scholarly journals Morphohistology and Biometric Characteristics of Cecal Tonsils of Sonali Chicken at Post-Hatching Ages

2021 ◽  
Vol 45 (2) ◽  
pp. 1-6
Author(s):  
Ummay Ayman ◽  
Md. A Jahid ◽  
Md. R Alam ◽  
Shonkor K Das
Keyword(s):  
Immune Status ◽  
Study Groups ◽  
Postnatal Life ◽  
Gut Health ◽  
Age Related ◽  
Cecal Tonsil ◽  
Related Development ◽  
Cervical Subluxation ◽  
Haematoxylin And Eosin Stain ◽  
Small And Large Intestine

Knowledge of basic structures is prerequisite for acquiring an in-depth idea about the physiology and immunology of the lymphoid system. The study evaluates the age related histomorphometry of cecal tonsil of Sonali chicken at different postnatal stages in Bangladesh as literatures regarding this are very scarce. The investigation was carried out on 25 healthy Sonali chickens representing different stage of postnatal life: days 1, 14, 28, 42, and 56 (n=5). After ethically sacrifice (cervical subluxation method), cecal tonsil was collected and subjected for both gross and histological studies. Haematoxylin and Eosin stain was done for microscopic study. Morphologically, cecal tonsils were located bilaterally at the junction of small and large intestine. It had tubular structure and yellowish white in color. All gross parameters (weight, length, and width) found to be increased significantly (P<0.05) throughout the whole study period. Weight was measured 0.022±0.001 g at day 1 and noticed 0.181±0.016 g at the end of study tenure. The microscopic observations revealed that at day 28 encapsulated lymphatic nodules was present along with the diffuse lymphocytes at the lamina propria and submucosa layer, which was absent at the previous study groups. At day 1, only small infiltration of lymphocytes was identified and at day 14, lymphocytes were aggregating to form lymphatic nodules. After that, age related development was noticed in histological features. The findings would be a milestone to give an idea about the gut health and immune status of Sonali chicken and provide a basis for further immunization research.

scholarly journals Indicators of the Immune Status in Children after a New Coronavirus Infection

2021 ◽  
Vol 6 (2) ◽  
pp. 58-62
Author(s):  
E. V. Moskaleva ◽  
A. G. Petrova ◽  
L. V. Rychkova ◽  
E. A. Novikova ◽  
A. S. Vanyarkinа
Keyword(s):  
Immune Response ◽  
Immune Status ◽  
Respiratory Infections ◽  
Study Groups ◽  
Long Term Outcomes ◽  
Humoral And Cellular Immunity ◽  
Age Related ◽  
Coronavirus Infection ◽  
Reported Data

Background. The mechanism of the immune response in patients with COVID-19 is still poorly understood and differs from other respiratory infections. Immunodeficiencies and age-related characteristics of immunity can be regarded as factors influencing reinfection and a predisposition to prolonged persistence of SARS-CoV-2. Most of the studies report about post-infection immunity to SARS-CoV-2 for adults and less for children. However, understanding the dynamics of antibody production to SARS-CoV-2 among children as well as other unique features of immune response is extremely important, because this provides to avoid possible complications and long-term outcomes of COVID-19, and predict the epidemic spread of the new coronavirus in the organized groups of children such as kindergartens, schools, study groups and clubs.Aim: to evaluate the humoral and cellular immunity after SARS-CoV-2 infection in children.Materials and methods. We reported data of the first phase prospective cohort study of immunity among 60 children living in Irkutsk, Russia within a month after SARS-CoV-2 infection, which took place in October and November 2020.Results. Immunity of children one month after SARS-Cov-2 infection was characterized by suppressed cell-mediated and humoral immunity, and phagocytosis dysfunction. Reduced phagocytosis by neutrophils was noted for 61.6 % of individuals.Conclusions. Children after COVID-19 had impaired immunity to SARS-CoV-2, which may be a predictor of chronic infection and other long-term outcomes of COVID-19. 

scholarly journals Change by challenge: A common genetic basis behind childhood cognitive development and cognitive training

