scholarly journals A study of some physiological aspects in mature male rabbits after oral administration of Citrullus colocynthis

2012 ◽  
Vol 36 (2) ◽  
pp. 209-216
Author(s):  
Saad S. Al-Dujaily
Keyword(s):  
Body Weight ◽  
Thyroid Gland ◽  
Low Dose ◽  
Hormone Level ◽  
Hematological Parameters ◽  
Physiological Effect ◽  
Mature Male ◽  
The Body ◽  
Citrullus Colocynthis ◽  
Control Groups

The goal of this study is to determine the effect of Citrullus colocynthis (CC) fruit (bitter apple) on some physiological aspects; the body weight, hematological parameters and the function of thyroid gland of male rabbits as a model for mammals. Two experiments were accomplished on sixty mature male rabbits that equally (30 animals in each experiment) and randomly divided into six groups each one contains five animals. In the experiment No.1 and experiment No.2 , independently, three groups were considered as treated groups in each experiment ( represented as T1, T2 and T3 groups ) and daily orally administrated low dose of CC (4.8mg/Kg/day, experiment No.1) for three groups in experiment No.1 and double dose of CC extract (9.6mg /Kg /day , experiment No.2) for 2, 4 and 8 weeks for the three groups in experimentNo.2,respectively. The other three groups in each experiment were considered as control (C1, C2 and C3 groups, respectively) groups were given orally distilled water (DW) at the same periods of treated groups. Different hematological parameters and thyroid hormones were studied. There was a significant (P<0.05) increase in the body weight gaining, with no significant changes in RBCs, WBCs, and Hb concentration through the first two weeks in all the treated rabbits compared to before treatment and control groups. Results of this study revealed that all the groups showed a significant (P<0.05) increased in the serum triiodothyronine hormone level and a decrease in the serum thyroxin hormone level of the thyroid gland when both doses were orally administrated through different periods of treatment compared to control groups. It is concluded that low dose of CC treatment has an advantageous physiological effect on the body weight and triiodothyronine hormone with no changes in certain hematological parameters through first two weeks .The significant differences that found following 4 and 8 weeks of CC treatment were within physiological normal level, and accordingly with the dose and treatment periods in rabbits.

scholarly journals Changes in the thyroid gland during the reproductive cycle of the male vespertilionid bat, Scotophilus heathi

1998 ◽  
Vol 58 (4) ◽  
pp. 707-716 ◽  
Author(s):  
A. KRISHNA ◽  
K. SINGH
Keyword(s):  
Body Weight ◽  
Seasonal Variation ◽  
Thyroid Gland ◽  
Seasonal Change ◽  
Reproductive Cycle ◽  
The Body ◽  
Winter Dormancy ◽  
High Concentration ◽  
Positive Correlation ◽  
Low Concentration

The aim of present study was to compare the changes in thyroid gland with the reproductive cycle of S. heathi. Thyroid showed marked seasonal variation in weight, quantity of colloid and follicular epithelial height, suggesting the thyroid gland to be inactive during quiescence and winter dormancy and active during the time of recrudescence and breeding similarly to the testicular cycle. Plasma thyroxin (T4) concentration showed a significant seasonal change with high concentration during breeding and post-breeding and low concentration during quiescence. However, the T4 concentration increased from breeding to post-breeding phase, when the testes weight was declining. It is suggested that in S. heathi the positive correlation between thyroid and testicular cycles occurs only during the phases of the reproductive cycle when the body weight and testicular activity are also closely correlated.

scholarly journals The Effects of Different Exercise Types on Hematological Parameters in Sedentary Women

2018 ◽  
Vol 6 (8) ◽  
pp. 96 ◽  
Author(s):  
Güner Çiçek
Keyword(s):  
Heart Rate ◽  
Body Weight ◽  
Blood Cell ◽  
Aerobic Exercise ◽  
Hematological Parameters ◽  
Exercise Group ◽  
The Body ◽  
Strength Exercise ◽  
Strength Exercises ◽  
Sedentary Women

