; OR = 7.355, 95% CI = 1.545-35.027, p = 0.01 respectively). Conclusion: Children with severe pneumonia had lower levels of vitamin D than those with the non-severe disease. Derangements in plasma levels of calcium and phosphate are common in children with pneumonia, and these abnormalities occur independently of low vitamin D levels.

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Comparison of Vitamin D Levels in AMI patients and Healthy Individuals

10.53350/pjmhs211581896 ◽

2021 ◽

Vol 15 (8) ◽

pp. 1896-1898

Author(s):

Aisha Bashir ◽

Asima Karim ◽

Asia Kanwal ◽

Asma Salam

Keyword(s):

Vitamin D ◽

Cell Biology ◽

Serum Vitamin ◽

Healthy Controls ◽

Healthy Individuals ◽

Lower Serum ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Mean

Background: Research reports that serum Vitamin D levels are deficient in AMI patients. Aim: To compare serum Vitamin D levels between AMI patients and healthy controls. Methods: Study design was Cross Sectional Comparative. The study was conducted at Department of Physiology & Cell Biology, University of Health Sciences, Lahore 2018 to 2019. Serum vitamin D levels were measured in 80 study subjects. Among 80 study subjects, 40 had AMI and 40 were healthy controls. Results: The serum Vitamin D levels less than 20ng/ml were considered deficient. Mann Whitney U test was used to compare the groups. The mean serum Vitamin D levels of the AMI patients were significantly lower (7±2.47ng/ml) as compared to healthy controls (17.17±4.8ng/ml) at (p=0.000). Conclusion: AMI patients have significantly lower serum Vit. D levels as compared to healthy individuals. Keywords: Acute myocardial infarction, Serum Vitamin D

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No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20160173 ◽

2017 ◽

Vol 75 (1) ◽

pp. 3-8 ◽

Cited By ~ 4

Author(s):

Yara Dadalti Fragoso ◽

Tarso Adoni ◽

Soniza Vieira Alves-Leon ◽

Samira L. Apostolos-Pereira ◽

Walter Oleschko Arruda ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Large Population ◽

Serum Vitamin ◽

Serum Levels ◽

Serum Vitamin D ◽

Control Subjects ◽

Vitamin D Levels ◽

The Mean ◽

25 Oh Vitamin D

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

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Vitamin D levels in children with COVID-19: a report from Turkey

Epidemiology and Infection ◽

10.1017/s0950268821001825 ◽

2021 ◽

Vol 149 ◽

Author(s):

Aysegul Alpcan ◽

Serkan Tursun ◽

Yaşar Kandur

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Statistical Significance ◽

Serum Vitamin ◽

University Hospital ◽

Control Group ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Normal Vitamin ◽

The Mean

Abstract Several studies have demonstrated that higher levels of vitamin D are associated with better prognosis and outcomes in infectious diseases. We aimed to compare the vitamin D levels of paediatric patients with mild/moderate coronavirus disease 2019 (COVID-19) disease and a healthy control group. We retrospectively reviewed the medical records of patients who were hospitalised at our university hospital with the diagnosis of COVID-19 during the period between 25 May 2020 and 24 December 2020. The mean age of the COVID-19 patients was 10.7 ± 5.5 years (range 1–18 years); 43 (57.3%) COVID-19 patients were male. The mean serum vitamin D level was significantly lower in the COVID-19 group than the control group (21.5 ± 10.0 vs. 28.0 ± 11.0 IU, P < 0.001). The proportion of patients with vitamin D deficiency was significantly higher in the COVID-19 group than the control group (44% vs. 17.5%, P < 0.001). Patients with low vitamin D levels were older than the patients with normal vitamin D levels (11.6 ± 4.9 vs. 6.2 ± 1.8 years, P = 0.016). There was a significant male preponderance in the normal vitamin D group compared with the low vitamin D group (91.7% vs. 50.8%, P = 0.03). C-reactive protein level was higher in the low vitamin D group, although the difference did not reach statistical significance (9.6 ± 2.2 vs. 4.5 ± 1.6 mg/l, P = 0.074). Our study provides an insight into the relationship between vitamin D deficiency and COVID-19 for future studies. Empiric intervention with vitamin D can be justified by low serum vitamin D levels.