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Bruno Sauce ◽  
John Wiedenhoeft ◽  
Nicholas Judd ◽  
Torkel Klingberg
Keyword(s):  
Cognitive Development ◽  
Brain Plasticity ◽  
Training Sample ◽  
Age Related ◽  
Central Piece ◽  
Gene Environment ◽  
Related Development ◽  
Explained Variation ◽  
Genetic And Environmental Factors ◽  
Cognitive Challenges

AbstractThe interplay of genetic and environmental factors behind cognitive development has preoccupied multiple fields of science and sparked heated debates over the decades. Here we tested the hypothesis that developmental genes rely heavily on cognitive challenges—as opposed to natural maturation. Starting with a polygenic score (cogPGS) that previously explained variation in cognitive performance in adults, we estimated its effect in 344 children and adolescents (mean age of 12 years old, ranging from 6 to 25) who showed changes in working memory (WM) in two distinct samples: (1) a developmental sample showing significant WM gains after 2 years of typical, age-related development, and (2) a training sample showing significant, experimentally-induced WM gains after 25 days of an intense WM training. We found that the same genetic factor, cogPGS, significantly explained the amount of WM gain in both samples. And there was no interaction of cogPGS with sample, suggesting that those genetic factors are neutral to whether the WM gains came from development or training. These results represent evidence that cognitive challenges are a central piece in the gene-environment interplay during cognitive development. We believe our study sheds new light on previous findings of interindividual differences in education (rich-get-richer and compensation effects), brain plasticity in children, and the heritability increase of intelligence across the lifespan.

scholarly journals Identification of Type II Interferon Receptors in Geese: Gene Structure, Phylogenetic Analysis, and Expression Patterns

2015 ◽  
Vol 2015 ◽  
pp. 1-14
Author(s):  
Hao Zhou ◽  
Shun Chen ◽  
Yulin Qi ◽  
Qin Zhou ◽  
Mingshu Wang ◽  
...  
Keyword(s):  
Expression Profiles ◽  
Expression Patterns ◽  
Harderian Gland ◽  
Distribution Analysis ◽  
Expression Levels ◽  
Age Related ◽  
Cecal Tonsil ◽  
Immune Tissues ◽  
First Time

Interferonγreceptor 1 (IFNGR1) and IFNGR2 are two cell membrane molecules belonging to class II cytokines, which play important roles in the IFN-mediated antiviral signaling pathway. Here, goose IFNGR1 and IFNGR2 were cloned and identified for the first time. Tissue distribution analysis revealed that relatively high levels of goose IFNγmRNA transcripts were detected in immune tissues, including the harderian gland, cecal tonsil, cecum, and thymus. Relatively high expression levels of both IFNGR1 and IFNGR2 were detected in the cecal tonsil, which implicated an important role of IFNγin the secondary immune system of geese. No specific correlation between IFNγ, IFNGR1, and IFNGR2 expression levels was observed in the same tissues of healthy geese. IFNγand its cognate receptors showed different expression profiles, although they appeared to maintain a relatively balanced state. Furthermore, the agonist R848 led to the upregulation of goose IFNγbut did not affect the expression of goose IFNGR1 or IFNGR2. In summary, trends in expression of goose IFNγand its cognate receptors showed tissue specificity, as well as an age-related dependency. These findings may help us to better understand the age-related susceptibility to pathogens in birds.

scholarly journals Bifidobacterial Succession and Correlation Networks in a Large Unselected Cohort of Mothers and Their Children

2012 ◽  
Vol 79 (2) ◽  
pp. 497-507 ◽  
Author(s):  
E. Avershina ◽  
O. Storrø ◽  
T. Øien ◽  
R. Johnsen ◽  
R. Wilson ◽  
...  
Keyword(s):  
Human Populations ◽  
Bifidobacterium Adolescentis ◽  
Content Type ◽  
Individual Level ◽  
Correlation Networks ◽  
Age Related ◽  
Related Development ◽  
Healthy Cohort ◽  
Stool Samples ◽  
The Individual