The purpose of this study is to investigate the effect of aerobic and strength exercises on hematological parameters in sedentary women. To achieve the purpose of this study, a total of 23 volunteers including aerobic exercise group (AE, n: 10), strength exercise group (SE, n:13) were selected as participants. Two different exercises were applied for 4 days a week, throughout 16 weeks, within 60 minutes for each exercise with the intensity of heart rate (HR) 60-70 percent. The HR was measured using a heart rate monitor for each subject.The women's white blood cell (WBC), thrombocyte (PLT), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT) and mean corpuscular volume (MCV) were measured before and after exercise. For statistical analysis, the Wilcoxon signed-rank test was used for intra-group evaluations, and the Mann Whitney U test was used for inter-group evaluations. After the exercise program, there were a meaningful decrease in the body weight and body mass index (BMI) the women in both intervention groups. In addition, in the hematological results of strength exercise group, some meaningful decreases were determined in the values of RBC, HGB, HCT and MCV (p<0.01). As a results, it was observed that regular aerobic and strength exercises can positively influence the body weight and BMI parameters of sedentary women. Along with this, a meaningful decrease has been found in the values of RBC, HGB, HCT and MCV of strength exercise group compared to aerobic exercise.

scholarly journals Anti-arthritic Evaluation of Different Extracts of Boerhaavia diffusa Linn. in FCA Induced Arthritis In Rats

2018 ◽  
Vol 8 (5-s) ◽  
pp. 388-393 ◽  
Author(s):  
Deepika Parmar ◽  
Neetesh Kumar Jain ◽  
Vivek Tomar
Keyword(s):  
Body Weight ◽  
Phenolic Compounds ◽  
Methanolic Extract ◽  
Hematological Parameters ◽  
Extraction Methods ◽  
The Body ◽  
Haematological Parameters ◽  
Phytochemical Study ◽  
Methanolic Extracts ◽  
Boerhaavia Diffusa

The main aim of study is to evaluate the anti-arthritic effect of different extracts of Boerhaavia diffusa in arthritic rats. Different extracts were prepared by successive solvent extraction methods by using the various polar and non polar solvents and their % yields were calculated. Arthritis was induced by FCA induced arthritis model in rats and paw volume was measured on different days. Body weights of all animals were also measured simultaneously and at the end of experiment some haematological parameters were measured. On preliminary phytochemical studies extracts showed the presence of alkaloids, fatty acids, terpenoids, flavonoids and phenolic compounds. Among all extracts, methanolic extract significantly decreased the paw volume in all treated groups. Methanolic extracts also restored the body weight significantly. The results of our study revealed that all the extracts treated group’s causes significant alterations in the hematological parameters and maximal effects were observed at 400 mg/kg. Since methanolic extract showed best activity in arthritic model and its phytochemical study showed presence of flavonoids and phenolic compounds, so it may be possible that anti-arthritic activity of root extracts may be due to presence flavonoids.  Keywords: Arthritis, FCA induced arthritis, Boerhaavia diffusa, haematological parameters, and Body weight

Acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii (Miq.) Miq. stem bark in rats

2021 ◽  
Vol 10 (2) ◽  
pp. 89-97
Author(s):  
EL Lappa ◽  
◽  
C Bogning Zangueu ◽  
EL Nguemfo ◽  
JJ Kojom Wanche ◽  
...  
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Chronic Toxicity ◽  
Hematological Parameters ◽  
Lethal Dose ◽  
Relative Weight ◽  
Stem Bark ◽  
The Body ◽  
Female Rats ◽  
Male Rats