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Vitamin D levels in children with otitis media with effusion

QJM ◽

10.1093/qjmed/hcab094.017 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Ahmed Adly Mohamed ◽

Marwa Mohamed EL-Begermy ◽

Ahmed Abdelmoneim Teaima ◽

Mohamed Ali Abdelghafar

Keyword(s):

Vitamin D ◽

Otitis Media ◽

Otitis Media With Effusion ◽

Serum Vitamin ◽

Control Group ◽

University Hospitals ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D ◽

The Mean

Abstract Objective To investigate the relationship between otitis media with effusion (OME) and serum vitamin D level in children. Methods This prospective case control study was conducted at Ain Shams University Hospitals between February 2018 and May 2019. The study population included 50 children with OME confirmed by tympanometry type (B) who will undergo adenotonsillectomy and grommet tube insertion compared to 50 children without OME confirmed by tympanometry type (A) who will undergo adenotonsillectomy. Measurement of serum 25-hydroxy vitamin D using electrochemiluminescence technique from a blood sample (3cm) taken from them on the day of surgery. Results In this study, the mean age of the cases was 4.24 ± 0.80 and 5.34 ± 1.19 years for the controls besides 23 (46%) of the OME group were boys and 27 (54%) were girls, compared with 29 (58%) boys and 21 (42%) were girls in the control group. The mean levels of vitamin D in children with OME was 16.24 ± 7.14 ng/mL and in children in the control group was 15.89 ± 5.84 ng/mL (P = 0.815) and it was statistically non significant. Conclusion There was no significant relation between vitamin D serum level and the incidence of OME in children.

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Association of Serum Vitamin D Levels and Stress Fractures in Collegiate Athletes

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120966967 ◽

2020 ◽

Vol 8 (12) ◽

pp. 232596712096696

Author(s):

David Millward ◽

Allison D. Root ◽

Jeremy Dubois ◽

Randall P. Cohen ◽

Luis Valdivia ◽

...

Keyword(s):

Vitamin D ◽

Stress Fracture ◽

Serum Vitamin ◽

Stress Fractures ◽

Serum Vitamin D ◽

Outdoor Sports ◽

Vitamin D Levels ◽

Study Results ◽

The Mean ◽

Indoor Sports

Background: Low vitamin D levels along with high-intensity athletic training may put an athlete at increased risk for a stress fracture. Purpose: To assess whether supplementation with vitamin D is associated with a reduced risk of stress fractures in college athletes. We also assessed differences in vitamin D levels among athletes participating in outdoor versus indoor sports. Study Design: Cohort study; Level of evidence, 2. Methods: The study participants included 802 National Collegiate Athletic Association Division I intercollegiate athletes (497 men and 305 women) on a sports team for at least 1 semester from 2012 to 2018. All athletes who had a baseline vitamin D level in their medical record were included. Athletes with vitamin D levels <40 ng/mL were given vitamin D supplements. We assessed differences in the rate of stress fracture among those who maintained or improved vitamin D levels to ≥40 ng/mL and those who did not, as well as differences in average baseline vitamin D levels by sport type (indoor vs outdoor). Results: The rate of stress fracture was 12% higher (95% CI, 6-19; P < .001) for those who remained low in vitamin D compared with those who were low at baseline but improved their vitamin D status to ≥40 ng/mL. The rate of stress fracture was also 12% higher (95% CI, 5-18; P < .001) for those who had low vitamin D levels compared with those who maintained normal levels. The mean baseline vitamin D values were significantly higher for men participating in outdoor sports versus indoor sports. For men, the mean vitamin D level was 5.7 ng/mL higher (95% CI, 0.9-10.5; P = .01) in outdoor athletes. For women, the mean vitamin D level was 3.7 ng/mL higher (95% CI, –0.58 to 8.03; P < .04) for outdoor versus indoor sports. Conclusion: Study results indicated that correcting low serum vitamin D levels reduces the risk of stress fracture. This study also presented evidence that athletes who participate in indoor sports may be at greater risk for vitamin D deficiency than those who compete in outdoor sports.

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Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients With SARS Corona Virus-2 Infection

ACTA MEDICA IRANICA ◽

10.18502/acta.v59i11.7779 ◽

2021 ◽

Author(s):

Ali Asgari ◽

Ebrahim Hazrati ◽

Saeed Soleiman-Meigooni ◽

Mohsen Rajaeinejad ◽

Sam Alahyari ◽

...