ABSTRACTBifidobacteria are a major microbial component of infant gut microbiota, which is believed to promote health benefits for the host and stimulate maturation of the immune system. Despite their perceived importance, very little is known about the natural development of and possible correlations between bifidobacteria in human populations. To address this knowledge gap, we analyzed stool samples from a randomly selected healthy cohort of 87 infants and their mothers with >90% of vaginal delivery and nearly 100% breast-feeding at 4 months. Fecal material was sampled during pregnancy, at 3 and 10 days, at 4 months, and at 1 and 2 years after birth. Stool samples were predicted to be rich in the speciesBifidobacterium adolescentis,B. bifidum,B. dentium,B. breve, andB. longum. Due to high variation, we did not identify a clear age-related structure at the individual level. Within the population as a whole, however, there were clear age-related successions. Negative correlations between theB. longumgroup andB. adolescentiswere detected in adults and in 1- and 2-year-old children, whereas negative correlations betweenB. longumandB. brevewere characteristic for newborns and 4-month-old infants. The highly structured age-related development of and correlation networks between bifidobacterial species during the first 2 years of life mirrors their different or competing nutritional requirements, which in turn may be associated with specific biological functions in the development of healthy gut.

Postnatal development of the renin-angiotensin system in rats

1980 ◽  
Vol 238 (5) ◽  
pp. R432-R437 ◽  
Author(s):  
K. B. Wallace ◽  
J. B. Hook ◽  
M. D. Bailie
Keyword(s):  
Steady State ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Rat Plasma ◽  
Neonatal Rat ◽  
Postnatal Life ◽  
Renin Substrate ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Age Related

The purpose of this investigation was to correlate the development of the various enzyme activities associated with the renin-angiotensin system with age-related differences in the steady-state concentrations of angiotensin I (AI) and II (AII). Angiotensin was quantified by radioimmunoassay. Plasma renin activity and concentration increased between birth and 3 wk of age, and declined thereafter to adult values. Renal renin content, on the other hand, increased throughout the first 6 wk of postnatal life. The concentration of AII in plasma also increased following birth; however, maximum concentrations were not attained until 5 wk of age. In contrast, plasma AI did not increase between 3 and 6 wk of age. These data suggest that the steady-state concentration of AII in neonatal rat plasma may be partially limited by the low plasma renin substrate concentration. The increase in AII between 3 and 6 wk of age may reflect the increasing converting enzyme activity.

scholarly journals Effects of dietary seaweed extract supplementation in sows and post-weaned pigs on performance, intestinal morphology, intestinal microflora and immune status

2011 ◽  
Vol 106 (5) ◽  
pp. 688-699 ◽  
Author(s):  
S. G. Leonard ◽  
T. Sweeney ◽  
B. Bahar ◽  
B. P. Lynch ◽  
J. V. O'Doherty
Keyword(s):  
Growth Performance ◽  
Intestinal Microflora ◽  
Immune Status ◽  
Average Daily Gain ◽  
Intestinal Morphology ◽  
Seaweed Extract ◽  
Gut Health ◽  
Weaned Pigs ◽  
Treatment Groups ◽  
Daily Gain

The present study investigated the effects of dietary supplementation of a seaweed extract (SWE) to sows and weaned pigs on post-weaning growth performance, intestinal morphology, intestinal microflora, volatile fatty acid concentrations and immune status of pigs at days 11 and 117 post-weaning. Gestating sows (n20) were supplemented with a SWE (0v.10·0 g/d) from day 107 of gestation until weaning (day 26). At weaning, pigs (four pigs per sow) were divided into two groups based on sow diet during lactation and supplemented with a SWE (0v.2·8 g/kg diet), resulting in four treatment groups: (1) BB (basal sows–basal pigs); (2) BS (basal sows–treated pigs); (3) SB (treated sows–basal pigs); (4) SS (treated sows–treated pigs). Pigs weaned from SWE-supplemented sows had a higher average daily gain (ADG) between days 0 and 21 (P < 0·05) post-weaning compared with pigs weaned from non-SWE-supplemented sows. Pigs offered post-weaning diets (PW) containing SWE had decreased colonicEscherichia colipopulations on day 11 (P < 0·01) and decreased colonic Enterobacteriaceae numbers on day 117 (P < 0·05). Pigs offered PW containing SWE had a greater mRNA abundance ofMUC2in the colon at day 11 post-weaning (P < 0·05) compared with pigs offered unsupplemented diets. In conclusion, these results demonstrate that SWE supplementation post-weaning provides a dietary means to improve gut health and to enhance growth performance in starter pigs. Dietary SWE supplementation increased ADG during the grower–finisher (GF) phases. However, there was no growth response to SWE inclusion in GF diets when pigs were weaned from SWE-supplemented sows.