Ficus vogelii is a medicinal plant mainly found in tropical Africa and reported to treat inflammatory complaints. This study aims to evaluate the acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii stem bark in wistar rats. For acute study, aqueous extract at a single dose of 5000 mg/kg body weight was administered to female rats and observed for 14 days. In the sub-chronic study, the extract was administered daily to both sex rats at the doses of 100, 200, 400, and 600 mg/kg body weight for 28 consecutive days. Body weight was measured weekly, while hematological, biochemical, and histopathological parameters were analyzed after euthanize. Aqueous extract of Ficus vogelii at all tested doses didn’t produced any mortality or significant change on the body weight and relative weight of rats on acute and sub-chronic studies. The lethal dose 50 was estimated greater than 5000 mg/kg (DL50˃5000 mg/kg). Hematological parameters were recorded non-significant in all treated rats. Aqueous extract at 600 mg/kg significantly changed transaminases and alkaline phosphatase activities, these changes were reversible in satellites. The concentrations of bilirubin was increased at 200 and 600 mg/kg in male rats, at 100, 400 mg/kg in female rats. The levels of lipids markers didn’t changed, except the significant decrease of LDL-cholesterol. Histological examination didn’t showed any change in the architecture of the liver and kidney of rats treated compared to control. Thus aqueous extract of Ficus vogelii stem bark didn’t produced adverse effects in rats after oral acute and sub-chronic treatment.

scholarly journals The Clinical and Hematological changes in Rabbits exposed to Melia azedarach fruits under experimental conditions

2015 ◽  
Vol 1 (1) ◽  
pp. 12 ◽  
Author(s):  
AL- Zubaedi Raad Mahmood
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Bleeding Time ◽  
Hematological Parameters ◽  
The Body ◽  
Melia Azedarach ◽  
Control Group ◽  
Clotting Time ◽  
Experimental Conditions ◽  
Hb Concentration

The study was conducted on 10 local breed rabbits, of 1-2 years age, of 1- 1.5 kg body weight. They were feed concentrated and green food, and left ad libitum for water, and kept in room of 20- 25 oC. The animals divided into two groups of 5 each. First as treated group received the plant in powder form mixed with the food at a dose rate of 5 g/ animal / day for three weeks , while the second left without exposure as a control group .The main dependent parameters in the study were , clinical parameters ( body temperature , heartbeat , respiratory rate, body weight , in addition to monitor any abnormal signs appear on the animals . While the main hematological parameters were included , RBC count , WBC count , Hb concentration,PCV percentage , Red cell indices , Bleeding time and Clotting time. The body temperature, respiratory rates, heart rate were increased .The body weight decreased .The bleeding time and clotting time were prolonged. The erythrocyte count, Hb concentration, and MCV values were decreased; PCV and MCHC did not showed any significant changes. The MCH increased. The total leucocytes count and the basophiles percentage did not showed any significant changes. The Heterophils and monocytes percentage increased .The lymphocytic and Eosinophil percentage were decreased during the study.

ASSAY OF THYROTROPHIN BY THE ACCUMULATION OF RADIOACTIVE IODINE IN THE THYROID OF THE INTACT RAT

1955 ◽  
Vol 33 (3) ◽  
pp. 248-255 ◽  
Author(s):  
N. R. Stephenson ◽  
W. P. McKinley ◽  
P. J. Kavanagii
Keyword(s):  
Adverse Effect ◽  
Body Weight ◽  
Thyroid Gland ◽  
Radioactive Iodine ◽  
The Body ◽  
Dosage Group ◽  
Maximum Value ◽  
Weanling Rats ◽  
Response Line ◽  
Dose Levels

The ability of the thyroid gland of intact weanling rats to collect injected radioactive iodine was diminished by inclusion of a small amount of iodinated casein in the diet. The administration of exogenous thyrotrophin increased the thyroidal uptake of I131 in rats treated in this manner. Both the degree of inhibition of the thyroid and the ability of the animals to differentiate between dosage levels of thyrotrophin were dependent upon the amount of iodinated casein in the diet. Graded doses of thyrotrophin provided a linear log dose –response line over the range 0.01 to 0.08 U.S.P. units. The response approached a maximum value at dose levels above 0.16 U.S.P. units. The thyroid gland of the female weanling rat retained, on the average, significantly more radioactive iodine than that of the male weanling rat when stimulated by thyrotrophin. Although the hormonal response was not correlated with the body weight of the rats within dosage groups, more precise assays were obtained by equalizing the total weight of the rats in each dosage group before the assay. Relatively large doses of I131 appeared to have an adverse effect on the precision of the assay but did not influence the response to thyrotrophin.