Keyword(s):

Vitamin D ◽

Disease Severity ◽

Odds Ratio ◽

Laboratory Data ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Corona Virus ◽

Vitamin D Levels ◽

The Mean ◽

General Wards

The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease. To evaluate the relation between serum vitamin D3 level, the disease severity, and prognosis of the patients with SARS Corona virus-2 infection. Patients with COVID-19 were evaluated for serum vitamin D levels and laboratory data. Correlation between vitamin D levels and laboratory data with disease severity and prognosis was assessed. Cox and logistic regression tests, as well as ROC curves, were used for data analysis. Ninety-eight patients with Corona virus-2 disease (COVID-19), which consisted of sixty patients with moderate COVID-19 in the general wards, and thirty-eight patients with severe COVID-19 in the intensive care unit (ICU), were evaluated. The mean age in the general wards was lower than in ICU (60.96±14.86 compared to 67.94±16.46, P=0.001), and the mean serum vitamin D level in the patients admitted in the general wards was higher than in the ICU (31 ng/mL compared to 20.57 ng/mL, P=0.003). Furthermore, vitamin D deficiency (25 (OH) D <25 ng/ml) significantly increased the risk of severe disease. (odds ratio=2.91, P=0.019) and mortality (odds ratio=3.64, P=0.026). Vitamin D deficiency is a risk factor for disease severity and poor prognosis in COVID-19. Vitamin D levels of 25 ng/mL can be used as a cut-off value for predicting severity and prognosis.

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Serum vitamin D and immunoglobulin E levels in children of allergic rhinitis: a case-control study from Central India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20212044 ◽

2021 ◽

Vol 8 (6) ◽

pp. 1038

Author(s):

Payasvi Baweja Sachdeva ◽

Sheloj Joshi ◽

Shweta Anand

Keyword(s):

Vitamin D ◽

Case Control Study ◽

Immunoglobulin E ◽

Serum Vitamin ◽

Serum Ige ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

The Mean ◽

Control Study

Background: Allergic rhinitis (AR) is the commonest type of non-infective rhinitis. Genetic and environmental factors play an important role in the development of the disease. Researchers are having interest in knowing the role of vitamin D in the pathogenesis of allergy. Immunoglobulin E (IgE) is integral to the pathogenesis of allergic disorders. However, the relationship between serum IgE levels and AR is still a matter of debate. Thus, this study aimed to know serum IgE and serum 25 (OH) vitamin D levels in patients with clinically diagnosed AR and control group.Methods: A case-control study was performed from May 2019 to October 2019 in LNMC and JK hospital. All 54 children with physician diagnosed AR aged 12 to 18 years of both genders who have come in the OPD (total enumeration sampling) during the above mentioned period were enrolled into the study and their 54 healthy counterparts are taken as controls. Other parameters such as age, gender, occupation and region of residence were also compared between the groups.Results: This study found highly significant difference in the mean serum IgE levels while there is a significant difference in the mean serum vitamin D levels between two groups.Conclusions: The study group with AR had significantly higher mean level of serum IgE and lower mean serum vitamin D levels as compared to control groups. However, upon stratification of vitamin D levels, the differences were insignificant. Further studies should be conducted to know the value of IgE as a prognostic factor of AR severity and to throw more light on association of vitamin D with AR.

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association of Serum Vitamin D levels with Hypertension

Esculapio ◽

10.51273/esc20.2516312 ◽

2020 ◽

Vol 16 (03, july 2020-Septmber 2020) ◽

Author(s):

Maryam Rao ◽

◽

Tabinda Kazmi ◽

Muhammad Imran ◽

Aamir Mahmood ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Healthy Controls ◽

Healthy Individuals ◽

Key Words Hypertension ◽

Cross Sectional ◽

Serum Vitamin D ◽

Cardiology Department ◽

Potential Association ◽

Vitamin D Levels

Objectives: The objective of our study was to identify the effect of low serum vitamin D levels on hypertension & to make a comparison of levels of vitamin D in hypertensives and healthy individuals. Materials and Method: A cross-sectional comparative study carried out in Cardiology Department of Shaikh Zayed Hospital and Punjab Institute of Cardiology, which involved measurement and comparison of serum Vitamin D levels in 64 subjects, categorized in two groups; hypertensives and normotensives, in order to establish a potential association between vitamin D levels and hypertension. Results: Our study showed that Serum Vitamin D was equally sub-optimal in all participants of study, including both hypertensive group and the healthy controls. As a result of this finding, a clear pattern of association of vitamin D deficiency with hypertension could not be seen. Mean ±SD Vitamin D levels was 19.5±10.0 ng/L in hypertensives and 19.5±13.6 in healthy individuals. This study did not lead to establishment of an association between hypertension and vitamin D levels. Conclusion: Because of deficiency of Vitamin D in general population in this region, our study failed to show an association between Vitamin D and hypertension. Further exploration is needed in this regard. Key words: Hypertension, serum Vitamin D levels