scholarly journals Differential Effects of Breed and Nursing on Early-Life Colonic Microbiota and Immune Status as Revealed in a Cross-Fostering Piglet Model

2019 ◽  
Vol 85 (9) ◽  
Author(s):  
Chunlong Mu ◽  
Gaorui Bian ◽  
Yong Su ◽  
Weiyun Zhu
Keyword(s):  
Early Life ◽  
Inflammatory Cytokine ◽  
Immune Status ◽  
Interspecific Cross ◽  
Cytokine Expression ◽  
Gut Health ◽  
Content Type ◽  
Nursing Mother ◽  
Colonic Microbiota ◽  
Cross Fostering

ABSTRACT Nursing mother and breed can differently regulate early-life microbiota succession in pigs. However, it remains unclear whether they affect gastrointestinal microbiota and immune status, which are critical for early-life gut health. Here, an interspecific cross-fostering piglet model was employed by fostering neonatal Yorkshire and Meishan piglets to the same or another breed of sows. Jejunal and colonic microbiotas and mucosal immune parameters were analyzed at postnatal days 14 (preweaning) and 49 (postweaning). Nursing mother affected 10 genera in the colon and 3 minor genera in the jejunum. At day 14, Meishan sow-nursed piglets had lower Streptococcus suis and higher Cloacibacillus counts in the colonic digesta and larger amounts of interleukin 10 and Foxp3-positive cells in the colonic mucosa than did Yorkshire sow-nursed piglets. At day 49, nursing mother had no significant effects on cytokine expression. Breed effects were observed; Meishan piglets had lower relative abundances of Prevotella and lower gene expression of tumor necrosis factor alpha (TNF-α) than those of Yorkshire piglets at days 14 and 49. Collectively, nursing mother mainly affected preweaning colonic microbiota and immune status, while breed effects persisted after weaning. Piglets nursed by Meishan sows had different microbiota compositions and inflammatory cytokine profiles in the colon compared with those of piglets nursed by Yorkshire sows. These results highlight the different role of nursing mother and breed in affecting early gut microenvironment. IMPORTANCE Early-life gut microbiota and immune status are pivotal for postnatal growth. By using an interspecific cross-fostering piglet model, we find that change in nursing mother transiently reshapes preweaning colon microbiota and immune status, while breed shows persistent effects both pre- and postweaning. Piglets nursed by Meishan sows had lower Streptococcus suis counts and higher anti-inflammatory cytokine expression. These results highlight the significance of nursing mother in regulating early-life gut health.

scholarly journals Age Related Changes in Weight of the Thymus Gland of Bangladeshi People

1970 ◽  
Vol 8 (1) ◽  
pp. 10-12
Author(s):  
Meherunnessa Begum ◽  
Uttam Kumar Paul ◽  
Md Jahangir Alam
Keyword(s):  
Related Problem ◽  
Immune Status ◽  
Regulatory Mechanism ◽  
Age Groups ◽  
The Body ◽  
Thymus Gland ◽  
Thymus Weight ◽  
Age Related ◽  
Key Words Thymus ◽  
Age Related Changes

Context: Thymus is intimately related to the immuno regulatory mechanism of the body, its weight in general as well as at different age in a particular population might also be related to the overall immune status of that population. Thus the knowledge of the weight of the thymus at different ages may be helpful in planning of the medical and surgical treatment of thymus related problem as well as dealing patients from immunologic aspects Objective: To measure the age related changes in weight of the thymus gland of Bangladeshi people Study design: A descriptive type of study Place and period of study: The study was carried out in the Department of Anatomy, IPGMR Dhaka from October 1996 to March 1997. Materials: 40 (forty) thymuses from Bangladeshi cadaver of either sex were taken for this study. Method: The collected samples were divided into four age groups ranged from still born to sixty years old individuals and comparative studies were done between different age groups. Result: The thymuses increased significantly in weight steadily through the increasing age groups from the still born babies to <16yrs and then declines through the age still higher. Conclusion: In the present study the weight of the thymus increases through the increasing age groups and then declined. Key words: Thymus; Weight DOI: 10.3329/bja.v8i1.6101 Bangladesh Journal of Anatomy January 2010, Vol. 8 No. 1 pp. 10-12

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