ASSAY OF THYROTROPHIN BY THE ACCUMULATION OF RADIOACTIVE IODINE IN THE THYROID OF THE INTACT RAT

1955 ◽  
Vol 33 (1) ◽  
pp. 248-255
Author(s):  
N. R. Stephenson ◽  
W. P. McKinley ◽  
P. J. Kavanagii
Keyword(s):  
Adverse Effect ◽  
Body Weight ◽  
Thyroid Gland ◽  
Radioactive Iodine ◽  
The Body ◽  
Dosage Group ◽  
Maximum Value ◽  
Weanling Rats ◽  
Response Line ◽  
Dose Levels

The ability of the thyroid gland of intact weanling rats to collect injected radioactive iodine was diminished by inclusion of a small amount of iodinated casein in the diet. The administration of exogenous thyrotrophin increased the thyroidal uptake of I131 in rats treated in this manner. Both the degree of inhibition of the thyroid and the ability of the animals to differentiate between dosage levels of thyrotrophin were dependent upon the amount of iodinated casein in the diet. Graded doses of thyrotrophin provided a linear log dose –response line over the range 0.01 to 0.08 U.S.P. units. The response approached a maximum value at dose levels above 0.16 U.S.P. units. The thyroid gland of the female weanling rat retained, on the average, significantly more radioactive iodine than that of the male weanling rat when stimulated by thyrotrophin. Although the hormonal response was not correlated with the body weight of the rats within dosage groups, more precise assays were obtained by equalizing the total weight of the rats in each dosage group before the assay. Relatively large doses of I131 appeared to have an adverse effect on the precision of the assay but did not influence the response to thyrotrophin.

scholarly journals Amelioration of complete Freund’s adjuvant-induced arthritis by Calotropis procera latex in rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Roshni Patel ◽  
Shahrukh Kadri ◽  
Priyanshee Gohil ◽  
Shrikalp Deshpande ◽  
Gaurang Shah
Keyword(s):  
Body Weight ◽  
Bone Erosion ◽  
Hematological Parameters ◽  
Adult Population ◽  
The Body ◽  
Complete Freund’S Adjuvant ◽  
Calotropis Procera ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

Abstract Background Rheumatoid arthritis is the most common cause of disability, affecting 0.3–1% of the adult population worldwide. The latex of Calotropis procera possesses potent anti-inflammatory as well as analgesic properties. In light above facts, the present study was designed to evaluate anti-arthritic activity of Calotropis procera latex in complete Freund's adjuvant (CFA)-induced arthritis in Wistar albino rats. Complete Freund's adjuvant was injected into the left hind paw on day 0, and treatment of prednisolone and Calotropis procera latex was given from day 0 to 28. Various biochemical, hematological and functional parameters as well as radiological and histopathological changes of joint along with body weight and paw volume were measured. Results Calotropis procera treatment significantly lowered paw volume in CFA-induced arthritic rats. Significant improvement was observed in functional, biochemical and hematological parameters in Calotropis procera-treated rats. However, the body weight remained unaffected. Histological and radiographical examination of synovial joints in Calotropis procera-treated animals exhibited less synovial hyperplasia, infiltration and accumulation of inflammatory cell in synovial fluid, cartilage and bone erosion and joint space narrowing. Conclusion Calotropis procera latex possesses anti-arthritic activity, which is facilitated by modulation in the level of inflammatory mediators and oxidative stress. The improvement in hematological as well as biochemical parameters might be reflected on functional, histopathological, radiological changes and thereby disease progression.

scholarly journals Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

2021 ◽  
Author(s):  
Mostafa A. Askar ◽  
Mona S. Guida ◽  
Seham. M. AbuNour ◽  
Essam A. Ragab ◽  
Eiman N. Ali ◽  
...  
Keyword(s):  
Body Weight ◽  
Gamma Rays ◽  
Hematological Parameters ◽  
The Body ◽  
Histopathological Study ◽  
Biological Processes ◽  
T Helper ◽  
Γ Rays ◽  
Cd4 Cell ◽  
Morphological State