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COMBINATORIAL EFFECT OF LEPTIN, TUMOR NECROSIS FACTOR-ΑLPHA, AND VITAMIN D IN PROGRESSION OF TYPE 2 DIABETES IN KASHMIRI POPULATION

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i10.28097 ◽

2018 ◽

Vol 11 (10) ◽

pp. 477 ◽

Cited By ~ 1

Author(s):

Sabhiya Majid ◽

Fouzia Rashid ◽

Ishrat Hussain ◽

Rakesh K Koul ◽

Jasiya Qadir ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Tumor Necrosis ◽

Serum Vitamin ◽

Healthy Controls ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Tnf Α ◽

Necrosis Factor

Objectives: Type 2 diabetes mellitus (T2DM) is a metabolic disorder usually characterized by hyperglycemia. Adipose tissue secretes bioactive substances known as adipocytokines including leptin, tumor necrosis factor-alpha (TNF-α), and adiponectin. These are considered as a bridge connecting obesity and insulin resistance. There is considerable epidemiological evidence to suggest a role of Vitamin D deficiency in the etiology of T2DM. This study was performed to evaluate and compare serum Vitamin D and adipocytokine levels in T2DM patients and healthy controls of Jammu and Kashmir region of India.Methods: A total of 200 T2DM patients and normal 200 healthy controls were considered for the study. Enzyme-linked immunosorbent assay was used to measure serum leptin and TNF-α levels. The Vitamin D levels were measured by chemiluminescent microparticle immunoassay method. Biochemical parameters were measured by the enzymatic method.Results: Our results concluded that basic metabolic parameters, TNF-α and leptin levels were significantly higher in cases than controls. The serum Vitamin D levels were found significantly lower among T2DM patients. No correlation of Vitamin D with leptin was observed in cases and controls. However, a positive correlation between leptin and TNF-α was noted in T2DM subjects as well as in controls with statistical significance being higher in females (r=0.500; p=0.001) as compared to males (r=0.298; p=0.036) in T2DM subjects as well as in controls (r=0.659; p=0.001; r=0.621; p=001).Conclusion: These results concluded that lowering of Vitamin D levels and upregulation of leptin and TNF-α altogether play an important role in the development of T2DM, and from correlation analysis, it could be predicted that leptin and TNF-α act in a synergistic manner toward the development of T2DM.

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Vitamin D and Ulcerative Colitis: Is There a Relationship with Disease Extent?

Digestive Diseases ◽

10.1159/000494439 ◽

2018 ◽

Vol 37 (3) ◽

pp. 208-213

Author(s):

Stefania Chetcuti Zammit ◽

John Schembri ◽

Anthea Pisani ◽

Sarah Vella ◽

Matthias Azzopardi ◽

...

Keyword(s):

Ulcerative Colitis ◽

Vitamin D ◽

Activity Index ◽

Serum Vitamin ◽

Healthy Controls ◽

Mineral Density ◽

Disease Extent ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Low Serum

Introduction: Patients with ulcerative colitis (UC) can suffer from low serum vitamin D that can result in complications such as low bone mineral density. It can also reflect underlying disease severity. Methods: One hundred and ninety-seven patients previously diagnosed with UC from 2 European centers were prospectively recruited through the out-patient clinics. Clinical features (Montreal Classification, age, gender, previous and current medications, surgery), disease activity (Simple Clinical Colitis Activity Index [SCCAI]), blood investigations including serum inflammatory markers, and serum vitamin D were analyzed. The vitamin D levels were compared to a group of age- and gender-matched healthy controls. Results: Mean vitamin D levels were lower in patients with UC (54.6 nmol/L) than in controls (80.7 nmol/L; p = 0.0001). Mean vitamin D levels was lowest in patients with extensive UC (E3; p = 0.0001). Serum vitamin D was not significantly different across treatment groups (p = 0.876). There was no statistical difference in vitamin D levels across patients receiving calcium and vitamin D supplements (p = 0.35) and there was no statistical correlation with SCCAI (p = 0.22). Conclusions: This study confirms the existence of low serum vitamin D in patients with UC when compared to healthy controls. It also provides evidence of an existing relationship between disease extent and serum vitamin D.

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