Abstract Zinc Coumarate and zinc caffeiatenano-particles (ZCoNPs, ZCaNPs) have been shown to affectthe different biological processes. This work was undertaken to evaluate the mitigating action of ZCoNPs in combination with ZCaNPsagainst liver damage induced by gamma rays (γ-rays). Rats were exposed to 7Gy of γ-rays, and theninjected intraperitoneally (i.p.) with ZCoNPs [2U / rat / day (5 mg/kg)], and ZCaNPs [2U / rat / day (15 mg/kg)] for 7 consecutive days.The results showed that irradiated rats treated with ZCoNPs (5 mg/kg/body weight) in combination with ZCaNPs (15 mg/kg/body weight) for 7 days revealed a significant increase in the body weight, antioxidants levels, T Helper (CD4) Cell and T Cytotoxic (CD8), associated with amarked decrease in the level of lipid peroxidation (LP), nitric oxide(NOx), total free radicals concentrate (TFRC), and DNA fragmentation. Moreover, positive alterations in the morphological state, hematological parameters, and thecell cycle phases were noticed. Additionally, the histopathological study demonstrated an improvement in the liver tissue of irradiated rats after treatment.Thus, ZCoNPs and ZCaNPscould be usedas a natural mitigating agent to reduce the hazards of ionizing radiation.

scholarly journals Effects of neem, betel leaf, devil's tree, jute and turmeric against gastrointestinal nematodes in sheep

1970 ◽  
Vol 8 (2) ◽  
pp. 259-263 ◽  
Author(s):  
MR Amin ◽  
M Mostofa ◽  
MN Islam ◽  
MA Asgar
Keyword(s):  
Body Weight ◽  
Hematological Parameters ◽  
Water Extract ◽  
Gastrointestinal Nematode ◽  
Experimental Period ◽  
Gastrointestinal Nematodes ◽  
The Body ◽  
Control Group ◽  
Betel Leaf ◽  
Group A

Effects of neem, betel leaf, devil’s tree, jute and turmeric against natural gastrointestinal nematodes in sheep and on some hematological parameters (TEC, Hb and PCV) and body weight were studied. Thirty (30) naturally parasitized sheep were randomly divided into six groups(A, B, C, D, E and F), each consisting of five sheep. Ten percent water extract of leaves of neem, betel leaf, devil’s tree and jute were administered orally to the sheep of group A, B, C and D, respectively. Sheep of group E was treated orally with 10% water extract of rhizome of turmeric. Sheep of group F was kept as infected control group. Fecal samples, hematological parameters and body weight were examined before treatment and on 7th, 14th, 21st and 28th day. A significant (p<0.01) reduction of EPG count was found following administration of neem (37.60-47.03%), betel leaf (6.43-14.00%), devil’s tree (3.04-11.04%), jute (0.50-5.26%) and turmeric (0.46-8.30) in sheep. The EPG count of the control group (F) were significantly (p<0.01) increased up to the last day of experimental period. After treatment with neem, betel leaf, devil’s tree, jute and turmeric total erythrocyte count (TEC), hemoglobin (Hb) content and packed cell volume (PCV) were increased significantly (p<0.01 and p<0.05) in sheep. The body weight was increased significantly (p<0.01 and p<0.05) in neem, betel leaf, devil’s tree, jute and turmeric treated sheep. On the other hand, body weight was decreased in untreated control group. The present study reveal that 10% water extract of neem was moderately effective and betel leaf, devil’s tree, jute and turmeric were relatively less effective against gastrointestinal nematodes in sheep. Keywords: Neem; Betel leaf; Devil’s tree; Jute; Turmeric; Gastrointestinal nematode DOI: 10.3329/jbau.v8i2.7935 J. Bangladesh Agril. Univ. 8(2): 259-263, 2010  

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